Alternative Methods for the Detection of Emerging Marine Toxins: Biosensors, Biochemical Assays and Cell-Based Assays

Cyclic imines, as emerging marine toxins: Chemical properties, distribution, toxicological aspects and detection methods

(2017) M. CHATZIANASTASIOU (Μ. ΧΑΤΖΗΑΝΑΣΤΑΣΙΟΥ) et al.   Journal of the Hellenic Veterinary Medical Society

Synthesis and biology of cyclic imine toxins, an emerging class of potent, globally distributed marine toxins

(2015) Craig E. Stivala et al.   NATURAL PRODUCT REPORTS

Development of a haemolytic–enzymatic assay with mediated amperometric detection for palytoxin analysis: application to mussels

(2014) G. Volpe et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

First Report of a Direct Surface Plasmon Resonance Immunosensor for a Small Molecule Seafood Toxin

(2014) Betsy Jean Yakes et al.   ANALYTICAL CHEMISTRY

Interlaboratory Comparison of Two AOAC Liquid Chromatographic Fluorescence Detection Methods for Paralytic Shellfish Toxin Analysis through Characterization of an Oyster Reference Material

(2014) Andrew D. Turner et al.   JOURNAL OF AOAC INTERNATIONAL

Preparation of Anti-Ciguatoxin Monoclonal Antibodies Using Synthetic Haptens: Sandwich ELISA Detection of Ciguatoxins

(2014) Takeshi Tsumuraya et al.   JOURNAL OF AOAC INTERNATIONAL

Flow Cytometric-Membrane Potential Detection of Sodium Channel Active Marine Toxins: Application to Ciguatoxins in Fish Muscle and Feasibility of Automating Saxitoxin Detection

(2014) Ronald Manger et al.   JOURNAL OF AOAC INTERNATIONAL

Development and Utilization of a Fluorescence-Based Receptor-Binding Assay for the Site 5 Voltage-Sensitive Sodium Channel Ligands Brevetoxin and Ciguatoxin

(2014) Jennifer R. McCall et al.   JOURNAL OF AOAC INTERNATIONAL

Complex Toxin Profile of French Mediterranean Ostreopsis cf. ovata Strains, Seafood Accumulation and Ovatoxins Prepurification

(2014) Charline Brissard et al.   Marine Drugs

In vitro labelling of muscle type nicotinic receptors using a fluorophore-conjugated pinnatoxin F derivative

(2014) Shane D. Hellyer et al.   TOXICON

Construction of a single chain variable fragment antibody (scFv) against tetrodotoxin (TTX) and its interaction with TTX

(2014) Rongzhi Wang et al.   TOXICON

Tetrodotoxin: Chemistry, Toxicity, Source, Distribution and Detection

(2014) Vaishali Bane et al.   Toxins

Development and single laboratory validation of an optical biosensor assay for tetrodotoxin detection as a tool to combat emerging risks in European seafood

(2013) Katrina Campbell et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Development of a Solid-Phase Receptor-Based Assay for the Detection of Cyclic Imines Using a Microsphere-Flow Cytometry System

(2013) Laura P. Rodríguez et al.   ANALYTICAL CHEMISTRY

Vulcanodinium rugosumgen. et sp. nov. (Dinophyceae), un Nouveau Dinoflagellé Marin de la Côte Méditerranéenne Française

(2013) Elisabeth Nézan et al.   CRYPTOGAMIE ALGOLOGIE

Sandwich ELISA Assay for the Quantitation of Palytoxin and Its Analogs in Natural Samples

(2013) S. Boscolo et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Microbial diversity associated with tetrodotoxin production in marine organisms

(2013) V. Pratheepa et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Occurrence of palytoxins in marine organisms from different trophic levels of the French Mediterranean coast harvested in 2009

(2013) R. Biré et al.   HARMFUL ALGAE

EFFICIENCY OF A RAPID TEST FOR DETECTION OF TETRODOTOXIN IN PUFFER FISH

(2013) Aree Thattiyaphong et al.   JOURNAL OF IMMUNOASSAY & IMMUNOCHEMISTRY

Invasive Lionfish (Pterois volitans): A Potential Human Health Threat for Ciguatera Fish Poisoning in Tropical Waters

(2013) Alison Robertson et al.   Marine Drugs

Cytotoxicity, Fractionation and Dereplication of Extracts of the Dinoflagellate Vulcanodinium rugosum, a Producer of Pinnatoxin G

(2013) Marie Geiger et al.   Marine Drugs

Bioavailability and intravenous toxicokinetic parameters for Pacific ciguatoxin P-CTX-1 in rats

(2013) Aurélie Ledreux et al.   TOXICON

High-throughput receptor-based assay for the detection of spirolides by chemiluminescence

(2013) Laura P. Rodríguez et al.   TOXICON

Differences in the toxicity of six Gambierdiscus (Dinophyceae) species measured using an in vitro human erythrocyte lysis assay

(2013) William C. Holland et al.   TOXICON

Surface Plasmon Resonance Biosensor Method for Palytoxin Detection Based on Na+,K+-ATPase Affinity

(2013) Amparo Alfonso et al.   Toxins

Highly Sensitive Electrochemiluminescent Nanobiosensor for the Detection of Palytoxin

(2012) Valeria Anna Zamolo et al.   ACS Nano

Palytoxin detection and quantification using the fluorescence polarization technique

(2012) A. Alfonso et al.   ANALYTICAL BIOCHEMISTRY

Coupling the Torpedo Microplate-Receptor Binding Assay with Mass Spectrometry to Detect Cyclic Imine Neurotoxins

(2012) Rómulo Aráoz et al.   ANALYTICAL CHEMISTRY

Influence of temperature on growth, toxicity and carbohydrate production of a Japanese Ostreopsis ovata strain, a toxic-bloom-forming dinoflagellate

(2012) NK Vidyarathna et al.   AQUATIC MICROBIAL ECOLOGY

An improved competitive inhibition enzymatic immunoassay method for tetrodotoxin quantification

(2012) Amber N Stokes et al.   BIOLOGICAL PROCEDURES ONLINE

Unique Toxin Profile of a Mediterranean Ostreopsis cf. ovata Strain: HR LC-MSn Characterization of Ovatoxin-f, a New Palytoxin Congener

(2012) Patrizia Ciminiello et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Towards the standardisation of the neuroblastoma (neuro-2a) cell-based assay for ciguatoxin-like toxicity detection in fish: application to fish caught in the Canary Islands

(2012) A. Caillaud et al.   Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment

Evaluation of seafood toxicity in the Australes archipelago (French Polynesia) using the neuroblastoma cell-based assay

(2012) Ralph Pawlowiez et al.   Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment

Physiological responses of Ostreopsis ovata to changes in N and P availability and temperature increase

(2012) Nayani K. Vidyarathna et al.   HARMFUL ALGAE

Identification of Pinnatoxins and Discovery of Their Fatty Acid Ester Metabolites in Mussels (Mytilus edulis) from Eastern Canada

(2012) Pearse McCarron et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

New Gastropod Vectors and Tetrodotoxin Potential Expansion in Temperate Waters of the Atlantic Ocean

(2012) Marisa Silva et al.   Marine Drugs

Linking ciguatera poisoning to spatial ecology of fish: A novel approach to examining the distribution of biotoxin levels in the great barracuda by combining non-lethal blood sampling and biotelemetry

(2012) Amanda C. O'Toole et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Development of a monoclonal antibody against the left wing of ciguatoxin CTX1B: Thiol strategy and detection using a sandwich ELISA

(2012) Takeshi Tsumuraya et al.   TOXICON

First direct fluorescence polarization assay for the detection and quantification of spirolides in mussel samples

(2011) Paz Otero et al.   ANALYTICA CHIMICA ACTA

Antibody characterization and immunoassays for palytoxin using an SPR biosensor

(2011) Betsy Jean Yakes et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Validation of an accelerated solvent extraction liquid chromatography–tandem mass spectrometry method for Pacific ciguatoxin-1 in fish flesh and comparison with the mouse neuroblastoma assay

(2011) Jia Jun Wu et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Solid-Phase Receptor-Based Assay for the Detection of Cyclic Imines by Chemiluminescence, Fluorescence, or Colorimetry

(2011) Laura P. Rodríguez et al.   ANALYTICAL CHEMISTRY

On the origins and biosynthesis of tetrodotoxin

(2011) Rocky Chau et al.   AQUATIC TOXICOLOGY

Cyclic Imines: Chemistry and Mechanism of Action: A Review

(2011) Alberto Otero et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Monitoring of dissolved ciguatoxin and maitotoxin using solid-phase adsorption toxin tracking devices: Application to Gambierdiscus pacificus in culture

(2011) Amandine Caillaud et al.   HARMFUL ALGAE

Gambierdiscus excentricus sp. nov. (Dinophyceae), a benthic toxic dinoflagellate from the Canary Islands (NE Atlantic Ocean)

(2011) Santiago Fraga et al.   HARMFUL ALGAE

Growth and toxin profile of Ostreopsis cf. ovata (Dinophyta) from Rio de Janeiro, Brazil

(2011) Silvia M. Nascimento et al.   HARMFUL ALGAE

First Evidence of Palytoxin and 42-Hydroxy-palytoxin in the Marine Cyanobacterium Trichodesmium

(2011) Anne Sophie Kerbrat et al.   Marine Drugs

Development and demonstration of a disposable low-cost microelectrode array for cultured neuronal network recording

(2011) Hamid Charkhkar et al.   SENSORS AND ACTUATORS B-CHEMICAL

Occurrence of 12-methylgymnodimine in a spirolide-producing dinoflagellate Alexandrium peruvianum and the biogenetic implications

(2011) Ryan M. Van Wagoner et al.   TETRAHEDRON LETTERS

Toxicokinetics of the ciguatoxin P-CTX-1 in rats after intraperitoneal or oral administration

(2011) Marie-Yasmine Dechraoui Bottein et al.   TOXICOLOGY

Case definitions for human poisonings postulated to palytoxins exposure

(2011) A. Tubaro et al.   TOXICON

Cytotoxic and antimitotic activities in aqueous extracts of eight cyanobacterial strains isolated from the marine sponge Petrosia ficiformis

(2011) Patrizia Pagliara et al.   TOXICON

Influence of temperature and salinity on Ostreopsis cf. ovata growth and evaluation of toxin content through HR LC-MS and biological assays

(2011) Laura Pezzolesi et al.   WATER RESEARCH

Tetrodotoxin Detection by a Surface Plasmon Resonance Sensor in Pufferfish Matrices and Urine

(2011) Allen D. Taylor et al.   Journal of Sensors

Detection of 13,19-didesmethyl C spirolide by fluorescence polarization using Torpedo electrocyte membranes

(2010) Eva S. Fonfría et al.   ANALYTICAL BIOCHEMISTRY

Development of competitive indirect ELISA for the detection of tetrodotoxin and a survey of the distribution of tetrodotoxin in the tissues of wild puffer fish in the waters of south-east China

(2010) J. Tao et al.   Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment

Production of pinnatoxins by a peridinoid dinoflagellate isolated from Northland, New Zealand

(2010) L. Rhodes et al.   HARMFUL ALGAE

Isolation, Structural Determination and Acute Toxicity of Pinnatoxins E, F and G

(2010) Andrew I. Selwood et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Evaluation of Surface Plasmon Resonance Biosensors for Detection of Tetrodotoxin in Food Matrices and Comparison to Analytical Methods

(2010) Betsy Jean Yakes et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

A phylogeographical study of the toxic benthic dinoflagellate genusOstreopsisSchmidt

(2010) Antonella Penna et al.   JOURNAL OF BIOGEOGRAPHY

Evaluating the Risk of Ciguatera Fish Poisoning from Reef Fish Grown at Marine Aquaculture Facilities in Hawai'i

(2010) Cara Empey Campora et al.   JOURNAL OF THE WORLD AQUACULTURE SOCIETY

Fluidic Force Discrimination Assays: A New Technology for Tetrodotoxin Detection

(2010) Betsy Jean Yakes et al.   Marine Drugs

Update on Methodologies Available for Ciguatoxin Determination: Perspectives to Confront the Onset of Ciguatera Fish Poisoning in Europe

(2010) Amandine Caillaud et al.   Marine Drugs

Detection of ciguatoxin-like and paralysing toxins in Trichodesmium spp. from New Caledonia lagoon

(2010) Anne-Sophie Kerbrat et al.   MARINE POLLUTION BULLETIN

Spiroimine shellfish poisoning (SSP) and the spirolide family of shellfish toxins: Isolation, structure, biological activity and synthesis

(2010) Stéphanie M. Guéret et al.   NATURAL PRODUCT REPORTS

Structural determinants in phycotoxins and AChBP conferring high affinity binding and nicotinic AChR antagonism

(2010) Y. Bourne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complex palytoxin-like profile of Ostreopsis ovata. Identification of four new ovatoxins by high-resolution liquid chromatography/mass spectrometry

(2010) Patrizia Ciminiello et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Gold nanoparticle probe-based immunoassay as a new tool for tetrodotoxin detection in puffer fish tissues

(2010) Yu Zhou et al.   SENSORS AND ACTUATORS B-CHEMICAL

Global distribution of ciguatera causing dinoflagellates in the genus Gambierdiscus

(2010) R. Wayne Litaker et al.   TOXICON

Rapid isolation of single-chain antibodies by phage display technology directed against one of the most potent marine toxins: Palytoxin

(2010) E. Garet et al.   TOXICON

Modulation of protein kinase signaling cascades by palytoxin

(2010) Elizabeth V. Wattenberg   TOXICON

The cytolytic and cytotoxic activities of palytoxin

(2010) Mirella Bellocci et al.   TOXICON

Palytoxin action on the Na+,K+-ATPase and the disruption of ion equilibria in biological systems

(2010) Gian Paolo Rossini et al.   TOXICON

Palytoxin toxicology: Animal studies

(2010) Rex Munday   TOXICON

Occurrence of palytoxin-group toxins in seafood and future strategies to complement the present state of the art

(2010) Katerina Aligizaki et al.   TOXICON

Feasibility of gymnodimine and 13-desmethyl C spirolide detection by fluorescence polarization using a receptor-based assay in shellfish matrixes

(2009) Eva S. Fonfría et al.   ANALYTICA CHIMICA ACTA

Detection of Gymnodimine-A and 13-Desmethyl C Spirolide Phycotoxins by Fluorescence Polarization

(2009) Natalia Vilariño et al.   ANALYTICAL CHEMISTRY

Detection of hemolytic bacteria from Palythoa caribaeorum (Cnidaria, Zoantharia) using a novel palytoxin-screening assay

(2009) Petra Seemann et al.   ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY

Stereostructure and Biological Activity of 42-Hydroxy-palytoxin: A New Palytoxin Analogue from HawaiianPalythoaSubspecies

(2009) Patrizia Ciminiello et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Rapid screening of tetrodotoxin in urine and plasma of patients with puffer fish poisoning by HPLC with creatinine correction

(2009) Chung-Him Yu et al.   Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment

The hemolytic activity of Karenia selliformis and two clones of Karenia brevis throughout a growth cycle

(2009) Avery O. Tatters et al.   JOURNAL OF APPLIED PHYCOLOGY

Liquid chromatography–tandem mass spectrometry method for the detection of marine lipophilic toxins under alkaline conditions

(2009) Arjen Gerssen et al.   JOURNAL OF CHROMATOGRAPHY A

Improvements in the use of neuroblastomaxglioma hybrid cells (NG108-15) for the toxic effect quantification of marine toxins

(2009) Elisabeth Cañete et al.   TOXICON

Production of monoclonal antibodies for sandwich immunoassay detection of Pacific ciguatoxins

(2009) Takeshi Tsumuraya et al.   TOXICON

Human risk associated with palytoxin exposure

(2009) Jonathan R. Deeds et al.   TOXICON

Toxic dinoflagellates (Dinophyceae) from Rarotonga, Cook Islands

(2009) Lesley L. Rhodes et al.   TOXICON

Growth and toxin production in the ciguatera-causing dinoflagellate Gambierdiscus polynesiensis (Dinophyceae) in culture

(2009) Mireille Chinain et al.   TOXICON

First Toxicity Report of Tetrodotoxin and 5,6,11-TrideoxyTTX in the Trumpet Shell Charonia lampas lampas in Europe

(2008) Paula Rodriguez et al.   ANALYTICAL CHEMISTRY

Specific and dynamic detection of palytoxins by in vitro microplate assay with human neuroblastoma cells

(2008) Begoña Espiña et al.   BIOSCIENCE REPORTS

Identification of tetrodotoxin antigens and a monoclonal antibody

(2008) Y. Zhou et al.   FOOD CHEMISTRY

Morphogenetic diversity and biotoxin composition of Alexandrium (Dinophyceae) in Irish coastal waters

(2008) Nicolas Touzet et al.   HARMFUL ALGAE

Karenia brevis red tides, brevetoxins in the food web, and impacts on natural resources: Decadal advancements

(2008) J.H. Landsberg et al.   HARMFUL ALGAE

Detection of ciguatoxin in fish tissue using sandwich ELISA and neuroblastoma cell bioassay

(2008) Cara Empey Campora et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Development of an enzyme‐linked immunosorbent assay for the detection of ciguatoxin in fish tissue using chicken immunoglobulin Y

(2008) Cara Empey Campora et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Neurotoxic Shellfish Poisoning

(2008) Sharon Watkins et al.   Marine Drugs

The conformational features of palytoxin in aqueous solution

(2008) Toshiyasu Inuzuka et al.   TETRAHEDRON

Lessepsian migration and tetrodotoxin poisoning due to Lagocephalus sceleratus in the eastern Mediterranean

(2008) Yedidia Bentur et al.   TOXICON

Comparative study of the use of neuroblastoma cells (Neuro-2a) and neuroblastoma×glioma hybrid cells (NG108-15) for the toxic effect quantification of marine toxins

(2008) Elisabeth Cañete et al.   TOXICON

Suitability of the Neuro-2a cell line for the detection of palytoxin and analogues (neurotoxic phycotoxins)

(2008) Aurélie Ledreux et al.   TOXICON

A cytolytic assay for the measurement of palytoxin based on a cultured monolayer cell line

(2007) Mirella Bellocci et al.   ANALYTICAL BIOCHEMISTRY

Proposal for a simple and sensitive haemolytic assay for palytoxin

(2007) P. Riobó et al.   HARMFUL ALGAE

Putative palytoxin and its new analogue, ovatoxin-a, in Ostreopsis ovata collected along the ligurian coasts during the 2006 toxic outbreak

(2007) Patrizia Ciminiello et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Quantitative detection of tetrodotoxin (TTX) by a surface plasmon resonance (SPR) sensor

(2007) A TAYLOR et al.   SENSORS AND ACTUATORS B-CHEMICAL