Article
Polymer Science
Suyang Dai, Ni Jiang, Zhenbo Ning, Zhihua Gan
Summary: The length of the PDLA block was found to have a significant impact on the degradation behavior of PLLA/4-DL-D blend films.
POLYMER INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Naoto Ogiwara, Takenobu Nakano, Tsukuru Masuda, Keiichiro Kushiro, Madoka Takai
Summary: Multi-block copolymers composed of poly(2-methoxyethyl acrylate) (PMEA) and polyethylene glycol (PEG) were developed as biocompatible polymers for drug screening. The copolymers showed higher stability in water than PMEA and exhibited a micro-sized swelling structure composed of a PEG chain. The cell spheroid formation rate and internal necrotic state were controlled by changing the PEG content in the copolymers, making them useful for 3D cell culture.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Rami Hador, Michael Shuster, Vincenzo Venditto, Moshe Kol
Summary: This study proposes a new approach to tolerate stereoerrors in the polymer by crowding them in a stereogradient copolymer. A zirconium complex of an amine tris(phenolate) ligand is used as a catalyst for the ring opening polymerization of meso-lactide at room temperature, and stereogradient copolymers are formed in the polymerization of mixtures of meso-lactide/L-lactide at 180 degrees C. These stereogradient copolymers exhibit enhanced crystallinities compared to stereorandom copolymers obtained with tin octanoate.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Polymer Science
Moritz Meier-Merziger, Marcel Fickenscher, Frank Hartmann, Bjoern Kuttich, Tobias Kraus, Markus Gallei, Holger Frey
Summary: Bifunctional initiators were used to synthesize complex triblock copolymer structures in carbanionic polymerization. Isoprene was polymerized using 1,3-bis(1-phenylethenyl)benzene (PEB), resulting in a high content of 93% 1,4-PI units. Hydroxyl groups were then introduced simultaneously in the alpha- and omega-position using end-functionalization of the living anionic di-lithiated polyisoprene (PI) chains with 1,2-isopropylidene glyceryl glycidyl ether (IGG) and subsequent acidic deprotection. The resulting hexa-hydroxy functional PI-macroinitiators were used to initiate l-lactide (LLA) polymerization, leading to the formation of super-H-shaped (PLLA)(3)-b-PI-b-(PLLA)(3) triblock structures with narrow molecular weight distributions.
Article
Polymer Science
Alexandra Grigoreva, Kseniia Tarankova, Olga Zamyshlyayeva, Sergey Zaitsev
Summary: The formation of monolayers of PFA-b-PAA amphiphilic copolymers at the air/water interface was characterized using Langmuir film balance technique and atomic force microscopy. Both internal and external effects on the aggregation behavior of the copolymers were considered. The study found that the structure of the copolymer and the pH and salt concentration of the subphase have significant impacts on the surface behavior of the copolymers.
JOURNAL OF POLYMER RESEARCH
(2021)
Article
Polymer Science
Zhuoxin Zhuang, Tiantian Li, Zhenbo Ning, Ni Jiang, Zhihua Gan
Summary: The synthesis of lignin-grafted-poly (o-lactide) (LGPD) with different poly(o-lactide) (PDLA) block lengths improved the crystallization, mechanical properties, and UV-absorbance properties of poly(L-lactide) (PLLA). The longer PDLA block length in LGPD led to faster crystallization rates and broader melting ranges of stereocomplex (SC) crystallites. Moreover, the LGPD blends showed improved tensile strength and UV-absorbance properties compared to neat PLLA.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Polymer Science
Lei Hua, Xiaodong Wang
Summary: New biodegradable aliphatic PLLA-PBA-PLLA copolymers with different PLLA block lengths showed different structures and crystallization behaviors of PBA-mid, which were studied using various analytical techniques.
Article
Polymer Science
Amel Oucif, Nabila Haddadine, Dria Zakia, Naima Bouslah, Ahmed Benaboura, Khaled Beyaz, Bendiba Guedouar, M. Samy El-Shall
Summary: Different ratios of poly (HEMA-co-HEA) hydrogels were successfully prepared for therapeutic soft contact lenses applications, with the hydrogels containing HEA showing improved microstructure and swelling capacity. In vitro studies revealed a non-Fickian drug release behavior for all hydrogel ratios, with the 40/60 ratio exhibiting the highest drug release/loading capacity. These findings suggest that the corresponding hydrogel is a promising material for sustainable drug release in curative SCLs.
Article
Polymer Science
Ishah H. Alshehri, David Pahovnik, Ema Zagar, Devon A. Shipp
Summary: Gradient copolymers of n-butyl acrylate (nBA) and isobornyl acrylate (IBA) were prepared using reversible addition-fragmentation chain transfer (RAFT) emulsion polymerization. The stepwise monomer addition process allowed for pre-specified gradient compositions to be obtained. H-1 NMR characterization revealed the gradient behavior of the copolymers. Differential scanning calorimetry analysis showed that gradient copolymers had broader glass-transition regions compared to homopolymers and statistical copolymers. The thermal properties of the copolymers can be controlled by the choice of comonomer feed composition and the steepness of the comonomer feed.
Article
Biochemistry & Molecular Biology
Yulia A. Kadina, Ekaterina V. Razuvaeva, Dmitry R. Streltsov, Nikita G. Sedush, Eleonora V. Shtykova, Alevtina I. Kulebyakina, Alexander A. Puchkov, Dmitry S. Volkov, Alexey A. Nazarov, Sergei N. Chvalun
Summary: Nanoparticles based on biocompatible mPEG(113)-b-P(D,L)LA(n) copolymers were prepared for the delivery of the anticancer agent oxaliplatin via a nanoprecipitation technique. It was found that an increase in the hydrophobic PLA block length resulted in larger nanoparticle size and decreased oxaliplatin loading content.
Article
Polymer Science
Hideto Tsuji, Kazumasa Iguchi, Yuki Arakawa
Summary: The research studied the effects of different molecular weights of crystalline blocks but similar overall molecular weights on the crystallization behavior, structure, morphology, and thermal properties of PLLA-b-PDLLA/PDLA-b-PDLLA blends. It was found that the incorporated long amorphous PDLLA blocks facilitated unique SC crystallization in the blends with different crystalline block fractions.
Article
Polymer Science
Amirhesam Arabsorkhi-Mishabi, Mojgan Zandi, Fahimeh Askari, Mohamad Pezeshki-Modaress
Summary: Different polycaprolactone (PCL) soft blocks were incorporated into poly(glycerol sebacate) (PGS) structure to prepare a series of PGS-based elastomers with varied chemical compositions and mechanical properties. The PGS and PGS-co-PCL elastomers were prepared through thermal curing without any catalysts. The synthesized PGS-co-PCL elastomers exhibited tunable mechanical properties in the range of soft tissues and showed promising potential in biomedical applications and soft tissue engineering.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Li-Han Rong, Xiang Cheng, Jin Ge, Hanyu Wang, Peng-Fei Cao, Eugene B. Caldona, Rigoberto C. Advincula
Summary: This study reports for the first time the interfacial behavior of catenated poly(L-lactide) (C-PLA) at the air-water interface and compares it with its linear analogue (LPLA). The results show significant interfacial behavioral differences between the two polymers, with C-PLA demonstrating higher stability at the air-water interface.
Article
Polymer Science
Shuxiao Li, Harriet Lindsay, John Texter
Summary: Initial attempts at bulk polymerization of bromoundecyl acrylate unexpectedly resulted in cross-linked gels, Gel(CH2Cl2) and Gel(DMF), with Gel(DMF) having a higher cross-linking density and thermally driven bromine evolution properties. These gel materials represent a new class of telechelic gels that can be easily reacted with diverse reagents for interfacial compatibility with other phases.
Article
Materials Science, Multidisciplinary
Evgenii A. Ksendzov, Pavel A. Nikishau, Irina M. Zurina, Viktoria S. Presniakova, Peter Timashev, Yuri A. Rochev, Svetlana Kotova, Sergei Kostjuk
Summary: A series of well-defined macromonomers and copolymers were synthesized via ROP and RAFT-mediated copolymerization, respectively. The cloud point temperature and transition temperature of the graft copolymers showed dependence on the copolymer composition. Films prepared from these copolymers displayed better cell adhesion compared to neat PNIPAM.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Polymer Science
Vincent Pertici, Thomas Trimaille, Didier Gigmes
Article
Materials Science, Biomaterials
Maxime Bonnet, Thomas Trimaille, Jean-Michel Brezun, Francois Feron, Didier Gigmes, Tanguy Marqueste, Patrick Decherchi
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Celine Lacroix, Almudena Humanes, Celine Coiffier, Didier Gigmes, Bernard Verrier, Thomas Trimaille
PHARMACEUTICAL RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Maxime Bonnet, Gaelle Guiraudie-Capraz, Tanguy Marqueste, Stephane Garcia, Charlotte Jaloux, Patrick Decherchi, Francois Feron
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Chemistry, Multidisciplinary
Maxime Bonnet, Olivier Alluin, Thomas Trimaille, Didier Gigmes, Tanguy Marqueste, Patrick Decherchi
Article
Engineering, Industrial
Mathieu Lecocq, Pascaline Lantoine, Clement Bougard, Jean-Marc Allegre, Laurent Bauvineau, Christophe Bourdin, Tanguy Marqueste, Erick Dousset
APPLIED ERGONOMICS
(2020)
Article
Psychology, Multidisciplinary
Nicolas Mascret, Olivier Vors, Tanguy Marqueste, Francois Cury
Summary: This study used the TSST as an experimental stress paradigm to investigate its impact on free-throw performance of skilled basketball players. The results showed that free-throw performance remained stable when players were put in a competition immediately after the TSST, and other-approach goals were significant predictors of performance in the competition condition.
PSYCHOLOGICAL REPORTS
(2022)
Review
Medicine, General & Internal
C. Jaloux, M. Witters, J. Veran, L. Giraudo, F. Sabatier, R. Lacroix, F. Dignat-George, M. Bonnet, T. Marqueste, P. Decherchi, M. Montava, G. Guiraudie Capraz, F. Feron
Summary: The research team focuses on the potential of olfactory stem cells for treating peripheral nerve injuries and has validated the effectiveness of this treatment method. Through clinical trials and animal model studies, olfactory stem cell grafting is beneficial for nerve regeneration and has a lower potential carcinogenic risk.
BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE
(2021)
Article
Neurosciences
Marie-Helene Canu, Valerie Montel, Julie Dereumetz, Tanguy Marqueste, Tanguy Decherchi, Jacques-Olivier Coq, Erwan Dupont, Bruno Bastide
Summary: Research indicates that early movement restriction can lead to severe atrophy and functional disorganization in the soleus muscle of rats, resulting in issues such as sensorimotor restriction and increased neuromuscular excitability. However, some of these changes can be reversed when typical activity is resumed, suggesting the importance of proprioceptive feedback in promoting typical motor function development.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Pascaline Lantoine, Mathieu Lecocq, Clement Bougard, Erick Dousset, Tanguy Marqueste, Christophe Bourdin, Jean-Marc Allegre, Laurent Bauvineau, Serge Mesure
Summary: This study evaluated the effects of three different seats on driver's sitting behavior and discomfort during prolonged driving under real conditions. Soft seats (S-1 & S-3) were found to limit local perceived discomfort, especially in areas like the buttocks, thighs, neck, and upper back. Automotive manufacturers could enhance seat design by combining a soft seat cushion, firm backrest, and suspension system for reduced driver discomfort.
Article
Engineering, Industrial
Pascaline Lantoine, Mathieu Lecocq, Clement Bougard, Erick Dousset, Tanguy Marqueste, Christophe Bourdin, Jean-Marc Allegre, Laurent Bauvineau, Serge Mesure
Summary: This study compares the effects of different seats and road types on pressure distribution and perceived discomfort during driving. The softer seat showed better pressure distribution, while mountain and city roads had less homogeneous pressure distribution. Despite pressure differences between seats, both led to similar increases in perceived discomfort during driving, with the neck and lower back areas experiencing the highest discomfort.
APPLIED ERGONOMICS
(2022)
Article
Multidisciplinary Sciences
Mathieu Lecocq, Pascaline Lantoine, Clement Bougard, Jean-Marc Allegre, Laurent Bauvineau, Damian Gonzalez, Christophe Bourdin, Tanguy Marqueste, Erick Dousset
Summary: Through long duration real driving sessions, we found that the suspended seat (S-3) may be the most suitable seat to delay discomfort and neuromuscular fatigue appearance.
Review
Biochemistry & Molecular Biology
Mostafa Seblani, Patrick Decherchi, Jean-Michel Brezun
Summary: Edema after spinal cord injury is a significant concern and can worsen the condition. The mechanisms behind the increase in water content after SCI are still not fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)