Editorial Material
Cell Biology
Bennett G. Childs, Sara I. Graves, Darren J. Baker
Summary: A study suggests that the accumulation of senescent cells and changes in gut microbiota with age are more closely related than previously thought, through a B cell-IgA-microbiota axis.
NATURE CELL BIOLOGY
(2023)
Article
Cell Biology
Shimpei Kawamoto, Ken Uemura, Nozomi Hori, Lena Takayasu, Yusuke Konishi, Kazutaka Katoh, Tomonori Matsumoto, Masae Suzuki, Yusuke Sakai, Tatsuyuki Matsudaira, Takahiro Adachi, Naoko Ohtani, Daron M. Standley, Wataru Suda, Shinji Fukuda, Eiji Hara
Summary: The mechanisms and control methods of ageing have been extensively studied. It has been discovered that the accumulation of senescent cells and the change in gut microbiota composition are two important factors in ageing. However, the relationship between these two phenomena during ageing is not well understood. In this study, researchers found that commensal bacteria gradually induce cellular senescence in gut germinal centre B cells, leading to reduced production and diversity of immunoglobulin A antibodies and changes in gut microbiota composition in aged mice. These findings reveal the existence of IgA-mediated crosstalk between gut microbiota and cellular senescence, providing insights into the mechanism of gut microbiota changes with age and potential strategies for control.
NATURE CELL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rabia Bilge Ozgul Ozdemir, Alper Tunga Ozdemir, Cengiz Kirmaz, Ayla Eker Sariboyaci, Erdal Karaoz, Gulay Erman, H. Seda Vatansever, Nihal Mete Gokmen
Summary: This study investigated the impact of aging on the immunomodulatory abilities of mesenchymal stem cells (MSCs). While the effects of MSCs on Th1 and Th2 cells were not affected by aging, there were differences in the effects on Th17 and Treg cells between young and elderly MSCs. The expression of key molecules such as IL-6 and HGF, important in tissue regeneration, decreased significantly in elderly DP-MSCs, potentially impacting their modulation effects on Th17 and Treg cells.
Article
Cell & Tissue Engineering
Xin He, Zhan Yang, Xiao-Yang Chu, Yun-Xia Li, Biao Zhu, Yan-Xia Huang, Wei Wang, Chun-Yan Gao, Xu Chen, Chun-Yan Zheng, Kai Yang, Dong-Liang Zhang
Summary: The present study revealed the vital role of the ROR2/MSX2/NSUN2 axis in the regulation of DPSC senescence, thereby providing a potential target for antagonizing DPSC aging.
Article
Cell Biology
Xing-yue Dong, Yan-xia Huang, Zhan Yang, Xiao-yang Chu, Jue Wu, Shan Wang, Xin He, Chun-Yan Gao, Xu Chen, Kai Yang, Dong-liang Zhang
Summary: The research revealed the crucial role of ROR2 in DPSC aging, where it regulates the proliferation of DPSCs by inhibiting the synthesis of SM through the STK4 and FOXO1 pathway, presenting a new target for combating aging.
Article
Biochemistry & Molecular Biology
Bo Liu, Chenzhong Wang, Ziyu Weng, Yi Yang, Hong Zhao, Yueqi Zhang, Qinming Fei, Yi Shi, Chi Zhang
Summary: The glycolytic enzyme PKM2 plays a role in regulating chondrocyte senescence, but not inflammation. Silencing PKM2 affects the expressions of MMP13, PKM2, and COL2A1 in chondrocytes, and also reduces the expression of the senescent biomarker p16(INK4a).
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Biochemistry & Molecular Biology
Shelly Arora, Paul R. Cooper, Lara T. Friedlander, Benedict Seo, Shakila B. Rizwan, Alison M. Rich, Haizal Mohd Hussaini
Summary: This study successfully isolated and cultured cHDPCs and ncHDPCs from healthy and inflamed dental pulp tissue respectively. The growth characteristics and differentiation abilities were not significantly different between the two types of HDPCs. However, the expression of certain genes such as TLR-2 and IL-6 was significantly higher in cHDPCs, indicating an inflammatory phenotype in the inflamed dental pulp.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Kailin Li, Ji Bian, Yao Xiao, Da Wang, Lin Han, Caian He, Lan Gong, Min Wang
Summary: In recent years, there has been a significant increase in age-related diseases worldwide due to longer life expectancy. The aging pancreas undergoes various morphological and pathological changes, which can predispose individuals to diseases such as diabetes, dyspepsia, pancreatic ductal adenocarcinoma, and pancreatitis. Pancreatic senescence is associated with underlying factors including genetic damage, DNA methylation, endoplasmic reticulum stress, mitochondrial dysfunction, and inflammation. This review article discusses the alterations in morphologies and functions of the aging pancreas, particularly beta-cells, and summarizes the mechanisms of pancreatic senescence to identify potential targets for treating aging-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Tania Xu Yar Lee, Jinfu Wu, Wei-Horng Jean, Giancarlo Condello, Ahmad Alkhatib, Chao-Chieh Hsieh, Yu-Wen Hsieh, Chih-Yang Huang, Chia-Hua Kuo
Summary: This study showed that acute resistance exercise can increase endothelial progenitor cells (EPC) in skeletal muscle while decreasing p16(INK4a) mRNA expression. The supplementation of Rg1 further enhanced these effects and lowered tissue inflammation levels.
Review
Cell Biology
Kyu Hwan Kwack, Hyeon-Woo Lee
Summary: Dental caries is a common disease that causes damage to teeth and pulp tissue. Dental pulp stem cells have multipotency, high proliferation rate, and immunosuppressive properties, making them ideal for regenerating damaged pulp tissue.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Emanuel J. Novais, Victoria A. Tran, Shira N. Johnston, Kayla R. Darris, Alex J. Roupas, Garrett A. Sessions, Irving M. Shapiro, Brian O. Diekman, Makarand Risbud
Summary: Intervertebral disc degeneration is a common issue in the elderly population, leading to chronic back pain and disability. The study shows that long term treatment with senolytic compounds Dasatinib and Quercetin can reduce disc senescence burden and ameliorate age-dependent degeneration in mice.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Eleanor J. Tyler, Ana Gutierrez del Arroyo, Bethany K. Hughes, Ryan Wallis, James C. Garbe, Martha R. Stampfer, Jim Koh, Robert Lowe, Michael P. Philpott, Cleo L. Bishop
Summary: EGR2 is identified as a novel regulator of senescence, with up-regulated expression during senescence. It activates the ARF and p16 promoters and directly binds to them. Loss of EGR2 results in down-regulation of p16 levels and an increase in the population of p16- p21- 'reversed' cells.
Article
Biochemistry & Molecular Biology
Yui Shimada-Takayama, Takayuki Yasuda, Tomoyo Ukai, Jumpei Taguchi, Manabu Ozawa, Nao Sankoda, Sho Ohta, Yasuhiro Yamada
Summary: p16(Ink4a) is a key player in cellular senescence, but its localization and dynamics in tissues in vivo are poorly understood. A mouse model with HA-tagged p16(Ink4a revealed changes in protein expression during senescence, but p16(Ink4a) was not detected in tissues exposed to pro-senescence conditions, suggesting limited induction of the protein. These findings highlight the importance of caution when evaluating p16(Ink4a) protein expression in vivo.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Tanja Limberger, Michaela Schlederer, Karolina Trachtova, Ines Garces de los Fayos Alonso, Jiaye Yang, Sandra Hoegler, Christina Sternberg, Vojtech Bystry, Jan Oppelt, Boris Tichy, Margit Schmeidl, Petra Kodajova, Anton Jaeger, Heidi A. Neubauer, Monika Oberhuber, Belinda S. Schmalzbauer, Sarka Pospisilova, Helmut Dolznig, Wolfgang Wadsak, Zoran Culig, Suzanne D. Turner, Gerda Egger, Sabine Lagger, Lukas Kenner
Summary: This study reveals the functional consequences of truncation mutations of the KMT2C gene in prostate cancer, showing that these mutations drive proliferation and formation of PIN. Loss of both KMT2C and PTEN in prostate cancer leads to loss of senescence, metastatic dissemination, and reduced life expectancy. The study highlights the prognostic significance of KMT2C mutation status and suggests MYC signalling axis inhibition as a potential treatment option for patients with KMT2C truncations and poor prognosis.
Article
Biology
Xiaoyu Li, Liang Feng, Chunmei Zhang, Jinsong Wang, Songlin Wang, Lei Hu
Summary: IGFBP7 plays a crucial role in preventing DPSCs senescence and functions by regulating the transcription of H3K36ac and p21, providing a potential target for tissue regeneration in an aging environment.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Cell & Tissue Engineering
Ke Xu, Jingwen Xiao, Ke Zheng, Xingmei Feng, Jinlong Zhang, Donghui Song, Chenfei Wang, Xiang Shen, Xin Zhao, Changbo Wei, Dan Huang, Guijuan Feng
CELLULAR REPROGRAMMING
(2018)
Article
Cell Biology
Yihua Song, Chenfei Wang, Zhifeng Gu, Peipei Cao, Dan Huang, Guijuan Feng, Min Lian, Ye Zhang, Xingmei Feng, Zhenran Gao
CONNECTIVE TISSUE RESEARCH
(2019)
Article
Cell & Tissue Engineering
Xingmei Feng, Chenfei Wang, Zhifeng Gu, Jian Ni, Dan Huang, Guijuan Feng, Min Lian, Qi Lu, Yihua Song
CELLULAR REPROGRAMMING
(2019)
Article
Cell Biology
Ya Zheng, Chen Dong, Junling Yang, Yi Jin, Wenjie Zheng, Qiao Zhou, Yi Liang, Liuliu Bao, Guijuan Feng, Juan Ji, Xingmei Feng, Zhifeng Gu
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Cell Biology
Dan Huang, Shuling Shen, Ming Cai, Lin Jin, Jun Lu, Ke Xu, Jinlong Zhang, Guijuan Feng, Yingzi Hu, Ke Zheng, Xingmei Feng
JOURNAL OF MOLECULAR HISTOLOGY
(2019)
Article
Cell & Tissue Engineering
Xiaohui Lu, Xi Chen, Jing Xing, Min Lian, Dan Huang, Yuanzhou Lu, Guijuan Feng, Xingmei Feng
STEM CELL RESEARCH & THERAPY
(2019)
Article
Immunology
Lujun Ji, Liuliu Bao, Zhifeng Gu, Qiao Zhou, Yi Liang, Ya Zheng, Yang Xu, Xiang Zhang, Xingmei Feng
IMMUNOLOGIC RESEARCH
(2019)
Article
Dentistry, Oral Surgery & Medicine
Rui Zhao, Chaoyu Gu, Qiuxiang Zhang, Wei Zhou, Guijuan Feng, Xingmei Feng, Chen Dong, Zhifeng Gu
Article
Cell & Tissue Engineering
Liuliu Bao, Xiang Zhang, Yang Xu, Miao Wang, Yihua Song, Yongchun Gu, Ya Zheng, Jingwen Xiao, Yuzhe Wang, Qiao Zhou, Jie Qian, Yi Liang, Lujun Ji, Xingmei Feng
CELLULAR REPROGRAMMING
(2019)
Article
Biotechnology & Applied Microbiology
Jihua Wang, Ya Zheng, Bingbing Bai, Yihua Song, Ke Zheng, Jinwen Xiao, Yi Liang, Liuliu Bao, Qiao Zhou, Lujun Ji, Xingmei Feng
Article
Neurosciences
Ke Zheng, Guijuan Feng, Jinlong Zhang, Jing Xing, Dan Huang, Min Lian, Wei Zhang, Wenli Wu, Yingzi Hu, Xiaohui Lu, Xingmei Feng
Summary: The study showed that chitosan scaffolds combined with bFGF promoted neural differentiation of DPSCs without affecting cell viability. This combination may be a safe and effective method for treating SCI and other neuronal diseases.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2021)
Review
Engineering, Biomedical
Eiji Tanaka, Yao Liu, Linze Xia, Naoko Ogasawara, Takuma Sakamaki, Fumiya Kano, Noboru Hashimoto, Xingmei Feng, Akihito Yamamoto
ANNALS OF BIOMEDICAL ENGINEERING
(2020)
Article
Cell Biology
Ye Zhang, Min Lian, Xin Zhao, Peipei Cao, Jingwen Xiao, Shuling Shen, Wanxian Tang, Jiaxuan Zhang, Jie Hao, Xingmei Feng
Summary: The study revealed that RICK regulates TNF-alpha-mediated odontogenic differentiation of DPSCs through the ERK signaling pathway. Low concentrations of TNF-alpha promote odontogenic differentiation while high concentrations inhibit it; RICK expression increases over time and is associated with odontogenic differentiation.
CELL BIOLOGY INTERNATIONAL
(2021)
Article
Cell Biology
Hui-Min Xie, Xing Su, Feng-Yuan Zhang, Chao-Lun Dai, Rong-Hua Wu, Yan Li, Xiao-Xiao Han, Xing-Mei Feng, Bin Yu, Shun-Xing Zhu, Song-Lin Zhou
Summary: Exosomes from glial cells, especially astrocytes and microglia, are involved in various functions and diseases of the central nervous system, particularly neurodegenerative diseases. Gene expression and protein-protein interaction network analysis revealed the mechanisms by which these exosomes influence disease progression, including metabolic balance, ubiquitin-dependent protein balance, immune inflammation, and oxidative stress.
NEURAL REGENERATION RESEARCH
(2022)
Article
Cell & Tissue Engineering
Rongrong Jiang, Miao Wang, Xiaobo Shen, Shuai Huang, Jianpeng Han, Lei Li, Zhiliang Xu, Chengfeng Jiang, Qiao Zhou, Xingmei Feng
Summary: The study demonstrated that SUMO1 modification of IGF-1R inhibited osteogenic differentiation of PDLSCs by binding to SNAI2 in a high glucose environment, potentially a key factor leading to alveolar bone loss in diabetic patients. Adding IGF-1R inhibitors to high glucose osteogenic medium enhanced osteogenic differentiation of PDLCSs, offering potential new hope for alveolar bone regeneration in diabetic patients.
STEM CELL RESEARCH & THERAPY
(2021)