Article
Biochemistry & Molecular Biology
Martin Direder, Tamara Weiss, Dragan Copic, Vera Vorstandlechner, Maria Laggner, Karin Pfisterer, Caterina Selina Mildner, Katharina Klas, Daniel Bormann, Werner Haslik, Christine Radtke, Matthias Farlik, Lisa Shaw, Bahar Golabi, Erwin Tschachler, Konrad Hoetzenecker, Hendrik Jan Ankersmit, Michael Mildner
Summary: This study identifies a unique population of Schwann cells in keloids and highlights the interaction between Schwann cells and macrophages in keloid formation.
Review
Cell Biology
Hongbo Chen, Kai Hou, Yiping Wu, Zeming Liu
Summary: Hypertrophic scars or keloid formation is a complex process involving multiple cells and factors. Adipose stem cells (ASCs) have shown potential in treating hypertrophic scarring or keloid, making them a promising approach for treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell & Tissue Engineering
Olivia N. Tran, Hanzhou Wang, Shengxian Li, Andrey Malakhov, Yuyang Sun, Parveez A. Abdul Azees, Aaron O. Gonzalez, Brian Cao, Milos Marinkovic, Brij B. Singh, David D. Dean, Chih-Ko Yeh, Xiao-Dong Chen
Summary: The study demonstrates that induced trans-differentiation of bone marrow-derived mesenchymal stem cells (BM-MSCs) into salivary gland (SG) epithelial cells is a feasible approach for treating SG hypofunction, potentially restoring saliva production.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Developmental Biology
Ping Wu, Ting-Xin Jiang, Mingxing Lei, Chih-Kuan Chen, Shu-Man Hsieh Li, Randall B. Widelitz, Cheng-Ming Chuong
Summary: The dermis plays a crucial role in maintaining tissue homeostasis during cycles of growth and wounding in feather follicles of chickens. Different states of dermal cells are identified, with specific cellular flows involved in the regeneration process. Transcriptome analysis helps identify marker genes and molecular signaling associated with dermal specification, providing insights into homeostasis and tissue remodeling of mesenchymal progenitors.
Article
Cell Biology
Krystle Joy Ng, Jamien Lim, Yolanda Nwayhtetmaw Tan, Delia Quek, Zoe Lim, Nikolaos Pantelireis, Carlos Clavel
Summary: This study reveals that dermal papilla cells within the hair follicle not only induce hair growth but also regulate hair color. Sox2 is identified as a key regulator of melanocyte signaling, affecting the expression of genes related to melanin production through the regulation of Agouti, Corin, and bone morphogenic protein signaling.
Review
Biochemistry & Molecular Biology
Emilia Manole, Cristina Niculite, Ioana Maria Lambrescu, Gisela Gaina, Octavian Ioghen, Laura Cristina Ceafalan, Mihail Eugen Hinescu
Summary: Macrophages play a crucial role in maintaining tissue homeostasis and repair, displaying heterogeneity in response to environmental cues. Their diverse functions as M1 and M2 phenotypes contribute to tissue damage and wound healing, emphasizing the importance of understanding their intervention in stem cell behavior and niche regulation for developing novel therapeutic strategies in different diseases.
Article
Anatomy & Morphology
Hongzhi Song, Xu-Bo Zhao, Qing-Song Chu, Jianyu Zhang, Lipeng Gao, Xin-Hua Liao
Summary: In this study, the expression dynamics of transcription factor lymphoid enhancer-binding factor 1 (LEF1) in skin during development and hair cycle were revealed. LEF1 is expressed in terminal Schwann cells (TSCs), indicating that the LEF1/Wnt signal might help establish a niche at the isthmus region for the lanceolate complex, bulge stem cells, and other neighboring cells.
DEVELOPMENTAL DYNAMICS
(2023)
Review
Cell Biology
Raheleh Farahzadi, Behnaz Valipour, Soheila Montazersaheb, Ezzatollah Fathi
Summary: Adult stem cells (ASCs) throughout the body can support tissue growth and repair. The function of stem cells is influenced by signals derived from their specific microenvironment or niche. Studies have shown that aging of the niche can lead to a decline in stem cell function and is associated with aging and age-related disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Oncology
Sifan Wu, Xiaoxia Xing, Yaohui Wang, Xi Zhang, Miao Li, Mimi Wang, Zhiming Wang, Jie Chen, Dongmei Gao, Yan Zhao, Rongxin Chen, Zhenggang Ren, Kezhi Zhang, Jiefeng Cui
Summary: The study revealed that LOXL2 released by primary HCC tumors promotes the formation of lung pre-metastatic niche and occurrence of lung metastasis. LOXL2-induced matrix stiffening synergistically regulates the formation of lung pre-metastatic niche. Targeting LOXL2-induced lung pre-metastatic niche may be a novel intervention approach against HCC metastasis.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Cell Biology
Na Yuan, Wen Wei, Li Ji, Jiawei Qian, Zhicong Jin, Hong Liu, Li Xu, Lei Li, Chen Zhao, Xueqin Gao, Yulong He, Mingyuan Wang, Longhai Tang, Yixuan Fang, Jianrong Wang
Summary: The bone marrow niche, responsible for maintaining hematopoietic stem cell homeostasis, declines in function with aging and hematological malignancies. This study reveals that disrupting autophagy in HSCs accelerates niche aging, while transplantation of young donor HSCs repairs the niche environment. Further investigation shows that HSCs transdifferentiate into functional niche cells, including mesenchymal stromal cells and endothelial cells, in an autophagy-dependent manner. These findings provide a clinical solution to rejuvenate an aged or damaged bone marrow hematopoietic niche.
Article
Multidisciplinary Sciences
Ningbo Wu, Hongxiang Sun, Xiaoyun Zhao, Yao Zhang, Jianmei Tan, Yuanyuan Qi, Qun Wang, Melissa Ng, Zhaoyuan Liu, Lingjuan He, Xiaoyin Niu, Lei Chen, Zhiduo Liu, Hua-Bing Li, Yi Arial Zeng, Manolis Roulis, Dou Liu, Jinke Cheng, Bin Zhou, Lai Guan Ng, Duowu Zou, Youqiong Ye, Richard A. Flavell, Florent Ginhoux, Bing Su
Summary: The study identified a subset of intestinal stromal cells, MRISCs, as the primary cellular source of WNT agonist R-spondin 1 following intestinal injury in mice. These MRISCs are located at the bases of colon crypts, maintain LGR5(+) intestinal stem cells, and protect against acute intestinal damage through enhanced R-spondin 1 production. The mechanism involves a reactive oxygen species (ROS)-MAP3K2-ERK5-KLF2 axis to augment WNT signaling for intestinal regeneration.
Article
Cell Biology
Pieter Martino, Raghava Sunkara, Nicholas Heitman, Martina Rangl, Alexia Brown, Nivedita Saxena, Laura Grisanti, Donald Kohan, Masashi Yanagisawa, Michael Rendl
Summary: The researchers found that endothelin produced by hair follicle progenitors binds to endothelin receptors on dermal sheath cells, triggering their contraction and hair follicle regression. This study reveals that the endothelin signaling pathway plays a crucial role in regulating dermal sheath contraction.
NATURE CELL BIOLOGY
(2023)
Article
Cell & Tissue Engineering
Jennifer Steens, Lea Klar, Christine Hansel, Alexis Slama, Thomas Hager, Verena Jendrossek, Clemens Aigner, Diana Klein
Summary: Human lungs contain endogenous mesenchymal stem cells, with lung-resident MSCs predominantly located in the vascular stem cell niche of lung arteries. These LR-MSCs bear similarities to MSCs derived from adult human blood vessel walls, expressing a specific HOX code. The identification of LR-MSCs as VW-MSCs has implications for understanding lung physiology, pulmonary diseases, and therapeutic approaches.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Dermatology
Fang Liu, Tingting Yu, Jianlan Liu, Quyang Yang, Jinyan Wu, Jie Ren, Ningwen Zhu
Summary: This study found that adipose tissue-derived stem cells (ASCs) can inhibit keloid formation by inhibiting IGFBP-7, and further research found that ASCs prevent keloid formation by inhibiting the BRAF/MEK/ERK signaling pathway.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Delin Liu, Yidi Zhang, Lisha Zhen, Rong Xu, Zhenling Ji, Zheng Ye
Summary: This study investigated the endothelial cells of keloids using scRNAseq combined with bulk-RNAseq data, identifying the key regulators driving keloid development. The researchers explored the pattern of changes in vascular endothelial cells during keloid development by inferring endothelial cell differentiation trajectories. The activation of the NF kappa B signaling pathway was found to be a characteristic feature of early keloid formation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Tong Cheng, Zhusheng Chen, Yibin Qin, Xiang Zhu, Hongsheng Chen, Zhongling Xu, Xiaqing Ma
Summary: Morphine is commonly used and effective for pain relief, but its side effect of itching limits its clinical use. This paper discusses the potential of using esketamine to treat morphine-induced itching.
MEDICAL HYPOTHESES
(2024)
Article
Medicine, Research & Experimental
Sung Eun Lee, Eunjung Park, Ji-yun Kim, HyukHoon Kim
Summary: Hyperbaric oxygen therapy (HBOT) is a potential therapeutic modality that has been recognized for its favorable mechanisms in various diseases, including sepsis-associated encephalopathy (SAE). HBOT has neuroprotective effects through its anti-inflammatory and antiapoptotic effects as well as increased tissue oxygenation capacity. However, there are caveats and limitations in applying HBOT in sepsis.
MEDICAL HYPOTHESES
(2024)