Update on the Protective Molecular Pathways Improving Pancreatic Beta-Cell Dysfunction

Overexpression of the antioxidant enzyme catalase does not interfere with the glucose responsiveness of insulin-secreting INS-1E cells and rat islets

(2013) S. Lortz et al.   DIABETOLOGIA

Update on incretin hormones

(2012) Liza K. Phillips et al.   Annals of the New York Academy of Sciences

Diabetic β Cells: To Be or Not To Be?

(2012) Sapna Puri et al.   CELL

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

miR-33a Modulates ABCA1 Expression, Cholesterol Accumulation, and Insulin Secretion in Pancreatic Islets

(2012) N. Wijesekara et al.   DIABETES

Changes in MicroRNA Expression Contribute to Pancreatic  -Cell Dysfunction in Prediabetic NOD Mice

(2012) E. Roggli et al.   DIABETES

MicroRNAs in pancreas development

(2012) O. Dumortier et al.   DIABETES OBESITY & METABOLISM

Epigenetics: The missing link to understanding β-cell dysfunction in the pathogenesis of type 2 diabetes

(2012) Elizabeth R. Gilbert et al.   Epigenetics

Effects of long-term treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin on islet endocrine cells in non-obese type 2 diabetic Goto-Kakizaki rats

(2012) Wataru Inaba et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

MicroRNA-30d Induces Insulin Transcription Factor MafA and Insulin Production by Targeting Mitogen-activated Protein 4 Kinase 4 (MAP4K4) in Pancreatic β-Cells

(2012) Xiaomin Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation ofmicroRNA-375by cAMP in Pancreatic β-Cells

(2012) David M. Keller et al.   MOLECULAR ENDOCRINOLOGY

Pioglitazone attenuates the detrimental effects of Advanced Glycation End-Products in the pancreatic beta cell line HIT-T15

(2012) A. Puddu et al.   REGULATORY PEPTIDES

Involvement of the Nrf2-proteasome pathway in the endoplasmic reticulum stress response in pancreatic β-cells

(2012) Sanghwan Lee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Deficiency in the nuclear factor E2-related factor 2 renders pancreatic β-cells vulnerable to arsenic-induced cell damage

(2012) Bei Yang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Clinical Pharmacokinetics of Metformin

(2011) Garry G. Graham et al.   CLINICAL PHARMACOKINETICS

miRNAs control insulin content in pancreatic β-cells via downregulation of transcriptional repressors

(2011) Tal Melkman-Zehavi et al.   EMBO JOURNAL

Sirt1 and mir-9 expression is regulated during glucose-stimulated insulin secretion in pancreatic β-islets

(2011) Deepti Ramachandran et al.   FEBS Journal

Glucagon-like Peptide 1 Stimulates Post-translational Activation of Glucokinase in Pancreatic β Cells

(2011) Shi-Ying Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exendin-4 Protects Against Sulfonylurea-Induced β-Cell Apoptosis

(2011) Ju-Young Kim et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

ROS Acts as a Double-Edged Sword in the Pathogenesis of Type 2 Diabetes Mellitus: Is Nrf2 a Potential Target for the Treatment?

(2011) X. Wang et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

AGEs Decrease Insulin Synthesis in Pancreatic β-Cell by Repressing Pdx-1 Protein Expression at the Post-Translational Level

(2011) Tingting Shu et al.   PLoS One

Glucagon-like peptide-1 counteracts the detrimental effects of Advanced Glycation End-Products in the pancreatic beta cell line HIT-T 15

(2010) A. Puddu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Advanced Glycation End-Products affect transcription factors regulating insulin gene expression

(2010) A. Puddu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Causes and cures for endoplasmic reticulum stress in lipotoxic β-cell dysfunction

(2010) M. Cnop et al.   DIABETES OBESITY & METABOLISM

Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-α in mice

(2010) A. Maida et al.   DIABETOLOGIA

New aspects of an old drug: metformin as a glucagon-like peptide 1 (GLP-1) enhancer and sensitiser

(2010) Y. M. Cho et al.   DIABETOLOGIA

Calcium as a Crucial Cofactor for Low Density Lipoprotein Receptor Folding in the Endoplasmic Reticulum

(2010) Florentina Pena et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PERK Activation at Low Glucose Concentration Is Mediated by SERCA Pump Inhibition and Confers Preemptive Cytoprotection to Pancreatic β-Cells

(2010) Claire E. Moore et al.   MOLECULAR ENDOCRINOLOGY

The rise of antioxidant signaling—The evolution and hormetic actions of Nrf2

(2010) Jonathan Maher et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Transcription factors involved in glucose-stimulated insulin secretion of pancreatic beta cells

(2009) Shiying Shao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glucolipotoxicity of the pancreatic beta cell

(2009) Vincent Poitout et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Long-Acting GLP-1 Analogs for the Treatment of Type 2 Diabetes Mellitus

(2009) Tina Vilsbøll et al.   BIODRUGS

Pioglitazone suppresses the lipopolysaccharide-induced production of inflammatory factors in mouse macrophages by inactivating NF-κB

(2009) Caihui Ao et al.   CELL BIOLOGY INTERNATIONAL

Incretin-Based Therapy of Type 2 Diabetes Mellitus

(2009) Filip Knop et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB

(2009) Daniel A. Cunha et al.   DIABETES

Exendin-4 regulates glucokinase expression by CaMKK/CaMKIV pathway in pancreatic β-cell line

(2009) K. Murao et al.   DIABETES OBESITY & METABOLISM

Effect of pioglitazone on insulin resistance in fructose-drinking rats correlates with AGEs/RAGE inhibition and block of NAPDH oxidase and NF kappa B activation

(2009) Xueping Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Current views on type 2 diabetes

(2009) Yi Lin et al.   JOURNAL OF ENDOCRINOLOGY

Peroxisome Proliferator-Activated Receptor   Activation Restores Islet Function in Diabetic Mice through Reduction of Endoplasmic Reticulum Stress and Maintenance of Euchromatin Structure

(2009) C. Evans-Molina et al.   MOLECULAR AND CELLULAR BIOLOGY

Assessing the potential of glucokinase activators in diabetes therapy

(2009) Franz M. Matschinsky   NATURE REVIEWS DRUG DISCOVERY

Novel therapeutics for type 2 diabetes: Incretin hormone mimetics (glucagon-like peptide-1 receptor agonists) and dipeptidyl peptidase-4 inhibitors

(2009) E.J. Verspohl   PHARMACOLOGY & THERAPEUTICS

ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function

(2009) Jingbo Pi et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

β-Cell deterioration during diabetes: what's in the gun?

(2009) R. Paul Robertson   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Akt and PTEN: β-cell mass and pancreas plasticity

(2009) Lynda Elghazi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Regulation of the susceptibility to oxidative stress by cysteine availability in pancreatic β-cells

(2008) Satoshi Numazawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic β-cells

(2008) Elida Lai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A chemical chaperone 4-PBA ameliorates palmitate-induced inhibition of glucose-stimulated insulin secretion (GSIS)

(2008) Sung-E Choi et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Glucose regulation of insulin gene expression in pancreatic β-cells

(2008) Sreenath S. Andrali et al.   BIOCHEMICAL JOURNAL

Mitochondrial Reactive Oxygen Species Are Obligatory Signals for Glucose-Induced Insulin Secretion

(2008) C. Leloup et al.   DIABETES

Rosiglitazone and pioglitazone similarly improve insulin sensitivity and secretion, glucose tolerance and adipocytokines in type 2 diabetic patients

(2008) Y. Miyazaki et al.   DIABETES OBESITY & METABOLISM

PDX-1 and MafA Play a Crucial Role in Pancreatic β-Cell Differentiation and Maintenance of Mature β-Cell Function

(2008) Hideaki KANETO et al.   ENDOCRINE JOURNAL

The Role for Endoplasmic Reticulum Stress in Diabetes Mellitus

(2008) Décio L. Eizirik et al.   ENDOCRINE REVIEWS

Expression of islet-specific microRNAs during human pancreatic development

(2008) Mugdha V. Joglekar et al.   GENE EXPRESSION PATTERNS

Glucagon-like Peptide-1 Activation of TCF7L2-dependent Wnt Signaling Enhances Pancreatic Beta Cell Proliferation

(2008) Zhengyu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GRP78, but Not Protein-disulfide Isomerase, Partially Reverses Hyperglycemia-induced Inhibition of Insulin Synthesis and Secretion in Pancreatic β-Cells

(2008) Liling Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular Signaling by Akt: Bound to Be Specific

(2008) T. F. Franke   Science Signaling

Pioglitazone attenuates fatty acid–induced oxidative stress and apoptosis in pancreatic β-cells

(2007) Y. Saitoh et al.   DIABETES OBESITY & METABOLISM

Protection of pancreatic beta-cells: Is it feasible?

(2007) Enzo Bonora   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES