Article
Biochemistry & Molecular Biology
Grazia Pastorelli, Rachida Benamri, Massimo Faustini, Roberta De Bellis, Valentina Serra, Lauretta Turin, Marc Haumont, Philippe Durand, Laura Bianchessi, Emmanuelle Prost-Camus, Thomas Pecqueur, Michel Prost
Summary: This study investigated the effect of dietary inclusion of commercial polyphenol products (PPs) on the growth performance, antioxidant status, and immunity of post-weaning piglets. The results showed that replacing vitamin E with PPs can partially substitute vitamin E in post-weaning piglets.
Review
Nutrition & Dietetics
Aneta Otocka-Kmiecik
Summary: Paraoxonase 1 (PON1) is an antioxidant enzyme that is associated with HDL and has potential anti-atherogenic effects. Carotenoids, such as astaxanthin, beta-carotene, and lycopene, can increase PON1 activity and gene expression by quenching singlet oxygen and scavenging free radicals. Understanding the mechanisms by which carotenoids modulate PON1 may lead to the development of targeted therapies for cardiovascular diseases.
Article
Food Science & Technology
Xueyi Zhang, Wenjun Pei, Yiwen Guo, Minjie Cao, Emad Karrar, Lin Tang, Kangning Li, Ming Chang, Ruijie Liu
Summary: This study found that the use of the compound antioxidants α-tocopherol and EGCG in margarine has a much better effect than using any single antioxidant. Through various experimental methods, it was proved that α-tocopherol and EGCG can promote and cooperate with each other in antioxidant reactions, which is of great significance for practical production.
JOURNAL OF FOOD SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Mercedes Roncero-Diaz, Begona Panea, Anastasio Arguello, Maria J. Alcalde
Summary: The milk production systems in goats are mainly intensive and semi-extensive, with different management systems providing varying levels of vitamins that may serve as markers for the production system. A study found an inverse relationship of vitamin amounts between milk and plasma in goats, suggesting potential use as traceability biomarkers. Further research is needed to understand the passage of these compounds to kid meat.
Article
Chemistry, Multidisciplinary
Xuemeng Guo, Junlei Zhang, Xu Liu, Yichao Lu, Yingying Shi, Xiang Li, Sije Wang, Jiaxin Huang, Huihui Liu, Huanli Zhou, Qingpo Li, Lihua Luo, Jian You
Summary: Glaucoma, the third leading cause of blindness worldwide, is primarily characterized by elevated intraocular pressure. Prolonged high intraocular pressure damages retinal cells and current treatments primarily focus on reducing intraocular pressure. Researchers have developed a novel nanoemulsion that prolongs ocular retention and effectively mitigates retinal cell damage associated with glaucoma.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
T. Shalini, Sarin S. Jose, P. S. Prasanthi, N. Balakrishna, K. Viswanath, G. Bhanuprakash Reddy
Summary: The study found that diabetic retinopathy (DR) patients had lower plasma carotenoid levels and lower dietary intakes compared to those without DR. Plasma carotenoid levels were negatively associated with the duration of diabetes and blood glucose levels.
Article
Agriculture, Dairy & Animal Science
Y. X. Zhang, W. C. Ke, D. Vyas, A. T. Adesogan, M. Franco, F. H. Li, J. Bai, X. S. Guo
Summary: This study found that inoculation with the high-antioxidant Lactobacillus plantarum strain 24-7 improved the fermentation quality and antioxidant status of ensiled alfalfa forage.
ANIMAL FEED SCIENCE AND TECHNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Carlos Romero, Maria Nardoia, Agustin Brenes, Ignacio Arija, Agustin Viveros, Susana Chamorro
Summary: The combination of grape seeds and skins in chicken diets improved plasma and meat a-tocopherol content and mitigated meat lipid oxidation. Combinations with at least 50% grape skins provided optimal results of meat oxidative stability during 7-day storage.
Article
Acoustics
Libin Sun, Hong Wang, Xiang Li, Sheng Lan, Junguo Wang, Dianyu Yu
Summary: In this study, casein was used as a carrier system for alpha-tocopherol, forming an amphiphilic self-assembling micellar nanostructure with ultrasound treatment. The UV-Vis spectra of alpha-TOC/CN nanoparticles complexes varied with different ultrasonic treatments, indicating improved stability of alpha-TOC and stronger antioxidant activity of the nanoparticles compared to free samples.
ULTRASONICS SONOCHEMISTRY
(2021)
Article
Chemistry, Applied
Paulo Rogerio Siriano Borges, Merete Edelenbos, Erik Larsen, Thais Hernandes, Elisangela Elena Nunes, Eduardo Valerio de Barros Vilas Boas, Caroline Roberta Freitas Pires
Summary: This comprehensive study analyzed ten fruits from the Brazilian Cerrado and found that they are rich sources of various bioactive compounds, with levels comparable to commonly consumed fruits.
Article
Cell & Tissue Engineering
Maryam Ghahremani-nasab, Naeimeh Akbari-Gharalari, Azizeh Rahmani Del Bakhshayesh, Armita Ghotaslou, Abbas Ebrahimi-kalan, Mahdi Mahdipour, Ahmad Mehdipour
Summary: The study provides evidence that 3D CA/AA/TP composite hydrogels seeded by rMSCs in hypoxic conditions have great potential to improve wound healing.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Food Science & Technology
Sabrina S. Andrade, Ramon S. B. Ferreira, Fabiane O. Farias, Rafael de P. Soares, Mariana C. Costa, Pedro P. Corbi, Antonio J. A. Meirelles, Eduardo A. C. Batista, Guilherme J. Maximo
Summary: Oils and fats are vital for the food and pharmaceutical industries, and their main components, such as triacylglycerols, play a crucial role in determining their physical properties. Lipid-rich foods also contain compounds like vitamin E, which can interact with the primary lipid molecules and affect their physicochemical properties. This study investigated the phase behavior between vitamin E and various triacylglycerols using experimental methods and thermodynamic modeling. The results showed a strong attraction between the two, leading to a decrease in the melting temperature of the triacylglycerols. Microscopic observations and X-ray diffraction also suggested the formation of solid solutions. Understanding this phase behavior could help improve the antioxidant effectiveness of vitamin E in lipid-based systems.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Food Science & Technology
Silvia Tagliamonte, Raffaele Romano, Manuela Flavia Chiacchio, Alessandra Aiello, Lucia De Luca, Vincenzo Salzano, Paola Vitaglione
Summary: This study aimed to reutilize tomato pomace, a by-product of the tomato-processing industry, in the development of tomato sauce and assess its nutritional content and bioaccessibility. The innovative tomato sauce products showed higher levels of carotenoids, α-tocopherol, and total antioxidant capacity (TAC) compared to traditional sauce. Bioaccessibility of carotenoids and α-tocopherol varied among the different tomato sauce formulations, while total polyphenols content was higher in the sauce with 100% tomato pomace.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jailane de Souza Aquino, Kamila Sabino Batista, Gabriel Araujo-Silva, Darlan Coutinho dos Santos, Naira Josele Neves de Brito, Jorge A. Lopez, Joao Andrade da Silva, Maria das Graca Almeida, Carla Guzman Pincheira, Marciane Magnani, Debora C. Nepomuceno de Pontes Pessoa, Tania L. Montenegro Stamford
Summary: This study aimed to assess the effects of buriti oil intake in iron-overloaded rats by FeSO4 administration. It was found that buriti oil showed systemic and hepatic antioxidant protection in iron-overloaded rats, which may be related to its high carotenoid, tocopherol, and fatty acid profile.
Article
Chemistry, Medicinal
Andrzej L. Dawidowicz, Malgorzata Olszowy-Tomczyk, Rafal Typek
Summary: The study demonstrates that the antioxidant properties of binary mixtures of cannabinoids vary depending on the type of cannabinoids and their amounts ratio, showing additive, synergistic, and antagonistic effects. This finding is important in light of the increasing number of reports showing the greater pharmacological effectiveness of binary cannabinoid mixtures compared to individual components.
Article
Multidisciplinary Sciences
Federica Pessina, Maria Frosini, Paola Marcolongo, Fabio Fusi, Simona Saponara, Alessandra Gamberucci, Massimo Valoti, Daniela Giustarini, Paolo Fiorenzani, Beatrice Gorelli, Valeria Francardi, Maurizio Botta, Elena Dreassi
Article
Chemistry, Medicinal
Annalaura Brai, Adele Boccuto, Martina Monti, Serena Marchi, Ilaria Vicenti, Francesco Saladini, Claudia Immacolata Trivisani, Alessandro Pollutri, Claudia Maria Trombetta, Emanuele Montomoli, Valentina Riva, Anna Garbelli, Emanuele Maria Nola, Maurizio Zazzi, Giovanni Maga, Elena Dreassi, Maurizio Botta
ACS MEDICINAL CHEMISTRY LETTERS
(2020)
Article
Chemistry, Medicinal
Annalaura Brai, Valentina Riva, Francesco Saladini, Claudio Zamperini, Claudia Immacolata Trivisani, Anna Garbelli, Carla Pennisi, Alessia Giannini, Adele Boccuto, Francesca Bugli, Maurizio Martini, Maurizio Sanguinetti, Maurizio Zazzi, Elena Dreassi, Maurizio Botta, Giovanni Maga
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Biochemical Research Methods
Gianfranco Corbini, Elena Dreassi, Luisa Chiasserini, Matteo Maria Girolamo, Pierfrancesco Mellace
Summary: The study found that the concentration of copper ions in the tear fluid of patients with keratoconus (KC) was significantly higher compared to healthy patients, indicating a potential specific marker for KC.
ANALYTICAL BIOCHEMISTRY
(2021)
Article
Nutrition & Dietetics
Roberto Stella, Caterina Peggion, Caterina Bergantin, Giancarlo Biancotto, Maria Frosini, Elena Dreassi, Paola Marcolongo, Anna Maria Aloisi, Federica Pessina
Summary: Hypertension is a leading risk factor for premature death globally, and TM dietary supplementation has been shown to be effective in treating hypertension. This study used proteomics and metabolomics techniques to uncover the underlying mechanism of TM's effects on hypertension treatment.
Article
Biochemistry & Molecular Biology
Claudia Ardino, Filomena Sannio, Carolina Pasero, Lorenzo Botta, Elena Dreassi, Jean-Denis Docquier, Ilaria D'Agostino
Summary: Trifluoroacetic acid (TFA) is commonly used in synthetic strategies due to its strong acidity and low boiling point. However, residual amounts of TFA may affect the accuracy of cellular assays. This study evaluates the effect of different counterions on the biological activity of an antibacterial compound and optimizes the preparation methods.
MOLECULAR DIVERSITY
(2023)
Article
Biochemistry & Molecular Biology
Annalaura Brai, Federica Poggialini, Chiara Vagaggini, Claudia Pasqualini, Sauro Simoni, Valeria Francardi, Elena Dreassi
Summary: A novel, cheap and convenient toxicity model using Tenebrio molitor coleoptera (TMC) was developed for preliminary evaluation of drug safety and metabolite formation. The results demonstrate that TMC can be used as a preliminary toxicity model to assess the safety of experimental compounds and the formation of main metabolites, and to reduce the costs and number of rodents, according to 3R principles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Silvia Cesarini, Ilaria Vicenti, Federica Poggialini, Massimiliano Secchi, Federica Giammarino, Ilenia Varasi, Camilla Lodola, Maurizio Zazzi, Elena Dreassi, Giovanni Maga, Lorenzo Botta, Raffaele Saladino
Summary: Current therapy against SARS-CoV-2 relies on Remdesivir, Molnupiravir, and Nirmatrelvir, but they have limitations. By synthesizing and evaluating derivatives, a promising compound with antiviral activity and low cytotoxicity was identified as a candidate for future optimization studies.
Article
Agriculture, Multidisciplinary
A. Brai, C. Vagaggini, C. Pasqualini, F. Poggialini, F. Tarchi, V. Francardi, E. Dreassi
Summary: This study demonstrates that distillery by-products contain abundant antioxidant compounds and beneficial fatty acids even after processing. Using them as feed for Tenebrio molitor larvae not only increases the average weight gain of the larvae but also has no effect on their survival rate. Furthermore, the use of these by-products can enhance the total antioxidant activity and improve the nutraceutical properties of the larvae.
JOURNAL OF INSECTS AS FOOD AND FEED
(2023)
Article
Agriculture, Multidisciplinary
A. Brai, F. Poggialini, C. I. Trivisani, C. Vagaggini, F. Tarchi, V. Francardi, E. Dreassi
Summary: Circular economy principles combined with the search for novel sustainable functional foods can transform agricultural waste into feed supplements, creating benefits for the environment, industries, and consumers. The study found that using tomato peels and seeds, olive and mastic leaves as feed supplements efficiently supported the growth of Tenebrio molitor larvae, increased antioxidant activities, and improved fatty acid composition.
JOURNAL OF INSECTS AS FOOD AND FEED
(2023)
Review
Biochemistry & Molecular Biology
Annalaura Brai, Federica Poggialini, Claudia Pasqualini, Claudia Immacolata Trivisani, Chiara Vagaggini, Elena Dreassi
Summary: Vaccines are crucial for preventing pathogen diffusion and cancer. The addition of adjuvants enhances the immune response to antigens, improving the effectiveness and duration of protection. The search for new adjuvants has increased in recent decades, uncovering novel classes and mechanisms of action, but there is still much to learn.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Lorenzo Jacopo Ilic Balestri, Claudia Immacolata Trivisani, Francesco Orofino, Diego Fiorucci, Giuseppina Ivana Truglio, Ilaria D'Agostino, Federica Poggialini, Lorenzo Botta, Jean-Denis Docquier, Elena Dreassi
Summary: Our research group has been studying the development of macrocyclic amidinoureas (MCAs) as antifungal agents. Through in silico target fishing study, we identified chitinases as one of their potential targets. Compound 3f emerged as a promising inhibitor of acidic mammalian chitinase (AMCase) with improved potency and selectivity.
ACS MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Analytical
Chiara Vagaggini, Annalaura Brai, Denise Bonente, Jessica Lombardi, Federica Poggialini, Claudia Pasqualini, Virginia Barone, Claudio Nicoletti, Eugenio Bertelli, Elena Dreassi
Summary: In this study, a sensitive and reproducible LC-MS/MS method was developed and validated for the quantification of short-chain fatty acids (SCFAs) in human, rat, and mouse plasma. The method showed good performance in terms of recovery (> 80%), precision (RSD <14%), accuracy (RE < ± 10%), and sensitivity (LOQ of 0.01 μM for acetic, butyric, propionic, and isobutyric acid). The results highlighted the correlation between plasma concentrations of SCFAs and age, emphasizing the importance of developing a reliable method for their quantification to study their biological role.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Marisanna Centini, Isabel Martinez-Sanudo, Marco Biagi, Elena Dreassi, Luca Mazzon, Laura Marri
Summary: In recent years, the use of bacteria for carotenoid production has gained attention as a sustainable alternative to expensive and technically challenging chemical synthesis. This study reports the isolation of an orange-pigmented bacterium from the gut of adult olive flies, contributing to the repertoire of carotenogenic bacteria. The isolated bacterium, designated as M3d10, was found to be a derivative of hydroxylated astaxanthin through preliminary characterization.
Article
Chemistry, Multidisciplinary
Claudia Pasqualini, Federica Poggialini, Chiara Vagaggini, Annalaura Brai, Elena Dreassi
Summary: A single, clean, and environmentally friendly microwave-assisted method for O-silylation of uridine and subsequent silyl ether deprotection using a reusable acidic resin has been developed. This method has been applied to a range of pharmaceutical alcohols.
CHEMISTRY-SWITZERLAND
(2022)
