Article
Biochemistry & Molecular Biology
Cristina- Bucchi, Ella Ohlsson, Josep Maria de Anta, Melanie Woelflick, Kerstin Galler, Maria Cristina Manzanares-Cespedes, Matthias Widbiller
Summary: Pluripotent stem cells derived from the amnion show the ability to adhere to dentin and mineralize in vitro, but exhibit unfavorable proliferation behavior and fail to undergo odontoblastic transition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Natsumi Fujiwara, Shohei Yamashita, Motoki Okamoto, Marion A. Cooley, Kazumi Ozaki, Eric T. Everett, Maiko Suzuki
Summary: In this study, it was found that perfluorooctanoic acid (PFOA) negatively affects tooth enamel development through cell death mechanisms involving necrosis/necroptosis and apoptosis, mediated by the ROS-MAPK/ERK signaling pathway. PFOA also suppressed cell proliferation and viability. This research provides initial evidence that PFOA could potentially contribute to cryptogenic enamel malformation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Aya Tentaku, Shusaku Kurisu, Kurumi Sejima, Toshiki Nagao, Akira Takahashi, Shigenobu Yonemura
Summary: The basement membrane (BM) is a crucial extracellular matrix that maintains tissue integrity and function. The mechanisms of how stroma-derived macromolecules, such as collagen IV, are transported and assembled during BM formation remained unclear. This study established an in vitro co-culture model and found that fibroblasts proximal to epithelial cells exclusively contribute to collagen IV assembly.
Article
Biochemistry & Molecular Biology
Donald F. Ready, Henry C. Chang
Summary: Drosophila compound eye morphogenesis involves sequential assembly and activation of a supramolecular tensile network. This network is formed by the emergence of a new laminin-rich basement membrane, deposition of collagen at fenestrae by interommatidial cells, assembly of stress fibers in the endfeet of interommatidial cells, and contraction of these stress fibers to fold the pliable basement membrane into a hexagonal grid. This process applies essential morphogenetic tension to the rapidly growing rhabdomeres and governs retinal morphogenesis in Drosophila.
Article
Cell Biology
Samarpita Banerjee, Wen-Cheng Lo, Payel Majumder, Debleena Roy, Mimosa Ghorai, Nusrat K. Shaikh, Nishi Kant, Mahipal S. Shekhawat, Vijaykumar Shivaji Gadekar, Suchanda Ghosh, Ercan Bursal, Faris Alrumaihi, Navneet Kumar Dubey, Sanjay Kumar, Danish Iqbal, Wael Alturaiki, Vijay Jagdish Upadhye, Niraj Kumar Jha, Abhijit Dey, Rohit Gundamaraju
Summary: Metastasis is a major challenge in cancer therapy, and the epithelial-mesenchymal transition plays a critical role in this process. Collagen, laminin, and integrin are important components involved in tumor cell metastasis and can also serve as biomarkers for metastatic cells. This review summarizes the current knowledge of therapeutics in preclinical or clinical stages.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Weiwei Zhang, Jingling Shen, Shuang Zhang, Xu Liu, Shuang Pan, Yanping Li, Lin Zhang, Lina He, Yumei Niu
Summary: This study revealed that ITG alpha 6 promotes stemness of human dental pulp stem cells by inhibiting the RHO/ROCK signaling pathway and restoring cytoskeleton organization.
Article
Endocrinology & Metabolism
Mathepan Jeya Mahendralingam, Hyeyeon Kim, Curtis William McCloskey, Kazeera Aliar, Alison Elisabeth Casey, Pirashaanthy Tharmapalan, Davide Pellacani, Vladimir Ignatchenko, Mar Garcia-Valero, Luis Palomero, Ankit Sinha, Jennifer Cruickshank, Ronak Shetty, Ravi N. Vellanki, Marianne Koritzinsky, Vid Stambolic, Mina Alam, Aaron David Schimmer, Hal Kenneth Berman, Connie J. Eaves, Miquel Angel Pujana, Thomas Kislinger, Rama Khokha
Summary: Cancer cells adapt their metabolic network from the tissue of origin. Normal mammary cells exhibit diverse metabolic programs, with basal cells enriched in glycolysis and luminal progenitors in oxidative phosphorylation. Targeting these metabolic vulnerabilities in mammary progenitors could potentially advance breast cancer therapy, as breast cancer subtypes retain metabolic features of their putative cell of origin.
Article
Engineering, Biomedical
Elrade Rofaani, Yong He, Juan Peng, Yong Chen
Summary: This study developed a method to overcome the lack of in vivo-like basement membrane (BM) for in vitro modeling by culturing primordial lung progenitors (PLPs) on an artificial basement membrane (ABM) composed of collagen IV and laminin. The forces generated by the growing epithelial monolayer on the ABM led to geometry-dependent folding and enhanced expression of surfactant protein C and aquaporin 5 compared with a nanofiber-covered substrate. This work emphasizes the importance of recapitulating natural BM for advanced epithelial modeling.
ACTA BIOMATERIALIA
(2023)
Review
Cell Biology
Kyu Hwan Kwack, Hyeon-Woo Lee
Summary: Dental caries is a common disease that causes damage to teeth and pulp tissue. Dental pulp stem cells have multipotency, high proliferation rate, and immunosuppressive properties, making them ideal for regenerating damaged pulp tissue.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Hatice O. Ozguldez, Niraimathi Govindasamy, Rui Fan, Hongyan Long, Karina Mildner, Dagmar Zeuschner, Britta Trappmann, Adrian Ranga, Ivan Bedzhov
Summary: By studying the polar trophectoderm of mouse blastocysts, it was discovered that the extra-embryonic tissues of the placenta originate from a small population of trophectoderm cells with stem cell properties. Instead of tissue folding, the reorganization of the stem cell compartment of the trophoblast lineage through inversion of the epithelial polarity axis plays a crucial role in the morphogenetic transitions during the peri-implantation trophoblast development.
Article
Biochemistry & Molecular Biology
Yoshifumi Kobayashi, Angela Quispe-Salcedo, Sanika Bodas, Satoko Matsumura, Erhao Li, Richard Johnson, Marwa Choudhury, Daniel H. Fine, Siva Nadimpalli, Henry F. Duncan, Amel Dudakovic, Andre J. van Wijnen, Emi Shimizu
Summary: The study shows that depletion of EZH2 in dental mesenchymal cells leads to hyper-mineralization of enamel in teeth and reduces enamel matrix formation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell & Tissue Engineering
Mohammed Zayed, Koichiro Iohara, Hideto Watanabe, Mami Ishikawa, Michiyo Tominaga, Misako Nakashima
Summary: The study found that hypoxia-preconditioned DPSCs (hpDPSCs) have advantages in proliferation rate and stemness, making them a potential effective source for pulp regeneration.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Engineering, Biomedical
Hyuna Kim, Anna Wirasaputra, Farnaz Mohammadi, Aritra Nath Kundu, Jennifer A. E. Esteves, Laura M. M. Heiser, Aaron S. S. Meyer, Shelly R. R. Peyton
Summary: Breast cancer is a major cause of cancer-related deaths worldwide, primarily due to metastasis and dormancy. Dormancy, a prolonged period between tumor resection and relapse, poses significant challenges in current therapies. To overcome this, a live cell lineage approach is used to track and distinguish dormant cells from proliferative and dying cells in various in vitro microenvironments. The study reveals that the proportion of long-term quiescent cells is regulated by both intrinsic and extrinsic factors, with the highest percentage found in 3D collagen gels. This approach is expected to benefit the study of dormant tumor cells for biologists and bioengineers in the dormancy community.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Dentistry, Oral Surgery & Medicine
Jose Luis Alvarez-Vasquez, Cristina Paola Castaneda-Alvarado
Summary: This article highlights the active roles of dental pulp fibroblasts (DPFs) in pulp biology beyond being passive cells, and provides an integrative analysis of their roles and functions.
JOURNAL OF ENDODONTICS
(2022)
Article
Cell Biology
Mathilde Kerherve, Sara Rosinska, Kilian Trillet, Alya Zeinaty, Magalie Feyeux, Steven Nedellec, Julie Gavard
Summary: Glioblastoma multiforme (GBM) is a rare but devastating brain tumor in adults, with current treatments being generally ineffective. This study focused on a population of self-sustaining transformed cells with stem-like properties (GSCs) within GBM, which play a crucial role in tumor initiation, growth, invasion, and recurrence. An ex vivo model was established to explore the invasive behavior of GSCs, and it was found that the glycoprotein Neuropilin-1 (NRP1) contributes to their spreading and invasion. This study proposes a reliable approach to studying invasive properties of patient glioma cells and identifies NRP1 as a mediator in this malignant process.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Chung-Min Kang, Jae-Ho Lee, Mijeong Jeon, Je Seon Song, Seong-Oh Kim
JOURNAL OF CLINICAL PEDIATRIC DENTISTRY
(2018)
Article
Dentistry, Oral Surgery & Medicine
Jin-Myoung Jang, Je Seon Song, Jae-Ho Lee, Hyung-Jun Choi, Seong-Oh Kim
JOURNAL OF CLINICAL PEDIATRIC DENTISTRY
(2018)
Article
Anatomy & Morphology
Junliang Chen, Yun He, Ludger Keilig, Susanne Reimann, Istabrak Hasan, Joachim Weinhold, Ralf Radlanski, Christoph Bourauel
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2019)
Review
Anatomy & Morphology
Daniel Nunez-Leon, Gabriel Aguirre-Fernandez, Andrea Steiner, Hiroshi Nagashima, Per Jensen, Esther Stoeckli, Richard A. Schneider, Marcelo R. Sanchez-Villagra
DEVELOPMENTAL DYNAMICS
(2019)
Review
Evolutionary Biology
Katherine C. Woronowicz, Richard A. Schneider
Article
Biology
Daniel Chu, An Nguyen, Spenser S. Smith, Zuzana Vavrusova, Richard A. Schneider
Article
Dentistry, Oral Surgery & Medicine
Ko Eun Lee, Chung-Min Kang, Mijeong Jeon, Seong-Oh Kim, Jae-Ho Lee, Hyung-Jun Choi
Summary: This study compared the gene expression patterns of gingival and dental pulp tissues, revealing significant differences in the expression of general and MSC genes between the two tissues. These findings have important implications for future regenerative medicine.
JOURNAL OF DENTAL SCIENCES
(2022)
Article
Anatomy & Morphology
R. J. Radlanski, J. Weinhold, S. Jerichow, M. Mehner, H. Schwandt, L. Keilig, C. Bourauel
Summary: Researchers utilized mu CT imaging and histological methods to study craniofacial morphogenesis, and described a method to calibrate mu CT for precise observation of subtle changes during development.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2021)
Article
Chemistry, Multidisciplinary
Ik-Hwan Kim, Mijeong Jeon, Kyounga Cheon, Sun Ha Kim, Han-Sung Jung, Yooseok Shin, Chung Min Kang, Seong-Oh Kim, Hyung-Jun Choi, Hyo-Seol Lee, Ko Eun Lee, Je Seon Song
Summary: This study evaluated the use of decellularized human tooth as a scaffold for regeneration of periodontal ligaments (PDL) and pulp tissue with PDLSCs and DPSCs, respectively. The experiment demonstrated successful differentiation and potential for regeneration in both PDLSCs and DPSCs on the decellularized tooth scaffolds. This suggests a novel treatment method for tooth regeneration utilizing decellularized human tooth as a scaffold.
APPLIED SCIENCES-BASEL
(2021)
Article
Pediatrics
YounJung Park, Taeyang Lee, Minkyeong Seog, Seong-Oh Kim, Joohee Kim, Jeong-Seung Kwon, Chung-Min Kang
Summary: This study aimed to establish safe guidelines for pediatric dental practice regarding temporomandibular joint (TMJ) range of motion (ROM) and mouth area (MA) based on a sample of 438 children aged 3-15 years old. The findings suggest that mouth width, maximum mouth opening (MMO) and mouth area (MA) values differ between males and females and increase with age, height, and weight. Caution should be exercised in forcibly opening the mouth over 40 mm, especially in children shorter than 105 cm, lighter than 18 kg, and under 5 years old.
Article
Pediatrics
Min Sun Song, Chung-Min Kang, Je Seon Song, Hyung-Jun Choi, Jaeho Lee, Seong-Oh Kim
Summary: The Rect-spring appliance has weak retention on mesially tilted molars for the management of ectopically erupting molars. Three modifications have been made for better engagement, with the modified Rect-spring (mRS) successfully bringing ectopically erupting molars into proper occlusion without discomfort. The mRS is suitable for various locking cases and can be used as the first choice for unlocking first molars.
Article
Pediatrics
Ik-Hwan Kim, Chung-Min Kang, Je Seon Song, Jaeho Lee, Hyung-Jun Choi, Seong-Oh Kim
Summary: This case report introduces a novel device called piston-elastic for addressing issues caused by ectopic eruption of permanent molars. By binding it to the locked tooth to improve the eruption path, this device can effectively assist the teeth in returning to normal growth.
Article
Anatomy & Morphology
E. M. Fernandez Rubio, R. J. Radlanski
Summary: This study investigated the morphogenesis of the murine temporomandibular joint with a focus on masticatory muscles, shedding light on the mechanical aspects of developmental processes in relation to temporomandibular joint malfunctions. The research identified changes in muscle formation and highlighted potential mechanical reasons for joint dysfunction.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2022)
Article
Oncology
Chi Hoon Kim, Kisuk Bae, Tae Yang Lee, Je Seon Song, Seong-Oh Kim, Chung - Min Kang
Summary: This study evaluated the differences in quantitative measures obtained from the quantitative light-induced fluorescence method and microbial composition of carious dentin and saliva based on the activity status of caries lesions. The results showed that quantitative measures of red fluorescence, levels of Lactobacillus species in carious dentin, and levels of S. sobrinus in saliva were significantly higher in active caries lesions.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Multidisciplinary Sciences
Mi-Sun Hur, Seunggyu Lee, Han-Sung Jung, Richard A. Schneider
Summary: This study investigates the anatomical connections of the depressor supercilii (DS) with the levator labii superioris alaeque nasi (LLSAN) and inferior fibers of the orbicularis oculi (OOc INF) in the human midface. The findings reveal that the DS is connected to the LLSAN and OOc INF through muscle fibers or thin aponeuroses, influencing the movement of the eyebrows, nasal ala, and upper lip.