Article
Multidisciplinary Sciences
Marian I. Hamilton, Diego P. Fernandez, Sherry V. Nelson
Summary: Strontium isotope ratios can be used to track changes in an animal's mobility throughout its life and predict sex-biases in dispersal patterns. Different methodological approaches have been introduced to differentiate between 'local' and 'non-local' individuals, with tooth-to-bone offsets reliably indicating sex-biases in dispersal for primates with small home ranges. Overall, tooth-to-environment offsets yield the most reliable predictions of species' sex-biases in dispersal.
ROYAL SOCIETY OPEN SCIENCE
(2021)
Article
Infectious Diseases
Camille Lacroux, Emmanuelle Pouydebat, Marie Rossignol, Sophie Durand, Alfred Aleeje, Edward Asalu, Fabrice Chandre, Sabrina Krief
Summary: Chimpanzees may choose specific tree species to avoid mosquito bites.
Article
Infectious Diseases
Nguyen Van Dung, Nguyen Quang Thieu, Hoang Dinh Canh, Bui Le Duy, Vu Viet Hung, Nguyen Thi Hong Ngoc, Nguyen Vu Tuyet Mai, Ngo Thi Van Anh, Le Duy Son, Win Han Oo, Win Htike, May Chan Oo, Naw Hkawng Galau, Kaung Myat Thu, Aung Khine Zaw, Ei Phyu Htwe, Julia C. Cutts, Ellen A. Kearney, Bangyuan Wang, Paul A. Agius, Freya J. I. Fowkes, Katherine O'Flaherty
Summary: A study was conducted to investigate the abundance, composition, and biting behavior of Anopheles mosquitoes in forest and agricultural areas in Gia Lai province, Vietnam. The results showed that the number of primary malaria vectors and the infection rate of Plasmodium spp. were low at the end of the rainy season in the Central Highlands of Vietnam. However, it is recommended to use additional personal protective measures to prevent malaria transmission in this region.
Review
Immunology
Himanshu Gupta, Samuel C. Wassmer
Summary: Despite progress made in the past decade, malaria remains a major global health challenge, with early diagnosis being crucial for positive outcomes. Current tools are unable to detect severe malaria-related organ dysfunction, emphasizing the importance of identifying cheap and reliable early biomarkers. miRNAs show promise as potential biomarkers, highlighting the need for further evaluation in human populations.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Microbiology
Gunjan Arora, Andaleeb Sajid, Yu-Min Chuang, Yuemei Dong, Akash Gupta, Kristen Gambardella, Kathleen DePonte, Lionel Almeras, George Dimopolous, Erol Fikrig
Summary: Malaria is a vector-borne disease caused by Plasmodium sporozoites, and mosquito saliva proteins can influence pathogen transmission and early infection. Anopheles gambiae Sporozoite-Associated Protein (AgSAP) interacts directly with Plasmodium sporozoites, inhibits inflammatory responses, and plays a role in early infection modulation. Individuals in endemic malaria regions generate antibodies against AgSAP, suggesting its potential as a biomarker for disease prevalence and epidemiological analysis.
Article
Microbiology
Christina Grogan, Marissa Bennett, Shannon Moore, David Lampe
Summary: Research on altering the microbiota of mosquitoes through paratransgenesis strategy may help control vector-transmitted diseases. Some signal sequences were found to increase the release of antiplasmodial effector molecules in mosquitoes, enhancing the suppression of diseases.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Plant Sciences
Gervais Mouthe Happi, Pamela Kemda Nangmo, Liliane Clotide Dzouemo, Sorelle Fotsing Kache, Ariane Dolly Kenmogne Kouam, Jean Duplex Wansi
Summary: Meliaceae plants are important herbal sources for treating malaria in traditional African medicine. Studies have found significant antiplasmodial and insecticidal activities in this plant family, suggesting their potential as eco-friendly pesticides.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Immunology
Kathrin Witmer, Farah Aida Dahalan, Tom Metcalf, Arthur M. Talman, Virginia M. Howick, Mara K. N. Lawniczak
Summary: The study using single-cell RNA-seq revealed transcriptional variation in malaria parasite ookinetes in mosquito midguts, showing that while most transcriptional changes are development-driven, there are still candidate genes responding to environmental cues or showing clonal variation in the population. This highlights the importance of single-cell and low-input technologies in understanding clonal variation of parasite populations.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Parasitology
Narenrit Wamaket, Oranicha Khamprapa, Sittinont Chainarin, Panisa Thamsawet, Ubolrat Ninsaeng, Suttipong Thongsalee, Veerast Suwan, Jira Sakolvaree, Ratree Takhampunya, Silas A. Davidson, Patrick W. McCardle, Patiwat Sa-angchai, Mavuto Mukaka, Kirakorn Kiattibutr, Amnat Khamsiriwatchara, Wang Nguitragool, Jetsumon Sattabongkot, Jeeraphat Sirichaisinthop, Kevin C. Kobylinski
Summary: This study in Surat Thani province, Thailand, characterized the bionomics of Anopheles mosquitoes and found that the area is ideal for evaluating the impact of ivermectin MDA on An. minimus parity. Results showed differences in mosquito species and parity rates, providing valuable information for future malaria elimination efforts.
PARASITES & VECTORS
(2021)
Review
Biochemistry & Molecular Biology
Vysakh K. Viswanath, Suraj T. Gore, Ashwathi Valiyaparambil, Subhendhu Mukherjee, Anirudha Lakshminarasimhan
Summary: Malaria is caused by Plasmodium species with Plasmodium falciparum being the most deadly. These parasites depend on vertebrate hosts and blood-sucking insects for their life cycle. Plasmodium chitinases play a crucial role in parasite penetration and are different between long and short forms.
Article
Immunology
Luis Carlos Salazar Alvarez, Vanessa Carneiro Barbosa, Omaira Vera Lizcano, Djane Clarys Baia da Silva, Rosa Amelia Goncalves Santana, Camila Fabbri, Paulo Filemon Paoluci Pimenta, Wuelton Marcelo Monteiro, Letusa Albrecht, Marcus Vinicius Guimaraes de Lacerda, Fabio Trindade Maranhao Costa, Stefanie Costa Pinto Lopes
Summary: Plasmodium vivax is the most common type of malaria outside sub-Saharan Africa, and its ability to adhere to cells, form rosettes, and develop in the liver can impact treatment and disease control. In this study, we used ex vivo methods to evaluate the rosetting capacity of P. vivax gametocytes and investigated its effect on infection in the mosquito vector Anopheles aquasalis. We found a high frequency of cytoadhesive phenomena and a positive correlation between rosetting and infection rate and intensity in the mosquito. Disruption of rosette formation resulted in lower infection rates and intensities.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biology
Wei Huang, Joel Vega-Rodriguez, Chritopher Kizito, Sung-Jae Cha, Marcelo Jacobs-Lorena
Summary: This study provides an in-depth assessment of transgenesis and paratransgenesis for combating malaria. The combination of these two approaches significantly reduces Plasmodium development and effectively inhibits transmission in mice.
Review
Parasitology
Ibrahim Bin Said, Yobouet Ines Kouakou, Roukayatou Omorou, Anne-Lise Bienvenu, Kamruddin Ahmed, Richard Culleton, Stephane Picot
Summary: The planned capital relocation in Indonesia may increase the risks of deforestation, decreased biodiversity, and the emergence of zoonotic infections like Plasmodium knowlesi malaria. Based on our analysis, the main vectors of P. knowlesi are present in the area of the future capital, emphasizing the need for strengthened surveillance. We reported 545 documented cases of P. knowlesi in Indonesia, mostly occurring in the last 4 years.
PARASITES & VECTORS
(2022)
Article
Evolutionary Biology
Theo Mouillaud, Audric Berger, Marie Buysse, Nil Rahola, Josquin Daron, Jean-Pierre Agbor, Sandrine N. Sango, Daniel E. Neafsey, Olivier Duron, Diego Ayala
Summary: This study investigated the influence of Wolbachia bacterium in Anopheles moucheti, a major malaria mosquito in Central Africa. The study found that the prevalence of Wolbachia infection in the mosquito population was almost fixed and higher than previously recorded. The bacterium was also found in other parts of the mosquitoes at a lower density. However, there was no correlation observed between the presence and density of Wolbachia and the development of Plasmodium falciparum, the malaria parasite.
EVOLUTIONARY APPLICATIONS
(2023)
Article
Parasitology
Lionel Brice Feufack-Donfack, Elangwe Milo Sarah-Matio, Luc Marcel Abate, Aline Gaelle Bouopda Tuedom, Albert Ngano Bayibeki, Christelle Maffo Ngou, Jean-Claude Toto, Maurice Marcel Sandeu, Carole Else Eboumbou Moukoko, Lawrence Ayong, Parfait Awono-Ambene, Isabelle Morlais, Sandrine Eveline Nsango
Summary: The study revealed a high malaria endemicity in Tibati, Adamawa Region, Cameroon, with varying infection rates among individuals of different clinical status, ages, and collection sites. Hotspots of disease transmission have been identified in the area.
PARASITES & VECTORS
(2021)
Article
Medicine, General & Internal
Lorenz von Seidlein, Thomas J. Peto, Jordi Landier, Thuy-Nhien Nguyen, Rupam Tripura, Koukeo Phommasone, Tiengkham Pongvongsa, Khin Maung Lwin, Lilly Keereecharoen, Ladda Kajeechiwa, May Myo Thwin, Daniel M. Parker, Jacher Wiladphaingern, Suphak Nosten, Stephane Proux, Vincent Corbel, Nguyen Tuong-Vy, Truong Le Phuc-Nhi, Do Hung Son, Pham Nguyen Huong-Thu, Nguyen Thi Kim Tuyen, Nguyen Thanh Tien, Le Thanh Dong, Dao Van Hue, Huynh Hong Quang, Chea Nguon, Chan Davoeung, Huy Rekol, Bipin Adhikari, Gisela Henriques, Panom Phongmany, Preyanan Suangkanarat, Atthanee Jeeyapant, Benchawan Vihokhern, Rob W. van der Pluijm, Yoel Lubell, Lisa J. White, Ricardo Aguas, Cholrawee Promnarate, Pasathorn Sirithiranont, Benoit Malleret, Laurent Renia, Carl Onsjo, Xin Hui Chan, Jeremy Chalk, Olivo Miotto, Krittaya Patumrat, Kesinee Chotivanich, Borimas Hanboonkunupakarn, Podjanee Jittmala, Nils Kaehler, Phaik Yeong Cheah, Christopher Pell, Mehul Dhorda, Mallika Imwong, Georges Snounou, Mavuto Mukaka, Pimnara Peerawaranun, Sue J. Lee, Julie A. Simpson, Sasithon Pukrittayakamee, Pratap Singhasivanon, Martin P. Grobusch, Frank Cobelens, Frank Smithuis, Paul N. Newton, Guy E. Thwaites, Nicholas P. J. Day, Mayfong Mayxay, Tran Tinh Hien, Francois H. Nosten, Arjen M. Dondorp, Nicholas J. White
Review
Infectious Diseases
Ingrid Felger, Georges Snounou, Ian Hastings, Joerg J. Moehrle, Hans-Peter Beck
LANCET INFECTIOUS DISEASES
(2020)
Article
Zoology
Stanislas Talaga, Jean-Charles Gantier, Romain Girod
Article
Microbiology
Laurent Dembele, Jean-Francois Franetich, Valerie Soulard, Nadia Amanzougaghene, Shahin Tajeri, Teun Bousema, Geert-Jan van Gemert, Roger Le Grand, Nathalie Dereuddre-Bosquet, J. Kevin Baird, Dominique Mazier, Georges Snounou
Summary: This study found that chloroquine can potentiate the activity of 8-aminoquinoline compound primaquine against several malarial parasites in normal primary hepatocytes, but not in a hepatocarcinoma cell line.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Editorial Material
Medicine, General & Internal
Jean-Marc Chavatte, Georges Snounou
Article
Microbiology
Benoit Malleret, Abbas El Sahili, Matthew Zirui Tay, Guillaume Carissimo, Alice Soh Meoy Ong, Wisna Novera, Jianqing Lin, Rossarin Suwanarusk, Varakorn Kosaisavee, Trang T. T. Chu, Ameya Sinha, Shanshan Wu Howland, Yiping Fan, Jakub Gruszczyk, Wai-Hong Tham, Yves Colin, Sebastian Maurer-Stroh, Georges Snounou, Lisa F. P. Ng, Jerry Kok Yen Chan, Ann-Marie Chacko, Julien Lescar, Rajesh Chandramohanadas, Francois Nosten, Bruce Russell, Laurent Renia
Summary: This study identified CD98 heavy chain as a receptor for the PvRBP2a parasite ligand, further demonstrating its role in P. vivax reticulocyte invasion. The interaction between CD98 and PvRBP2a suggests its potential as a vaccine target against P. vivax malaria.
NATURE MICROBIOLOGY
(2021)
Article
Zoology
Loic Pougnault, Alban Lemasson, Baptiste Mulot, Florence Levrero
Summary: The vocal behavior of a group of chimpanzees is influenced by caller characteristics, production context, and social needs. Vocal turn-taking plays a key role in affiliative encounters, with the number and speed of calls affecting audience reaction. However, social integration, age, and sex have a weaker influence on call rates and interaction patterns.
INTERNATIONAL JOURNAL OF PRIMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Arthur Kocher, Josselin Cornuault, Jean-Charles Gantier, Sophie Manzi, Agathe Chavy, Romain Girod, Isabelle Dusfour, Pierre-Michel Forget, Marine Ginouves, Ghislaine Prevot, Jean-Francois Guegan, Anne-Laure Banuls, Benoit Thoisy, Jerome Murienne
Summary: Changes in biodiversity can impact the transmission of infectious diseases through multiple mechanisms. This study explored the impact of biodiversity changes on the transmission of Amazonian leishmaniases, a group of wild zoonoses transmitted by sand flies. The researchers found that the prevalence of Leishmania parasites in sand flies was positively correlated with the abundance of mammal species known as Leishmania reservoirs. Additionally, higher mammal diversity was associated with higher sand fly density. These results provide further evidence that changes in biodiversity can both dilute and amplify vector-borne disease transmission.
Article
Behavioral Sciences
Clement Cornec, Muzungu Ngofuna, Alban Lemasson, Claude Monghiemo, Victor Narat, Florence Levrero
Summary: Non-human primates engage in non-agonistic vocal exchanges that follow basic temporal rules, similar to human conversations. While a study on wild great apes did not find evidence of vocal turn-taking, a pilot study on wild bonobos revealed that they respect the fundamental temporal rules of vocal turn-taking. Despite the need for further research to confirm these findings, this study fills a major gap in understanding the vocal communication of wild great apes and paves the way for more extensive comparative studies.
ETHOLOGY ECOLOGY & EVOLUTION
(2022)
Review
Parasitology
Richard Culleton, Arnab Pain, Georges Snounou
Summary: Plasmodium malariae is a neglected malaria parasite, with less research conducted compared to its more notorious cousins, P. falciparum and P. vivax. However, there has been increasing interest in this parasite due to improved detection techniques revealing a wider prevalence and high numbers of chronic, asymptomatic infections, particularly in Africa.
TRENDS IN PARASITOLOGY
(2023)
Article
Infectious Diseases
Ali Bouattour, Amine Amri, Jaber Amine Belkhiria, Adel Rhim, Ons Fezaa, Jean-Charles Gantier, Youmna M'ghirbi
Summary: Leishmania infantum, an intracellular protozoan responsible for zoonotic canine leishmaniosis, has a high prevalence in dogs in Tunisia, varying by bioclimatic area and age group. The expansion of infection in dog population may be attributed to ecological, agronomic, social, and climatic factors.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Behavioral Sciences
Sumir Keenan, Nicolas Mathevon, Jeroen M. G. Stevens, Florence Nicole, Klaus Zuberbuhler, Jean-Pascal Guery, Florence Levrero
Article
Parasitology
Amirah Amir, Shahhaziq Shahari, Jonathan Wee Kent Liew, Jeremy Ryan de Silva, Mohammad Behram Khan, Meng Yee Lai, Georges Snounou, Mohd Lutfi Abdullah, Millawati Gani, Jeffrine J. Rovie-Ryan, Yee-Ling Lau
Article
Parasitology
Antoine Blavier, Laetitia Laroche, Fano Jose Randrianambinintsoa, Vincent Lucas, Jean-Charles Gantier, Nicole Leger, Vincent Robert, Jerome Depaquit
Article
Immunology
Jorian Prudhomme, Albin Fontaine, Guillaume Lacour, Jean-Charles Gantier, Laure Diancourt, Enkelejda Velo, Silva Bino, Paul Reiter, Aurelien Mercier
EMERGING MICROBES & INFECTIONS
(2019)