Cyanobacterial Cyclopeptides as Lead Compounds to Novel Targeted Cancer Drugs

Altered expression of organic anion transporter polypeptide (OATP) genes in human breast carcinoma

(2010) Katrin Wlcek et al.   CANCER BIOLOGY & THERAPY

Molecular Mechanisms of Microcystin Toxicity in Animal Cells

(2010) Alexandre Campos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structure-based thermodynamic analysis of the dissociation of protein phosphatase-1 catalytic subunit and microcystin-LR docked complexes

(2010) Pierre Lavigne et al.   PROTEIN SCIENCE

Contribution of organic anion transporting polypeptide OATP2B1 to amiodarone accumulation in lung epithelial cells

(2009) Satoru Seki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Recombination, cryptic clades and neutral molecular divergence of the microcystin synthetase (mcy) genes of toxic cyanobacterium Microcystis aeruginosa

(2009) Yuuhiko Tanabe et al.   BMC EVOLUTIONARY BIOLOGY

Impact of OATP transporters on pharmacokinetics

(2009) A Kalliokoski et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effects of Temperature on the Stability of Microcystins in Muscle of Fish and Its Consequences for Food Safety

(2009) Dawen Zhang et al.   BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY

Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening

(2009) Piyush B. Gupta et al.   CELL

Rifampicin alters atorvastatin plasma concentration on the basis of SLCO1B1 521T>C polymorphism

(2009) Yi-Jing He et al.   CLINICA CHIMICA ACTA

Endogenous Gene and Protein Expression of Drug-Transporting Proteins in Cell Lines Routinely Used in Drug Discovery Programs

(2009) G. Ahlin et al.   DRUG METABOLISM AND DISPOSITION

Human Platelets Express Organic Anion-Transporting Peptide 2B1, an Uptake Transporter for Atorvastatin

(2009) J. Niessen et al.   DRUG METABOLISM AND DISPOSITION

Identification of toxigenic Microcystis strains after incidents of wild animal mortalities in the Kruger National Park, South Africa

(2009) Paul J. Oberholster et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

EFFECTS OF DIETARY N-ACETYLCYSTEINE ON THE OXIDATIVE STRESS INDUCED IN TILAPIA (OREOCHROMIS NILOTICUS) EXPOSED TO A MICROCYSTIN-PRODUCING CYANOBACTERIAL WATER BLOOM

(2009) María Puerto et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Timing of morphological and ecological innovations in the cyanobacteria – a key to understanding the rise in atmospheric oxygen

(2009) C. E. BLANK et al.   Geobiology

Consensus Report of the National Cancer Institute Clinical Trials Planning Meeting on Pancreas Cancer Treatment

(2009) Philip A. Philip et al.   JOURNAL OF CLINICAL ONCOLOGY

Molecular characterization of cyanobacterial diversity and yearly fluctuations of Microcystin loads in a suburban Mediterranean Lake (Lake Pamvotis, Greece)

(2009) Katerina Vareli et al.   JOURNAL OF ENVIRONMENTAL MONITORING

Freshwater Cyanobacterial Blooms and Primary Liver Cancer Epidemiological Studies in Serbia

(2009) ZORICA SVIRČEV et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

Expression of OATP1B3 determines uptake of Gd-EOB-DTPA in hepatocellular carcinoma

(2009) Masato Narita et al.   JOURNAL OF GASTROENTEROLOGY

Genetic analysis of the microcystin biosynthesis gene cluster in Microcystis strains from four bodies of eutrophic water in Japan

(2009) Takahiko Noguchi et al.   JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY

Acyloxymethyl Esterification of Nodularin-R and Microcystin-LA Produces Inactive Protoxins that Become Reactivated and Produce Apoptosis inside Intact Cells

(2009) Lars Herfindal et al.   JOURNAL OF MEDICINAL CHEMISTRY

Influence of Cyclooxygenase Inhibitors on the Function of the Prostaglandin Transporter Organic Anion-Transporting Polypeptide 2A1 Expressed in Human Gastroduodenal Mucosa

(2009) K. Mandery et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Structure and organization of drug-target networks: insights from genomic approaches for drug discovery

(2009) Sarath Chandra Janga et al.   Molecular BioSystems

A change of strategy in the war on cancer

(2009) Robert A. Gatenby   NATURE

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Cell Death

(2009) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

Shortcomings of current therapies for non-small-cell lung cancer: unmet medical needs

(2009) H A Burris   ONCOGENE

Pharmacogenetics of the organic anion transporting polypeptide 1A2

(2009) Ryan M Franke et al.   PHARMACOGENOMICS

The Increasing Complexity of the Cancer Stem Cell Paradigm

(2009) J. M. Rosen et al.   SCIENCE

Complete Reconstitution of a Highly Reducing Iterative Polyketide Synthase

(2009) S. M. Ma et al.   SCIENCE

Abrogation of microcystin cytotoxicity by MAP kinase inhibitors and N-acetyl cysteine is confounded by OATPIB1 uptake activity inhibition

(2009) Abigail Daily et al.   TOXICON

Citizen monitoring: Testing hypotheses about the interactive influences of eutrophication and mussel invasion on a cyanobacterial toxin in lakes

(2009) Orlando Sarnelle et al.   WATER RESEARCH

Redox Regulation and Its Emerging Roles in Stem Cells and Stem-Like Cancer Cells

(2008) Marcia A. Ogasawara et al.   ANTIOXIDANTS & REDOX SIGNALING

Cultured CD4T cells and primary human lymphocytes express hOATPs: intracellular accumulation of saquinavir and lopinavir

(2008) O Janneh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Overexpression of OATP1B3 Confers Apoptotic Resistance in Colon Cancer

(2008) W. Lee et al.   CANCER RESEARCH

Activation of Protein Phosphatase 1 by a Small Molecule Designed to Bind to the Enzyme's Regulatory Site

(2008) Erin Tappan et al.   CHEMISTRY & BIOLOGY

Hepatic Uptake and Excretion of (-)-N- -4-fluorobenzamide (YM758), a Novel If Channel Inhibitor, in Rats and Humans

(2008) K.-i. Umehara et al.   DRUG METABOLISM AND DISPOSITION

Use of mechanistic data in IARC evaluations

(2008) Vincent James Cogliano et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

In vivogenotoxic potential of microcystin-LR: A cyanobacterial toxin, investigated both by the unscheduled DNA synthesis (UDS) and the comet assays after intravenous administration

(2008) Julien Gaudin et al.   ENVIRONMENTAL TOXICOLOGY

Molecular confirmation of Planktothrix rubescens as the cause of intense, microcystin—Synthesizing cyanobacterial bloom in Lake Ziros, Greece

(2008) Katerina Vareli et al.   HARMFUL ALGAE

Crystal Structure of DltA

(2008) Huma Yonus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Progress in Cancer Care: The Hope, the Hype, and the Gap Between Reality and Perception

(2008) Leonard B. Saltz   JOURNAL OF CLINICAL ONCOLOGY

Dynamic thiolation–thioesterase structure of a non-ribosomal peptide synthetase

(2008) Dominique P. Frueh et al.   NATURE

Structural basis for the selectivity of the external thioesterase of the surfactin synthetase

(2008) Alexander Koglin et al.   NATURE

The exploration of macrocycles for drug discovery — an underexploited structural class

(2008) Edward M. Driggers et al.   NATURE REVIEWS DRUG DISCOVERY

Crystal Structure of the Termination Module of a Nonribosomal Peptide Synthetase

(2008) A. Tanovic et al.   SCIENCE

Chronic Microcystin Exposure Induces Hepatocyte Proliferation with Increased Expression of Mitotic and Cyclin-associated Genes in P53-deficient Mice

(2008) Shawn P. Clark et al.   TOXICOLOGIC PATHOLOGY

Toxic response indicators of microcystin-LR in F344 rats following a single-dose treatment

(2008) Madhavi Billam et al.   TOXICON

Comparison of S-adenosyl-l-methionine (SAMe) and N-acetylcysteine (NAC) protective effects on hepatic damage when administered after acetaminophen overdose

(2007) Marcus V. Terneus et al.   TOXICOLOGY

Microcystin production by Microcystis aeruginosa exposed to different stages of herbivorous zooplankton

(2007) Min-Ho Jang et al.   TOXICON

Patterns of microcystin-LR induced alteration of the expression of genes involved in response to DNA damage and apoptosis

(2007) Bojana Žegura et al.   TOXICON