Article
Fisheries
Vinh Huynh-Phuoc, Wahyu Purbiantoro, Thuyen Quyen Ly, Fernando Afonso, Ngoc Ut Vu, Ta-Chih Cheng
Summary: This study evaluated the inhibitory effects and adhesion properties of the isolated Bacillus safensis strain VQV8 against pathogenic Vibrio species under different culture conditions. The results showed that VQV8 had the highest antibacterial activities against the tested Vibrio species when cultured in a medium containing 2% NaCl and incubated at a temperature ranging from 25 to 37 degrees C. High adhesion ability was also confirmed through the results of hydrophobicity, aggregation, and biofilm formation assays. These findings suggest that VQV8 could be a potential probiotic candidate for preventing Vibrio spp. infections in aquaculture.
AQUACULTURE INTERNATIONAL
(2023)
Article
Chemistry, Applied
Dhruba Bhattacharya, Tapan Kumar Lai, Amit Saha, Joseph Selvin, Joydeep Mukherjee
Summary: A novel diketopiperazine, (3S, 6S)-3,6-diisobutylpiperazine-2,5-dione, was isolated from a sponge-associated microbe for the first time, characterized through various analytical techniques, and its antibacterial activity against Escherichia coli and Staphylococcus aureus subsp. aureus was reported for the first time. The single crystal X-ray diffraction analysis of this compound was performed, revealing its melting point and providing valuable supplemental data accessible online.
NATURAL PRODUCT RESEARCH
(2021)
Article
Food Science & Technology
Gozde Konuray Altun, Zerrin Erginkaya
Summary: The isolated Bacillus coagulans strains showed excellent heat resistance, resistance to bile and lysozyme, biofilm formation, and antimicrobial activity. They also demonstrated adhesion and auto-aggregation properties, with no detection of enterotoxins and hemolytic activity.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Evgeniya Prazdnova, Maria S. Mazanko, Vladimir A. Chistyakov, Anna A. Bogdanova, Aleksandr G. Refeld, Evgeniya Y. Kharchenko, Michael L. Chikindas
Summary: This study systematically compiles data on the antimutagenic activity of probiotics and emphasizes the significance of antimutagenic activity as a criterion for selecting probiotic strains.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2022)
Article
Microbiology
Gabriela N. Tenea, Gabriela Lizeth Gonzalez, Jose Luis Moreno
Summary: A strain of Bacillus subtilis Fa17.2 isolated from a plant inflorescence in Ecuador showed potential antimicrobial properties, inhibiting the growth of both Gram-negative and Gram-positive bacteria without antibiotic resistance.
Article
Infectious Diseases
Ricardo Sanchez-Diaz, Zinnia Judith Molina-Garza, Lucia Elizabeth Cruz-Suarez, Joseph Selvin, George Seghal Kiran, Bruno Gomez-Gil, Lucio Galaviz-Silva, Jose Cuauhtemoc Ibarra-Gamez
Summary: In this study, two bacterial strains with antagonist activity against Vibrio parahaemolyticus were isolated from saline sediment in Mexico. The draft genome sequences of these strains were determined, and the analysis revealed the presence of biosynthetic gene clusters responsible for antimicrobial metabolite production. The findings suggest the potential of these strains as probiotics in shrimp aquaculture.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Biochemistry & Molecular Biology
Yongchang Tian, Rong Zhang, Binbin Guan, Yaowei Zhu, Li Chen
Summary: In this study, a novel acid-responsive oxidized dextran-based nanoplatform (OTP NP) was developed for photodynamic antibacterial therapy. OTP NP, composed of oxidized dextran and photosensitizer monoaminoporphyrin, exhibited excellent antibacterial activity against E. coli and S. aureus. Additionally, a new mechanism of bacterial membrane damage was discovered, where the bacterial cell membrane was peeled off and formed spherical particles under the combined action of reactive oxygen species (ROS) and nanomaterials. Moreover, OTP NP showed potential as a carrier for the slightly soluble drug levofloxacin (Lev).
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Microbiology
Xiaoyan Pang, Weihao Chen, Xin Wang, Xuefeng Zhou, Bin Yang, Xinpeng Tian, Junfeng Wang, Shihai Xu, Yonghong Liu
Summary: This study isolated multiple new compounds from cultures of the deep-sea-derived fungus Penicillium sp., and determined their structures and activities through various analyses. Compound 3 exhibited potent inhibitory activities against Staphylococcus aureus and methicillin-resistant S. aureus, as well as some weak antiviral activity against the SARS-CoV-2 main protease responsible for the COVID-19 pandemic.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Food Science & Technology
Xiaoxi Gao, Jie Yu, Lixuan Chang, Yunchao Wang, Xinping Sun, Guangqing Mu, Fang Qian
Summary: This study investigated the antibacterial activity of Bacillus coagulans (B. coagulans) T242 and its ability to alleviate Salmonella Typhimurium (S. Typhimurium) SL1344 infection in Caco-2 cells. B. coagulans T242 exhibited broad-spectrum antibacterial activity, inhibiting the growth of S. Typhimurium SL1344 and causing changes in its cell morphology. B. coagulans T242 reduced adhesion and invasion of S. Typhimurium SL1344 to Caco-2 cells, decreased inflammatory cytokine production, and enhanced intestinal barrier function.
Article
Chemistry, Multidisciplinary
Hyeji Lim, Sujin Oh, Sungryul Yu, Misook Kim
Summary: This study aimed to isolate functional Bacillus strains from Korean fermented soybeans, with MKHJ 1-1 showing the highest L-asparaginase activity. MKHJ 1-1 was identified as Bacillus subtilis subsp. stercoris D7XPN1 and exhibited high acid resistance and strong autoaggregation ability. It has potential as a probiotic with L-asparaginase activity, especially in the food and pharmaceutical industry.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Applied
Cancan Wang, Ying Zhou, Lei Yang, Hangqi Hu, Jianwei Chen, Youmin Ying, Hong Wang
Summary: A new 2,5-DKP derivative (1) and seven known congeners (2-8) were isolated from the marine fungus Penicillium sp. ZJUT-34 cultured on rice medium. Compound 1 showed significant inhibitory activity on quorum sensing (QS) and compound 8 exhibited comparable antibacterial activity against Enterococcus faecalis FA2-2.
NATURAL PRODUCT RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Jessica Vaca, Aurelio Ortiz, Estibaliz Sansinenea
Summary: This review provides an overview of bacteriocins isolated from different species of Bacillus, including their applications and improvements in production.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Biology
Saniya Aktayeva, Kairat Baltin, Assel Kiribayeva, Zhiger Akishev, Dmitriy Silayev, Yerlan Ramankulov, Bekbolat Khassenov
Summary: This study described the keratinolytic properties of a strain of Bacillus isolated from sites of feather waste accumulation. The strain, Bacillus sp. A5.3, secretes serine proteases that are alkaline enzymes with wide substrate specificity and high thermal stability. It effectively hydrolyzes feathers and can be used in feather-processing technologies and as a source of proteases and keratinases.
Article
Plant Sciences
Abujunaid Khan, Madhukar S. Said, Balasaheb R. Borade, Rajesh Gonnade, Vitthal Barvkar, Ravindar Kontham, Syed G. Dastager
Summary: Three novel compounds and a new acid were identified from the strain Amycolatopsis sp. MCC 0218, and their chemical structures and activities against methicillin-susceptible and -resistant Staphylococcus aureus were determined.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Biotechnology & Applied Microbiology
Riteshri Soni, Hareshkumar Keharia, Krina Shah, Neeraj Jain
Summary: The aim of this study was to investigate the probiotic traits and safety aspects of Bacillus velezensis K1 through experimental and genome studies. K1 showed tolerance to gastrointestinal stress, adherence to intestinal surfaces, and inhibition of enteropathogens. It also exhibited the ability to hydrolyze phytate and complex polysaccharides. Genes related to stress tolerance, adhesion, antimicrobial activity, and vitamin production were annotated in the K1 genome. K1 was found to be non-hemolytic, noncytotoxic, and susceptible to antibiotics. No virulence or toxin-encoding genes were identified in its genome.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Aravind Sundararaman, Mousumi Ray, P. Ravindra, Prakash M. Halami
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2020)
Review
Immunology
M. Mrityunjaya, V. Pavithra, R. Neelam, P. Janhavi, P. M. Halami, P. V. Ravindra
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Ann Catherine Archer, Serva Peddha Muthukumar, Prakash Motiram Halami
Summary: The study investigated the effects of potential probiotic Lactobacillus fermentum on intestinal markers of inflammation in diabetes and obesity models. Results showed improved oral glucose tolerance, plasma insulin levels, and reduced inflammatory tone, suggesting Lact. fermentum as a potential probiotic for lifestyle-related disorders.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2021)
Article
Chemistry, Multidisciplinary
Meena Kumari Palani Kumar, Prakash Motiram Halami, Muthukumar Serva Peddha
Summary: The probiotic strain Lactobacillus fermentum MCC2760 has shown beneficial effects in high-cholesterol diet-fed mice, including reducing serum lipids, anti-inflammatory properties, and improving gut barrier function. These findings highlight the potential of probiotic supplementation in managing hypercholesterolemia.
Article
Microbiology
H. S. Rohith, Prakash Motiram Halami
Summary: The study demonstrates the colonizing efficiency of probiotic Bacillus licheniformis MCC 2514 compared to Bifidobacterium breve NCIM 5671 on epithelial cell line HT-29. B. licheniformis showed higher adhesion and invasion capabilities on pathogen Kocuria rhizophila ATCC 9341 compared to Bif. breve. The in vitro studies showed no cytotoxic effects of the tested bacterial strains on HT-29 cells, indicating their potential for probiotic applications.
ARCHIVES OF MICROBIOLOGY
(2021)
Article
Biology
Salwa Naushin, Viren Sardana, Rajat Ujjainiya, Nitin Bhatheja, Rintu Kutum, Akash Kumar Bhaskar, Shalini Pradhan, Satyartha Prakash, Raju Khan, Birendra Singh Rawat, Karthik Bharadwaj Tallapaka, Mahesh Anumalla, Giriraj Ratan Chandak, Amit Lahiri, Susanta Kar, Shrikant Ramesh Mulay, Madhav Nilakanth Mugale, Mrigank Srivastava, Shaziya Khan, Anjali Srivastava, Bhawana Tomar, Murugan Veerapandian, Ganesh Venkatachalam, Selvamani Raja Vijayakumar, Ajay Agarwal, Dinesh Gupta, Prakash M. Halami, Muthukumar Serva Peddha, Gopinath M. Sundaram, Ravindra P. Veeranna, Anirban Pal, Vinay Kumar Agarwal, Anil Ku Maurya, Ranvijay Kumar Singh, Ashok Kumar Raman, Suresh Kumar Anandasadagopan, Parimala Karuppanan, Subramanian Venkatesan, Harish Kumar Sardana, Anamika Kothari, Rishabh Jain, Anupama Thakur, Devendra Singh Parihar, Anas Saifi, Jasleen Kaur, Virendra Kumar, Avinash Mishra, Iranna Gogeri, Geethavani Rayasam, Praveen Singh, Rahul Chakraborty, Gaura Chaturvedi, Pinreddy Karunakar, Rohit Yadav, Sunanda Singhmar, Dayanidhi Singh, Sharmistha Sarkar, Purbasha Bhattacharya, Sundaram Acharya, Vandana Singh, Shweta Verma, Drishti Soni, Surabhi Seth, Sakshi Vashisht, Sarita Thakran, Firdaus Fatima, Akash Pratap Singh, Akanksha Sharma, Babita Sharma, Manikandan Subramanian, Yogendra S. Padwad, Vipin Hallan, Vikram Patial, Damanpreet Singh, Narendra Vijay Tripude, Partha Chakrabarti, Sujay Krishna Maity, Dipyaman Ganguly, Jit Sarkar, Sistla Ramakrishna, Balthu Narender Kumar, Kiran A. Kumar, Sumit G. Gandhi, Piyush Singh Jamwal, Rekha Chouhan, Vijay Lakshmi Jamwal, Nitika Kapoor, Debashish Ghosh, Ghanshyam Thakkar, Umakanta Subudhi, Pradip Sen, Saumya Ray Chaudhury, Rashmi Kumar, Pawan Gupta, Amit Tuli, Deepak Sharma, Rajesh P. Ringe, D. Amarnarayan, Mahesh Kulkarni, Dhansekaran Shanmugam, Mahesh S. Dharne, Sayed G. Dastager, Rakesh Joshi, Amita P. Patil, Sachin N. Mahajan, Abujunaid Habib Khan, Vasudev Wagh, Rakesh Kumar Yadav, Ajinkya Khilari, Mayuri Bhadange, Arvindkumar H. Chaurasiya, Shabda E. Kulsange, Krishna Khairnar, Shilpa Paranjape, Jatin Kalita, Narahari G. Sastry, Tridip Phukan, Prasenjit Manna, Wahengbam Romi, Pankaj Bharali, Dibyajyoti Ozah, Ravi Kumar Sahu, Elapavalooru Vssk Babu, Rajeev Sukumaran, Aiswarya R. Nair, Prajeesh Kooloth Valappil, Anoop Puthiyamadam, Adarsh Velayudhanpillai, Kalpana Chodankar, Samir Damare, Yennapu Madhavi, Ved Varun Aggarwal, Sumit Dahiya, Anurag Agrawal, Debasis Dash, Shantanu Sengupta
Summary: The Council of Scientific and Industrial Research in India conducted a serosurvey in August and September 2020 to understand the spread of SARS-CoV2 and found that some individuals may be infected with the virus even without symptoms. Personal factors such as high-exposure work, use of public transport, non-smoking, non-vegetarian diet, and blood type B are associated with higher odds of seropositivity.
Article
Microbiology
Aravind Sundararaman, Kanika Bansal, Jameema Sidhic, Prabhu Patil, Prakash M. Halami
Summary: Bifidobacterium longum NCIM 5672 is a probiotic strain isolated from Indian infant feces, and its probiotic properties and acid-tolerance mechanism were determined through whole-genome sequencing. Genome analysis identified candidate acid-tolerance-associated genes, as well as genes associated with immunomodulation and cell adhesion, with RT-qPCR results supporting the role of these genes in acid tolerance. This study provides insights for selecting acid-resistant strains for the food industry and enhancing the industrial applications and health-promoting properties of this species.
ARCHIVES OF MICROBIOLOGY
(2021)
Review
Biology
Ashwini Manjunath, Surya Chandra Rao Thumu, Sumana Kumar, Prakash Motiram Halami
Summary: Heteroresistance is a phenomenon where a subset of bacterial cells shows higher resistance towards antibiotics, making it difficult to treat infections caused by these bacteria due to challenges in identification and study of subpopulations.
Article
Microbiology
Basista Rabina Sharma, Dharana Jayant, Kumari Rajshee, Yashika Singh, Prakash M. Halami
Summary: This study aimed to characterize natural antibiotics or lantibiotics from unconventional sources and their antibacterial spectrum. LAB producing bacteriocin were isolated from traditional fermented foods, with 129 cultures found to produce antimicrobial compounds. The identified Nisin-like bacteriocin showed inhibitory effects against foodborne pathogens and drug-resistant bacteria.
CURRENT MICROBIOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Mousumi Ray, Ashwini Manjunath, Prakash M. Halami
Summary: Antimicrobial resistance poses a significant challenge to global health. Inappropriate use of antibiotics, particularly in farming, has led to resistance to last-resort antibiotics such as colistin and polymyxin B. The mechanism of resistance to these antibiotics involves genetic alterations in chromosomal genes, as well as the presence of a mobile colistin/polymyxin B resistance gene (mcr) in Enterobacteriales. It is crucial to increase surveillance for detecting resistance to these antibiotics and to consider the implications of their usage in food safety.
JOURNAL OF ANTIBIOTICS
(2022)
Review
Biotechnology & Applied Microbiology
Rwivoo Baruah, Mousumi Ray, Prakash M. Halami
Summary: In recent years, there has been a rapid increase in the recognition of fermented foods as functional foods that provide health benefits in specific disease conditions. The health benefits of fermented foods are attributed to the presence of probiotic microbes and bioactive compounds formed during fermentation. The impact of fermented foods on conditions such as diabetes, cardiovascular disease, obesity, gastrointestinal disorder, cancer, and neurodegenerative disorders has been the focus of numerous studies using animal models and human clinical trials.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
H. S. Rohith, Prakash Motiram Halami
Summary: The study evaluates the effects of a combination of Bacillus licheniformis and Bifidobacterium breve on the gene expression and immune response of HT-29 cells. The combination of these probiotic bacteria showed anti-inflammatory activity and improved the gastrointestinal environment, making it a promising treatment for intestinal disorders.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Food Science & Technology
M. Ashwini, Mousumi Ray, K. Sumana, Prakash M. Halami
Summary: This study investigates the prevalence of antibiotic resistance in lactic acid bacteria (LAB) and identifies diverse phenotypic and genotypic MLS resistance among LAB species isolated from food samples and food-producing animals. The results suggest that food samples and food-producing animals can be potential sources of antibiotic-resistant LAB, highlighting the importance of raising awareness about antibiotic use to prevent resistance spread.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2023)
Correction
Biotechnology & Applied Microbiology
Ann Catherine Archer, Serva Peddha Muthukumar, Prakash Motiram Halami
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Food Science & Technology
Aditi Goel, Attar Singh Chauhan, Prakash M. Halami
Summary: This study developed a vegetable-based probiotic carrot nectar by incorporating Lactiplantibacillus plantarum MCC5231 into carrot nectar. The probiotic carrot nectar maintained high viability under refrigerated conditions and exhibited antimicrobial activity and high vitamin A content, providing several health benefits.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2023)
