EFab domain substitution as a solution to the light-chain pairing problem of bispecific antibodies

The making of bispecific antibodies

(2017) Ulrich Brinkmann et al.   mAbs

Biophysical properties of the clinical-stage antibody landscape

(2017) Tushar Jain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutational landscape of antibody variable domains reveals a switch modulating the interdomain conformational dynamics and antigen binding

(2017) Patrick Koenig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient production of bispecific IgG of different isotypes and species of origin in single mammalian cells

(2016) Michael Dillon et al.   mAbs

Comparing domain interactions within antibody Fabs with kappa and lambda light chains

(2016) Raheleh Toughiri et al.   mAbs

A Novel Antibody Engineering Strategy for Making Monovalent Bispecific Heterodimeric IgG Antibodies by Electrostatic Steering Mechanism

(2015) Zhi Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fab-based bispecific antibody formats with robust biophysical properties and biological activity

(2015) Xiufeng Wu et al.   mAbs

Alternative molecular formats and therapeutic applications for bispecific antibodies

(2015) Christoph Spiess et al.   MOLECULAR IMMUNOLOGY

Non–antigen-contacting region of an asymmetric bispecific antibody to factors IXa/X significantly affects factor VIII-mimetic activity

(2014) Zenjiro Sampei et al.   mAbs

Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface

(2014) Steven M Lewis et al.   NATURE BIOTECHNOLOGY

Comparison of the Inhibition Mechanisms of Adalimumab and Infliximab in Treating Tumor Necrosis Factor α-Associated Diseases from a Molecular View

(2013) Shi Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improving biophysical properties of a bispecific antibody scaffold to aid developability

(2013) Thomas Spreter Von Kreudenstein et al.   mAbs

Tetravalent Antibody-scTRAIL Fusion Proteins with Improved Properties

(2013) O. Seifert et al.   MOLECULAR CANCER THERAPEUTICS

A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity

(2011) Jianying Dong et al.   mAbs

Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI

(2011) Mary D Holdom et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Antibody Engineering Using Phage Display with a Coiled-Coil Heterodimeric Fv Antibody Fragment

(2011) Xinwei Wang et al.   PLoS One

Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies

(2011) W. Schaefer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Enhancing Antibody Fc Heterodimer Formation through Electrostatic Steering Effects

(2010) Kannan Gunasekaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY