Modification of cysteine residues by cyclopentenone prostaglandins: Interplay with redox regulation of protein function

Generation of Monoclonal Antibody for 15-deoxy-Δ12,14-Prostaglandin J2 and Development of Enzyme-Linked Immunosorbent Assay for Its Quantification in Culture Medium of Adipocytes

(2012) Pinky Karim Syeda et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Observation of Two Modes of Inhibition of Human Microsomal Prostaglandin E Synthase 1 by the Cyclopentenone 15-Deoxy-Δ12,14-prostaglandin J2

(2012) Edward B. Prage et al.   BIOCHEMISTRY

A-class prostaglandins: Early findings and new perspectives for overcoming tumor chemoresistance

(2012) Beatriz Díez-Dacal et al.   CANCER LETTERS

The glutathionylation of p65 modulates NF-κB activity in 15-deoxy-Δ12,14-prostaglandin J2-treated endothelial cells

(2012) Yuan-Chun Lin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Validation of the multiple sensor mechanism of the Keap1-Nrf2 system

(2012) Kai Takaya et al.   FREE RADICAL BIOLOGY AND MEDICINE

Utilization of fluorescent probes for the quantification and identification of subcellular proteomes and biological processes regulated by lipid peroxidation products

(2012) Timothy D. Cummins et al.   FREE RADICAL BIOLOGY AND MEDICINE

A Monoclonal Antibody Specific for Δ12-Prostaglandin J2 and Its Utilization in the Immunological Assay in Cell Culture System of Adipocytes

(2012) Pinky Karim Syeda et al.   HYBRIDOMA

Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration

(2012) Motohiro Nishida et al.   Nature Chemical Biology

Identification of Aldo-Keto Reductase AKR1B10 as a Selective Target for Modification and Inhibition by Prostaglandin A1: Implications for Antitumoral Activity

(2011) B. Diez-Dacal et al.   CANCER RESEARCH

Multidrug Resistance-Associated Protein 1 Mediates 15-Deoxy-Δ12,14-prostaglandin J2-Induced Expression of Glutamate Cysteine Ligase Expression via Nrf2 Signaling in Human Breast Cancer Cells

(2011) Na-Young Song et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Formation and Signaling Actions of Electrophilic Lipids

(2011) Francisco J. Schopfer et al.   CHEMICAL REVIEWS

Human aldo–keto reductases 1B1 and 1B10: A comparative study on their enzyme activity toward electrophilic carbonyl compounds

(2011) Yi Shen et al.   CHEMICO-BIOLOGICAL INTERACTIONS

HSF1-Dependent Upregulation of Hsp70 by Sulfhydryl-Reactive Inducers of the KEAP1/NRF2/ARE Pathway

(2011) Ying Zhang et al.   CHEMISTRY & BIOLOGY

Oxidation of HRas cysteine thiols by metabolic stress prevents palmitoylation in vivo and contributes to endothelial cell apoptosis

(2011) Joseph R. Burgoyne et al.   FASEB JOURNAL

Proteomic studies on protein modification by cyclopentenone prostaglandins: Expanding our view on electrophile actions

(2011) Beatriz Garzón et al.   Journal of Proteomics

Site-specific proteomic analysis of lipoxidation adducts in cardiac mitochondria reveals chemical diversity of 2-alkenal adduction

(2011) Juan D. Chavez et al.   Journal of Proteomics

The C-Terminus of H-Ras as a Target for the Covalent Binding of Reactive Compounds Modulating Ras-Dependent Pathways

(2011) Clara L. Oeste et al.   PLoS One

Anti-Inflammatory Prostanoids: Focus on the Interactions between Electrophile Signaling and Resolution of Inflammation

(2011) Beatriz Díez-Dacal et al.   TheScientificWorldJOURNAL

Redox signaling in inflammation: interactions of endogenous electrophiles and mitochondria in cardiovascular disease

(2010) Jeffrey R. Koenitzer et al.   Annals of the New York Academy of Sciences

The Nrf2-Keap1-ARE Signaling Pathway: The Regulation and Dual Function of Nrf2 in Cancer

(2010) Donna D. Zhang   ANTIOXIDANTS & REDOX SIGNALING

Cancer Chemoprevention Mechanisms Mediated Through the Keap1–Nrf2 Pathway

(2010) John D. Hayes et al.   ANTIOXIDANTS & REDOX SIGNALING

Site-Specific Protein Adducts of 4-Hydroxy-2(E)-Nonenal in Human THP-1 Monocytic Cells: Protein Carbonylation Is Diminished by Ascorbic Acid

(2010) Juan Chavez et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Redox Regulation of Soluble Epoxide Hydrolase by 15-Deoxy-Δ-Prostaglandin J 2 Controls Coronary Hypoxic Vasodilation

(2010) Rebecca L. Charles et al.   CIRCULATION RESEARCH

Alteration of biochemical and pathological properties of TDP-43 protein by a lipid mediator, 15-deoxy-Δ12,14-prostaglandin J2

(2010) Hai-Xin Zhang et al.   EXPERIMENTAL NEUROLOGY

The Anti-inflammatory Prostaglandin 15-Deoxy-Δ12,14-PGJ2Inhibits CRM1-dependent Nuclear Protein Export

(2010) Mark Hilliard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclopentenone Prostaglandins with Dienone Structure Promote Cross-Linking of the Chemoresistance-Inducing Enzyme Glutathione Transferase P1-1

(2010) F. J. Sanchez-Gomez et al.   MOLECULAR PHARMACOLOGY

Modification of ubiquitin-C-terminal hydrolase-L1 by cyclopentenone prostaglandins exacerbates hypoxic injury

(2010) Hao Liu et al.   NEUROBIOLOGY OF DISEASE

15-Deoxy-Δ12,14-prostaglandin J2 stabilizes, but functionally inactivates p53 by binding to the cysteine 277 residue

(2010) D-H Kim et al.   ONCOGENE

Selective binding of the fluorescent dye 1-anilinonaphthalene-8-sulfonic acid to peroxisome proliferator-activated receptor γ allows ligand identification and characterization

(2009) Silvia Zorrilla et al.   ANALYTICAL BIOCHEMISTRY

Mitochondrial targeting of the electrophilic lipid 15-deoxy-Δ12,14prostaglandin J2increases apoptotic efficacy via redox cell signalling mechanisms

(2009) Anne R. Diers et al.   BIOCHEMICAL JOURNAL

15-Deoxi-Δ12,14-prostaglandin J2 is a tubulin-binding agent that destabilizes microtubules and induces mitotic arrest

(2009) Claudia Cocca et al.   BIOCHEMICAL PHARMACOLOGY

A biotinylated analog of the anti-proliferative prostaglandin A1 allows assessment of PPAR-independent effects and identification of novel cellular targets for covalent modification

(2009) Beatriz Garzón et al.   CHEMICO-BIOLOGICAL INTERACTIONS

15d-PGJ2 Induces Apoptosis by Reactive Oxygen Species-mediated Inactivation of Akt in Leukemia and Colorectal Cancer Cells and Shows In vivo Antitumor Activity

(2009) S.-W. Shin et al.   CLINICAL CANCER RESEARCH

15-Deoxy-Δ12,14-prostaglandin J2 inhibits HIV-1 transactivating protein, Tat, through covalent modification

(2009) Parisa Kalantari et al.   FASEB JOURNAL

Regulation of Nrf2-dependent gene expression by 15-deoxy-Δ12,14-prostaglandin J2

(2009) Emilia Kansanen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Subchronic infusion of the product of inflammation prostaglandin J2 models sporadic Parkinson's disease in mice

(2009) Sha-Ron Pierre et al.   Journal of Neuroinflammation

Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer

(2009) Michael C. Byrns et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Δ12-Prostaglandin J2as a Product and Ligand of Human Serum Albumin: Formation of an Unusual Covalent Adduct at His146

(2009) Satoru Yamaguchi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nitro-fatty Acids Occur in Human Plasma in the Picomolar Range: a Targeted Nitro-lipidomics GC–MS/MS Study

(2009) Dimitrios Tsikas et al.   LIPIDS

Accumulation of 15-deoxy-Δ12,14-prostaglandin J2adduct formation with Keap1 over time: effects on potency for intracellular antioxidant defence induction

(2008) Joo Yeun Oh et al.   BIOCHEMICAL JOURNAL

The role of 15-deoxy-Δ12,14-prostaglandin J2, an endogenous ligand of peroxisome proliferator-activated receptor γ, in tumor angiogenesis

(2008) Eun-Hee Kim et al.   BIOCHEMICAL PHARMACOLOGY

Structural Insight into PPARγ Activation Through Covalent Modification with Endogenous Fatty Acids

(2008) Tsuyoshi Waku et al.   JOURNAL OF MOLECULAR BIOLOGY

The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds

(2008) M. Kobayashi et al.   MOLECULAR AND CELLULAR BIOLOGY

Neuroprotective effects of prostaglandin A1 in rat models of permanent focal cerebral ischemia are associated with nuclear factor-κB inhibition and peroxisome proliferator-activated receptor-γ up-regulation

(2007) Hui-Ling Zhang et al.   JOURNAL OF NEUROSCIENCE RESEARCH