The Discovery of Novel Experimental Therapies for Inflammatory Arthritis

Costimulation blockade in rheumatic diseases: where we are?

(2010) Vincent Goëb et al.   CURRENT OPINION IN RHEUMATOLOGY

Clinical value of blocking IL-6 receptor

(2010) Toru Mima et al.   CURRENT OPINION IN RHEUMATOLOGY

A novel T cell cytokine, secreted osteoclastogenic factor of activated T cells, induces osteoclast formation in a RANKL-independent manner

(2009) Leonard Rifas et al.   ARTHRITIS AND RHEUMATISM

Elevated expression of interleukin-7 receptor in inflamed joints mediates interleukin-7-induced immune activation in rheumatoid arthritis

(2009) Sarita A. Y. Hartgring et al.   ARTHRITIS AND RHEUMATISM

Outside-to-inside signaling through transmembrane tumor necrosis factor reverses pathologic interleukin-1β production and deficient apoptosis of rheumatoid arthritis monocytes

(2009) Undine Meusch et al.   ARTHRITIS AND RHEUMATISM

Induction of apoptosis in the synovium of mice with autoantibody-mediated arthritis by the intraarticular injection of double-stranded MicroRNA-15a

(2009) Yoshihiko Nagata et al.   ARTHRITIS AND RHEUMATISM

Long term treatment of rheumatoid arthritis with rituximab

(2009) Roberto Caporali et al.   AUTOIMMUNITY REVIEWS

Prospective new biological therapies for rheumatoid arthritis

(2009) Ladislav Šenolt et al.   AUTOIMMUNITY REVIEWS

Golimumab

(2009) Vicki Oldfield et al.   BIODRUGS

Biologic Therapy for Rheumatoid Arthritis

(2009) Laura J. Gibbons et al.   BIODRUGS

Regulation of T cell-dendritic cell interactions by IL-7 governs T-cell activation and homeostasis

(2009) M. Saini et al.   BLOOD

Novel function for interleukin-7 in dendritic cell development

(2009) T. K. Vogt et al.   BLOOD

The pleiotropic effect of TRAIL on tumor-like synovial fibroblasts from rheumatoid arthritis patients is mediated by caspases

(2009) R Audo et al.   CELL DEATH AND DIFFERENTIATION

PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5

(2009) Sergiy Kostenko et al.   CELLULAR SIGNALLING

Modulation of T-Cell Co-Stimulation in Rheumatoid Arthritis

(2009) Bruno Laganà et al.   CLINICAL DRUG INVESTIGATION

Targeting interleukin-6 in pediatric rheumatic diseases

(2009) Fabrizio De Benedetti   CURRENT OPINION IN RHEUMATOLOGY

Successful Structure-Based Design of Recent p38 MAP Kinase Inhibitors

(2009) Solveigh Karcher et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Small Molecule Inhibitors of Phosphoinositide 3-Kinase (PI3K) δ and γ

(2009) Michael Ameriks et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

ERK inhibitors as a potential new therapy for rheumatoid arthritis

(2009) M. Ohori   DRUG NEWS & PERSPECTIVES

Therapeutic options for rheumatoid arthritis

(2009) Michael G Feely et al.   EXPERT OPINION ON PHARMACOTHERAPY

Regulation of macrophage function by sphingosine-1-phosphate

(2009) Andreas Weigert et al.   IMMUNOBIOLOGY

Docking of PRAK/MK5 to the Atypical MAPKs ERK3 and ERK4 Defines a Novel MAPK Interaction Motif

(2009) Espen Åberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NF-κB regulation: the nuclear response

(2009) Arun K. Mankan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Proteasome inhibition activates the mitochondrial pathway of apoptosis in human CD4+T cells

(2009) Carsten Berges et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

PLC-γ2 is essential for formation and maintenance of memory B cells

(2009) Masaki Hikida et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: IL-7 Regulates the Peripheral Pool of Adult ROR + Lymphoid Tissue Inducer Cells

(2009) S. Schmutz et al.   JOURNAL OF IMMUNOLOGY

Inhibition of Sphingosine-1-Phosphate Lyase for the Treatment of Autoimmune Disorders

(2009) Jeffrey T. Bagdanoff et al.   JOURNAL OF MEDICINAL CHEMISTRY

Aberrant integrin activation induces p38 MAPK phosphorylation resulting in suppressed Fas-mediated apoptosis in T cells: Implications for rheumatoid arthritis

(2009) Yu-ping Lin et al.   MOLECULAR IMMUNOLOGY

Certolizumab pegol—what role does this new TNF inhibitor have in the treatment of RA?

(2009) Daniel E Furst   Nature Reviews Rheumatology

Epigenetic control in rheumatoid arthritis synovial fibroblasts

(2009) Emmanuel Karouzakis et al.   Nature Reviews Rheumatology

BH3-only proteins in rheumatoid arthritis: potential targets for therapeutic intervention

(2009) J Hutcheson et al.   ONCOGENE

Histone deacetylase inhibitors cooperate with IFN-γ to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8

(2009) S Häcker et al.   ONCOGENE

FoxM1 Is a General Target for Proteasome Inhibitors

(2009) Uppoor G. Bhat et al.   PLoS One

Increased Numbers of IL-7 Receptor Molecules on CD4+CD25−CD107a+ T-Cells in Patients with Autoimmune Diseases Affecting the Central Nervous System

(2009) Nalini Kumar Vudattu et al.   PLoS One

Methotrexate in combination with sulfasalazine is more effective in rheumatoid arthritis patients who failed sulfasalazine than in patients naive to both drugs

(2009) L. G. Schipper et al.   RHEUMATOLOGY

Susceptibility of rheumatoid arthritis synovial fibroblasts to FasL- and TRAIL-induced apoptosis is cell cycle-dependent

(2009) Noreen Pundt et al.   ARTHRITIS RESEARCH & THERAPY

Garden of therapeutic delights: new targets in rheumatic diseases

(2009) Jean M Waldburger et al.   ARTHRITIS RESEARCH & THERAPY

Tumor Necrosis Factor Antagonist Responsiveness in a United States Rheumatoid Arthritis Cohort

(2008) Jeffrey D. Greenberg et al.   AMERICAN JOURNAL OF MEDICINE

Bortezomib attenuates murine collagen-induced arthritis

(2008) S-W Lee et al.   ANNALS OF THE RHEUMATIC DISEASES

Risk of serious infections during rituximab, abatacept and anakinra treatments for rheumatoid arthritis: meta-analyses of randomised placebo-controlled trials

(2008) C Salliot et al.   ANNALS OF THE RHEUMATIC DISEASES

The safety of anti-tumour necrosis factor treatments in rheumatoid arthritis: meta and exposure-adjusted pooled analyses of serious adverse events

(2008) J P Leombruno et al.   ANNALS OF THE RHEUMATIC DISEASES

Treatment of rheumatoid arthritis with a syk kinase inhibitor: A twelve-week, randomized, placebo-controlled trial

(2008) Michael E. Weinblatt et al.   ARTHRITIS AND RHEUMATISM

Expression of microRNA-146 in rheumatoid arthritis synovial tissue

(2008) Tomoyuki Nakasa et al.   ARTHRITIS AND RHEUMATISM

Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis

(2008) Joanna Stanczyk et al.   ARTHRITIS AND RHEUMATISM

Proteasome inhibitors induce osteoclast survival by activating the Akt pathway

(2008) Han Bok Kwak et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MicroRNAs

(2008) Muller Fabbri et al.   CANCER JOURNAL

Abatacept: a T-cell co-stimulation modulator for the treatment of rheumatoid arthritis

(2008) Andrew J K Östör   CLINICAL RHEUMATOLOGY

Advances in and applications of proteasome inhibitors

(2008) Bradley S Moore et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

At the horizon of innovative therapy in rheumatology: new biologic agents

(2008) Axel Finckh et al.   CURRENT OPINION IN RHEUMATOLOGY

Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease

(2008) Ann E. Kearns et al.   ENDOCRINE REVIEWS

Spleen tyrosine kinase: a novel target for therapeutic intervention of rheumatoid arthritis

(2008) Malini Bajpai et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Does MK5 reconcile classical and atypical MAP kinases?

(2008) Maria Perander   Frontiers in Bioscience-Landmark

Bcl-3, a multifaceted modulator of NF-κB-mediated gene transcription

(2008) Scott Palmer et al.   IMMUNOLOGIC RESEARCH

Tyrosine kinases as targets in rheumatoid arthritis

(2008) Antonio G. Tristano   INTERNATIONAL IMMUNOPHARMACOLOGY

Targeting NF-κB: A Promising Molecular Therapy in Inflammatory Arthritis

(2008) Jorge A. Roman-Blas et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Proteasome inhibition as a novel therapy in treating rheumatoid arthritis

(2008) Jan Brun   MEDICAL HYPOTHESES

Interleukin-7 in rheumatoid arthritis

(2008) S. M. Churchman et al.   RHEUMATOLOGY

Aggressive combination therapy with intra-articular glucocorticoid injections and conventional disease-modifying anti-rheumatic drugs in early rheumatoid arthritis: second-year clinical and radiographic results from the CIMESTRA study

(2007) M L Hetland et al.   ANNALS OF THE RHEUMATIC DISEASES

Sphingosine kinase signalling in immune cells: Potential as novel therapeutic targets

(2007) Alirio J. Melendez   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS