Article
Multidisciplinary Sciences
Joon Ho Park, Yao Jiang, Jiarong Zhou, Hua Gong, Animesh Mohapatra, Jiyoung Heo, Weiwei Gao, Ronnie H. Fang, Liangfang Zhang
Summary: By exploiting the specific affinity between VLA-4 and VCAM-1, a biomimetic nanoparticle formulation capable of targeting inflammation sites was developed. These nanoparticles coated with cell membranes showed enhanced affinity to target cells, improving the delivery of anti-inflammatory drugs to inflamed lungs and demonstrating significant therapeutic efficacy in vivo.
Article
Nanoscience & Nanotechnology
Haiyan Yang, Fujie Jiang, Xiaojuan Ji, Lu Wang, Yaotai Wang, Liang Zhang, Yu Tang, Disen Wang, Yong Luo, Ningshan Li, Qi Wang, Jianzhong Zou
Summary: The novel strategy of combining bacteriotherapy with HIFU therapy in this study showed significantly higher tumor inhibition rate up to 87% compared to monotherapies, providing a promising approach for more effective breast cancer treatment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Tao Wang, Liang Sun, Tianyu Ren, Min Hou, Ying Long, Jian-Hui Jiang, Jianjun He
Summary: Protein-degrading chimeras, such as lysosome-targeting exosomes (LYTEXs), are effective drug modalities for treating diseases caused by abnormal protein expression. LYTEXs, genetically engineered exosomes expressing multivalent single-chain fragment variables, can selectively degrade membrane protein targets, providing a generalizable and easy-to-prepare platform for modulating surface protein expression.
Review
Oncology
Yuriko Saiki, Can Jiang, Masaki Ohmuraya, Toru Furukawa
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy and a major cause of cancer-related deaths worldwide. Recent multi-gene analysis methods have provided valuable insight into the molecular characteristics of pancreatic tumors, with different types of pancreatic cancer and precursor lesions showing specific molecular alterations. Genetically engineered mouse models (GEMMs) driven by oncogenic Kras have proven to be useful in understanding the roles of altered genes and recapitulating key features of human PDAC.
Review
Engineering, Biomedical
Yu Chen, Xiaoqing Liu, Yanxia Guo, Jianchuan Wang, Dingxiao Zhang, Yang Mei, Junfeng Shi, Wenzhi Tan, Jin Hai Zheng
Summary: Drug delivery systems based on genetically engineered oncolytic bacteria have unique properties that enable them to target tumor tissues and suppress tumor growth effectively, showing potential value for clinical applications. By integrating oncolytic bacteria into cancer therapies, novel strategies are being developed to improve and standardize current treatment regimens in the near future.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Physical
Jianhai Chen, Jianwei Tan, Jian Li, Wenxiang Cheng, Liqing Ke, Anqiao Wang, Qiqing Wang, Sien Lin, Gang Li, Benguo Wang, Jingqin Chen, Peng Zhang
Summary: This study presents a genetically engineered biomimetic membrane-coated mRNA (MR@P-mPTEN) carrier that effectively delivers mRNA-PTEN directly to the rheumatoid arthritis (RA) joint. The carrier is prepared by overexpressing tumor necrosis factor (TNF-α) receptors on macrophage biomimetic membranes, which serve as decoys to reduce inflammatory pathway activation. The results show that MR@P-mPTEN exhibits good stability, RA targeting, and competitive binding with TNF-α, activating the PTEN pathway to inhibit synovitis and joint damage.
Review
Materials Science, Biomaterials
Saba Fooladi, Navid Rabiee, Siavash Iravani
Summary: Genetically engineered bacteria have emerged as an exciting frontier in targeted drug delivery, with significant promise for revolutionizing modern medicine. However, addressing safety concerns and ensuring ethical considerations are crucial for their successful development and use.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Microbiology
Jonatan Nino-Sanchez, Li-Hung Chen, Jorge Teodoro De Souza, Sandra Mosquera, Ioannis Stergiopoulos
Summary: This study explored a non-transformative method of utilizing RNA interference (RNAi) to control fungal pathogens using non-pathogenic bacteria as a delivery system. By silencing target genes in fungi, the researchers demonstrated that bacteria-mediated RNAi can effectively reduce fungal pathogen production and growth, laying the groundwork for translational research.
Article
Biochemistry & Molecular Biology
Hyun Kim, Ju Hye Jang, In Young Jung, Ha Rang Kim, Ju Hyun Cho
Summary: The study focuses on the development of genetically engineered probiotics capable of detecting and eliminating Pseudomonas aeruginosa in the intestines. The engineered probiotics successfully expressed and secreted a selective antimicrobial peptide in response to a specific quorum-sensing molecule of P. aeruginosa. In vitro and in vivo experiments demonstrated the ability of the engineered probiotics to inhibit P. aeruginosa growth and reduce colonization levels in mice.
Article
Materials Science, Multidisciplinary
Xingang Liu, Yukun Duan, Dehong Hu, Min Wu, Chengjian Chen, Pramila Baban Ghode, Gayathiri Magarajah, Nitish Thakor, Xin Liu, Chengbo Liu, Zonghai Sheng, Hairong Zheng, Bin Liu
Summary: The study developed a lipid-decorated molecular photoacoustic contrast agent TFML, which effectively labeled live neutrophils for targeted brain tumor imaging in mice glioblastoma multiforme detection. This approach presents a promising prospect for neutrophil-based nanotherapeutics research.
ACS MATERIALS LETTERS
(2021)
Article
Pharmacology & Pharmacy
Qiuwang Zhang, Sebastian Duncan, Daniel A. Szulc, Michael J. B. Kutryk
Summary: This study aimed to capture genetically engineered pig endothelial colony-forming cells (ECFCs) using ex vivo antibody-coated intravascular devices as a proof of concept for their potential for in vivo targeted drug delivery.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Janelle M. Tobias, Gabriela Rajic, Alexander E. G. Viray, David Icka-Araki, James A. Frank
Summary: Fatty acid amides (FAAs) are lipids that target cannabinoid receptors and regulate insulin secretion. The Optically-Cleavable Targeted (OCT)-ligand approach was developed to investigate the mechanisms by which FAAs regulate beta-cell excitability, showing potential for new experimental possibilities in targeted pharmacology.
Article
Gastroenterology & Hepatology
Yuan Lin, Meng-Qi Dong, Zhi-Min Liu, Meng Xu, Zhi-Hao Huang, Hong-Juan Liu, Yi Gao, Wei-Jie Zhou
Summary: There are currently no effective treatments for liver fibrosis, a disease that involves angiogenesis. The role of different microvessels in the liver during fibrogenesis is unclear, and it is difficult to treat liver fibrosis through vascular targeting. This study proposes a combined regulation of multiple different endothelial cell regulatory signaling pathways as a new strategy for liver fibrosis therapy.
Review
Chemistry, Multidisciplinary
Prerak Gupta, Biman B. Mandal
Summary: Vascular tissue engineering has made significant progress in recent years, with new technological advancements fostering the development of next-generation tissue-engineered vascular grafts. Traditional therapeutic methods involve bypassing damaged vessels with synthetic counterparts, while contemporary perspectives focus on biodegradable conduits with inherent remodeling capabilities.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Cell Biology
Christine M. Sorenson, Shoujian Wang, Soesiawati R. Darjatmoko, Zafer Gurel, Bo Liu, Nader Sheibani
Summary: TSP1 is a vital regulator of angiogenesis and inflammation in the eye, with its loss contributing to increased retinal vascular density and pathological ocular neovascularization. The study found that while global knockout of TSP1 led to increased retinal vascular density, only lack of TSP1 expression in endothelial cells was sufficient to increase choroidal neovascularization. Individual cell type loss of TSP1 resulted in decreased retinal endothelial cell numbers in a cell type-specific manner, highlighting the unique role TSP1 plays in each cell type.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Rammohan Devulapally, Narayana M. Sekar, Thillai V. Sekar, Kira Foygel, Tarik F. Massoud, Juergen K. Willmann, Ramasamy Paulmurugan
Article
Radiology, Nuclear Medicine & Medical Imaging
Kesav Raghavan, R. Brooke Jeffrey, Bhavik N. Patel, Michael A. DiMaio, Juergen K. Willmann, Eric W. Olcott
AMERICAN JOURNAL OF ROENTGENOLOGY
(2015)
Article
Oncology
Sunitha V. Bachawal, Kristin C. Jensen, Katheryne E. Wilson, Lu Tian, Amelie M. Lutz, Juergen K. Willmann
Article
Radiology, Nuclear Medicine & Medical Imaging
Lotfi Abou-Elkacem, Sunitha V. Bachawal, Juergen K. Willmann
EUROPEAN JOURNAL OF RADIOLOGY
(2015)
Article
Radiology, Nuclear Medicine & Medical Imaging
Huaijun Wang, Osamu F. Kaneko, Lu Tian, Dimitre Hristov, Juergen K. Willmann
INVESTIGATIVE RADIOLOGY
(2015)
Article
Chemistry, Multidisciplinary
Tzu-Yin Wang, Jung Woo Choe, Kanyi Pu, Rammohan Devulapally, Sunitha Bachawal, Steven Machtaler, Sayan Mullick Chowdhury, Richard Luong, Lu Tian, Butrus Khuri-Yakub, Jianghong Rao, Ramasamy Paulmurugan, Juergen K. Willmann
JOURNAL OF CONTROLLED RELEASE
(2015)
Article
Acoustics
Aya Kamaya, Ali M. Tahvildari, Bhavik N. Patel, Juergen K. Willmann, R. Brooke Jeffrey, Terry S. Desser
JOURNAL OF ULTRASOUND IN MEDICINE
(2015)
Article
Radiology, Nuclear Medicine & Medical Imaging
Huaijun Wang, Dimitre Hristov, Jiale Qin, Lu Tian, Juergen K. Willmann
Review
Radiology, Nuclear Medicine & Medical Imaging
Paul F. Laeseke, Ru Chen, R. Brooke Jeffrey, Teresa A. Brentnall, Juergen K. Willmann
Article
Radiology, Nuclear Medicine & Medical Imaging
Stephanie T. Chang, R. Brooke Jeffrey, Bhavik N. Patel, Michael A. DiMaio, Jarrett Rosenberg, Juergen K. Willmann, Eric W. Olcott
Article
Radiology, Nuclear Medicine & Medical Imaging
Krista E. Weiss, Juergen K. Willmann, R. Brooke Jeffrey, Terry S. Desser
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2016)
Review
Radiology, Nuclear Medicine & Medical Imaging
Keerthi S. Valluru, Juergen K. Willmann
Article
Medicine, General & Internal
Gloria L. Hwang, Maurice A. van den Bosch, Young I. Kim, Regina Katzenberg, Juergen K. Willmann, Ramasamy Paulmurugan, Sanjiv S. Gambhir, Lawrence Hofmann
CUREUS JOURNAL OF MEDICAL SCIENCE
(2015)
Article
Radiology, Nuclear Medicine & Medical Imaging
Srinath C. Sampath, Srihari C. Sampath, Camila Mosci, Amelie M. Lutz, Juergen K. Willmann, Erik S. Mittra, Sanjiv S. Gambhir, Andrei Iagaru
CLINICAL NUCLEAR MEDICINE
(2015)