Synthesis and biology of cyclic imine toxins, an emerging class of potent, globally distributed marine toxins

Synthesis of the C10-C24-Bis-Spiroacetal Core of 13-Desmethyl Spirolide C Based on a Sila-Stetter-Acetalization Process

(2014) Jessica Labarre-Lainé et al.   CHEMISTRY-A EUROPEAN JOURNAL

Determination of lipophilic marine toxins in mussels. Quantification and confirmation criteria using high resolution mass spectrometry

(2014) Albert Domènech et al.   JOURNAL OF CHROMATOGRAPHY A

Recent progress in neuroactive marine natural products

(2014) Ryuichi Sakai et al.   NATURAL PRODUCT REPORTS

A roadmap for hazard monitoring and risk assessment of marine biotoxins on the basis of chemical and biological test systems

(2014) Mardas Daneshian   ALTEX-Alternatives to Animal Experimentation

Development of a Solid-Phase Receptor-Based Assay for the Detection of Cyclic Imines Using a Microsphere-Flow Cytometry System

(2013) Laura P. Rodríguez et al.   ANALYTICAL CHEMISTRY

Vulcanodinium rugosumgen. et sp. nov. (Dinophyceae), un Nouveau Dinoflagellé Marin de la Côte Méditerranéenne Française

(2013) Elisabeth Nézan et al.   CRYPTOGAMIE ALGOLOGIE

Benefit of 13-desmethyl Spirolide C Treatment in Triple Transgenic Mouse Model of Alzheimer Disease: Beta-Amyloid and Neuronal Markers Improvement

(2013) Eva Alonso et al.   Current Alzheimer Research

Cytotoxicity, Fractionation and Dereplication of Extracts of the Dinoflagellate Vulcanodinium rugosum, a Producer of Pinnatoxin G

(2013) Marie Geiger et al.   Marine Drugs

Activation and allosteric modulation of a muscarinic acetylcholine receptor

(2013) Andrew C. Kruse et al.   NATURE

Graphene based pipette tip solid phase extraction of marine toxins in shellfish muscle followed by UPLC–MS/MS analysis

(2013) Qing Shen et al.   TALANTA

Portimine: a bioactive metabolite from the benthic dinoflagellate Vulcanodinium rugosum

(2013) Andrew I. Selwood et al.   TETRAHEDRON LETTERS

High-throughput receptor-based assay for the detection of spirolides by chemiluminescence

(2013) Laura P. Rodríguez et al.   TOXICON

Pinnatoxin G is responsible for atypical toxicity in mussels (Mytilus galloprovincialis) and clams (Venerupis decussata) from Ingril, a French Mediterranean lagoon

(2013) Philipp Hess et al.   TOXICON

Coupling the Torpedo Microplate-Receptor Binding Assay with Mass Spectrometry to Detect Cyclic Imine Neurotoxins

(2012) Rómulo Aráoz et al.   ANALYTICAL CHEMISTRY

Spirolide uptake and detoxification by Crassostrea gigas exposed to the toxic dinoflagellate Alexandrium ostenfeldii

(2012) Walid Medhioub et al.   AQUACULTURE

A Perspective on the Toxicology of Marine Toxins

(2012) Luis M. Botana   CHEMICAL RESEARCH IN TOXICOLOGY

Alexandrium peruvianum (Balech and Mendiola) Balech and Tangen a new toxic species for coastal North Carolina

(2012) Carmelo R. Tomas et al.   HARMFUL ALGAE

Prevalence and persistence of gymnodimines in clams from the Gulf of Gabes (Tunisia) studied by mouse bioassay and LC–MS/MS

(2012) Idriss Ben Naila et al.   HARMFUL ALGAE

Regulation of spiroimine neurotoxins and hemolytic activity in laboratory cultures of the dinoflagellate Alexandrium peruvianum (Balech & Mendiola) Balech & Tangen

(2012) Avery O. Tatters et al.   HARMFUL ALGAE

Identification of Pinnatoxins and Discovery of Their Fatty Acid Ester Metabolites in Mussels (Mytilus edulis) from Eastern Canada

(2012) Pearse McCarron et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The implementation of liquid chromatography tandem mass spectrometry for the official control of lipophilic toxins in seafood: Single-laboratory validation under four chromatographic conditions

(2012) M. García-Altares et al.   JOURNAL OF CHROMATOGRAPHY A

Stability of Cyclic Imine Toxins: Interconversion of Pinnatoxin Amino Ketone and Pinnatoxin A in Aqueous Media

(2012) Jeffrey J. Jackson et al.   JOURNAL OF ORGANIC CHEMISTRY

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist

(2012) Kazuko Haga et al.   NATURE

Structure and dynamics of the M3 muscarinic acetylcholine receptor

(2012) Andrew C. Kruse et al.   NATURE

Comparison of acetylcholine receptor interactions of the marine toxins, 13-desmethylspirolide C and gymnodimine

(2012) Terry A. Hauser et al.   NEUROPHARMACOLOGY

Studies toward the Synthesis of Spirolide C: Exploration into the Formation of the 23-Membered All-Carbon Macrocyclic Framework

(2012) Craig E. Stivala et al.   ORGANIC LETTERS

Acute toxicity of pinnatoxins E, F and G to mice

(2012) Rex Munday et al.   TOXICON

First direct fluorescence polarization assay for the detection and quantification of spirolides in mussel samples

(2011) Paz Otero et al.   ANALYTICA CHIMICA ACTA

Screening for multiple classes of marine biotoxins by liquid chromatography–high-resolution mass spectrometry

(2011) Pearl Blay et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Solid-Phase Receptor-Based Assay for the Detection of Cyclic Imines by Chemiluminescence, Fluorescence, or Colorimetry

(2011) Laura P. Rodríguez et al.   ANALYTICAL CHEMISTRY

The Cholinergic Antagonist Gymnodimine Improves Aβ and Tau Neuropathology in an in Vitro Model of Alzheimer Disease

(2011) Eva Alonso et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Pharmacokinetic and toxicological data of spirolides after oral and intraperitoneal administration

(2011) Paz Otero et al.   FOOD AND CHEMICAL TOXICOLOGY

New perspectives on biotoxin detection in Rangaunu Harbour, New Zealand arising from the discovery of pinnatoxins

(2011) P.S. McNabb et al.   HARMFUL ALGAE

Total Synthesis of the Spirocyclic Imine Marine Toxin (−)-Gymnodimine and an Unnatural C4-Epimer

(2011) Ke Kong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of Pinnatoxins A and G and Revision of the Mode of Action of Pinnatoxin A

(2011) Romulo Araoz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

13-Desmethyl spirolide-C is neuroprotective and reduces intracellular Aβ and hyperphosphorylated tau in vitro

(2011) Eva Alonso et al.   NEUROCHEMISTRY INTERNATIONAL

Production of pinnatoxins E, F and G by scrippsielloid dinoflagellates isolated from Franklin Harbour, South Australia

(2011) L Rhodes et al.   NEW ZEALAND JOURNAL OF MARINE AND FRESHWATER RESEARCH

6,6-Spiroimine analogs of (−)-gymnodimine A: synthesis and biological evaluation on nicotinic acetylcholine receptors

(2011) Leslie Duroure et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Dinoflagellate Vulcanodinium rugosum identified as the causative organism of pinnatoxins in Australia, New Zealand and Japan

(2011) Lesley Rhodes et al.   PHYCOLOGIA

Occurrence of 12-methylgymnodimine in a spirolide-producing dinoflagellate Alexandrium peruvianum and the biogenetic implications

(2011) Ryan M. Van Wagoner et al.   TETRAHEDRON LETTERS

First report on the detection of pectenotoxin groups in Chinese shellfish by LC–MS/MS

(2011) Renyan Liu et al.   TOXICON

Marine algal pinnatoxins E and F cause neuromuscular block in an in vitro hemidiaphragm preparation

(2011) Shane D. Hellyer et al.   TOXICON

Pinnatoxins and spirolides in Norwegian blue mussels and seawater

(2011) Thomas Rundberget et al.   TOXICON

Investigations into the Toxicology of Spirolides, a Group of Marine Phycotoxins

(2011) Rex Munday et al.   Toxins

In-house validation of a liquid chromatography tandem mass spectrometry method for the analysis of lipophilic marine toxins in shellfish using matrix-matched calibration

(2010) Arjen Gerssen et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Detection of 13,19-didesmethyl C spirolide by fluorescence polarization using Torpedo electrocyte membranes

(2010) Eva S. Fonfría et al.   ANALYTICAL BIOCHEMISTRY

Human Muscarinic Acetylcholine Receptors Are a Target of the Marine Toxin 13-Desmethyl C Spirolide

(2010) Carolina B. Wandscheer et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Marine Toxins with Spiroimine Rings: Total Synthesis of Pinnatoxin A

(2010) Stéphane Beaumont et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Production of pinnatoxins by a peridinoid dinoflagellate isolated from Northland, New Zealand

(2010) L. Rhodes et al.   HARMFUL ALGAE

Isolation, Structural Determination and Acute Toxicity of Pinnatoxins E, F and G

(2010) Andrew I. Selwood et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

OCEAN CLIMATE CHANGE, PHYTOPLANKTON COMMUNITY RESPONSES, AND HARMFUL ALGAL BLOOMS: A FORMIDABLE PREDICTIVE CHALLENGE

(2010) Gustaaf M. Hallegraeff   JOURNAL OF PHYCOLOGY

Spiroimine shellfish poisoning (SSP) and the spirolide family of shellfish toxins: Isolation, structure, biological activity and synthesis

(2010) Stéphanie M. Guéret et al.   NATURAL PRODUCT REPORTS

Structural determinants in phycotoxins and AChBP conferring high affinity binding and nicotinic AChR antagonism

(2010) Y. Bourne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of 27-hydroxy-13-desmethyl spirolide C and 27-oxo-13,19-didesmethyl spirolide C. Further insights into the complex Adriatic Alexandrium ostenfeldii toxin profile

(2010) Patrizia Ciminiello et al.   TOXICON

Feasibility of gymnodimine and 13-desmethyl C spirolide detection by fluorescence polarization using a receptor-based assay in shellfish matrixes

(2009) Eva S. Fonfría et al.   ANALYTICA CHIMICA ACTA

Detection of Gymnodimine-A and 13-Desmethyl C Spirolide Phycotoxins by Fluorescence Polarization

(2009) Natalia Vilariño et al.   ANALYTICAL CHEMISTRY

Enantioselective Total Synthesis of the Marine Toxin (−)-Gymnodimine Employing a Barbier-Type Macrocyclization

(2009) Ke Kong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of the Antibiotic Kendomycin by Macrocyclization using Photo-Fries Rearrangement and Ring-Closing Metathesis

(2009) Thomas Magauer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ring-Closing Metathesis and Photo-Fries Reaction for the Construction of the Ansamycin Antibiotic Kendomycin: Development of a Protecting Group Free Oxidative Endgame

(2009) Thomas Magauer et al.   CHEMISTRY-A EUROPEAN JOURNAL

Detoxification enhancement in the gymnodimine-contaminated grooved carpet shell, Ruditapes decussatus (Linné)

(2009) Medhioub Walid et al.   HARMFUL ALGAE

Liquid chromatography–tandem mass spectrometry method for the detection of marine lipophilic toxins under alkaline conditions

(2009) Arjen Gerssen et al.   JOURNAL OF CHROMATOGRAPHY A

Characterization of a Dispiroketal Spirolide Subclass fromAlexandrium ostenfeldii

(2009) Joy S. Roach et al.   JOURNAL OF NATURAL PRODUCTS

Quantitative Determination of Gymnodimine-A by High Performance Liquid Chromatography in Contaminated Clams from Tunisia Coastline

(2009) Riadh Marrouchi et al.   MARINE BIOTECHNOLOGY

Studies Toward the Synthesis of Spirolides: Assembly of the Elaborated E-Ring Fragment

(2009) Craig E. Stivala et al.   ORGANIC LETTERS

Complex toxin profile of Mytilus galloprovincialis from the Adriatic sea revealed by LC–MS

(2009) Patrizia Ciminiello et al.   TOXICON

LC-MS-MS aboard ship: tandem mass spectrometry in the search for phycotoxins and novel toxigenic plankton from the North Sea

(2008) Bernd Krock et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Total Synthesis of Pinnatoxin A

(2008) Seiichi Nakamura et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Morphogenetic diversity and biotoxin composition of Alexandrium (Dinophyceae) in Irish coastal waters

(2008) Nicolas Touzet et al.   HARMFUL ALGAE

Bloom forming Alexandrium ostenfeldii (Dinophyceae) in shallow waters of the Åland Archipelago, Northern Baltic Sea

(2008) Anke Kremp et al.   HARMFUL ALGAE

Lipophilic Toxins Analyzed by Liquid Chromatography−Mass Spectrometry and Comparison with Mouse Bioassay in Fresh, Frozen, and Processed Molluscs

(2008) M. J. Chapela et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Total Synthesis of (+)-Pinnatoxin A

(2008) Craig E. Stivala et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nicotinic receptor agonists and antagonists increase sAPPα secretion and decrease Aβ levels in vitro

(2008) M. Mousavi et al.   NEUROCHEMISTRY INTERNATIONAL

A non-radioactive ligand-binding assay for detection of cyanobacterial anatoxins using Torpedo electrocyte membranes

(2008) Rómulo Aráoz et al.   TOXICON