Article
Infectious Diseases
Guoming Li, Yueming Yuan, Shaoqin Zheng, Chenguang Lu, Mingqiang Li, Ruixiang Tan, Hongying Zhang, Rahamatou Silai, Ruimei Liu, Kamal Said Abdallah, Affane Bacar, Qin Xu, Jianping Song, Wanting Wu, Changsheng Deng
Summary: The study found that artemisinin-piperaquine and artemether-lumefantrine maintained high efficacy and tolerance in treating uncomplicated falciparum malaria in the Comoros. However, asymptomatic malaria infections may pose new challenges to malaria control.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Review
Pharmacology & Pharmacy
Phoebe Hazenberg, Kate Navaratnam, Paula Busuulwa, Catriona Waitt
Summary: Significant anatomical and physiological changes occur during pregnancy and labor, impacting drug absorption, distribution, metabolism, and elimination. Limited data are available on pregnancy-specific pharmacokinetics of anti-infectives, with further research needed to understand the clinical implications of pharmacokinetic differences between pregnant and nonpregnant individuals. Challenges in applying quality grading systems to these studies highlight the need for a refined appraisal system for pharmacokinetic studies in special populations.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Biochemical Research Methods
Amber Kunkel, Michael White, Patrice Piola
Summary: Study aimed to understand impacts of triple ACTs and chemoprophylaxis in Cambodia using a mathematical model. Triple ACTs may limit spread of mefloquine resistance but have minimal impact on malaria incidence and could slow declines in piperaquine resistance. Chemoprophylaxis may reduce cases temporarily, but increases risks of resistance.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
M. Silva, M. Malmberg, S. D. Otienoburu, A. Bjorkman, B. Ngasala, A. Martensson, J. P. Gil, M. I. Veiga
Summary: The study found significant co-expression patterns of the pfmdr1 and pfcrt genes before and during ACT treatment. This co-expression may play an important role when the parasite is exposed to drug stress.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Infectious Diseases
Chris Ebong, Asadu Sserwanga, Jane Frances Namuganga, James Kapisi, Arthur Mpimbaza, Samuel Gonahasa, Victor Asua, Sam Gudoi, Ruth Kigozi, James Tibenderana, John Bosco Bwanika, Agaba Bosco, Denis Rubahika, Daniel Kyabayinze, Jimmy Opigo, Damian Rutazana, Gloria Sebikaari, Kassahun Belay, Mame Niang, Eric S. Halsey, Leah F. Moriarty, Naomi W. Lucchi, Samaly S. Svigel Souza, Sam L. Nsobya, Moses R. Kamya, Adoke Yeka
Summary: In Uganda, DP remains highly effective and safe for the treatment of uncomplicated malaria, while monitoring of AL efficacy shows recurrent infections.
Article
Public, Environmental & Occupational Health
Bakary Fofana, Shannon Takala-Harrison, Amed Ouattara, Issaka Sagara, Amadou H. Togo, Hamadoun Diakite, Mohamed Keita, Kassim Sanogo, Sekou Toure, Ogobara K. Doumbo, Abdoulaye A. Djimde
Summary: A study conducted in a high-transmission setting in Mali found significant heterogeneity in the number of clinical episodes of malaria, with age, residence, and treatment regimen identified as risk factors. Fine-mapping malaria risks at subdistrict levels is crucial for targeted and customized interventions.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Microbiology
Nelli Westercamp, Mary Owidhi, Kephas Otieno, Winnie Chebore, Ann M. Buff, Meghna Desai, Simon Kariuki, Aaron M. Samuels
Summary: The study compared the efficacy of artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP) in the treatment of uncomplicated malaria. The results showed that both AL and DP were efficacious and well tolerated, but the efficacy of AL appeared to be waning.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Public, Environmental & Occupational Health
Vy Bui, Colleen R. Higgins, Sarah Laing, Sachiko Ozawa
Summary: This study examines the impact of substandard and falsified antimalarials on health and economy in Benin, showing the significant cost and death associated with poor-quality antimalarials. Replacing all antimalarials with quality-assured artemisinin combination therapies has the potential to save costs and prevent deaths.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Immunology
Biraj Shrestha, Zalak Shah, Andrew P. Morgan, Piyaporn Saingam, Chaiyaporn Chaisatit, Suwanna Chaorattanakawee, Chantida Praditpol, Nonlawat Boonyalai, Paphavee Lertsethtakarn, Mariusz Wojnarski, Molly Deutsch-Feldman, Matthew Adams, Darapiseth Sea, Soklyda Chann, Stuart D. Tyner, Charlotte A. Lanteri, Michele D. Spring, David L. Saunders, Philip L. Smith, Chanthap Lon, Panita Gosi, Somethy Sok, Prom Satharath, Huy Rekol, Dysoley Lek, Brian A. Vesely, Jessica T. Lin, Norman C. Waters, Shannon Takala-Harrison
Summary: This study estimated the prevalence of piperaquine resistance mutations in Plasmodium falciparum isolates collected in northern Cambodia from 2009 to 2017. The results showed a significant increase in newly emerged PfCRT mutations after the change to dihydroartemisinin-piperaquine in 2010, with a decline in PfCRT F145I prevalence after 2014. Additionally, there was a decrease in parasites with amplified pfpm2 after the switch to artesunate-mefloquine.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Gabriel Kishoyian, Eliud N. M. Njagi, George O. Orinda, Francis T. Kimani, Kevin Thiongo, Damaris Matoke-Muhia
Summary: After a decade of use, artemether-lumefantrine remains highly effective in clearing Plasmodium falciparum parasites in children aged between 6 and 60 months in Kenya. Continued monitoring is essential to prevent potential resistance to the drug in all target users.
EPIDEMIOLOGY AND INFECTION
(2021)
Article
Infectious Diseases
Joseph A. Lewnard, Ayesha Mahmud, Tejas Narayan, Brian Wahl, T. S. Selvavinayagam, Chandra B. Mohan, Ramanan Laxminarayan
Summary: Mortality in Chennai substantially increased during the COVID-19 pandemic, with the greatest burden falling on disadvantaged communities. Reported COVID-19 deaths greatly underestimated the true pandemic-associated mortality.
LANCET INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Gaston Tona Lutete, Ghyslain Mombo-Ngoma, Serge-Brice Assi, Jude D. Bigoga, Felix Koukouikila-Koussounda, Nsengi Y. Ntamabyaliro, Francine Ntoumi, Selidji T. Agnandji, Mirjam Groger, Jangsik Shin, Isabelle Borghini-Fuhrer, Sarah Arbe-Barnes, Stephen J. Allen, Peter G. Kremsner, Robert Miller, Stephan Duparc, Michael Ramharter
Summary: In a study conducted in Africa, pyronaridine-artesunate showed good tolerability and effectiveness in the treatment of acute uncomplicated malaria under conditions similar to everyday clinical practice, supporting its use as a useful addition in managing this condition.
Article
Microbiology
Makoto Saito, Widi Yotyingaphiram, Zillah Cargill, Mary Ellen Gilder, Aung Myat Min, Aung Pyae Phyo, Thi Dar San, Hilda Poe, Cindy Chu, Nicholas J. White, Francois Nosten, Rose McGready
Summary: Quinoline antimalarials can cause drug-induced QT prolongation, with different effects observed for different antimalarial drugs in pregnant women with malaria. However, none of the antimalarial drug treatments exceeded conventional thresholds for an increased risk of torsade de pointes in pregnant women.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
Emma Hughes, Erika Wallender, Ali Mohamed Ali, Prasanna Jagannathan, Radojka M. Savic
Summary: Pharmacokinetic/pharmacodynamic models can optimize antimalarial dosing recommendations for vulnerable populations like children and pregnant women. Integrating PK data into clinical studies and incorporating drug resistance and host immunity data into PK/PD models can further improve malaria treatment outcomes.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Public, Environmental & Occupational Health
Mateusz M. Plucinski, Joel L. N. Barratt
Summary: This study introduces a novel method for nonparametric statistical testing of relatedness for P. falciparum parasites. The approach showed high sensitivity and reliability in identifying related genotypes.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Microbiology
Sam Jones, Mateusz Plucinski, Katherine Kay, Eva Maria Hodel, Ian M. Hastings
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2020)
Review
Pharmacology & Pharmacy
Thomas Straubinger, Katherine Kay, Robert Bies
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Immunology
Kenneth Kintu, Thoko Malaba, Jesca Nakibuka, Christiana Papamichael, Angela Colbers, Kelly Byrne, Kay Seden, Eva Maria Hodel, Tao Chen, Adelline Twimukye, Josaphat Byamugisha, Helen Reynolds, Victoria Watson, David Burger, Duolao Wang, Catriona John Waitt, Miriam Taegtmeyer, Catherine Orrell, Mohammed Lamorde, Landon Myer, Saye Khoo
Article
Evolutionary Biology
Ian M. Hastings, Diggory Hardy, Katherine Kay, Raman Sharma
EVOLUTIONARY APPLICATIONS
(2020)
Article
Microbiology
Sam Jones, Katherine Kay, Eva Maria Hodel, Maria Gruenberg, Anita Lerch, Ingrid Felger, Ian Hastings
Summary: The study demonstrates that AmpSeq significantly improves the detection of low-density clones in molecular correction and provides accurate estimates of drug failure rates. Using 3 to 5 amplicons is sufficient, and simple criteria can be used to classify recurrent infections as drug failures or new infections.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Medicine, General & Internal
Rashid Mansoor, Robert J. Commons, Nicholas M. Douglas, Benjamin Abuaku, Jane Achan, Ishag Adam, George O. Adjei, Martin Adjuik, Bereket H. Alemayehu, Richard Allan, Elizabeth N. Allen, Anupkumar R. Anvikar, Emmanuel Arinaitwe, Elizabeth A. Ashley, Hazel Ashurst, Puji B. S. Asih, Nathan Bakyaita, Hubert Barennes, Karen Barnes, Leonardo Basco, Quique Bassat, Elisabeth Baudin, David J. Bell, Delia Bethell, Anders Bjorkman, Caroline Boulton, Teun Bousema, Philippe Brasseur, Hasifa Bukirwa, Rebekah Burrow, Verena Carrara, Michel Cot, Umberto D'Alessandro, Debashish Das, Sabyasachi Das, Timothy M. E. Davis, Meghna Desai, Abdoulaye A. Djimde, Arjen M. Dondorp, Grant Dorsey, Chris J. Drakeley, Stephan Duparc, Emmanuelle Espie, Jean-Francois Etard, Catherine Falade, Jean Francois Faucher, Scott Filler, Carole Fogg, Mark Fukuda, Oumar Gaye, Blaise Genton, Awab Ghulam Rahim, Julius Gilayeneh, Raquel Gonzalez, Rebecca F. Grais, Francesco Grandesso, Brian Greenwood, Anastasia Grivoyannis, Christoph Hatz, Eva Maria Hodel, Georgina S. Humphreys, Jimee Hwang, Deus Ishengoma, Elizabeth Juma, S. Patrick Kachur, Piet A. Kager, Erasmus Kamugisha, Moses R. Kamya, Corine Karema, Kassoum Kayentao, Adama Kazienga, Jean-Rene Kiechel, Poul-Erik Kofoed, Kwadwo Koram, Peter G. Kremsner, David G. Lalloo, Moses Laman, Sue J. Lee, Bertrand Lell, Amelia W. Maiga, Andreas Martensson, Mayfong Mayxay, Wilfred Mbacham, Rose McGready, Herve Menan, Didier Menard, Frank Mockenhaupt, Brioni R. Moore, Olaf Muller, Alain Nahum, Jean-Louis Ndiaye, Paul N. Newton, Billy E. Ngasala, Frederic Nikiema, Akindeh M. Nji, Harald Noedl, Francois Nosten, Bernhards R. Ogutu, Olusola Ojurongbe, Lyda Osorio, Jean-Bosco Ouedraogo, Seth Owusu-Agyei, Anil Pareek, Louis K. Penali, Patrice Piola, Mateusz Plucinski, Zul Premji, Michael Ramharter, Caitlin L. Richmond, Lars Rombo, Philip J. Rosenthal, Sam Salman, Albert Same-Ekobo, Carol Sibley, Sodiomon B. Sirima, Frank M. Smithuis, Fabrice A. Some, Sarah G. Staedke, Peter Starzengruber, Nathalie Strub-Wourgaft, Inge Sutanto, Todd D. Swarthout, Din Syafruddin, Ambrose O. Talisuna, Walter R. Taylor, Emmanuel A. Temu, Julie Thwing, Halidou Tinto, Emiliana Tjitra, Offianan A. Toure, T. Hien Tran, Johan Ursing, Innocent Valea, Giovanni Valentini, Michele van Vugt, Lorenz von Seidlein, Stephen A. Ward, Vincent Were, Nicholas J. White, Charles J. Woodrow, William Yavo, Adoke Yeka, Issaka Zongo, Julie A. Simpson, Philippe J. Guerin, Kasia Stepniewska, Ric N. Price, Cally Roper
Summary: In patients with uncomplicated P. falciparum malaria, the nadir hemoglobin occurs 2 days after starting treatment. Factors associated with moderately severe anemia on day 7 in Africa and Asia include severe anemia at baseline, young age, high parasitemia, and delayed parasite clearance. In Asia, artemisinin-based treatments are associated with a greater risk of anemia during recovery compared to non-artemisinin-based treatments.
Article
Multidisciplinary Sciences
Bhagteshwar Singh, Suzannah Lant, Sofia Cividini, Jonathan W. S. Cattrall, Lynsey C. Goodwin, Laura Benjamin, Benedict D. Michael, Ayaz Khawaja, Aline de Moura Brasil Matos, Walid Alkeridy, Andrea Pilotto, Durjoy Lahiri, Rebecca Rawlinson, Sithembinkosi Mhlanga, Evelyn C. Lopez, Brendan F. Sargent, Anushri Somasundaran, Arina Tamborska, Glynn Webb, Komal Younas, Yaqub Al Sami, Heavenna Babu, Tristan Banks, Francesco Cavallieri, Matthew Cohen, Emma Davies, Shalley Dhar, Anna Fajardo Modol, Hamzah Farooq, Jeffrey Harte, Samuel Hey, Albert Joseph, Dileep Karthikappallil, Daniel Kassahun, Gareth Lipunga, Rachel Mason, Thomas Minton, Gabrielle Mond, Joseph Poxon, Sophie Rabas, Germander Soothill, Marialuisa Zedde, Konstantin Yenkoyan, Bruce Brew, Erika Contini, Lucette Cysique, Xin Zhang, Pietro Maggi, Vincent van Pesch, Jerome Lechien, Sven Saussez, Alex Heyse, Maria Lucia Brito Ferreira, Cristiane N. Soares, Isabel Elicer, Laura Eugenin-von Bernhardi, Waleng Nancupil Reyes, Rong Yin, Mohammed A. Azab, Foad Abd-Allah, Ahmed Elkady, Simon Escalard, Jean-Christophe Corvol, Cecile Delorme, Pierre Tattevin, Kevin Bigaut, Norbert Lorenz, Daniel Hornuss, Jonas Hosp, Siegbert Rieg, Dirk Wagner, Benjamin Knier, Paul Lingor, Andrea Sylvia Winkler, Athena Sharifi-Razavi, Shima T. Moein, SeyedAhmad SeyedAlinaghi, Saeidreza JamaliMoghadamSiahkali, Mauro Morassi, Alessandro Padovani, Marcello Giunta, Ilenia Libri, Simone Beretta, Sabrina Ravaglia, Matteo Foschi, Paolo Calabresi, Guido Primiano, Serenella Servidei, Nicola Biagio Mercuri, Claudio Liguori, Mariangela Pierantozzi, Loredana Sarmati, Federica Boso, Silvia Garazzino, Sara Mariotto, Kimani N. Patrick, Oana Costache, Alexander Pincherle, Frederikus A. Klok, Roger Meza, Veronica Cabreira, Sofia R. Valdoleiros, Vanessa Oliveira, Igor Kaimovsky, Alla Guekht, Jasmine Koh, Eva Fernandez Diaz, Jose Maria Barrios-Lopez, Cristina Guijarro-Castro, Alvaro Beltran-Corbellini, Javier Martinez-Poles, Alba Maria Diezma-Martin, Maria Isabel Morales-Casado, Sergio Garcia Garcia, Gautier Breville, Matteo Coen, Marjolaine Uginet, Raphael Bernard-Valnet, Renaud Du Pasquier, Yildiz Kaya, Loay H. Abdelnour, Claire Rice, Hamish Morrison, Sylviane Defres, Saif Huda, Noelle Enright, Jane Hassell, Lucio D'Anna, Matthew Benger, Laszlo Sztriha, Eamon Raith, Krishna Chinthapalli, Ross Nortley, Ross Paterson, Arvind Chandratheva, David J. Werring, Samir Dervisevic, Kirsty Harkness, Ashwin Pinto, Dinesh Jillella, Scott Beach, Kulothungan Gunasekaran, Ivan Rocha Ferreira Da Silva, Krishna Nalleballe, Jonathan Santoro, Tyler Scullen, Lora Kahn, Carla Y. Kim, Kiran T. Thakur, Rajan Jain, Thirugnanam Umapathi, Timothy R. Nicholson, James J. Sejvar, Eva Maria Hodel, Catrin Tudur Smith, Tom Solomon
Summary: This study investigated the spectrum of neurological disease in hospitalized COVID-19 patients and analyzed the clinical outcomes and factors associated with poor outcomes. The study found that encephalopathy and cerebrovascular events were the most common diagnoses, with cerebrovascular event patients more likely to have poor outcomes. Specific risk factors for poor outcomes included breathlessness on admission and elevated D-dimer. Overall, neurological COVID-19 disease poses a considerable burden in terms of disease outcomes and use of hospital resources.
Article
Biology
Thiery Masserey, Tamsin Lee, Monica Golumbeanu, Andrew J. Shattock, Sherrie L. Kelly, Ian M. Hastings, Melissa A. Penny, Amy Wesolowski
Summary: Low transmission settings are more likely to develop drug resistance, and the spread of resistance to artemisinin partner drugs depends on the period of low drug concentration. Molecular surveillance and adjusting treatment accordingly are crucial to slow the spread of artemisinin resistance. Additionally, extending parasite exposure to artemisinin derivatives and reducing the selection windows of partner drugs are key to implementing sustainable treatment strategies.
Article
Pharmacology & Pharmacy
Katherine Kay, Justin Goodwin, Hanna Ehrlich, Joyce Ou, Tracey Freeman, Kaicheng Wang, Fangyong Li, Martina Wade, Jonathan French, Liusheng Huang, Francesca Aweeka, Norah Mwebaza, Richard Kajubi, Matthew Riggs, Ana Ruiz-Garcia, Sunil Parikh
Summary: This study developed a population PK/PD model of artemether-lumefantrine in Ugandan children, and found that HIV infection status and lumefantrine concentration were significant factors associated with recurrence risk of malaria. Evidence of selection for reduced drug susceptibility was also observed.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Parasitology
Ian M. Hastings, Ingrid Felger
Summary: Estimating drug efficacy for malaria requires genetic profiling, which is notoriously difficult in practice. The recent update to WHO guidelines provides a wider range of analyses for more accurate estimates of drug failure rates. However, due to better detection of treatment failures, estimated failure rates may double.
TRENDS IN PARASITOLOGY
(2022)
Review
Immunology
Daryl Hodge, Eva Maria Hodel, Elen Hughes, Phoebe Hazenberg, Sandra Granana Castillo, Sara Gibbons, Duolao Wang, Fiona Marra, Catia Marzolini, David Back, Saye Khoo
Summary: This systematic review evaluated the prevalence of drug-drug interactions (DDI) among people receiving antiretrovirals over a span of three decades. The study found that the proportion of patients experiencing clinically significant DDI did not change over time. The most frequently reported classes of antiretrovirals involved in DDIs were protease inhibitors and non-nucleoside reverse transcriptase inhibitors.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2023)
Article
Immunology
Thokozile R. Malaba, Irene Nakatudde, Kenneth Kintu, Angela Colbers, Tao Chen, Helen Reynolds, Lucy Read, Jim Read, Lee-Ann Stemmet, Megan Mrubata, Kelly Byrne, Kay Seden, Adelline Twimukye, Helene Theunissen, Eva Maria Hodel, Justin Chiong, Nai-Chung Hu, David Burger, Duolao Wang, Josaphat Byamugisha, Yussif Alhassan, Sharon Bokako, Catriona Waitt, Miriam Taegtmeyer, Catherine Orrell, Mohammed Lamorde, Landon Myer, Saye Khoo
Summary: This study compared the efficacy and safety of dolutegravir and efavirenz in pregnant women and infants. The results showed that dolutegravir significantly reduced viral load more quickly, and it was safe and well tolerated in pregnant and breastfeeding women. However, HIV transmission to infants can still occur during breastfeeding despite persistent viral suppression in mothers.
Article
Clinical Neurology
Arina A. Tamborska, Bhagteshwar Singh, Sonja E. Leonhard, Eva Maria Hodel, Julia Stowe, Taylor Watson-Fargie, Peter M. Fernandes, Andreas C. Themistocleous, Jacob Roelofs, Kathryn Brennan, Caroline Morrice, Benedict D. Michael, Bart C. Jacobs, Helen McDonald, Tom Solomon
Summary: This study investigated the features of Guillain-Barre syndrome (GBS) following SARS-CoV-2 vaccines and evaluated the causal link between the two. The study found that most GBS cases occurred after the first dose of the ChAdOx1 vaccine and had different age distribution and unusual clinical features, supporting a causal link.
BMJ NEUROLOGY OPEN
(2022)
Article
Public, Environmental & Occupational Health
Mila Nu Nu Htay, Ian M. Hastings, Eva Maria Hodel, Katherine Kay
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
(2020)