Article
Fisheries
Shengping Li, Shun Zhou, Qiuhong Yang, Yongtao Liu, Yibin Yang, Ning Xu, Xiaohui Ai, Jing Dong
Summary: A study found that cinnamaldehyde, extracted from a natural plant, has inhibitory effects on Aeromonas hydrophila infection. Cinnamaldehyde disrupts the bacterial quorum sensing system, reducing the pathogenic behaviors of A. hydrophila without affecting bacterial growth. It was also observed that cinnamaldehyde downregulates the expression of related genes and can effectively decrease host cell injury and increase the survival rate in A. hydrophila-infected hosts. These results suggest that cinnamaldehyde could be a potential candidate as a quorum sensing inhibitor against A. hydrophila infection.
Article
Pharmacology & Pharmacy
Majid Rasool Kamli, Maqsood Ahmad Malik, Vartika Srivastava, Jamal S. M. Sabir, Ehab H. Mattar, Aijaz Ahmad
Summary: This study involves the inexpensive, eco-friendly, and simple green synthesis of ZnO nanoparticles using Origanum vulgare extract, which exhibit antibacterial and quorum sensing inhibition activities against bacteria.
Article
Chemistry, Medicinal
Andrea Muras, Ana Parga, Celia Mayer, Ana Otero
Summary: Interfering with quorum sensing systems of bacteria is a promising strategy to control biofilm formation, and the xCELLigence(R) system is proposed as an efficient method for quantifying biofilm formation.
Article
Environmental Sciences
Zhuqiu Sun, Jinying Xi, Marvin Yeung, Lichao Lu
Summary: This study investigated the effects of two quorum sensing (QS) enhancement methods on the performance and biofilm of biofilters treating chlorobenzene. The results showed that adding exogenous AHLs had a more significant enhancing effect on biofilm, while AHLs producing bacteria helped improve bacterial community diversity.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biotechnology & Applied Microbiology
Mohammadreza Ghaffarlou, Sedef Ilk, Hossein Rahimi, Hossein Danafar, Murat Barsbay, Ali Sharafi
Summary: In this study, BSA-coated silver nanoparticles (Ag-Ag2S@BSA NPs) were synthesized and investigated for their anti-quorum sensing (QS) activity. The results confirmed the potential of Ag-Ag2S@BSA NPs as novel therapeutic tools for antibacterial purposes.
Article
Engineering, Environmental
Zhuqiu Sun, Bairen Yang, Marvin Yeung, Jinying Xi
Summary: The addition of exogenous AHLs and AHL-producing bacteria in biofilters treating gaseous toluene at a low temperature significantly improved the removal and mineralization efficiency of VOCs. These enhancements also improved the biofilm characteristics and biomass distribution, leading to improved performance of the biofilters.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Microbiology
Subhasree Saha, Shifu Aggarwal, Durg Vijai Singh
Summary: This study found that phytomolecules, quercetin and naringenin, can modulate the quorum sensing pathway of Vibrio cholerae, reducing biofilm formation and expression of virulence factors. These phytochemicals were more effective compared to common quorum sensing inhibitors.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Chemistry, Medicinal
Sudipta Paul Bhattacharya, Snigdha Karmakar, Kusumita Acharya, Arijit Bhattacharya
Summary: The development of biofilms is a protective strategy used by bacterial pathogens against the immune response and antimicrobial treatments. Quorum sensing, which alters gene expression profiles, has been identified as a key regulator of biofilm dynamics. With the rapid emergence of antimicrobial resistance, it is urgent to find alternative interventions to control biofilm infections. Exploring phytochemical products has shown promise in inhibiting quorum sensing and preventing biofilm formation. Recent studies have focused on triterpenoids and their derivatives, which have been found to disrupt quorum sensing and impair biofilm formation against bacterial pathogens.
Review
Microbiology
Rohit Patel, Mansi Soni, Bilv Soyantar, Suruchi Shivangi, Swati Sutariya, Meenu Saraf, Dweipayan Goswami
Summary: The indiscriminate use of antibiotics has led to the emergence of drug-resistant strains. Many infectious diseases are caused by microbes that can communicate through quorum sensing (QS), and interfering with QS can effectively control their pathogenicity. Inhibition of QS has become a promising approach for developing new drugs, and various quorum sensing inhibitors (QSIs) have been identified. This review provides an overview of the QS mechanism, QS inhibition, and compounds with anti-QS potential, as well as the possibility of quorum sensing resistance.
ARCHIVES OF MICROBIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yongcheng Chen, Yifan Gao, Yue Huang, Qiao Jin, Jian Ji
Summary: This research focuses on the development of pH-sensitive curcumin-loaded nanoparticles for inhibiting quorum sensing (QS) and enhancing antibiotic therapy. The nanoparticles show enhanced biofilm penetration and increased bactericidal performance against antibiotics. Additionally, they can selectively accumulate in bacteria-infected tissues through active targeting. This research offers a promising approach to enhance the therapeutic effects of quorum sensing inhibitors and improve antibiotic treatment for biofilm-associated bacterial infections.
Article
Immunology
Jatin Chadha, Jogender Singh, Sanjay Chhibber, Kusum Harjai
Summary: The combination of cinnamaldehyde and gentamicin exhibited synergy and anti-QS activity, suppressing virulence factor production and biofilm formation, and improving the survival rate of Caenorhabditis elegans.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Christian Schuetz, Duy-Khiet Ho, Mostafa Mohamed Hamed, Ahmed Saad Abdelsamie, Teresa Roehrig, Christian Herr, Andreas Martin Kany, Katharina Rox, Stefan Schmelz, Lorenz Siebenbuerger, Marius Wirth, Carsten Boerger, Samir Yahiaoui, Robert Bals, Andrea Scrima, Wulf Blankenfeldt, Justus Constantin Horstmann, Rebekka Christmann, Xabier Murgia, Marcus Koch, Aylin Berwanger, Brigitta Loretz, Anna Katharina Herta Hirsch, Rolf Wolfgang Hartmann, Claus-Michael Lehr, Martin Empting
Summary: A new generation of quorum sensing inhibitors (QSI) is reported to effectively inhibit the virulence of Pseudomonas aeruginosa and enhance antibiotic efficacy, potentially preventing the development of antimicrobial resistance. Additionally, a significant synergistic effect of QSI in combination with tobramycin against P. aeruginosa biofilms is demonstrated, showing promising implications for adjunctive pathoblocker-mediated therapy.
Review
Pharmacology & Pharmacy
Mehran Alavi, Li Li, Ali Nokhodchi
Summary: Antibiotic resistance has become a significant challenge, leading to the need for efficient antibacterial agents. Traditional bactericidal agents can inadvertently promote the evolution of antibiotic-resistant strains. In this review, the use of metal-based nanoparticles or polymeric nanoparticles to target the quorum-sensing systems of bacteria is discussed as a potential powerful antibacterial treatment.
DRUG DISCOVERY TODAY
(2023)
Article
Biochemistry & Molecular Biology
Aditi Vashistha, Nikhil Sharma, Yerramsetti Nanaji, Deepak Kumar, Gurpal Singh, Ravi P. Barnwal, Ashok Kumar Yadav
Summary: The overuse and inappropriate use of antibiotics has led to the development of drug resistant bacterial strains. Biofilm, a complex microorganism aggregation, plays a crucial role in infectious diseases. Efforts to disrupt biofilms have identified molecules that can inhibit quorum sensing, offering potential treatments for bacterial infections with lower dosages of medications.
BIOORGANIC CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Lujun Yin, Yingjie Wang, Shiliang Xiang, Kaizhong Xu, Bo Wang, Ai-Qun Jia
Summary: In this study, it was found that tyramine could inhibit the production of virulence factors in Burkholderia cenocepacia by blocking the quorum sensing systems. It was also shown to have low toxicity and potential as a combination therapy with traditional antibiotics.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Microbiology
Busi Siddhardha, Uday Pandey, K. Kaviyarasu, Rajasekharreddy Pala, Asad Syed, Ali H. Bahkali, Abdallah M. Elgorban
Review
Nanoscience & Nanotechnology
Rajasekharreddy Pala, V. T. Anju, Madhu Dyavaiah, Siddhardha Busi, Surya M. Nauli
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Article
Plant Sciences
Paramanantham Parasuraman, Subha Swaraj Pattnaik, Siddhardha Busi, Najat Marraiki, Abdallah M. Elgorban, Asad Syed
Summary: In this study, two strains of Pseudomonas aeruginosa were isolated from the rhizosphere of brinjal and chilli plants, and found to enhance plant growth and inhibit fungal pathogens. These bacteria produced plant growth promoting compounds and significantly improved germination and growth of tomato plants, while also showing significant antagonistic effects against fungal pathogens.
Article
Immunology
Himani Meena, Rashmi Mishra, Sampathkumar Ranganathan, V. Venkateswara Sarma, Dinakara Rao Ampasala, Busi Siddhardha
Summary: The crude extract of endophytic fungus Colletotrichum gloeosporioides HM3 isolated from Carica papaya leaves showed potential for inhibiting the virulence factors and biofilm production of Pseudomonas aeruginosa PAO1. The study revealed a significant decrease in the production of pathogenic determinants and a reduction in the ability of bacteria to form dense biofilm structures after treatment with the fungal extract. In silico analysis demonstrated the binding efficiency of bioactive compounds with QS transcriptional regulators, suggesting the metabolites derived from C. gloeosporioides HM3 could be considered as potential inhibitors of QS regulated virulence factors.
MICROBIAL PATHOGENESIS
(2021)
Review
Pharmacology & Pharmacy
Rajasekharreddy Pala, Subhaswaraj Pattnaik, Siddhardha Busi, Surya M. Nauli
Summary: Cardiovascular diseases are the leading cause of death globally, emphasizing the importance of early diagnosis and treatment. The advent of nanotechnology has revolutionized disease understanding and treatment, with the concept of theranostics gaining attention in managing CVDs.
Article
Immunology
V. T. Anju, Siddhardha Busi, Sampathkumar Ranganathan, Dinakara Rao Ampasala, Sandeep Kumar, Kitlangki Suchiang, Ranjith Kumavath, Madhu Dyavaiah
Summary: The study discussed the anti-quorum sensing and antibiofilm properties of lignans found in sesame seeds against Pseudomonas aeruginosa, providing insights into the development of novel anti-infectives against this pathogen. The lignans showed effects on virulence factor production, biofilm formation, and bacterial motility, with potential therapeutic opportunities for human use. The mechanism of action of lignans included down-regulation of QS regulated gene expression, affecting biofilm constituents, and exerting an anti-infective property in vitro and in vivo models.
MICROBIAL PATHOGENESIS
(2021)
Article
Biotechnology & Applied Microbiology
V. T. Anju, Siddhardha Busi, Sandeep Kumar, Kitlangki Suchiang, Ranjith Kumavath, Sampathkumar Ranganathan, Dinakara Rao Ampasala, Madhu Dyavaiah
Summary: This study investigates the quorum quenching and biofilm inhibition properties of alantolactone (ALT) against Pseudomonas aeruginosa. The results show that ALT can affect the production of key virulence factors and biofilm components in bacteria, leading to a reduction in bacterial colonization and improved survival rates in infected Caenorhabditis elegans. Molecular interactions of ALT with quorum sensing proteins were also found to be stable.
Article
Microbiology
Jamseel Moopantakath, Madangchanok Imchen, Aathira Sreevalsan, Busi Siddhardha, Rosa Maria Martinez-Espinosa, Ranjith Kumavath
Summary: The biosynthesis of nanoparticles by pigmented extreme halophiles for biological applications has been explored in this study. Pigmented halophilic microorganisms were used to synthesize silver chloride nanoparticles, and their antimicrobial, antioxidative, and anti-inflammatory activities were assessed. The study demonstrated that pigmented halophiles can rapidly synthesize nanoparticles with unique characteristics and biological applications.
CURRENT MICROBIOLOGY
(2022)
Review
Microbiology
Subhaswaraj Pattnaik, Madangchanok Imchen, Ranjith Kumavath, Ram Prasad, Siddhardha Busi
Summary: This review explores the untapped potential of microbial products in mitigating cancer progression, including the rich heritage of microbial bioactive components and the use of computational tools in studying microbial secondary metabolites. The strategy of drug repurposing is also introduced as a method to regulate cancer cell growth and progression. Further investigations are required to examine the role of microbial metabolites in cancer therapeutics.
CURRENT MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
V. T. Anju, Siddhardha Busi, Mahima S. Mohan, Sampathkumar Ranganathan, Dinakara Rao Ampasala, Ranjith Kumavath, Madhu Dyavaiah
Summary: The present study demonstrated the QS inhibition properties of hispidulin against Pseudomonas aeruginosa PAO1. Hispidulin reduced the production of virulence factors and biofilm development, and also suppressed the pathogenesis of P. aeruginosa in infected worm models. Computational studies revealed its competitive binding with LasR protein. The potential lead obtained through this study could be utilized to design and develop anti-pathogenic agents for treating pseudomonal infections.
INTERNATIONAL BIODETERIORATION & BIODEGRADATION
(2022)
Article
Environmental Sciences
Shayantan Mukherji, Madangchanok Imchen, Sangita Mondal, Anish Bhattacharyya, Busi Siddhardha, Ranjith Kumavath, Abhrajyoti Ghosh
Summary: Mangroves in India are vulnerable to pollution and deforestation. This study investigates the microbiome of the Sundarban mangrove and its antibiotic resistance genes. Physicochemical parameters play a crucial role in maintaining the mangrove microbiome. The Sundarban mangrove has a higher diversity of antibiotic resistance genes compared to Chinese mangroves, but lower abundance. Anthropogenic activities and pollution can degrade microbiome diversity, disrupt function, and enrich resistance genes.
Article
Microbiology
Madangchanok Imchen, V. T. Anju, Siddhardha Busi, Mahima S. Mohan, Pattnaik Subhaswaraj, Madhu Dyavaiah, Ranjith Kumavath
Summary: Biofilms formed by microbial cells on surfaces serve as a breeding ground for drug-resistant pathogens and ARG enrichment, but they also play beneficial roles in promoting plant growth and wastewater treatment. Inhibiting biofilm formation through quorum quenching is a feasible approach. Surveillance of biofilm microbiome is crucial for assessing risks and harnessing bioactive potential. Metagenomics is a preferred method for studying biofilm microbiome and discovering new species.
MICROBIOLOGICAL RESEARCH
(2022)
Review
Infectious Diseases
V. T. Anju, Siddhardha Busi, Madangchanok Imchen, Ranjith Kumavath, Mahima S. S. Mohan, Simi Asma Salim, Pattnaik Subhaswaraj, Madhu Dyavaiah
Summary: This review focuses on polymicrobial interactions and therapeutic interventions for polymicrobial biofilms. Deciphering the mechanisms of polymicrobial interactions and microbial diversity in chronic infections is of great significance for antimicrobial research.
Review
Biotechnology & Applied Microbiology
V. T. Anju, Siddhardha Busi, Mahima S. Mohan, Simi Asma Salim, A. R. Sabna, Madangchanok Imchen, Ranjith Kumavath, Madhu Dyavaiah, Ram Prasad
Summary: Soil pollution is a serious global threat caused by anthropogenic activities and natural processes. It leads to the accumulation of various pollutants in the soil, including hydrocarbon compounds, metals, antibiotics, organic compounds, pesticides, and plastics. Bioremediation, using plants, microorganisms, and fungi, is an effective and cost-effective method to degrade pollutants. Metagenomics has emerged as a powerful tool for identifying and studying unculturable microorganisms and their potential in bioremediation, as well as exploring the negative effects of pathogens and resistant genes in polluted areas.
BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS
(2023)
Review
Microbiology
Jamseel Moopantakath, Madangchanok Imchen, V. T. Anju, Siddhardha Busi, Madhu Dyavaiah, Rosa Maria Martinez-Espinosa, Ranjith Kumavath
Summary: Marine and salty inland ecosystems have extreme environmental conditions, and haloarchaea have metabolic adaptations to withstand these conditions. They produce bioactive compounds like carotenoids, halocins, enzymes, and polyhydroxyalkanoates (PHAs) that have applications in biotechnology. Haloarchaea are also potential cell factories for the industrial production of bioplastics and nanoparticles. Recent studies have shown that exopolysaccharides from haloarchaea can bind the SARS-CoV-2 spike protein.
FRONTIERS IN MICROBIOLOGY
(2023)
