Article
Otorhinolaryngology
Yibin Liu, Nan Huang, Junxiao Gao, Bin He, Hongming Huang, Liangcai Wan, Qinming Cai, Zhenchao Zhu, Suizi Zhou, Jing Wang, Xiaohui Wang, Qianhui Qiu, Fei Han
Summary: This study compared the clinical outcomes and complications of salvage endoscopic nasopharyngectomy (ENPG) with intensity-modulated radiotherapy (IMRT) in patients with locally advanced recurrent nasopharyngeal carcinoma (rNPC). The results showed that ENPG had comparable efficacy to IMRT but lower incidence of treatment-related complications.
JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2023)
Article
Oncology
Zhouying Peng, Yumin Wang, Yaxuan Wang, Ruohao Fan, Kelei Gao, Hua Zhang, Weihong Jiang
Summary: This meta-analysis compared the efficacy of IMRT and ES for high T-stage recurrent NPC. Results suggest that ES may improve survival in recurrent NPC with rT3-4, with potentially fewer complications. More studies are needed to confirm these findings.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jiwei Mao, Wanli Ye, Dongping Wu, Jianjiang Liu, Ting Li, Weili Ma, Yang Zhou
Summary: For patients with locally unresectable recurrent nasopharyngeal carcinoma who relapsed after 2 years of radiotherapy, re-radiotherapy is the preferred treatment. However, its use is limited for patients who relapsed within 2 years due to adverse effects. Therefore, finding a new strategy to prolong the time of re-radiotherapy is necessary. Anlotinib combined with ticeorgio showed beneficial effects in a nasopharyngeal carcinoma patient with local recurrence after radical radiotherapy.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Jing-Feng Zong, Qian-Dong Liang, Qiong-Jiao Lu, Yu-Hong Liu, Han-Chuan Xu, Bi-Juan Chen, Qiao-Juan Guo, Yun Xu, Cai-Rong Hu, Jian-Ji Pan, Shao-Jun Lin
Summary: This study compared the efficacy and toxicity of radiotherapy combined with nimotuzumab versus chemoradiotherapy in patients with locally recurrent nasopharyngeal carcinoma. The results showed no significant difference in survival rates between the two groups, but the CRT group had a higher incidence of severe late radiation injuries. Further studies are needed to confirm these findings.
Article
Otorhinolaryngology
Wanpeng Li, Qianqian Zhang, Fu Chen, Haoyuan Xu, Qiang Liu, Huan Wang, Huankang Zhang, Quan Liu, Yurong Gu, Houyong Li, Xicai Sun, Hongmeng Yu, Dehui Wang
Summary: This study compared the efficacy of endoscopic surgery and intensity-modulated radiotherapy (IMRT) in patients with advanced recurrent nasopharyngeal carcinoma (rNPC). The results showed that endoscopic surgery had a higher survival rate and fewer complications, suggesting that it may be a more promising salvage treatment for advanced rNPC.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2023)
Article
Otorhinolaryngology
Raymond K. Tsang, Walter C. P. Chan, Floyd Christopher Holsinger, Joseph C. K. Chung, Velda L. Y. Chow, Jimmy Y. W. Chan, Wai-Kuen Ho, William Wei
Summary: This study presents the experience of 33 cases of robotic-assisted nasopharyngectomy, with a focus on local recurrent nasopharyngeal carcinoma. The study shows a high local control rate of 85.1% and a median follow-up period of 38 months.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Review
Otorhinolaryngology
Wai Tong Ng, Raymond K. Y. Tsang, Jonathan J. Beitler, Remco de Bree, Andres Coca-Pelaz, Avraham Eisbruch, Orlando Guntinas-Lichius, Anne W. M. Lee, Antti A. Makitie, William M. Mendenhall, Sandra Nuyts, Alessandra Rinaldo, K. Thomas Robbins, Juan P. Rodrigo, Carl E. Silver, Ricard Simo, Robert Smee, Primoz Strojan, Robert P. Takes, Alfio Ferlito
Summary: Nasopharyngeal carcinoma patients often have regional nodal metastasis, with individualized treatment options being preferred. Understanding nodal risk and achieving optimal nodal control during radiotherapy is crucial.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Oncology
Pihla Pakkanen, Heikki Irjala, Taru Ilmarinen, Elina Halme, Paula Lindholm, Antti Makitie, Tuija Wigren, Leena-Maija Aaltonen
Summary: This study compared the outcomes of transoral laser surgery (TLS) and radiation therapy (RT) in patients with glottic T1a laryngeal squamous cell carcinoma (LSCC). The study found that the oncological outcomes of both treatment modalities were similar.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Review
Oncology
Yekai Feng, Zhimei Dai, Ruicheng Yan, Feng Li, Xiaosheng Zhong, Haoxin Ye, Caiqing Chen, Shaochong Fan, Cheng Qing, Yong Pan, Haiying Sun
Summary: This study found that salvage surgery can provide survival benefits for recurrent nasopharyngeal carcinoma patients through meta-analysis. Accurately assessing tumor stage and selecting appropriate surgical methods are crucial for the success of surgery, and the use of postoperative adjuvant therapy also brings benefits.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Xue-Song Sun, Man-Yi Zhu, Dong-Xiang Wen, Dong-Hua Luo, Rui Sun, Qiu-Yan Chen, Hai-Qiang Mai
Summary: This study aimed to establish and validate a prognostic model for locally recurrent nasopharyngeal carcinoma (lrNPC) patients and evaluate the benefit of re-radiotherapy (reRT) in different risk groups. Three independent prognostic factors were identified, and a prognostic model combining these factors was derived. The study found that reRT could benefit low and intermediate-risk subgroups, but not the high-risk subgroup. The findings provide guidance for individualized treatment of lrNPC.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Quan Liu, Xicai Sun, Han Li, Jiaying Zhou, Yurong Gu, Weidong Zhao, Houyong Li, Hongmeng Yu, Dehui Wang
Summary: In this study, types of Transnasal Endoscopic Nasopharyngectomy (TEN) for recurrent Nasopharyngeal Carcinoma (rNPC) were established, showing promising results in the treatment of rNPC. The types of TEN provide effective guidelines for the surgical treatment of rNPC, with factors such as recurrent T stage, type of TEN, and surgical margin being independent predictors of outcome.
FRONTIERS IN ONCOLOGY
(2021)
Article
Otorhinolaryngology
Wanpeng Li, Qiang Liu, Haoyuan Xu, Huan Wang, Huangkang Zhang, Quan Liu, Jingjing Wang, Li Hu, Houyong Li, Xicai Sun, Hongmeng Yu, Dehui Wang
Summary: The novel Fudan rT staging has a better predictive value for the survival of patients with recurrent nasopharyngeal carcinoma (rNPC) compared to the traditional AJCC/UICC rT staging.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Oncology
Ting Liu, Bo-Wen Shen, Li-Ting Liu, Zhen-Chong Yang, Shi-Qian Wang, Da-Feng Lin, Xue-Song Sun, Shan-Shan Guo, Sai-Lan Liu, Mei-Juan Luo, Qiu-Yan Chen, Lin-Quan Tang, Hai-Qiang Mai
Summary: A model (SARTOS) was developed to predict the efficacy of salvage radiotherapy in patients with locally recurrent nasopharyngeal carcinoma. The model identified variables such as gender, prior radiotherapy-induced severe toxicities, and suboptimal performance status that determined whether patients would benefit from salvage radiotherapy.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Benjian Zhang, Yiliang Li, Jingjin Weng, Bo Huang, Molu Ban, Guiping Lan, Yu Lu, Jianhui Luo, Shenhong Qu, Yongfeng Si
Summary: The study assessed the feasibility and safety of ENPG combined with LDRT in T1-2 NPC patients, demonstrating that this treatment provided satisfactory survival outcomes, improved QoL, and reduced the incidence of sequelae.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xue-Song Sun, Zhi-Wen Xiao, Sai-Lan Liu, Rui Sun, Dong-Hua Luo, Qiu-Yan Chen, Hai-Qiang Mai
Summary: This study developed and validated a nomogram model to predict the overall survival of patients with nasopharyngeal carcinoma without distant metastasis. The model incorporates clinical characteristics, serum biomarkers, and the presence of nasopharyngeal necrosis.
EUROPEAN RADIOLOGY
(2023)
Article
Medicine, Research & Experimental
Xi Ding, Qing-Guang Lin, Xiong Zou, You-Ping Liu, Yi-Jun Hua, Yu-Long Xie, Zhi-Qiang Wang, Yi-Nuan Zhang, Yang-Kui Gu, Rui You, Qi Yang, Meng-Xia Zhang, Si-Yuan Chen, Yan-Feng Ouyang, Zi-Kun Yu, Rui Sun, Ming-Yuan Chen
Summary: TORS-RPLND is a feasible, safe, and effective method for treating NPC patients with RPLN recurrence, especially when combined with intraoperative ultrasound positioning. The procedure resulted in en bloc resection in 8 out of 10 patients, with mild complications and a low rate of recurrence.
Letter
Oncology
Rui You, You-Ping Liu, Ming-Yuan Chen
Article
Oncology
You-Ping Liu, Yi-Hui Wen, Jun Tang, Yi Wei, Rui You, Xiao-Lin Zhu, Jian Li, Lin Chen, Li Ling, Ning Zhang, Xiong Zou, Yi-Jun Hua, You-Mou Chen, Lei Chen, Li-Xia Lu, Ming-Yuan Chen, Wei-Ping Wen
Summary: Surgery significantly improved overall survival compared with IMRT in patients with resectable locally recurrent NPC. ENPG could be considered as the standard treatment option for this patient population, although long-term follow-up is needed to further determine the efficacy and toxicity of this strategy.
Article
Oncology
Mei Lin, Qi Yang, Rui You, Xiong Zou, Chong-yang Duan, You-ping Liu, Pei-yu Huang, Yu-long Xie, Zhi-qiang Wang, Ting Liu, Si-Yuan Chen, Yi-jun Hua, Ming-yuan Chen
Summary: This study analyzed the survival outcomes of nasopharyngeal carcinoma patients with metastasis and found that patients with bone and/or liver involvement tended to have lower survival rates, emphasizing the need for careful treatment selection.
Article
Oncology
Qi Yang, Le Xia, Mei Lin, Meng-Xia Zhang, Chong-Yang Duan, You-Ping Liu, Yu-Long Xie, Zhi-Qiang Wang, Rui You, Xiong Zou, Yi-Jun Hua, Pei-Yu Huang, Rui Sun, Ming-Huang Hong, Ming-Yuan Chen
Summary: This study confirmed that induction chemotherapy (IC) followed by concurrent chemo-radiotherapy (CCRT) had better long-term quality of life outcomes compared with CCRT alone in patients with locoregionally advanced nasopharyngeal carcinoma. The IC followed by CCRT group showed significantly improved results in role functioning, cognitive functioning, social functioning, fatigue, pain, and constipation, while showing poorer results in senses problems.
Review
Oncology
Anna See, Clarisse Chu, Kimberley L. Kiong, Constance Teo, Hiang Khoon Tan, Eddy W. Y. Wong, Jason Y. K. Chan, Raymond K. Y. Tsang, Jimmy Chan, Kai-Ping Chang, Chih-Yen Chien, Sheng-Po Hao, Mingyuan Chen, Chwee Ming Lim
Article
Oncology
Yijun Hua, Rui You, Zhiqiang Wang, Peiyu Huang, Mei Lin, Yanfeng Ouyang, Yulong Xie, Xiong Zou, Youping Liu, Chongyang Duan, Yonglong Liu, Chenmei Gu, Rongzeng Liu, Qi Yang, Rou Jiang, Mengxia Zhang, Xi Ding, Siyuan Chen, Chao Lin, Rui Sun, Mingyuan Chen
Summary: The combination of toripalimab and IMRT was well-tolerated and showed promising antitumor activity in patients with recurrent nasopharyngeal carcinoma.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Ling-Long Tang, Yu-Pei Chen, Chuan-Ben Chen, Ming-Yuan Chen, Nian-Yong Chen, Xiao-Zhong Chen, Xiao-Jing Du, Wen-Feng Fang, Mei Feng, Jin Gao, Fei Han, Xia He, Chao-Su Hu, De-sheng Hu, Guang-Yuan Hu, Hao Jiang, Wei Jiang, Feng Jin, Jin-Yi Lang, Jin-Gao Li, Shao-Jun Lin, Xu Liu, Qiu-Fang Liu, Lin Ma, Hai-Qiang Mai, Ji-Yong Qin, Liang-Fang Shen, Ying Sun, Pei-Guo Wang, Ren-Sheng Wang, Ruo-Zheng Wang, Xiao-Shen Wang, Ying Wang, Hui Wu, Yun-Fei Xia, Shao-Wen Xiao, Kun-Yu Yang, Jun-Lin Yi, Xiao-Dong Zhu, Jun Ma
Summary: The Chinese Society of Clinical Oncology (CSCO) formed a multidisciplinary team to develop comprehensive guidelines for the diagnosis and management of nasopharyngeal carcinoma (NPC) in order to improve the management of NPC.
CANCER COMMUNICATIONS
(2021)
Article
Oncology
Xian-Wen Wang, Tian-Liang Xia, Hao-Cheng Tang, Xiong Liu, Ri Han, Xiong Zou, Yun-Teng Zhao, Ming-Yuan Chen, Gang Li
Summary: In this study, a living biobank using the NPCO model was successfully established, which has enormous potential in basic and clinical research on NPC.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Xi Ding, Wei-Jing Zhang, Rui You, Xiong Zou, Zhi-Qiang Wang, Yan-Feng Ouyang, Lan Peng, You-Ping Liu, Chong-Yang Duan, Qi Yang, Chao Lin, Yu-Long Xie, Si-Yuan Chen, Yong-Long Liu, Chen-Mei Gu, Ruo-Qi Xie, Pei-Yu Huang, Ming-Huang Hong, Yi-Jun Hua, Ming-Yuan Chen
Summary: This study investigated the activity and safety of combining immune checkpoint inhibitors and antiangiogenic therapy for recurrent/metastatic nasopharyngeal carcinoma. The results showed promising antitumor activity with camrelizumab plus apatinib in refractory patients, but there were also treatment-related adverse events.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Rui You, You -Ping Liu, Yu -Long Xie, Chao Lin, Chong -Yang Duan, Dong-Ping Chen, Yi Pan, Bin Qi, Xiong Zou, Ling Guo, Jing-Yu Cao, Yi-Nuan Zhang, Zhi-Qiang Wang, Yong -Long Liu, Yan-Feng Ouyang, Kai Wen, Qi Yang, Ruo-Qi Xie, Hui-Feng Li, Xiao-Tong Duan, Xi Ding, Lan Peng, Si -Yuan Chen, Jiong-Lin Liang, Zheng-Kai Feng, Tian-Liang Xia, Rui-Ling Xie, Rou Jiang, Chen-Mei Gu, Rong-Zeng Liu, Rui Sun, Xin Yang, Li-Zhi Liu, Li Ling, Qing Liu, Wai Tong Ng, Yi-Jun Hua, Pei-Yu Huang, Ming-Yuan Chen
Summary: This study compared the efficacy and safety of hyperfractionation with standard fractionation in intensity-modulated radiotherapy. The results showed that hyperfractionation significantly reduced the incidence of severe late complications and improved overall survival, suggesting that it could be used as the standard of care for patients with locally advanced recurrent nasopharyngeal carcinoma.
Article
Oncology
Ya-Ni Zhang, Yu-Pei Chen, Ji-Bin Li, Tai-Xiang Lu, Fei Han, Chun-Yan Chen
Summary: The study aimed to compare the efficacy and safety of concurrent chemotherapy using taxane plus cisplatin with cisplatin alone in high-risk LANPC patients. The objective response rate of the taxane plus cisplatin group was marginally higher than the cisplatin alone group, but not significant. There was no superiority in long-term survival for the taxane plus cisplatin group. However, the taxane plus cisplatin group had a significantly higher incidence of hematological toxicities.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2023)
Article
Oncology
Shuo-Gui Fang, Tian-Liang Xia, Jian-Chang Fu, Tong Li, Qian Zhong, Fei Han
Summary: This study identified a novel fusion gene, BS, in nasopharyngeal carcinoma (NPC), which may play an important role in the occurrence and development of this cancer. The presence of the BS fusion gene was found to be relatively low in NPC tissues, but the altered localization and transcriptional inhibitory function of the BCL6 protein as a result of the fusion may contribute to the development of NPC.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2022)
Article
Medicine, Research & Experimental
Rui You, Xiong Zou, Xi Ding, Wei-Jing Zhang, Meng-Xia Zhang, Xiao Wang, Han-Shi Xu, Yong-Long Liu, Yan-Feng Ouyang, Chong-Yang Duan, Chen-Mei Gu, Zhi-Qiang Wang, You-Ping Liu, Yi-Jun Hua, Pei Yu Huang, Ming-Yuan Chen
Summary: This study investigated the efficacy and safety of gemcitabine plus apatinib and toripalimab in RM-NPC, and found that this triple combination therapy exhibited promising antitumor activity and manageable toxicities. Patients with repeated radiotherapy and an interval of less than 12 months from the last radiotherapy should be carefully selected for antiangiogenic therapies.
Article
Oncology
Meng-Xia Zhang, Ting Liu, Rui You, Xiong Zou, Yong-Long Liu, Xi Ding, Chong-Yang Duan, Han-Shi Xu, You-Ping Liu, Rou Jiang, Zhi-Qiang Wang, Chao Lin, Yu-Long Xie, Si-Yuan Chen, Yan-Feng Ouyang, Ruo-Qi Xie, Yi-Jun Hua, Rui Sun, Pei-Yu Huang, Shun-Lan Wang, Ming-Yuan Chen
Summary: The study found that local therapy directed at liver and lung metastases from nasopharyngeal carcinoma can improve overall survival rates for patients, with a more significant benefit seen in liver and lung metastases. However, the survival benefits of local therapy for bone metastases were not as prominent, and a biological effective dose greater than 60 Gy was found to yield more survival benefit in these cases.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2022)
Article
Oncology
Derek A. Mumaw, Allison J. Hazy, Aleksander Vayntraub, Thomas J. Quinn, Kamran Salari, John H. Chang, Noah Kalman, Sanford Katz, James Urbanic, Robert H. Press, Arpi Thukral, Henry Tsai, George E. Laramore, Jason Molitoris, Carlos Vargas, Samir H. Patel, Craig Stevens, Rohan L. Deraniyagala
Summary: This study evaluated contralateral recurrences in patients with oropharyngeal squamous cell carcinoma who received unilateral proton beam therapy. The results showed a favorable contralateral neck failure rate that was comparable to photon irradiation.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Kangpyo Kim, Dongryul Oh, Jae Myoung Noh, Yang Won Min, Hong Kwan Kim, Yong Chan Ahn
Summary: This study suggests that hypofractionated radiation therapy alone is a feasible option for early stage esophageal squamous cell carcinoma patients. Particularly, in patients with tumor length < 3 cm, this treatment scheme shows favorable local control rates with low incidence of esophageal toxicities.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Lin Chen, Jing Li, Kunpeng Li, Jiang Hu, Qingjie Li, Chenglong Huang, Gaoyuan Wang, Na Liu, Linglong Tang
Summary: This study analyzed the probability of hearing impairment after radiotherapy for nasopharyngeal carcinoma and developed a predictive model, providing dose limitation suggestions to improve patients' quality of life.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yiwei Yang, Jianxin Wang, Feng Gao, Zhen Liu, Tangzhi Dai, Haowen Zhang, Hongyu Zhu, Tingting Wang, Dexin Xiao, Kui Zhou, Zheng Zhou, Dai Wu, Xiaobo Du, Sen Bai
Summary: This paper provides a comprehensive description of the current status of PARTER, which is the first experimental FLASH platform utilizing megavoltage X-rays. It showcases the reliable performance and stability of the dosimeters and monitors used in PARTER, as well as the satisfactory dose distribution and characteristics of the FLASH X-rays. The platform effectively meets the requirements of preclinical research on megavoltage X-ray FLASH and undergoes continuous upgrades.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Maria Thor, Kelly Fitzgerald, Aditya Apte, Jung Hun Oh, Aditi Iyer, Otasowie Odiase, Saad Nadeem, Ellen D. Yorke, Jamie Chaft, Abraham J. Wu, Michael Offin, Charles B. Simone Ii, Isabel Preeshagul, Daphna Y. Gelblum, Daniel Gomez, Joseph O. Deasy, Andreas Rimner
Summary: The purpose of this study was to identify predictors of disease progression in early-stage non-small cell lung cancer (NSCLC) patients after receiving definitive stereotactic body radiation therapy (SBRT). The results showed that tumor diameter and SUVmax were the most frequently reported features associated with progression/survival, and a re-fitted model including these two features had the best performance.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yong-Qiao He, Tong-Min Wang, Da-Wei Yang, Wen-Qiong Xue, Chang-Mi Deng, Dan-Hua Li, Wen-Li Zhang, Ying Liao, Ruo-Wen Xiao, Lu-Ting Luo, Hua Diao, Xia-Ting Tong, Yan-Xia Wu, Xue-Yin Chen, Jiang-Bo Zhang, Ting Zhou, Xi-Zhao Li, Pei-Fen Zhang, Xiao-Hui Zheng, Shao-Dan Zhang, Ye-Zhu Hu, Guan-Qun Zhou, Jun Ma, Ying Sun, Wei-Hua Jia
Summary: In this study, researchers aimed to establish a predictive model for radiation-induced brain injury (RBI) in nasopharyngeal carcinoma (NPC) patients by incorporating clinical factors and newly developed genetic variants. They conducted a large-scale retrospective study and a genome-wide association study to develop a polygenic risk score (PRS) for RBI risk prediction. The results showed that the PRS, combined with clinical factors, improved the accuracy of RBI risk stratification and suggested personalized radiotherapy.
RADIOTHERAPY AND ONCOLOGY
(2024)
Review
Oncology
Xiaoyong Xiang, Zhe Ji, Jing Jin
Summary: A review of studies suggests that brachytherapy as a salvage therapy for recurrent glioblastoma shows acceptable safety and good post-treatment clinical efficacy for selected patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
M. Berbee, C. T. Muijs, F. E. M. Voncken, L. Wee, M. Sosef, B. van Etten, J. W. van Sandick, F. A. R. M. Warmerdam, J. J. de Haan, E. Oldehinkel, J. M. van Dieren, L. Boersma, J. A. Langendijk, A. van der Schaaf, J. B. Reitsma, E. Schuit
Summary: This study externally validated a model for predicting 2-year total mortality in lung cancer patients in esophageal cancer patients. The intercept and/or slope of the original model needed adjustment to achieve good performance in esophageal cancer patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominique Reijtenbagh, Jeremy Godart, Joan Penninkhof, Sandra Quint, Andras Zolnay, Jan-Willem Mens, Mischa Hoogeman
Summary: This study compared the performance of the current PotD strategy with non-adaptive and fully online-adaptive techniques in the treatment of cervical cancer patients. The findings show that the PotD protocol is effective in improving normal tissue sparing compared to no adaptation, while fully online-adaptive approaches can further reduce target volume but come with a more complex workflow.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Albrecht Weiss, Steffen Loeck, Ting Xu, Zhongxing Liao, Aswin L. Hoffmann, Esther G. C. Troost
Summary: Traditional models for predicting radiation pneumonitis may not be applicable to non-small cell lung cancer patients treated with passively-scattered proton therapy. The use of effective alpha/beta parameter can predict the occurrence of radiation pneumonitis in these patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Z. A. R. Gouw, J. Jeong, A. Rimner, N. Y. Lee, A. Jackson, A. Fu, J-j. Sonke, J. O. Deasy
Summary: This study investigates the effectiveness of non-uniform fractionation schedules in radiotherapy for early-stage non-small cell lung cancer. Through modeling, optimized schedules are proposed to minimize local failures and toxicity risk. The results suggest that non-standard primer shot fractionation can reduce hypoxia-induced radioresistance and improve treatment outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Sara Ronchi, Alessandro Cicchetti, Maria Bonora, Rossana Ingargiola, Anna Maria Camarda, Stefania Russo, Sara Imparato, Paolo Castelnuovo, Ernesto Pasquini, Piero Nicolai, Mohssen Ansarin, Michele Del Vecchio, Marco Benazzo, Ester Orlandi, Barbara Vischioni
Summary: This study evaluates the efficacy and toxicity of carbon ion radiotherapy (CIRT) in locally advanced head and neck mucosal melanoma patients. The results show that CIRT is safe and effective in treating the local region, and immunotherapy after relapse can improve overall survival. However, further prospective trials are needed to assess the role of targeted/immune- systemic therapy in this disease.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominik Wawrzuta, Justyna Klejdysz, Marzanna Chojnacka
Summary: This study analyzed articles about radiation oncology published in The New York Times since its inception in 1851, and identified changes in media sentiment and prevalent themes related to radiotherapy. The findings suggest an increasing negative sentiment in media coverage towards radiotherapy, with a shift towards reporting treatment errors, toxicity, and ineffectiveness.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Elaine Limkin, Pierre Blanchard, Benjamin Lacas, Jean Bourhis, Mahesh Parmar, Lisa Licitra, Quynh-Thu Le, Sue S. Yom, Catherine Fortpied, Johannes Langendijk, Jan B. Vermorken, Jacques Bernier, Jens Overgaard, Jonathan Harris, Jean-Pierre Pignon, Anne Auperin
Summary: This study investigated the impact of season of radiotherapy on the outcomes of head and neck squamous cell cancer patients. The results showed that the season of radiotherapy did not have any significant effect on patient outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Fabio L. Cury, Gustavo A. Viani, Andre G. Gouveia, Camila V. S. Freire, Gabriel de A. Grisi, Fabio Y. Moraes
Summary: In limb-sparing treatment of soft tissue sarcoma patients, a 5-day course of preoperative radiotherapy results in high local control and favorable R0 margins, with acceptable complication rates, particularly for patients receiving higher biological equivalent doses.
RADIOTHERAPY AND ONCOLOGY
(2024)