Article
Biotechnology & Applied Microbiology
Xianggang Wang, Zhengyan Li, Zhonghan Wang, He Liu, Yutao Cui, Yuzhe Liu, Ming Ren, Hongsheng Zhan, Zuhao Li, Minfei Wu, Jincheng Wang
Summary: The study developed a thermosensitive hydrogel loaded with BMP-2 and OPG to promote bone formation and inhibit osteoclast activity, which was then used to construct 3D-printed composite scaffolds. These scaffolds facilitated osteogenic differentiation, reduced osteoclastic activation, and improved bone ingrowth and osseointegration through sustained release of BMP-2 and OPG.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biophysics
Jisun Park, Su Jeong Lee, Tae Gon Jung, Jun Hee Lee, Wan Doo Kim, Jae Young Lee, Su A. Park
Summary: Three-dimensional (3D) bioprinting allows for precise fabrication of scaffolds for tissue engineering, particularly those supporting cell attachment and osteogenic differentiation essential for bone tissue regeneration. Coating PCL scaffolds with PDA and depositing HA nanoparticles, followed by BMP-2 immobilization, promotes osteoblast proliferation and differentiation for potential bone tissue engineering applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Engineering, Biomedical
M. Bouyer, C. Garot, P. Machillot, J. Vollaire, V Fitzpatrick, S. Morand, J. Boutonnat, V Josserand, G. Bettega, C. Picart
Summary: The study suggests that using 3D-printed PLA scaffolds loaded with reduced doses of BMP-2 may be a safe and simple solution for large bone defects in the clinic. The dose of BMP-2 delivered from the scaffold significantly influences the amount of regenerated bone and the repair kinetics, showing good bone repair outcomes.
MATERIALS TODAY BIO
(2021)
Article
Materials Science, Multidisciplinary
Joalen P. Monte, Adriana Fontes, Beate S. Santos, Giovannia A. L. Pereira, Goreti Pereira
Summary: The development of multifunctional materials for bone tissue repair has attracted researchers' interest. Several materials classes have been studied and optimized for this aim, such as implants based on metals, ceramics, glasses, and composites. HAp-based scaffolds doped with AgNPs have shown promising antibacterial properties and good biocompatibility, which can potentially overcome the issue of implant-related infections.
Review
Biotechnology & Applied Microbiology
Liwei Zhu, Yuzhe Liu, Ao Wang, Zhengqing Zhu, Youbin Li, Chenyi Zhu, Zhenjia Che, Tengyue Liu, He Liu, Lanfeng Huang
Summary: Bone morphogenetic protein (BMP) plays an important role in promoting bone healing, but its mechanism needs further exploration. By modifying implants to carry BMP and achieve slow and sustained release, effective bone healing can be stimulated.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ana Dora Rodrigues Pontinha, Beatriz Barbosa Moreira, Bruna Lopes Melo, Duarte de Melo-Diogo, Ilidio Joaquim Correia, Patricia Alves
Summary: This study reports a hybrid composite scaffold of silica aerogel and poly-epsilon-caprolactone (PCL) with excellent physical properties for tissue engineering applications. The scaffold was extensively characterized and evaluated for osteoblast viability and morphology. The results suggest that this hybrid scaffold holds promise for future application in bone tissue engineering.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Katherine R. Hixon, Dakota B. Katz, Jennifer A. McKenzie, Anna N. Miller, Farshid Guilak, Matthew J. Silva
Summary: This study demonstrates the potential of cellularized cryogel scaffolds to enhance the healing of non-unions, particularly through the addition of BMP-2 to promote endochondral ossification.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Sumeyra Nur Fuerkaiti, Anil Sera Cakmak, Cagatay Karaaslan, Menemse Gumusderelioglu
Summary: This study demonstrated that silencing Noggin using siRNA induces osteogenic differentiation in reduced doses of BMP-2 for scaffold-based bone regeneration. The siNoggin-transfected cells showed enhanced osteogenic effects and mineralization, suggesting a potential safe therapeutic approach for tissue regeneration.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Seunghun S. Lee, Matthias Santschi, Stephen J. Ferguson
Summary: Bone regeneration is a complex physiological process regulated by factors such as bone-mimicking extracellular matrix and osteogenic growth factors like BMP-2. The development of a biomimetic hybrid scaffold with sustained release of BMP-2 showed enhanced bone formation in this study. Analysis of the scaffold's characteristics revealed improved cell proliferation rate and apatite formation, as well as sustained BMP-2 release, leading to enhanced osteogenic differentiation.
Article
Pharmacology & Pharmacy
Hala Jarrar, Damla Cetin Altindal, Menemse Gumusderelioglu
Summary: The study revealed that combining low doses of BMP-2 with MEL in a dual release system significantly enhanced the osteogenic activity of MC3T3-E1 cells, leading to increased cell number, ECM density, expression of differentiation markers, and mineralization compared to other groups.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Materials Science, Biomaterials
Anil Sera Cakmak, Sumeyra Fuerkaiti, Dilara Karaguzel, Cagatay Karaaslan, Menemse Gumusderelioglu
Summary: This study demonstrates that the CRISPR/Cas9 mechanism can be used to knockout the Noggin gene, thereby increasing the activity of BMP-2 signaling and promoting osteogenic differentiation. The findings suggest that CRISPR/Cas9 has great potential as a tool for obtaining new cell sources for tissue engineering studies.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Yurui Xu, Anwei Zhou, Weiwei Chen, Xinghai Ning
Summary: This study presents a novel bio-orthogonal engineering strategy (BIEN) to create advanced multicellular 3D tissue constructs (MTCs) using a scaffold-free approach. By harnessing the cellular biosynthetic machinery, BIEN incorporates bio-orthogonal azide reporters into cell surface glycoconjugates and assembles MTCs through a click reaction with multiarm PEG. The resulting MTCs demonstrate uniform, heterogeneous spheroids with high intercellular junction and pluripotency, simulating tumor features and improving research models.
Article
Biotechnology & Applied Microbiology
Ziyang Yang, Li Xie, Boqing Zhang, Gang Zhang, Fangjun Huo, Changchun Zhou, Xi Liang, Yujiang Fan, Weidong Tian, Yinghui Tan
Summary: This study demonstrates the potential of the BMP-2/PDA-BCP scaffold for the treatment of small craniofacial bone defects requiring high accuracy. The scaffold, constructed using DLP-based 3D printing, showed excellent properties and effectively promoted bone regeneration both in vitro and in vivo.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Xin Chen, Baoyu Tan, Zhiteng Bao, Shang Wang, Rongze Tang, Zhenmin Wang, Gaoyang Chen, Shuai Chen, William W. Lu, Dazhi Yang, Songlin Peng
Summary: The modification strategy using His6-T4L enhances the stability and solubility of BMP-2, allowing for controlled release and maximizing its activity to enhance bone regeneration. Additionally, the gelatin-based hydrogel incorporated with MPs-His6-T4L-BMP2 displays favorable properties for bone defect repair.
Article
Cell & Tissue Engineering
Angela Semitela, Goncalo Ramalho, Ana Capitao, Catia Sousa, Alexandrina F. Mendes, Paula A. A. P. Marques, Antonio Completo
Summary: Electrospinning is widely used in fabricating fibrous scaffolds for cartilage tissue engineering. However, small pores in the scaffold restrict cell infiltration. Bio-electrospraying provides a solution by incorporating chondrocytes into the fibers during electrospinning. Through experiments, it was found that chondrocytes survived and functioned well under certain electrospraying conditions. The combination of electrospraying and polymer electrospinning shows promising results for the delivery and development of cellularized cartilage tissue constructs.
JOURNAL OF TISSUE ENGINEERING
(2022)
Article
Chemistry, Physical
Hong Chen, Qixin Lu, Xia Cao, Ning Wang, Zhonglin Wang
Summary: This study explores the use of chitosansilk fibroin-airlaid paper composite film (CSA film) for triboelectric nanogenerator (TENG) applications, providing a new approach for natural polymers in triboelectric materials. The CSA-TENG shows high efficiency in harvesting environmental energy, while the CSA-D-TENG successfully integrates into hand clapper and trampoline, capable of monitoring human movement while harvesting biomechanical energies.
Article
Chemistry, Multidisciplinary
Jiehui Xue, Ning Zheng, Wenyu Zhao, Xia Cao, Zhong Lin Wang
Summary: SRC-TENG is a self-powered generator based on the principle of frictional electricity generation, capable of powering LEDs and charging commercial capacitors. It can be used as a self-powered sensor in smart toys and track the movement trajectory of a Rubik cube during recovery.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yang Jiang, Yufei Zhang, Chuan Ning, Qingqing Ji, Xiao Peng, Kai Dong, Zhong Lin Wang
Summary: This study presents an ultrathin eardrum-like triboelectric acoustic sensor (ETAS), which has high sensitivity and a broad frequency response range that can be adjusted by geometric parameters. When used in combination with artificial intelligence algorithms, the ETAS can achieve real-time voice conversion with high identification accuracy.
Article
Chemistry, Physical
Xin Guo, Jiajia Shao, Morten Willatzen, Yi Yang, Zhong Lin Wang
Summary: The technology of converting mechanical energy into electricity using triboelectric nanogenerators is advancing slowly due to challenges in accurately modeling the energy harvesting process. Previous theoretical models based on charged finite-sized planes are limited in applicability to complex geometric configurations. A new systematic theoretical analysis based on expanded Maxwell's equations for cylindrical triboelectric nanogenerators has been proposed, providing a standard framework for modeling non-planar geometric structures like cones and disks. This analysis helps improve the fundamental theory of triboelectric nanogenerators and enables the construction of more realistic mechanical energy harvesting systems.
Article
Chemistry, Multidisciplinary
Qi Gao, Yuhong Xu, Xin Yu, Zhaoxu Jing, Tinghai Cheng, Zhong Lin Wang
Summary: A gyroscope-structured triboelectric nanogenerator is proposed for harvesting multidirectional ocean wave energy. The experiments show that the generator exhibits good durability in water.
Article
Chemistry, Physical
Jiahui Xu, Xuelian Wei, Ruonan Li, Yapeng Shi, Yating Peng, Zhiyi Wu, Zhong Lin Wang
Summary: This study provides an intelligent self-powered take-off board sensor that can accurately detect the take-off status of athletes and provide take-off data for athletes and referees. This is important for intelligent sports monitoring and promoting the application of TENG-based sensors in intelligent sports.
Article
Chemistry, Physical
Jiayue Zhang, Shaoxin Li, Zhihao Zhao, Yikui Gao, Di Liu, Jie Wang, Zhong Lin Wang
Summary: This paper introduces a three-dimensional scanning system for obtaining a more realistic digital model. A point cloud collection probe is used to accurately collect data from the surface of objects with minimal damage. A productive post-processing system is proposed to recognize and compensate for noise and baseline drift errors, greatly improving the system's accuracy. This system has significant implications for the development of digital twin technology and its applications in intelligent manufacturing, intelligent healthcare, and cultural relics protection.
Article
Chemistry, Multidisciplinary
Pengwen Guo, Mengmeng Jia, Di Guo, Wei Wang, Yufei Zhang, Lele Ren, Aifang Yu, Zhong Lin Wang, Junyi Zhai
Summary: In addition to electrical, optical, and magnetic fields, mechanical forces have shown a strong ability to modulate semiconductor devices. This study reports a large mechanical modulation of electronic properties in semiconductor materials with a large Young's modulus-based force FET. The FET exhibits ultralow switching energy dissipation and almost zero leakage power, surpassing the performance of electronic FETs. These findings pave the way for practical applications of high-power efficiency nanoforce modulation devices.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Werner E. G. Mueller, Hadrian Schepler, Meik Neufurth, Shunfeng Wang, Veronica Ferrucci, Massimo Zollo, Rongwei Tan, Heinz C. Schroeder, Xiaohong Wang
Summary: The polyP hydrogel formulation can accelerate the healing of chronic wounds and provide more metabolic energy by encapsulating and killing bacteria.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Polymer Science
Wenjie Wu, Zhong Lin Wang, Liqun Zhang
Summary: Dielectric elastomers (DEs) are special materials that deform in response to an electric field. The current main mechanism suggests that the deformations in DEs are induced by Maxwell stress. However, a new molecular mechanism based on entropy-dominated elasticity has been proposed recently, highlighting its importance in the process.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Mousa AlTarabeen, Qosay Al-Balas, Amgad Albohy, Werner Ernst Georg Mueller, Peter Proksch
Summary: Manzamines are a group of compounds extracted from Acanthostrongylophora ingens species. We have identified and characterized seven compounds. Based on previous screening work by Mayer et al., who suggested that manzamine A could be an inhibitor of RSK1 kinase, our work focused on targeting the RSK1 N-terminal kinase domain. Docking using Autodock Vina software showed that Manzamine A N-oxide (5) exhibited the highest activity with an IC50 value of 3.1 μM.
Article
Pharmacology & Pharmacy
Shunfeng Wang, Meik Neufurth, Hadrian Schepler, Rongwei Tan, Zhending She, Bilal Al-Nawas, Xiaohong Wang, Heinz C. Schroeder, Werner E. G. Mueller
Summary: Amorphous calcium carbonate (ACC) precipitated in the presence of inorganic polyphosphate (polyP) has shown potential as a material for bone regeneration. ACC center dot PP particles, stabilized by polyP, have enzymatic activity that promotes the transformation of ACC into crystalline polymorphs. In experiments conducted in vitro and in vivo, ACC center dot PP was found to stimulate cell migration and accelerate wound healing, particularly in chronic wounds.
Article
Chemistry, Analytical
Xue Wang, Zhiping Feng, Gaoqiang Zhang, Luna Wang, Liang Chen, Jin Yang, Zhonglin Wang
Summary: Recent advances in flexible pressure sensors have made them promising technologies for human epidermal pulse wave monitoring. A 3 x 1 flexible pressure sensor array was developed using three single-electrode sensors with small area to measure pulse waves at different local positions of the radial artery. The designed single sensor has a small area of 6 x 6 mm² and demonstrates high pressure sensitivity, fast response time, wide frequency range, and stability.
Article
Computer Science, Information Systems
Jiabin Zhang, Erming Su, Chengyu Li, Shuxing Xu, Wei Tang, Leo N. Y. Cao, Ding Li, Zhong Lin Wang
Summary: This study introduces an intelligent artifact-monitoring system (SAMS) based on a porous carbon black (CB)/Ecoflex triboelectric nanogenerator (PCE-TENG) that can monitor collisions in real-time and absorb vibrations during artifact transportation. The system consists of six PCE-TENGs attached to the inner wall of the artifact transport package, allowing collision monitoring and protection in different directions. This research presents a practical strategy for artifact transportation monitoring and package engineering, which could have significant implications for the field.