Pyronaridine–artesunate real-world safety, tolerability, and effectiveness in malaria patients in 5 African countries: A single-arm, open-label, cohort event monitoring study

Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda

(2020) Aline Uwimana et al.   NATURE MEDICINE

Pyronaridine-artesunate efficacy and safety in uncomplicated Plasmodium falciparum malaria in areas of artemisinin-resistant falciparum in Viet Nam (2017–2018)

(2019) Phuc Bui Quang et al.   CLINICAL INFECTIOUS DISEASES

Pyronaridine-artesunate Shows Promise as an Effective and Well-tolerated Treatment for Artemisinin-resistant Plasmodium falciparum Malaria

(2019) John Okombo et al.   CLINICAL INFECTIOUS DISEASES

Determinants of dihydroartemisinin-piperaquine treatment failure in Plasmodium falciparum malaria in Cambodia, Thailand, and Vietnam: a prospective clinical, pharmacological, and genetic study

(2019) Rob W van der Pluijm et al.   LANCET INFECTIOUS DISEASES

Declining responsiveness of childhood Plasmodium falciparum infections to artemisinin-based combination treatments ten years following deployment as first-line antimalarials in Nigeria

(2019) Akintunde Sowunmi et al.   Infectious Diseases of Poverty

Pyronaridine–artesunate or dihydroartemisinin–piperaquine versus current first-line therapies for repeated treatment of uncomplicated malaria: a randomised, multicentre, open-label, longitudinal, controlled, phase 3b/4 trial

(2018) Issaka Sagara et al.   LANCET

Pyronaridine–artesunate and artemether–lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children: a randomized controlled non-inferiority trial

(2018) Johanna M. Roth et al.   MALARIA JOURNAL

Efficacy and Safety of Pyronaridine-Artesunate for Treatment of Uncomplicated Plasmodium falciparum Malaria in Western Cambodia

(2016) Rithea Leang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Safety and efficacy of re-treatments with pyronaridine-artesunate in African patients with malaria: a substudy of the WANECAM randomised trial

(2016) Issaka Sagara et al.   LANCET INFECTIOUS DISEASES

Safety and efficacy of pyronaridine-artesunate in uncomplicated acute malaria: an integrated analysis of individual patient data from six randomized clinical trials

(2013) Stephan Duparc et al.   MALARIA JOURNAL

Pyronaridine-artesunate granules versus artemether-lumefantrine crushed tablets in children with Plasmodium falciparum malaria: a randomized controlled trial

(2012) Kassoum Kayentao et al.   MALARIA JOURNAL

Pyronaridine–Artesunate versus Mefloquine plus Artesunate for Malaria

(2012) Ronnatrai Rueangweerayut et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pyronaridine-Artesunate versus Chloroquine in Patients with Acute Plasmodium vivax Malaria: A Randomized, Double-Blind, Non-Inferiority Trial

(2011) Yi Poravuth et al.   PLoS One

Efficacy and safety of a fixed-dose oral combination of pyronaridine-artesunate compared with artemether-lumefantrine in children and adults with uncomplicated Plasmodium falciparum malaria: a randomised non-inferiority trial

(2010) Antoinette K Tshefu et al.   LANCET

Fixed‐Dose Pyronaridine‐Artesunate Combination for Treatment of Uncomplicated Falciparum Malaria in Pediatric Patients in Gabon

(2008) Michael Ramharter et al.   JOURNAL OF INFECTIOUS DISEASES