Review
Medicine, General & Internal
Ekpereonne B. Esu, Chioma Oringanje, Martin M. Meremikwu
Summary: In sub-Saharan Africa, intermittent preventive treatment (IPT) with antimalarial drugs may reduce the risk of clinical malaria, anemia, and hospital admission in infants, but the efficacy of some drugs appears to decline over time. Studies show positive impacts on treating clinical malaria, anemia, and hospital admissions, while the effect on all-cause mortality remains unclear.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Editorial Material
Pharmacology & Pharmacy
Feiko O. ter Kuile
Summary: Malaria is a major cause of adverse pregnancy outcomes in sub-Saharan Africa and resistance to the recommended antimalarial, sulfadoxine-pyrimethamine, is threatening progress. A trial of dihydroartemisinin-piperaquine as an alternative to sulfadoxine-pyrimethamine showed significant reductions in placental malaria and adverse pregnancy outcomes. The results raise questions about the discrepancies with previous trials.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Public, Environmental & Occupational Health
David Kwame Dosoo, Kezia Malm, Felix Boakye Oppong, Richard Gyasi, Abraham Oduro, John Williams, Dorcas Atibilla, Nana Yaw Peprah, Mieks Twumasi, Seth Owusu-Agyei, Brian Greenwood, Daniel Chandramohan, Kwaku Poku Asante
Summary: The study found no significant difference in the risk of placental malaria, low birth weight, or maternal anemia among women receiving 3 doses compared with those receiving >= 4 doses of IPTp-SP. Receiving >= 3 doses was associated with a lower risk of overall placental malaria infection compared with 2 doses. Monthly administration of IPTp-SP appears to be a practical and safe option for pregnant women to receive multiple doses during pregnancy.
Article
Infectious Diseases
Augustin E. Fombah, Haily Chen, Kwabena Owusu-Kyei, Llorenc Quinto, Raquel Gonzalez, Julian Williams, Mireia LLach Berne, Myrte Wassenaar, Abubakarr Jalloh, Joe-Henry C. Sunders, Maximo Ramirez, Cesc Bertran-Cobo, Francisco Saute, Didier K. Ekouevi, Valerie Briand, Anitta R. Y. Kamara, Tom Sesay, Mohamed Samai, Clara Menendez
Summary: This article investigates the implementation of the intermittent preventive treatment of malaria in infants (IPTi) strategy and the prevalence of malaria in Sierra Leone. The survey results show that half of the children in Sierra Leone received the recommended three doses of IPTi, indicating an improvement in uptake but efforts are still needed to increase coverage.
Article
Medicine, General & Internal
Mwayiwawo Madanitsa, Hellen C. Barsosio, Daniel T. R. Minja, George Mtove, Reginald A. Kavishe, James Dodd, Queen Saidi, Eric Onyango, Kephas Otieno, Duolao Wang, Ulla Ashorn, Jenny Hill, Crispin Mukerebe, Samwel Gesase, Omari A. Msemo, Victor Mwapasa, Kamija S. Phiri, Kenneth Maleta, Nigel Klein, Pascal Magnussen, John P. A. Lusingu, Simon Kariuki, Jacklin F. Mosha, Michael Alifrangis, Helle Hansson, Christentze Schmiegelow, Julie R. Gutman, R. Matthew Chico, Feiko O. ter Kuile
Summary: This study evaluates the efficacy of intermittent preventive treatment in pregnancy (IPTp) with dihydroartemisinin-piperaquine compared to sulfadoxine-pyrimethamine in high-resistance areas in East Africa. The results demonstrate that IPTp with dihydroartemisinin-piperaquine and its combination with azithromycin lead to more adverse pregnancy outcomes compared to sulfadoxine-pyrimethamine. This suggests that combining sulfadoxine-pyrimethamine and dihydroartemisinin-piperaquine for IPTp should be considered.
Article
Public, Environmental & Occupational Health
Clara Pons-Duran, Mireia Llach, Charfudin Sacoor, Sergi Sanz, Eusebio Macete, Iwara Arikpo, Maximo Ramirez, Martin Meremikwu, Didier Mbombo Ndombe, Susana Mendez, Manu F. Manun'Ebo, Ranto Ramananjato, Victor R. Rabeza, Maya Tholandi, Elaine Roman, Franco Pagnoni, Raquel Gonzalez, Clara Menendez
Summary: The coverage of IPTp3+ in the surveyed districts in four sub-Saharan countries was generally low, falling short of universal coverage. However, one district in Mozambique showed significantly higher IPTp3+ coverage compared to other areas and the 2018 national average, indicating a need for further investigation into the reasons behind this discrepancy.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Infectious Diseases
Fatima Mahmud Muhammad, Saharnaz Nedjat, Haniye Sadat Sajadi, Mahboubeh Parsaeian, Abraham Assan, Reza Majdzadeh
Summary: The study identified poor policy implementation, low antenatal care attendance, inadequate access to intermittent preventive treatment at community levels, lack of sustainable funding, and poor community engagement as major barriers to IPTp usage among pregnant women in Nigeria.
BMC INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Laia Cirera, Charfudin Sacoor, Martin Meremikwu, Louise Ranaivo, Manu F. Manun'Ebo, Clara Pons-Duran, Dachi Arikpo, Maximo Ramirez, Francesco Ramponi, Antia Figueroa-Romero, Raquel Gonzalez, Christina Maly, Elaine Roman, Elisa Sicuri, Franco Pagnoni, Clara Menendez
Summary: The World Health Organization recommends the use of intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) for the control and prevention of malaria in pregnancy in sub-Saharan Africa. However, the coverage and uptake of IPTp-SP remains low. A pilot project was conducted to assess the cost-effectiveness of community-based delivery of IPTp (C-IPTp) in increasing IPTp uptake. The study found that C-IPTp is a highly cost-effective intervention.
Article
Public, Environmental & Occupational Health
Eugene Kofuor Maafo Darteh, Kwamena Sekyi Dickson, Bright Opoku Ahinkorah, Bernard Afriyie Owusu, Joshua Okyere, Tarif Salihu, Vincent Bio Bediako, Eugene Budu, Wonder Agbemavi, Jane Odurowaah Edjah, Abdul-Aziz Seidu
Summary: The study found that the uptake of IPTp-SP among pregnant women in sub-Saharan African countries is relatively low, with significant inter-country variations. Factors associated with higher odds of optimal IPTp-SP uptake include higher educational level, exposure to media, low parity, and older age group. National policies and interventions to improve coverage and uptake of IPTp-SP should target women with lower education levels, non-exposure to media, higher parity, and younger age group.
ARCHIVES OF PUBLIC HEALTH
(2021)
Article
Multidisciplinary Sciences
Yaa Nyarko Agyeman, Sam Newton, Raymond Boadu Annor, Ellis Owusu-Dabo
Summary: A study evaluated the protective effect of Sulphadoxine Pyrimethamine for anaemia among pregnant women in Ghana under the new WHO policy. It found that despite taking 3 or more doses of IPTp-SP, the prevalence of anaemia remained high. Maternal formal education was associated with a reduced burden of anaemia in pregnancy.
Article
Medicine, Research & Experimental
Zhenxin Duan, Xiaoying Zhou, Feng Chen, Huifang Chen, Guangyou Duan, Hong Li
Summary: This study demonstrates that sevoflurane anesthesia exerts a cardio-protective effect through down-regulation of THAP11, promoting cell survival, inhibiting apoptosis, and cell death in myocardial cells.
Article
Pharmacology & Pharmacy
Eulambius M. Mlugu, Omary Minzi, Appolinary A. R. Kamuhabwa, Eleni Aklillu
Summary: Monthly intermittent preventive treatment with dihydroartemisinin-piperaquine (IPTp-DHP) showed superior protective efficacy against malaria in pregnancy and low birth weight compared to sulfadoxine-pyrimethamine (IPTp-SP).
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Obstetrics & Gynecology
Bola Lukman Solanke, Rasheed Adebayo Yinusa, Olaoye James Oyeleye, Omolayo Bukola Oluwatope, Benjamin Bukky Ilesanmi, Tosin Olajide Oni
Summary: A study in Nigeria explored factors influencing usage of intermittent preventive treatment of malaria in pregnancy (IPTp) and found that the optimal usage rate of IPTp is low.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Infectious Diseases
Joshua A. Mutanyi, Daniel O. Onguru, Sidney O. Ogolla, Lawrence B. Adipo
Summary: This study found a high level of optimal uptake of IPTp-SP in the Sabatia Sub County of Kenya, with factors such as timing and frequency of antenatal care visits, women's understanding of the benefits and dosage of the service, influencing the likelihood of pregnant women receiving optimal care. Efforts should be directed towards early and more frequent ANC visits, along with intensive and targeted health education to improve IPTp-SP uptake.
INFECTIOUS DISEASES OF POVERTY
(2021)
Article
Public, Environmental & Occupational Health
Yara Alonso, Wade Lusengi, Manu F. Manun'Ebo, Aimee M. Rasoamananjaranahary, Noroharifetra Madison Rivontsoa, Estevao Mucavele, Neusa Torres, Charfudin Sacoor, Hope Okebalama, Ugo James Agbor, Ogonna Nwankwo, Martin Meremikwu, Elaine Roman, Franco Pagnoni, Clara Menendez, Khatia Munguambe, Cristina Enguita-Fernandez
Summary: Intermittent preventive treatment in pregnancy with sulphadoxine pyrimethamine (IPTp) is a key malaria prevention strategy in sub-Saharan African countries. This anthropological study aimed to understand the social context and identify key factors that could influence acceptability of community-based delivery of IPTp. The findings provide evidence on the reported acceptability of C-IPTp among a wide range of actors, as well as barriers and facilitators for delivery and uptake of the intervention.
Review
Parasitology
Hannah C. Slater, Lucy C. Okell, Azra C. Ghani
TRENDS IN PARASITOLOGY
(2017)
Article
Multidisciplinary Sciences
Joseph D. Challenger, Katia Bruxvoort, Azra C. Ghani, Lucy C. Okell
NATURE COMMUNICATIONS
(2017)
Article
Medicine, General & Internal
Peter Winskill, Hannah C. Slater, Jamie T. Griffin, Azra C. Ghani, Patrick G. T. Walker
Article
Biology
Oliver J. Watson, Hannah C. Slater, Robert Verity, Jonathan B. Parr, Melchior K. Mwandagarlirwa, Antoinette Tshefu, Steven R. Meshnick, Azra C. Ghani
Article
Medicine, General & Internal
Alexandra B. Hogan, Peter Winskill, Robert Verity, Jamie T. Griffin, Azra C. Ghani
Article
Immunology
Ozkan Aydemir, Mark Janko, Nick J. Hathaway, Robert Verity, Melchior Kashamuka Mwandagalirwa, Antoinette K. Tshefu, Sofonias K. Tessema, Patrick W. Marsh, Alice Tran, Thomas Reimonn, Azra C. Ghani, Anita Ghansah, Jonathan J. Juliano, Bryan R. Greenhouse, Michael Emch, Steven R. Meshnick, Jeffrey A. Bailey
JOURNAL OF INFECTIOUS DISEASES
(2018)
Editorial Material
Medicine, General & Internal
Azra C. Ghani
Article
Infectious Diseases
Michael T. White, Stephan Karl, Cristian Koepfli, Rhea J. Longley, Natalie E. Hofmann, Rahel Wampfler, Ingrid Felger, Tom Smith, Wang Nguitragool, Jetsumon Sattabongkot, Leanne Robinson, Azra Ghani, Ivo Mueller
Article
Infectious Diseases
Robert Verity, Nicholas J. Hathaway, Andreea Waltmann, Stephanie M. Doctor, Oliver J. Watson, Jaymin C. Patel, Kashamuka Mwandagalirwa, Antoinette K. Tshefu, Jeffrey A. Bailey, Azra C. Ghani, Jonathan J. Juliano, Steven R. Meshnick
Article
Multidisciplinary Sciences
Isobel Routledge, Jose Eduardo Romero Cheyez, Zulma M. Cucunuba, Manuel Gomez Rodriguez, Caterina Guinovart, Kyle B. Gustafson, Kammerle Schneider, Patrick Gt Walker, Azra C. Ghani, Samir Bhatt
NATURE COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
John M. Marshall, Sean L. Wu, Hector M. C. Sanchez, Samson S. Kiware, Micky Ndhlovu, Andre Lin Ouedraogo, Mahamoudou B. Toure, Hugh J. Sturrock, Azra C. Ghani, Neil M. Ferguson
SCIENTIFIC REPORTS
(2018)
Article
Biology
Ellie Sherrard-Smith, Katarzyna A. Sala, Michael Betancourt, Leanna M. Upton, Fiona Angrisano, Merribeth J. Morin, Azra C. Ghani, Thomas S. Churcher, Andrew M. Blagborough
Article
Infectious Diseases
Joel Hellewell, Patrick Walker, Azra Ghani, Bhargavi Rao, Thomas S. Churcher
Article
Multidisciplinary Sciences
Michael T. White, Patrick Walker, Stephan Karl, Manuel W. Hetzel, Tim Freeman, Andreea Waltmann, Moses Laman, Leanne J. Robinson, Azra Ghani, Ivo Mueller
NATURE COMMUNICATIONS
(2018)
Article
Parasitology
Gesham Magombedze, Neil M. Ferguson, Azra C. Ghani
PARASITES & VECTORS
(2018)