Article
Biochemistry & Molecular Biology
Jessica Correa Bezerra Bellei, Nicolas Glanzmann, Barbara Albuquerque Carpinter, Daniela Chaves Renhe, Carolina Brandi Marques, Marina Rocha Azevedo, Livia Maria Barreto, Vinicius Novaes Rocha, Isabelle Karine da Costa Nunes, Henrique Marcelo Gualberto Pereira, Elaine Soares Coimbra, Eduardo Antonio Ferraz Coelho, Adilson David da Silva, Fernando de Pilla Varotti, Kezia Katiani Gorza Scopel
Summary: Chloroquine remains the most effective drug for malaria treatment, although resistance to it has emerged. This study focuses on the synthesis of quinoline derivatives to develop new antimalarials. Compound 3 showed promising activity against malaria, inhibiting parasite growth and protecting against severe malaria development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Cell Biology
Ines Leleu, Delphine Genete, Sophie Salome Desnoulez, Nasreddine Saidi, Priscille Brodin, Frank Lafont, Stanislas Tomavo, Sylviane Pied
Summary: Cerebral malaria is a neuroinflammatory disease induced by P. falciparum infection. This study demonstrates a non-canonical autophagy-lysosomal pathway in astrocytes plays a key role in the transfer and degradation of parasite microvesicles. Inhibition of autophagy process affects the transfer of microvesicles and impacts the development of cerebral malaria.
Article
Microbiology
Clare K. Cimperman, Mirna Pena, Sohret M. Gokcek, Brandon P. Theall, Meha V. Patel, Anisha Sharma, ChenFeng Qi, Daniel Sturdevant, Louis H. Miller, Patrick L. Collins, Susan K. Pierce, Munir Akkaya
Summary: Hundreds of thousands of lives are lost each year due to brain damage caused by malaria. The majority of these deaths occur in sub-Saharan African children. Host genetic background plays a crucial role in determining the course and outcome of the disease.
Article
Immunology
Subulade A. Ademola, Oluwayemi J. Bamikole, Olukemi K. Amodu
Summary: Malaria remains a global public health issue, particularly in sub-Saharan Africa. The number of malaria deaths decreased steadily from 2000 to 2019, but there was an increase of 10% in 2020 due to disruptions caused by the COVID-19 pandemic. Four countries, namely Nigeria, the Democratic Republic of the Congo, Niger, and Tanzania, accounted for over half of the malaria deaths globally. Nigeria has the highest burden of diabetes in Africa, with a prevalence of 5.77%. Studies have shown an interaction between malaria and type 2 diabetes (T2D), with malaria infection in pregnancy potentially leading to low birth weight and an increased risk of T2D later in life. Inflammation, particularly involving tumor necrosis factor alpha (TNF-a), plays a crucial role in the co-existence of malaria and T2D.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Multidisciplinary Sciences
Nana K. Minkah, Stefan H. I. Kappe
Summary: Clinical evidence suggests that utilizing live parasites growing in the liver for vaccination can generate high levels of immune protection against malaria infection, highlighting the urgent need for effective malaria vaccines.
Article
Immunology
Hongxia Duan, Shuai Zhao, Jianquan Xiang, Chenhui Ju, Xuehui Chen, Irene Gramaglia, Xiyun Yan
Summary: The study found that endothelial CD146 plays a crucial role in experimental cerebral malaria, with its overexpression leading to the aggregation of infected red blood cells and lymphocytes, thereby disrupting BBB integrity. Deletion of endothelial CD146 or treatment with anti-CD146 antibody can prevent severe symptoms of cerebral malaria, and combined treatment with anti-CD146 antibody and antiparasitic drugs can improve cognition and memory in patients with cerebral malaria.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Casper Hempel, Dan Milner, Karl Seydel, Terrie Taylor
Summary: Recent studies suggest that endothelial glycocalyx plays a role in malaria pathogenesis. Using postmortem brain samples, changes in specific sugar epitopes were found in cerebral capillaries of children who died from cerebral malaria compared to nonmalarial comas. These findings suggest specific remodeling of cerebral microvessels in cerebral malaria patients.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Tarun Keswani, Aisha Obeidallah, Edward Nieves, Simone Sidoli, Melissa Fazzari, Terrie Taylor, Karl Seydel, Johanna P. Daily
Summary: This study explored the metabolic etiology of cerebral malaria coma and found abnormal concentrations of pipecolic acid (PA) in the plasma of CM patients, which were associated with renal insufficiency. PA levels were found to be correlated with normal behavior and blood-brain barrier (BBB) permeability in animal models. The findings suggest that malaria-generated PA induces coma in CM and ECM.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Parasitology
Anupriya Mehra, S. N. Balaji, Vishal Trivedi
Summary: The study found that exposure of uninfected RBCs to malarial pigment hemozoin induced structural abnormalities and increased oxidative stress, affecting the formation of cytoadherence complexes. Antioxidant molecules can reverse this effect, indicating that oxidative stress may be a key factor in controlling cerebral malaria pathology.
Article
Cell Biology
James A. Watson, Sophie Uyoga, Perpetual Wanjiku, Johnstone Makale, Gideon M. Nyutu, Neema Mturi, Elizabeth C. George, Charles J. Woodrow, Nicholas P. J. Day, Philip Bejon, Robert O. Opoka, Arjen M. Dondorp, Chandy C. John, Kathryn Maitland, Thomas N. Williams, Nicholas J. White
Summary: Severe malaria caused by Plasmodium falciparum is difficult to accurately diagnose in children in high-transmission settings. A combination of platelet count and plasma PfHRP2 concentration can be used to identify severe falciparum malaria in severely ill patients. About one-third of children enrolled in clinical studies of severe malaria in high-transmission settings in Africa had other causes of their severe illness.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Laughing Bear Torrez Dulgeroff, Miranda S. Oakley, Michal C. Tal, Ying Ying Yiu, Joy Q. He, Maia Shoham, Victoria Majam, Winter A. Okoth, Pallavi Malla, Sanjai Kumar, Irving L. Weissman
Summary: CD47 is an antiphagocytic signal that inhibits programmed cell removal of self. Blocking CD47 can significantly improve the therapeutic effect against malaria infection.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Haoan Yi, Weiyang Jiang, Fang Yang, Fan Li, Yirong Li, Wenjing Zhu, Qing Li, Syed Hassam Fakhar, Yaming Cao, Lan Luo, Wen Zhang, Yongshu He
Summary: Studies show that G6pd-deficient mice have a survival advantage, less severe ECM, and mild liver injury when combating malaria. This protection is related to proinflammatory responses, where Th1 differentiation and dendritic cell maturation in the liver and spleen are inhibited in G6pd-deficient mice. Our findings reveal a novel understanding of how G6PD deficiency protects against malaria in vivo.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Tahir Hussain, Jose Linera-Gonzalez, John M. Beck, Manuel A. Fierro, Gunnar R. Mair, Ryan C. Smith, Josh R. Beck
Summary: During vertebrate infection, Plasmodium parasites utilize a dual-function pore formed by EXP2 for nutrient transport and effector protein export. This study reveals the importance of EXP2 in intrahepatic parasite development, suggesting that PTEX components also function at the hepatocyte-parasite interface.
Article
Neurosciences
Yan Shen, Yinghui Li, Qinghao Zhu, Jun Wang, Yuxiao Huang, Jiao Liang, Xingan Wu, Ya Zhao
Summary: The study focuses on elucidating the negative regulation mechanism of microglia in the brain during ECM, as well as evaluating the protective effect of enhancing the PD-1/PD-L1 pathway through adenovirus injection. Results showed that upregulation of the PD-1/PD-L1 pathway in microglia alleviated neuroinflammation and synergized with artemisinin to improve ECM symptoms.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Psychology, Social
Lucas J. Dixon, Matthew J. Hornsey, Nicole Hartley
Summary: In this study, we investigated the psychology of those who believe in manifestation, which is the belief that one can attract success in life through positive self-talk, visualization, and symbolic actions. Through three studies involving a total of 1,023 participants, we developed a reliable and valid measure called the Manifestation Scale and found that over one third of participants endorsed manifestation beliefs. Those who scored higher on the scale perceived themselves as more successful, had stronger aspirations for success, and believed they were more likely to achieve future success. They were also more likely to engage in risky investments, have experienced bankruptcy, and believe in achieving unlikely success quickly. We discuss the potential advantages and disadvantages of this belief system in the context of a growing public desire for success and an industry that capitalizes on these desires.
PERSONALITY AND SOCIAL PSYCHOLOGY BULLETIN
(2023)
Review
Parasitology
Yuri C. Martins, Herbert B. Tanowitz, Kevin R. Kazacos
Article
Chemistry, Medicinal
Massimo Bertinaria, Pamela Orjuela-Sanchez, Elisabetta Marini, Stefano Guglielmo, Anthony Hofer, Yuri C. Martins, Graziela M. Zanini, John A. Frangos, Alberto Gasco, Roberta Fruttero, Leonardo J. M. Carvalho
JOURNAL OF MEDICINAL CHEMISTRY
(2015)
Article
Pathology
Yuri C. Martins, Brandi D. Freeman, Oscar B. Akide Ndunge, Louis M. Weiss, Herbert B. Tanowitz, Mahalia S. Desruisseaux
AMERICAN JOURNAL OF PATHOLOGY
(2016)
Article
Microbiology
Brandi D. Freeman, Yuri C. Martins, Oscar B. Akide-Ndunge, Fernando P. Bruno, Hua Wang, Herbert B. Tanowitz, David C. Spray, Mahalia S. Desruisseaux
Article
Medicine, Research & Experimental
Dermot P. Maher, Yuri Chaves Martins, Tina Doshi, Mark Bicket, Kui Zhang, George Hanna, Shihab Ahmed
Article
Rheumatology
L. R. Gomes, Y. C. Martins, M. F. Ferreira-da-Cruz, C. T. Daniel-Ribeiro
Article
Infectious Diseases
Yuri C. Martins, Leah Clemmer, Pamela Orjuela-Sanchez, Graziela M. Zanini, Peng Kai Ong, John A. Frangos, Leonardo J. M. Carvalho
Article
Parasitology
Leonardo Jose de Moura Carvalho, Aline da Silva Moreira, Claudio Tadeu Daniel-Ribeiro, Yuri Chaves Martins
MEMORIAS DO INSTITUTO OSWALDO CRUZ
(2014)
Article
Microbiology
Yuri Chaves Martins, Arnon Dias Jurberg, Claudio Tadeu Daniel-Ribeiro
Summary: The concept of molecular mimicry describes the antigen sharing between parasites and hosts, which can benefit pathogen evasion from host immune responses, but it can also trigger autoimmunity. This concept has been extensively studied in humans and has raised increasing interest among immunologists. Through genomics and bioinformatics studies, it has been found that there is massive antigenic sharing between different organisms, but the degree of sharing is not related to pathogenicity or virulence. It is also rare for autoimmunity to develop in response to infections with microorganisms that have cross-reacting antigens, suggesting that molecular mimicry alone is not sufficient to disrupt self-tolerance mechanisms.
Article
Medicine, General & Internal
Sung Hwan Park, Kristen Hunter, Hugh Berry, Yuri Chaves Martins
Summary: This article describes a case of a young African American male who developed atrial fibrillation after starting gabapentin. The patient underwent successful cardioversion and was discharged on medication. The importance of monitoring for adverse effects of gabapentin, especially in young individuals, is emphasized.
JOURNAL OF MEDICAL CASE REPORTS
(2023)
Review
Parasitology
Yuri Chaves Martins, Flavia Lima Ribeiro-Gomes, Claudio Tadeu Daniel-Ribeiro
Summary: Innate immunity is the first line of defense against pathogens, cancer cells, and toxins. It also plays a crucial role in activating the body's specific immune response. This overview highlights the key findings and ideas that have contributed to the development of innate immunity as a branch of modern immunology.
MEMORIAS DO INSTITUTO OSWALDO CRUZ
(2023)
Meeting Abstract
Endocrinology & Metabolism
B. Freeman, Y. C. Martins, F. P. Bruno, D. C. Spray, M. S. Desruisseaux
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2016)
Meeting Abstract
Public, Environmental & Occupational Health
Brandi D. Freeman, Yuri C. Martins, Mahalia S. Desruisseaux
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2015)
Meeting Abstract
Anesthesiology
Yuri C. Martins, Dermot P. Maher, Kui Zhang, George Hanna, Shihab Ahmed
ANESTHESIA AND ANALGESIA
(2017)
Article
Medicine, Research & Experimental
Tong Cheng, Zhusheng Chen, Yibin Qin, Xiang Zhu, Hongsheng Chen, Zhongling Xu, Xiaqing Ma
Summary: Morphine is commonly used and effective for pain relief, but its side effect of itching limits its clinical use. This paper discusses the potential of using esketamine to treat morphine-induced itching.
MEDICAL HYPOTHESES
(2024)
Article
Medicine, Research & Experimental
Sung Eun Lee, Eunjung Park, Ji-yun Kim, HyukHoon Kim
Summary: Hyperbaric oxygen therapy (HBOT) is a potential therapeutic modality that has been recognized for its favorable mechanisms in various diseases, including sepsis-associated encephalopathy (SAE). HBOT has neuroprotective effects through its anti-inflammatory and antiapoptotic effects as well as increased tissue oxygenation capacity. However, there are caveats and limitations in applying HBOT in sepsis.
MEDICAL HYPOTHESES
(2024)