Rearranging the domain order of a diabody-based IgG-like bispecific antibody enhances its antitumor activity and improves its degradation resistance and pharmacokinetics

Identification of Anti-ErbB2 Dual Variable Domain Immunoglobulin (DVD-Ig™) Proteins with Unique Activities

(2014) Jinming Gu et al.   PLoS One

Bispecific antibodies with natural architecture produced by co-culture of bacteria expressing two distinct half-antibodies

(2013) Christoph Spiess et al.   NATURE BIOTECHNOLOGY

Domain order of a bispecific diabody dramatically enhances its antitumor activity beyond structural format conversion: the case of the hEx3 diabody

(2013) Ryutaro Asano et al.   PROTEIN ENGINEERING DESIGN & SELECTION

A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications

(2013) Hannah Byrne et al.   TRENDS IN BIOTECHNOLOGY

Immunomodulatory therapy of cancer with T cell-engaging BiTE antibody blinatumomab

(2011) Dirk Nagorsen et al.   EXPERIMENTAL CELL RESEARCH

Engineering Upper Hinge Improves Stability and Effector Function of a Human IgG1

(2011) Boxu Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recombinant antibodies: Engineering and production in yeast and bacterial hosts

(2010) Ki Jun Jeong et al.   Biotechnology Journal

Stable IgG-like Bispecific Antibodies Directed toward the Type I Insulin-like Growth Factor Receptor Demonstrate Enhanced Ligand Blockade and Anti-tumor Activity

(2010) Jianying Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histidine Residue Mediates Radical-induced Hinge Cleavage of Human IgG1

(2010) Zac Yates et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Highly Enhanced Cytotoxicity of a Dimeric Bispecific Diabody, the hEx3 Tetrabody

(2010) Ryutaro Asano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytotoxic Enhancement of a Bispecific Diabody by Format Conversion to Tandem Single-chain Variable Fragment (taFv)

(2010) Ryutaro Asano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-tumor activity of stability-engineered IgG-like bispecific antibodies targeting TRAIL-R2 and LTβR

(2010) Jennifer S. Michaelson et al.   mAbs

Bispecific antibodies for cancer therapy

(2010) Patrick Chames et al.   mAbs

Application of the Fc fusion format to generate tag-free bi-specific diabodies

(2009) Ryutaro Asano et al.   FEBS Journal

Biodistribution of a Bispecific Single-chain Diabody and Its Half-life Extended Derivatives

(2009) Roland Stork et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycosylation as a strategy to improve antibody-based therapeutics

(2009) Roy Jefferis   NATURE REVIEWS DRUG DISCOVERY

Engineering of stable bispecific antibodies targeting IL-17A and IL-23

(2009) Robert Mabry et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Diabody-based Recombinant Formats of Humanized IgG-like Bispecific Antibody With Effective Retargeting of Lymphocytes to Tumor Cells

(2008) Ryutaro Asano et al.   JOURNAL OF IMMUNOTHERAPY

Tumor Regression in Cancer Patients by Very Low Doses of a T Cell-Engaging Antibody

(2008) R. Bargou et al.   SCIENCE