Article
Multidisciplinary Sciences
Matias Blomqvist, Ilmari Koskinen, Eliisa Loyttyniemi, Tuomas Mirtti, Peter J. Bostrom, Pekka Taimen
Summary: In bladder cancer patients, the stem cell markers ALDH1, SOX2, and SSEA-4 show little prognostic or predictive value, with weak or negative cytoplasmic SOX2 staining being associated with lymphovascular invasion and cancer-specific survival but not significantly.
SCIENTIFIC REPORTS
(2021)
Review
Multidisciplinary Sciences
Wentao Zhang, Fuhan Yang, Shiyu Mao, Ruiliang Wang, Haotian Chen, Yuefei Ran, Shenghua Liu, Pengfei Wu, Yang Yan, Wei Li, Junfeng Zhang, Xudong Yao
Summary: Recent evidence suggests that the genitourinary microbiome plays a significant role in the development and progression of urological tumors, including bladder cancer. However, there is limited information available about the interaction between bladder cancer and the genitourinary microbiome, compared to the gut microbiota and gastrointestinal tumors. This expanding field merits further investigation for its potential impact on bladder cancer diagnosis, prevention, and treatment prospects.
Article
Biochemistry & Molecular Biology
Yaming Liu, Guodong Wang, Tongwei Cui, Lin Lv
Summary: The study evaluated the expression and clinical significance of GPR123 in bladder cancer, showing that high GPR123 expression is associated with easier recurrence and poorer prognosis. Detecting GPR123 with IHC after operation could help identify high-risk patients and guide post-operational surveillance.
Article
Biochemistry & Molecular Biology
Despoina D. Gianniou, Aimilia D. Sklirou, Maria-Alexandra Papadimitriou, Katerina-Marina Pilala, Konstantinos Stravodimos, Margaritis Avgeris, Andreas Scorilas, Ioannis P. Trougakos
Summary: This study investigated the expression and role of HSPB2 and HSPB3 genes in bladder cancer patients and bladder cancer cells. The results showed increased expression levels of HSPB2 and HSPB3 genes and proteins in high-grade bladder cancer cells. In clinical samples, the expression levels of HSPB2 and HSPB3 genes were significantly downregulated in bladder tumors but showed an upregulation trend in muscle-invasive and high-grade tumors. These findings suggest that HSPB2 and HSPB3 have a pro-survival role in advanced bladder cancer and can be targeted as novel molecular markers for treatment optimization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Hexiang Wang, Meng Zhang, Jianguo Miao, Feng Hou, Yunqing Chen, Yonghua Huang, Lei Yang, Shifeng Yang, Chencui Huang, Yancheng Song, Haitao Niu
Summary: This study developed and validated a model for predicting the risk of recurrence in BCa patients postoperatively, using 3-phase enhanced CT images and deep learning techniques. The predictive performance and survival benefits of the model were assessed.
Article
Oncology
Shuai Liu, Yu Yao, Zhan-Kun Wang, Li-Jiang Sun, Gui-Ming Zhang
Summary: Sarcomatoid carcinoma of the bladder is a rare disease with limited knowledge about the prognostic impact of its components. This study aimed to assess the prognostic value of the proportion of sarcomatoid components and validate the worse survival outcomes of sarcomatoid carcinomas. Propensity score matching was used to compare the survival rates of patients with sarcomatoid and non-sarcomatoid carcinomas. The results showed that patients with sarcomatoid carcinoma had worse 5-year cancer-specific survival and recurrence-free survival rates, especially in the subgroup with muscle invasion. A higher proportion of sarcomatoid components was associated with poorer survival.
Review
Oncology
Guodong Chen, Yan Chen, Ruiquan Xu, Guoxi Zhang, Xiaofeng Zou, Gengqing Wu
Summary: This review summarizes the role and significance of SOX2 in bladder cancer, analyzes the regulatory mechanisms and signaling pathways related to SOX2, and proposes potential directions for future research, providing new insights for the treatment of bladder cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Qingyun Zhang, Qinqiao Lai, Shan Wang, Qinggui Meng, Zengnan Mo
Summary: The dynamic change of postoperative NLR is a potential marker for the early detection of bladder cancer recurrence. Patients with increased NLR after surgery tend to have higher risk of recurrence.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Oncology
Seung-hwan Jeong, Jang Hee Han, Chang Wook Jeong, Hyeon Hoe Kim, Cheol Kwak, Hyeong Dong Yuk, Ja Hyeon Ku
Summary: This study retrospectively examined pTa bladder cancer patients enrolled in the Seoul National University patient registry system SUPER-UC to determine the clinical risk factors for recurrence and its significance in relation to recurrence interval. Results showed that early recurrence was associated with poorer outcomes compared to late recurrence, highlighting the importance of close monitoring for patients with high-risk factors.
Article
Oncology
Jedrzej Borowczak, Krzysztof Szczerbowski, Mateusz Maniewski, Marek Zdrenka, Piotr Slupski, Paulina Antosik, Sylwia Kolodziejska, Marta Sekielska-Domanowska, Mariusz Dubiel, Magdalena Bodnar, Lukasz Szylberg
Summary: This article investigates the prognostic role of cyclin-dependent kinase 9 expression in urothelial carcinoma. The results show that high CDK9 expression is associated with a better prognosis, tumor grade, stage, and invasiveness, contradicting previous findings. CDK9 may play a crucial role in the early stages of urothelial carcinoma.
Article
Chemistry, Multidisciplinary
Ting Liang, Tao Tao, Kai Wu, Lisha Liu, Wuwu Xu, Dewang Zhou, Hu Fang, Qiuxia Ding, Guixiao Huang, Song Wu
Summary: This study investigates the heterogeneity of the tumor microenvironment (TME) in primary and recurrent bladder carcinoma (BC) using single-cell RNA sequencing. Two cancer stem cell (CSC) subtypes and an inflammatory cancer-associated fibroblasts (iCAFs) subtype, specifically associated with BC recurrence, are identified. iCAFs secrete FGF2, interacting with CD44 receptor on rCSC-M, thereby maintaining tumor stemness and epithelial-mesenchymal transition. Moreover, iCAFs secrete CCL2, which binds to CCR2 in myeloid-derived suppressor cells (MDSCs). The study highlights the role of iCAFs in cell-cell crosstalk within the TME during recurrent BC.
Article
Medicine, Research & Experimental
Yanan Liu, Zhiguang Gao, Cheng Peng, Xingli Jiang
Summary: We constructed a prognostic score (PS) model based on gene data to predict the recurrence risk in patients with laryngeal cancer (LC).
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Rina Di Bonaventura, Maurizio Martini, Tonia Cenci, Valerio Maria Caccavella, Valeria Barresi, Marco Gessi, Alessio Albanese, Liverana Lauretti, Roberto Pallini, Quintino Giorgio D'Alessandris, Alessandro Olivi
Summary: Meningiomas, mostly benign tumors, can sometimes display aggressive behavior and recurrence despite complete resection. This study investigated the role of SOX2 in predicting the aggressiveness of meningioma and found that SOX2 expression at first surgery is strongly related to the clinical behavior, histological grade, and risk of recurrence of meningioma. Additionally, SOX2 expression is associated with overall and recurrence-free survival in patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Chuanxu Luo, Shuang Zhao, Cheng Peng, Chengshi Wang, Kejia Hu, Xiaorong Zhong, Ting Luo, Juan Huang, Donghao Lu
Summary: The study identified 15 mammographic radiomics features associated with breast cancer iDFS in the craniocaudal view but none in the mediolateral oblique view. Two lead features, S(1,-1)SumAverg and WavEnLL_s-6, were found to be associated with favorable and poor iDFS, respectively. These features were linked to eight pathways primarily involving cell cycle regulation in tumor tissues.
BRITISH JOURNAL OF CANCER
(2022)
Article
Health Care Sciences & Services
Chih-Huang Tseng, Pei-Hsuan Lu, Yi-Ping Wang, Julia Yu Fong Chang
Summary: Ameloblastoma is a common benign odontogenic neoplasm with aggressive behavior and high recurrence rate. This study found the presence of SOX2-positive cells in ameloblastomas, possibly correlated with BRAF(V600E) mutation. These findings may guide the development of personalized treatments.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Multidisciplinary Sciences
Siobhan Crittenden, Marie Goepp, Jolinda Pollock, Calum T. Robb, Danielle J. Smyth, You Zhou, Robert Andrews, Victoria Tyrrell, Konstantinos Gkikas, Alexander Adima, Richard A. O'Connor, Luke Davies, Xue-Feng Li, Hatti X. Yao, Gwo-Tzer Ho, Xiaozhong Zheng, Amil Mair, Sonja Vermeren, Bin-Zhi Qian, Damian J. Mole, Konstantinos Gerasimidis, Jurgen K. J. Schwarze, Richard M. Breyer, Mark J. Arends, Valerie B. O'Donnell, John P. Iredale, Stephen M. Anderton, Shuh Narumiya, Rick M. Maizels, Adriano G. Rossi, Sarah E. Howie, Chengcan Yao
Summary: The study finds that the inflammation mediator prostaglandin E-2 inhibits T-reg cells by affecting gut microbiota, leading to exacerbation of intestinal inflammation. The mechanism involves PGE(2) altering gut microbiota, adjusting T-reg cell response and intestinal mononuclear phagocyte activity, ultimately resulting in aggravated inflammation.
Article
Biochemistry & Molecular Biology
Muhammad Yasir Asghar, Taru Lassila, Ilkka Paatero, Van Dien Nguyen, Pauliina Kronqvist, Jixi Zhang, Anna Slita, Christoffer Lof, You Zhou, Jessica Rosenholm, Kid Tornquist
Summary: Research shows that STIM1 and ORAI1 are upregulated in thyroid cancer, and their knockdown can attenuate SOCE, reduce invasion and expression of promigratory factors, inhibit cell proliferation, and increase sensitivity to chemotherapeutic drugs.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Rheumatology
Rabaa Takala, Dipak P. Ramji, Robert Andrews, You Zhou, James Burston, Ernest Choy
Summary: The study demonstrates the anti-inflammatory effects of pinolenic acid (PNLA) in human cell lines and peripheral blood mononuclear cells (PBMCs), and its impact on cell migration and macrophage function.
Article
Biochemistry & Molecular Biology
Amita Arora, Annukka M. Kivela, Ling Wang, Rimante Minkeviciene, Juuso H. Taskinen, Birong Zhang, Annika Koponen, Jing Sun, Michiko Shirane, You Zhou, Pirta Hotulainen, Camilla Raiborg, Vesa M. Olkkonen
Summary: During angiogenesis, Protrudin plays a key role in regulating angiogenic tube formation and promoting endothelial cell migration through its effects on FAK activation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Multidisciplinary Sciences
Rabaa Takala, Dipak P. Ramji, Robert Andrews, You Zhou, Mustafa Farhat, Mohammed Elmajee, Shelley Rundle, Ernest Choy
Summary: Pinolenic acid (PNLA), an omega-6 polyunsaturated fatty acid from pine nuts, has direct anti-inflammatory effects and anti-atherogenic effects on monocytes. It reduces the expression of inflammatory cytokines and activates pathways that interfere with the pathophysiological process of atherosclerosis. PNLA also regulates key miRNAs involved in metabolic, mitochondrial, and inflammatory pathways.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Biomedical
Chao Sun, Yinhua Dong, Jun Wei, Meng Cai, Dongfang Liang, Yongqing Fu, You Zhou, Yi Sui, Fangda Wu, Roman Mikhaylov, Hanlin Wang, Feifei Fan, Zhihua Xie, Mercedes Stringer, Zhiyong Yang, Zhenlin Wu, Liangfei Tian, Xin Yang
Summary: This study develops a highly effective acoustic stimulator working at -20 MHz to investigate the roles of acousto-mechanical stimuli in the differentiation of hESCs. Our results show that acoustic dose alters the expression of extracellular matrix and physiological activity-related genes, indicating that acoustic stimulation is an important tool in regulating the stem cells' differentiation processes in cell therapy.
ACTA BIOMATERIALIA
(2022)
Article
Biochemistry & Molecular Biology
Meghana Nagaraj, Marcus Horing, Maria A. Ahonen, Van Dien Nguyen, You Zhou, Helena Vihinen, Eija Jokitalo, Gerhard Liebisch, P. A. Nidhina Haridas, Vesa M. Olkkonen
Summary: By studying the role of GOLM1 in lipid metabolism through siRNA-mediated GOLM1 depletion in Huh-7 HCC cells, it was found that reduced GOLM1 levels affected protein and lipid trafficking, leading to distorted intracellular lipid homeostasis, impacting mitochondrial function and cell proliferation.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Maria A. Ahonen, Marcus Horing, Van Dien Nguyen, Sami Qadri, Juuso H. Taskinen, Meghana Nagaraj, Martin Wabitsch, Pamela Fischer-Posovszky, You Zhou, Gerhard Liebisch, P. A. Nidhina Haridas, Hannele Yki-Jarvinen, Vesa M. Olkkonen
Summary: This study found that thyroid hormone responsive protein (THRSP) is regulated by insulin in human adipose tissue and adipocytes. Insulin resistance leads to downregulation of THRSP expression. Silencing of THRSP results in impaired mitochondrial function and disrupted lipid metabolism.
MOLECULAR MEDICINE
(2022)
Article
Medicine, Research & Experimental
Aina Lluch, Sonia R. Veiga, Jessica Latorre, Jose M. Moreno-Navarrete, Nuria Bonifaci, Van Dien Nguyen, You Zhou, Marcus Hoering, Gerhard Liebisch, Vesa M. Olkkonen, David Llobet-Navas, George Thomas, Ruth Rodriguez-Barrueco, Jose M. Fernandez-Real, Sara C. Kozma, Francisco J. Ortega
Summary: Inhibiting the activity of ribosomal protein S6 kinase 1 (S6K1) can reduce fat mass expansion, improve dyslipidemia and hepatic steatosis. Additionally, decreased S6K1 activity is associated with defective epithelial-mesenchymal transition and impaired expression of fatty acid translocase and Galectin 1.
Article
Allergy
Calum T. Robb, You Zhou, Jennifer M. Felton, Birong Zhang, Marie Goepp, Privjyot Jheeta, Danielle J. Smyth, Rodger Duffin, Sonja Vermeren, Richard M. Breyer, Shuh Narumiya, Henry J. McSorley, Rick M. Maizels, Jurgen K. J. Schwarze, Adriano G. Rossi, Chengcan Yao
Summary: The study found that deficient EP2 receptor increases ILC2 responses and eosinophilic inflammation, while exogenous activation of EP4 and EP2 or inhibition of phosphodiesterase restricts IL-33-induced ILC2 responses.
Article
Acoustics
Hanlin Wang, Fan Yuan, Zhihua Xie, Chao Sun, Fangda Wu, Roman Mikhaylov, Minghong Shen, Jian Yang, You Zhou, Dongfang Liang, Xianfang Sun, Zhenlin Wu, Zhiyong Yang, Xin Yang
Summary: Acoustofluidic techniques are widely used for manipulating nano- and micro-particles in microfluidics. This work developed and modeled two hybrid acoustofluidic devices, a double surface acoustic wave (SAW) transducer and a PZT-SAW transducer. The numerical study showed that these devices achieved higher acoustic pressure and particle velocities in the microchannel, and the amplitude and distribution pattern of the pressure can be controlled. The particle trajectories demonstrated that both SAW-SAW and PZT-SAW configurations generated significantly higher acoustic pressure and particle velocity. This study provides new insights for designing acoustofluidic devices with multiple SAW transducers to efficiently manipulate micro- and nano-particles.
Article
Immunology
Huiqing Lin, Jiejie Liu, Ning Li, Birong Zhang, Van Dien Nguyen, Peipei Yao, Jiangpeng Feng, Qianyun Liu, Yu Chen, Guang Li, You Zhou, Li Zhou
Summary: In this study, the researchers identified common transcriptional changes in the lungs of individuals with SLE, COVID-19-induced pulmonary fibrosis, and IPF. They found that the expression of matrix metalloproteinase genes and the pathway of neutrophil extracellular trap formation were similar in these diseases. NETs were more abundant in the lungs of SLE and COVID-19 patients compared to IPF patients, and their formation promoted epithelial-mesenchymal transition. The JAK2 inhibitor Tofacitinib disrupted NETs and reversed NET-induced EMT in lung epithelial cells, suggesting its potential as a treatment for fibrosis in SLE and COVID-19.
CLINICAL IMMUNOLOGY
(2023)
Article
Cell Biology
Oliver Wright, Anna Harris, Van Dien Nguyen, You Zhou, Maxim Durand, Abbie Jayyaratnam, Darren Gormley, Luke A. J. O'Neill, Kathy Triantafilou, Eva Maria Nichols, Lee M. Booty
Summary: The study reveals that C5aR2 regulates the IFN-beta response induced by the cGAS-STING pathway in human macrophages, suggesting a potential therapeutic option in interferon-related pathologies. These findings shed light on the role of C5aR2 in nucleic acid sensing in macrophages and provide insights for further research in interferon-related diseases.
Review
Gastroenterology & Hepatology
Van-Dien Nguyen, Timothy R. Hughes, You Zhou
Summary: Non-alcoholic fatty liver disease (NAFLD) is a growing public health threat with no approved specific treatment. The complement system plays a significant role in the development and progression of NAFLD by activating the extracellular complement system, affecting liver cells, and interacting with hepatic zonation. Targeting the complement system may be a potential therapeutic strategy for NAFLD.
LIVER INTERNATIONAL
(2023)
Article
Oncology
Vaishali Chaurasiya, Dan Duc Pham, Jukka Harju, Anne Juuti, Anne Penttila, Sharath Kumar Goud Emmagouni, Van Dien Nguyen, Birong Zhang, Sanni Perttunen, Salla Keskitalo, You Zhou, Kirsi H. Pietilainen, P. A. Nidhina Haridas, Vesa M. Olkkonen
Summary: Communication between adipocytes and endothelial cells plays an important role in the metabolic function of white adipose tissue. This study developed a method to isolate adipose microvascular endothelial cells (AMvEC) from visceral adipose tissue (VAT) and established a co-culture system to study their communication. Various experiments validated the identity and functionality of the isolated cells. Additionally, the co-culture system can be used for drug screening.
EXPERIMENTAL CELL RESEARCH
(2023)