Review
Anatomy & Morphology
Chinmaya Mahapatra, Prasoon Kumar, Manash K. Paul, Awanish Kumar
Summary: Current tissue engineering strategies in bone repair and regeneration have limitations, thus there is a need to develop fully functional vascularized bone tissue. Angiogenesis plays a crucial role in providing oxygen, nutrients, cell migration, and biological factors for bone tissue. To address the complex relationship between angiogenesis and bone formation, current research focuses on biomaterial development to induce neovascularization and angiogenesis.
Article
Materials Science, Ceramics
Krishna Dixit, Senthilguru Kulanthaivel, Tarun Agarwal, Kunal Pal, Supratim Giri, T. K. Maiti, Indranil Banerjee
Summary: Bone tissue engineering is an important field in orthopaedic healthcare, and the development of biomaterials with angiogenic and osteogenic properties is crucial for successful implants. This study explores the biofunctionalization of nano-hydroxyapatite with gum tragacanth, resulting in a material with both angiogenic and osteogenic potential.
CERAMICS INTERNATIONAL
(2022)
Review
Engineering, Biomedical
Elia Bosch-Rue, Leire Diez-Tercero, Jenifer Olmos Buitrago, Emilio Castro, Roman A. Perez
Summary: Bone has the ability to self-regenerate, but extensive damage can hinder the natural regeneration process. Bone tissue engineering aims to mimic the extracellular matrix and promote the physiological regeneration process by stimulating osteogenesis and angiogenesis.
ACTA BIOMATERIALIA
(2023)
Article
Polymer Science
Miguel-Angel Martin-Piedra, Belen Girones-Camarasa, Antonio Espana-Lopez, Ricardo Fernandez-Valades Gamez, Cristina Blanco-Elices, Ingrid Garzon, Miguel Alaminos, Ricardo Fernandez-Valades
Summary: The use of cellular bone substitutes showed improvements in maxillofacial structures but did not fully succeed in generating dense bone tissue at the regeneration area. Preliminary signs suggest potential usefulness of cellular fibrin-agarose bone substitutes in severe critical mandibular bone defects.
Review
Cell Biology
Charlotte Owen-Woods, Anjali Kusumbe
Summary: Angiogenesis, hematopoiesis, and osteogenesis are essential processes for regulating biological functions. Endothelial cells (ECs) in the bone marrow play a crucial role in regulating hematopoietic and mesenchymal stem cells. The interactions between ECs and osteoblasts are fundamental for maintaining bone health and coordinating repair and regeneration.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Kamil Nelke, Klaudiusz Luczak, Maciej Janeczek, Edyta Pasicka, Krzysztof Zak, Marceli Lukaszewski, Radoslaw Jadach, Maciej Dobrzynski
Summary: There are various cysts and tumors in the mandibular and maxillary bones, with origins either odontogenic or otherwise. The odontogenic keratocyst (OKC) is a common example of an odontogenic cyst. Although the treatment methods for OKC have not changed significantly, it has a higher recurrence rate compared to other odontogenic cysts. The size, location, and cortical expansion of the OKC can influence the treatment and potential recurrence. Individual cases may require bone grafting or other reconstruction methods. Proper treatment of the bone cavity after cyst removal is crucial for preventing pathological fractures or improper healing. Healing potential can be improved with xenograft bone substitutes or allograft fresh-frozen bones. In rare cases, a titanium plate may be used for mandibular stability. This case report presents an atypical case of a large OKC treated with fresh-frozen bone grafts and supported with collagen barrier material.
APPLIED SCIENCES-BASEL
(2023)
Article
Orthopedics
Xiaopeng Tong, Tao Zhang, Shengcan Li, Yang Chen, Yan Xu, Chao Deng, Jianzhong Hu, Hongbin Lu
Summary: This study assessed the role of lymphatic vessels in the healing process of rotator cuff tears (RCT) and found that lymphangiogenesis plays a positive role in RCT healing. Targeting the lymphatic system to improve lymphatic drainage may be a potential new therapeutic approach to facilitate repair of RCT.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Oncology
Erna-Elise Paulsen, Sigve Andersen, Mehrdad Rakaee, Mona Irene Pedersen, Ana Paola Lombardi, Mette Pohl, Thomas Kilvaer, Lill-Tove Busund, Francesco Pezzella, Tom Donnem
Summary: This study investigates the different microvessel patterns in non-small cell lung carcinomas (NSCLC) and their associations with immune cell infiltration. The non-angiogenic alveolar pattern is found to be prevalent in NSCLC and is associated with poor prognosis.
FRONTIERS IN ONCOLOGY
(2023)
Review
Physiology
Ana Prates Soares, Heilwig Fischer, Sabrin Aydin, Claudius Steffen, Katharina Schmidt-Bleek, Carsten Rendenbach
Summary: The mandible is responsible for shaping the lower face, masticatory movements, and articulation of phonemes. Pathologies that damage the mandible severely impact patients. Mandibular reconstruction techniques using flaps, notably free vascularized fibula flaps, need to consider the unique clinical traits and differences of the mandible to achieve successful outcomes.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Engineering, Biomedical
Runze Li, Chen Zhou, Jun Chen, Haotian Luo, Ruoyu Li, Danying Chen, Xuenong Zou, Weicai Wang
Summary: Injectable hydrogels have attracted attention for bone repair due to their adaptability and minimally invasive nature. A novel injectable self-healing hydrogel system has been developed for enhancing vascularized bone regeneration.
BIOACTIVE MATERIALS
(2022)
Review
Endocrinology & Metabolism
Anna Ioannidou, Rachel M. Fisher, Carolina E. Hagberg
Summary: The vascular endothelial cells in adipose tissue play a crucial role in regulating nutrient uptake and tissue expansibility, affecting the development and function of adipocytes. Understanding the interplay between endothelial cells, adipocytes, and obesity could lead to new therapeutic approaches for obesity-related pathologies.
Article
Biochemistry & Molecular Biology
Saori Shibuya, Mitsushiro Nakatomi, Kaori Kometani-Gunjigake, Kayoko Nakao-Kuroishi, Kae Matsuyama, Shinji Kataoka, Takashi Toyono, Yuji Seta, Tatsuo Kawamoto
Summary: Optimal Msx1 gene is crucial for mandibular tip development, and its deficiency leads to rare abnormalities in the median cleft of the lower lip and cleft chin. The study found that the expression of Msx1 gene is reduced in the mandibular tip, resulting in incomplete fusion of the mandibular processes and failure to restore during development. In addition, the absence of the Msx1 gene also causes division of Meckel's cartilage and surrounding soft tissues. The results suggest that the Msx1 gene is indispensable for proper mandibular tip development.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Developmental Biology
Jessica M. Kraus, Dion Giovannone, Renata Rydzik, Jeremy L. Balsbaugh, Isaac L. Moss, Jennifer L. Schwedler, Julien Y. Bertrand, David Traver, Kurt D. Hankenson, J. Gage Crump, Daniel W. Youngstrom
Summary: This study shows that Notch signaling is induced during the early stages of bone healing and its modulation can affect the size and quality of bone regeneration. The findings suggest that targeting Notch signaling may provide a new strategy to enhance bone healing in mammals.
Article
Engineering, Biomedical
Hong zhen Xu, Jian sheng Su
Summary: The success of repairing large bone defects using tissue engineering technology depends on angiogenesis and osteogenesis. This study successfully prepared composite scaffolds loaded with small vascular stents, combined with osteoblasts and vascular endothelial cells, to repair critical mandibular defects in rabbits. The results showed good mechanical properties, biocompatibility, and bone regeneration potential, indicating the effectiveness of this approach for bone defect repair.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Cell & Tissue Engineering
Nupur Kohli, Vaibhav Sharma, Alodia Orera, Prasad Sawadkar, Nazanin Owji, Oliver G. Frost, Russell J. Bailey, Martyn Snow, Jonathan C. Knowles, Gordon W. Blunn, Elena Garcia-Gareta
Summary: This study aimed to develop new composite biomaterials with pro-angiogenic and osteogenic properties for bone tissue engineering applications. The materials were characterized as porous with evenly distributed deposits of CaP precursor phases, which facilitated cell adhesion, proliferation, migration, and differentiation down the osteogenic pathway. In addition, results from the CAM assay showed that the scaffolds were pro-angiogenic and biocompatible, highlighting their potential for further pre-clinical research prior to clinical translation.
JOURNAL OF TISSUE ENGINEERING
(2021)
Article
Medicine, Research & Experimental
Tong Cheng, Zhusheng Chen, Yibin Qin, Xiang Zhu, Hongsheng Chen, Zhongling Xu, Xiaqing Ma
Summary: Morphine is commonly used and effective for pain relief, but its side effect of itching limits its clinical use. This paper discusses the potential of using esketamine to treat morphine-induced itching.
MEDICAL HYPOTHESES
(2024)
Article
Medicine, Research & Experimental
Sung Eun Lee, Eunjung Park, Ji-yun Kim, HyukHoon Kim
Summary: Hyperbaric oxygen therapy (HBOT) is a potential therapeutic modality that has been recognized for its favorable mechanisms in various diseases, including sepsis-associated encephalopathy (SAE). HBOT has neuroprotective effects through its anti-inflammatory and antiapoptotic effects as well as increased tissue oxygenation capacity. However, there are caveats and limitations in applying HBOT in sepsis.
MEDICAL HYPOTHESES
(2024)