Lepidopteran cells, an alternative for the production of recombinant antibodies?

EB66 cell line, a duck embryonic stem cell-derived substrate for the industrial production of therapeutic monoclonal antibodies with enhanced ADCC activity

(2014) Stéphane Olivier et al.   mAbs

Co-expression vs. co-infection using baculovirus expression vectors in insect cell culture: Benefits and drawbacks

(2012) Stanislav Sokolenko et al.   BIOTECHNOLOGY ADVANCES

Bypassing glycosylation: engineering aglycosylated full-length IgG antibodies for human therapy

(2011) Sang Taek Jung et al.   CURRENT OPINION IN BIOTECHNOLOGY

Insect cell technology is a versatile and robust vaccine manufacturing platform

(2011) Jimmy A Mena et al.   Expert Review of Vaccines

A new glycoengineered insect cell line with an inducibly mammalianized protein N-glycosylation pathway

(2011) Jared J Aumiller et al.   GLYCOBIOLOGY

Transgenic crops for the production of recombinant vaccines and anti-microbial antibodies

(2011) Jenny Peters et al.   Human vaccines & immunotherapeutics

Mechanism of Action of Type II, Glycoengineered, Anti-CD20 Monoclonal Antibody GA101 in B-Chronic Lymphocytic Leukemia Whole Blood Assays in Comparison with Rituximab and Alemtuzumab

(2011) L. Bologna et al.   JOURNAL OF IMMUNOLOGY

Unique carbohydrate-carbohydrate interactions are required for high affinity binding between Fc RIII and antibodies lacking core fucose

(2011) C. Ferrara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Micro-algae come of age as a platform for recombinant protein production

(2010) Elizabeth Specht et al.   BIOTECHNOLOGY LETTERS

Ao38, a new cell line from eggs of the black witch moth, Ascalapha odorata (Lepidoptera: Noctuidae), is permissive for AcMNPV infection and produces high levels of recombinant proteins

(2010) Yoshifumi Hashimoto et al.   BMC BIOTECHNOLOGY

Superior In vivo Efficacy of Afucosylated Trastuzumab in the Treatment of HER2-Amplified Breast Cancer

(2010) Teemu T. Junttila et al.   CANCER RESEARCH

Transient expression systems for plant-derived biopharmaceuticals

(2010) Tatiana V Komarova et al.   Expert Review of Vaccines

Wegener’s granuloma harbors B lymphocytes with specificities against a proinflammatory transmembrane protein and a tetraspanin

(2010) Lorenz Thurner et al.   JOURNAL OF AUTOIMMUNITY

Efficient silkworm expression of single-chain variable fragment antibody against ginsenoside Re using Bombyx mori nucleopolyhedrovirus bacmid DNA system and its application in enzyme-linked immunosorbent assay for quality control of total ginsenosides

(2010) S. Sakamoto et al.   JOURNAL OF BIOCHEMISTRY

Characterization of N-glycan structures and biofunction of anti-colorectal cancer monoclonal antibody CO17-1A produced in baculovirus-insect cell expression system

(2010) Mira Song et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Efficient production of an antibody Fab fragment using the baculovirus–insect cell system

(2010) Takanori Furuta et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

B-Cell Depletion In Vitro and In Vivo with an Afucosylated Anti-CD19 Antibody

(2010) R. Herbst et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Production of pharmaceutical-grade recombinant aprotinin and a monoclonal antibody product using plant-based transient expression systems

(2010) Gregory P. Pogue et al.   PLANT BIOTECHNOLOGY JOURNAL

Efficient production of human Fas receptor extracellular domain–human IgG1 heavy chain Fc domain fusion protein using baculovirus/silkworm expression system

(2010) Michiro Muraki et al.   PROTEIN EXPRESSION AND PURIFICATION

The production, characterisation and enhanced pharmacokinetics of scFv–albumin fusions expressed in Saccharomyces cerevisiae

(2010) Leslie Evans et al.   PROTEIN EXPRESSION AND PURIFICATION

Directed evolution of a secretory leader for the improved expression of heterologous proteins and full-length antibodies inSaccharomyces cerevisiae

(2009) J. Andy Rakestraw et al.   BIOTECHNOLOGY AND BIOENGINEERING

Mouse × pig chimeric antibodies expressed in Baculovirus retain the same properties of their parent antibodies

(2009) Ana M. Jar et al.   BIOTECHNOLOGY PROGRESS

Multigene expression of protein complexes by iterative modification of genomic Bacmid DNA

(2009) Rob J Noad et al.   BMC MOLECULAR BIOLOGY

Humanised IgG1 antibody variants targeting membrane-bound carcinoembryonic antigen by antibody-dependent cellular cytotoxicity and phagocytosis

(2009) S Q Ashraf et al.   BRITISH JOURNAL OF CANCER

Production of a recombinant mouse monoclonal antibody in transgenic silkworm cocoons

(2009) Masashi Iizuka et al.   FEBS Journal

Optimal and consistent protein glycosylation in mammalian cell culture

(2009) P. Hossler et al.   GLYCOBIOLOGY

Molecular Chaperone-Assisted Production of Human α-1,4-N-Acetylglucosaminyltransferase in Silkworm Larvae Using Recombinant BmNPV Bacmids

(2009) Makoto Nakajima et al.   MOLECULAR BIOTECHNOLOGY

An Unfolded CH1 Domain Controls the Assembly and Secretion of IgG Antibodies

(2009) Matthias J. Feige et al.   MOLECULAR CELL

Engineering complex-type N-glycosylation in Pichia pastoris using GlycoSwitch technology

(2009) Pieter P Jacobs et al.   Nature Protocols

Glycosylation as a strategy to improve antibody-based therapeutics

(2009) Roy Jefferis   NATURE REVIEWS DRUG DISCOVERY

Generation, Characterization and Epitope Mapping of Two Neutralizing and Protective Human Recombinant Antibodies against Influenza A H5N1 Viruses

(2009) Lina Sun et al.   PLoS One

Intraclonal Protein Expression Heterogeneity in Recombinant CHO Cells

(2009) Warren Pilbrough et al.   PLoS One

How antibodies fold

(2009) Matthias J. Feige et al.   TRENDS IN BIOCHEMICAL SCIENCES

Recombinant antibody therapeutics: the impact of glycosylation on mechanisms of action

(2009) Royston Jefferis   TRENDS IN PHARMACOLOGICAL SCIENCES

Production of functional antibody Fab fragment by recombinant insect cells

(2008) Hideki Yamaji et al.   BIOCHEMICAL ENGINEERING JOURNAL

Recombinant Human IgG antibodies against Human Cytomegalovirus

(2008) Tao DUAN et al.   BIOMEDICAL AND ENVIRONMENTAL SCIENCES

Terminal sugars of Fc glycans influence antibody effector functions of IgGs

(2008) T Shantha Raju   CURRENT OPINION IN IMMUNOLOGY

Human IgG1 expression in silkworm larval hemolymph using BmNPV bacmids and its N-linked glycan structure

(2008) Enoch Y. Park et al.   JOURNAL OF BIOTECHNOLOGY

Cetuximab-Induced Anaphylaxis and IgE Specific for Galactose-α-1,3-Galactose

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

Aglycosylated immunoglobulin G1 variants productively engage activating Fc receptors

(2008) S. L. Sazinsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reflections on more than 10 years of TGE approaches

(2008) Sabine Geisse   PROTEIN EXPRESSION AND PURIFICATION

False positive reactivity of recombinant, diagnostic, glycoproteins produced in High Five™ insect cells: Effect of glycosylation

(2007) Kathy Hancock et al.   JOURNAL OF IMMUNOLOGICAL METHODS