Article
Biophysics
Ru Cheng, Fu Zhu, Min Huang, Qiang Zhang, Hui Hong Yan, Xiao Hui Zhao, Fu Kang Luo, Chun Mei Li, Hui Liu, Gao Lin Liang, Cheng Zhi Huang, Jian Wang
Summary: In this study, a new biosensor named hepatitis virus indicator was developed for the simultaneous detection of HBV and HCV. The biosensor utilized Exo III assisted signal amplification strategy and particle counting technology with a dark-field microscopy, enabling sensitive and selective detection.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Microbiology
Christelle Granier, Johan Toesca, Chloe Mialon, Maureen Ritter, Natalia Freitas, Bertrand Boson, Eve-Isabelle Pecheur, Francois-Loic Cosset, Solene Denolly
Summary: Hepatitis C virus (HCV) particles are stable when secreted from cells, but become highly unstable after freeze-thawing of producer cells. Cell-secreted proteins can protect HCV particles from degradation, specifically those that are lipidated and low-density. HCV particles are sensitive to oxidation, but can be protected from lipid oxidation by secreted factors.
Article
Biology
Lenka Stejskal, Mphatso D. Kalemera, Charlotte B. Lewis, Machaela Palor, Lucas Walker, Tina Daviter, William D. Lees, David S. Moss, Myrto Kremyda-Vlachou, Zisis Kozlakidis, Giulia Gallo, Dalan Bailey, William Rosenberg, Christopher J. R. Illingworth, Adrian J. Shepherd, Joe Grove
Summary: This study reveals that the hypervariable region-1 (HVR-1) of the fusion proteins E1E2 in Hepatitis C Virus (HCV) has an autoinhibitory function that controls the activity of the proteins. The mechanism is turned off by host receptor interactions, allowing virus entry. Mutations or deletion of HVR-1 results in enhanced virus entry but increased sensitivity to neutralising antibodies.
Article
Biochemistry & Molecular Biology
Lauren E. Williamson, Kristen M. Reeder, Kevin Bailey, Minh H. Tran, Vicky Roy, Mallorie E. Fouch, Nurgun Kose, Andrew Trivette, Rachel S. Nargi, Emma S. Winkler, Arthur S. Kim, Christopher Gainza, Jessica Rodriguez, Erica Armstrong, Rachel E. Sutton, Joseph Reidy, Robert H. Carnahan, W. Hayes McDonald, Clara T. Schoeder, William B. Klimstra, Edgar Davidson, Benjamin J. Doranz, Galit Alter, Jens Meiler, Kevin L. Schey, Justin G. Julander, Michael S. Diamond, James E. Jr Jr Crowe
Summary: Antibody responses to alphavirus E1 proteins are influenced by the exposure of epitopes on the glycoprotein and their presentation on the cell surface. Therapeutic efficacy in vivo corresponds with virus egress inhibition potency in vitro, and treatment does not require Fc-mediated effector functions.
Article
Pharmacology & Pharmacy
Keigo Yato, Mami Matsuda, Noriyuki Watanabe, Koichi Watashi, Hideki Aizaki, Takanobu Kato, Koji Tamura, Takaji Wakita, Masamichi Muramatsu, Ryosuke Suzuki
Summary: Direct-acting antivirals (DAAs) have been used for the treatment of hepatitis C virus (HCV), but a vaccine for preventing HCV infection is still unavailable. In this study, a Japanese encephalitis virus (JEV) subviral particle (SVP)-based vaccine was utilized as a platform for DNA immunization, and new positions for inserting HCV epitopes were identified. The results showed that the modified vaccine induced higher levels of neutralizing antibodies against HCV and had minimal impact on neutralization activity against JEV.
ANTIVIRAL RESEARCH
(2022)
Review
Microbiology
Anshuman Das, Efrain E. Rivera-Serrano, Xin Yin, Christopher M. Walker, Zongdi Feng, Stanley M. Lemon
Summary: In this Review, the authors discuss quasi-enveloped virions, their entry and release from human host cells, and their impact on host immunity and pathogenesis. They focus on hepatitis A and E viruses, which were previously considered non-enveloped but are now known to be released as quasi-enveloped virions cloaked in host membranes. Despite lacking virally encoded proteins on their surface, these virions efficiently enter cells and replicate. The authors also describe the mechanisms by which specific peptide sequences in the capsids of these virions mediate their release from hepatocytes and the current understanding of their cell entry mechanism.
NATURE REVIEWS MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qing Zhou, Yuhao Yang, Zhanxue Xu, Kai Deng, Zhenzhen Zhang, Jiawei Hao, Ni Li, Yanling Wang, Ziwen Wang, Haihang Chen, Yang Yang, Fei Xiao, Xiaohong Zhang, Song Gao, Yi-Ping Li
Summary: ATAD1 plays a crucial role in maintaining mitochondrial homeostasis and combating viral infection. HCV infection induces mitochondrial fragmentation and enhances the pro-infection effect of ATAD1 knockout. ATAD1 interacts with HCV NS5B protein and promotes its degradation, thereby exerting its antiviral function.
Article
Materials Science, Multidisciplinary
Hayam Yassin, Abdel Nasser Tawfik, Eman R. Abo Elyazeed
Summary: In this study, the transverse momentum spectra of various particles were analyzed using a statistical approach. A generic expression for the dependence of the chemical potential on rapidity was proposed and fitted to experimental results. The resulting energy dependence was found to agree with statistical thermal models. Precise estimations of different types of chemical potentials were also presented.
RESULTS IN PHYSICS
(2022)
Article
Virology
Joey McGregor, Joshua M. Hardy, Chan-Sien Lay, Irene Boo, Michael Piontek, Manfred Suckow, Fasseli Coulibaly, Pantelis Poumbourios, Rob J. Center, Heidi E. Drummer
Summary: There is currently no vaccine for hepatitis C virus, but researchers have developed a virus-like particle vaccine that can induce the production of neutralizing antibodies and has shown immunogenicity in guinea pigs. This vaccine platform holds promise as a low-cost candidate for large-scale production of an HCV vaccine.
JOURNAL OF VIROLOGY
(2022)
Article
Pharmacology & Pharmacy
Jiaxuan Chen, Jia Hou, Rong Na, Bin Zhou, Jinlin Hou, De-Ke Jiang
Summary: This study found that overexpression of BST2 can improve the anti-HBV effect of IFN-α treatment, and BST2_rs9576 is an effective indicator for predicting the therapy response of PegIFN alpha-treated patients with CHB. The PGS model has the potential to enhance the ability of PegIFN alpha therapy response.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Virology
Tengyue Hu, Jiayi Wang, Weixiu Li, Miao Liu, Ning Han, Man Yuan, Lingyao Du, Hong Tang
Summary: This review article discusses the process initiated by hepatocytes through ER stress to combat HBV and HCV infection, and explains how this information can be beneficial in the treatment of HBV/HCV-related diseases.
Article
Biochemistry & Molecular Biology
Yu Mu, Birke Andrea Tews, Christine Luttermann, Gregor Meyers
Summary: This study identified the crucial interactions between the E1 and E2 proteins of pestiviruses, including the key role of specific sites in forming heterodimers. Additionally, it was found that the retention signal of E1 is essential for the intracellular localization of the heterodimer, with the covalent linkage between E1 and E2 playing a vital role in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Maoshen Chen, Feifei Xu, John Nsor-Atindana, Xuemei Chen, Fei Liu, Jiale Wu, Fang Zhong
Summary: In this study, WPI, SC, and SPI were used as protein stabilizers along with different oils to prepare high protein and high oil emulsions. The chain length and saturability of oils had little effect on the storage stability of the emulsions. SPI showed lower nitrogen solubility index and surface hydrophobicity compared to WPI and SC, and exhibited different adsorption behavior with protein concentration changes.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Review
Gastroenterology & Hepatology
Alessandra Mangia, Rosa Cotugno, Giovanna Cocomazzi, Maria Maddalena Squillante, Valeria Piazzolla
Summary: The World Health Organization's goal of eliminating Hepatitis C virus (HCV) by 2030 using direct-acting antiviral treatments has become less attainable post the 2020 pandemic of coronavirus disease 2019. Therefore, a more realistic approach of micro-elimination in population segments where targeted strategies of prevention and treatment are easily attained has been promoted in Europe. Active involvement of stakeholders and community participation are essential components for the success of a micro-elimination project tailored at the geographical level according to HCV epidemiology and individual country's income.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Immunology
Wen Hou, Xiaoli Wu
Summary: This study investigates the roles of gamma delta T cells in HBV and HCV infections, discussing the different roles they play in the progression of liver diseases at various stages.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Organic
Praveen M. Parkali, A. Shyam Kumar, Pohamba K. Johanna, Shilomboleni T. Prodensia, Sruthi Turaga, Vinod Shaiva, Gurubasavaraj Pujar, Shrinivas D. Joshi, Tejraj M. Aminabhavi, Sheshagiri R. Dixit
Summary: Molecular docking and 3D-QSAR studies were conducted on a series of pyrimidine derivatives to develop inhibitors for Enoyl ACP Reductase, a key enzyme in fatty acid biosynthesis and antitubercular drug development. Results from the models and structural features analysis provided insights into predicting better inhibitory potency and the importance of specific amino acid residue interactions. This study contributes to the development of novel Enoyl ACP reductase inhibitors by understanding the specific activity of compounds.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Green & Sustainable Science & Technology
Sudhanshu Joshi, Manu Sharma, Rashmi Prava Das, Joanna Rosak-Szyrocka, Justyna Zywiolek, Kamalakanta Muduli, Mukesh Prasad
Summary: This study examines the significance of AI and its implementation barriers in healthcare systems in developing countries. It finds that there are critical implementation barriers at different levels, which provide insights for decision makers. The findings contribute to the understanding of various implementation issues related to governance, scalability, and privacy of AI in public healthcare.
Article
Management
Anup Kumar, Sudhanshu Joshi, Manu Sharma, Neeraj Vishvakarma
Summary: This study examines the impact of the dynamic capabilities of humanitarian organizations on disaster risk reduction, using the resource-based view and dynamic capability theory.
JOURNAL OF HUMANITARIAN LOGISTICS AND SUPPLY CHAIN MANAGEMENT
(2022)
Article
Green & Sustainable Science & Technology
Manu Sharma, Sunil Luthra, Sudhanshu Joshi, Anil Kumar, Akshat Jain
Summary: The study aims to investigate the impact of green logistics on the adoption of Circular Economy (CE) in the era of Industry 4.0 (I4.0). By implementing green initiatives, the logistics sector shows its strong concern for environmental issues and promotes sustainable logistics and circular practices to address critical issues such as waste generation, resource scarcity, renewable resource use, and climate change. The study examines the relationships between green logistics practices, I4.0 technologies, and CE adoption while also considering the moderating effects of institutional pressure and supply chain flexibility. The findings suggest that firms can enhance CE adoption driven by I4.0 technologies with green logistics practices as a mediator, and the moderating effect of supply chain flexibility is significant while the moderating effect of institutional pressure is insignificant. The study provides valuable insights for managers and contributes to the theoretical understanding of green logistics and CE adoption.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Management
Sudhanshu Joshi, Manu Sharma, Akhilesh Barve
Summary: This study employs the Best Worst Method (BWM) to identify the most critical implementation barriers of IoT and Blockchain technology in Waste Electrical and Electronic Equipment (WEEE) management. The findings reveal that developing a legislative support system, ineffective database management, low understanding of cognitive technologies, and concerns regarding information security and privacy are the key issues in implementing these technologies in closed-loop supply chains.
SUPPLY CHAIN FORUM
(2023)
Article
Green & Sustainable Science & Technology
Manu Sharma, Sudhanshu Joshi, Mukesh Prasad, Shalini Bartwal
Summary: This study proposes a model to examine the critical barriers and suggest strategies for implementing Circular Economy (CE) in the Oil & gas (O&G) industry. The results show that 'knowledge barriers' are the most critical, and the strategies 'Developing collaborative model' and 'Internal research and development, innovation' are the most significant for reducing the barriers.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Green & Sustainable Science & Technology
Sudhanshu Joshi, Manu Sharma, Banu Y. Ekren, Yigit Kazancoglu, Sunil Luthra, Mukesh Prasad
Summary: Food waste reduction and security are major concerns in agri-food supply chains, as more than a third of global food production is wasted or lost due to mismanagement. Resilient food supply chains need to address challenges such as resource scarcity, climate change, and waste generation. This study explores supply chain innovations, using SWARA analysis, to identify the most significant innovations for developing resilient food supply chains. The results highlight the importance of business strategy and technological innovations in bringing resilience to food supply chains.
Article
Business
Manu Sharma, Deepak Kaushal, Sudhanshu Joshi
Summary: Social media has become a major source of information for young users, but it has a severe impact on mental state due to information overload, which is still a concern for researchers. The addiction of Generation Z users to mobile phones/gadgets is increasing with the rise of social media, leading to a complete transformation in their behavioral outcomes. Behavioral issues such as stress, fatigue, fear of missing out, phubbing, and anxiety are on the rise, but the relationship between these issues and information overload has not been sufficiently examined. The study finds that social media platforms need to understand users' compulsive usage, which results in fatigue and anxiety, and government information support plays a positive role in reducing fatigue and anxiety.
JOURNAL OF RETAILING AND CONSUMER SERVICES
(2023)
Review
Multidisciplinary Sciences
Sunil Luthra, Shruti Agrawal, Anil Kumar, Manu Sharma, Sudhanshu Joshi, Jatin Kumar
Summary: Psychological and mental well-being of young adults has been greatly influenced by the COVID-19 pandemic, leading to a global concern. This research study provides an overview of the international scientific studies on the effect of COVID-19 on young adults' psychological well-being. It reveals the top-cited authors, documents, journals, productive countries, keywords, and themes in this area. The United States has contributed the most publications, followed by the United Kingdom and Italy. The study highlights the importance of addressing the psychological health of young adults worldwide.
Article
Health Policy & Services
Sudhanshu Joshi, Manu Sharma
Summary: The widespread use of Blockchain technology (BT) in developing nations is still in its early stages and requires a comprehensive evaluation. The healthcare sector is increasingly in need of digitalization to improve operational efficiency. However, the limited research on BT has hindered its full utilization in the healthcare sector. This study aims to identify the main obstacles to BT adoption in developing nations' public health systems, using a multi-level analysis and hybrid approach. The findings of this study provide guidance and insight for decision-makers on implementation challenges.
Article
Management
Manu Sharma, Sudhanshu Joshi
Summary: This study aims to explore the factors that affect the selection of digital suppliers and evaluate the alternatives for identifying the best supplier that enhances the quality management systems (QMS) for digital supply chains (DSCs). The study reveals that supplier competency is the most significant factor in selecting digital suppliers, and supplier S-8 has been ranked as the best supplier.
Article
Business
Sudhanshu Joshi, Rohit Kumar Singh, Manu Sharma
Summary: This study aims to identify the factors influencing the adoption of sustainable agribusiness practices in India and examines the most pertinent issues. The findings can provide guidance for agribusiness regulators and intermediaries, while contributing to a new understanding of sustainable agribusiness-based issues in India.
GLOBAL BUSINESS REVIEW
(2023)
Article
Management
Saket Shanker, Akhilesh Barve, Kamalakanta Muduli, Anil Kumar, Jose Arturo Garza-Reyes, Sudhanshu Joshi
Summary: This study aims to analyze the factors influencing perishable food supply chains during the pandemic and improve their resiliency. The research revealed that factors like import-export restrictions and fear of violating social distancing guidelines are primary factors causing disruptions, while price fluctuations of perishable products and panic buying are crucial effects impacting perishable food supply chains.
INTERNATIONAL JOURNAL OF LOGISTICS-RESEARCH AND APPLICATIONS
(2022)
Article
Management
Manu Sharma, Sunil Luthra, Sudhanshu Joshi, Anil Kumar
Summary: This study reveals that enhancing the viability of the supply chain network is crucial for managing buyer-supplier relationships and improving the survivability of sustainable supply chains during the COVID-19 pandemic. The findings of this research provide valuable guidance for companies, suppliers, and other stakeholders, contributing to a healthier future.
INTERNATIONAL JOURNAL OF LOGISTICS-RESEARCH AND APPLICATIONS
(2022)
Article
Business
Rohit Kumar Singh, Sudhanshu Joshi, Manu Sharna
GLOBAL BUSINESS REVIEW
(2023)
