Article
Virology
Ravi C. Dubey, Nazmir B. Alam, Ritu Gaur
Summary: The microRNA miR-150 plays a crucial role in HIV infection, increasing viral spread within cells by regulating the expression of glucose transporter-1 (GLUT1). The study reveals that HIV Tat protein enhances miR-150 expression, leading to elevated glucose uptake and promoting viral replication.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Chemistry, Analytical
Yun Wen, Wen-Ye Liu, Jian-Hua Wang, Yong-Liang Yu, Shuai Chen
Summary: Researchers developed a technique for simultaneous monitoring of multiple mitochondrial miRNAs in living cells using a near-infrared photoactivated controlled detection probe and a data-processing algorithm. This technique enables rapid imaging of abnormal miRNA expression and has potential clinical applications.
ANALYTICAL CHEMISTRY
(2023)
Article
Cell Biology
Ze-Hui Shi, Xiao-Yan Han, Mu-Di Yao, Chang Liu, Qin Jiang, Biao Yan
Summary: This study identified 72 miRNAs that were differentially expressed in EPCs following high glucose stress, with target genes involved in protein binding, cell differentiation, and cytoskeleton based on GO analysis. KEGG pathway analysis revealed the association between cGMP-PKG signaling pathway and miRNA-mediated EPC function. The up-regulation of miR-375-3p in clinical samples of DR patients was verified, and its inhibition protected EPCs against hyperglycemic or hypoxic stress-induced injury, enhancing cell viability, proliferation, migration, tube formation ability, and delaying apoptosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Miron Tokarski, Aneta Cierzniak, Dagmara Baczynska
Summary: This study investigates the effect of chemically-induced hypoxia on the expression of miRNA molecules in human endothelial cells and identifies several miRNAs that may affect the HGFA-HGF-c-Met signaling pathway. The findings shed new light on the role of miRNAs in hypoxia and highlight the importance of specific miRNAs in regulating this signaling pathway.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Hematology
Aranzazu Chamorro-Jorganes, Walid K. Sweaad, Rajesh Katare, Marie Besnier, Maryam Anwar, N. Beazley-Long, Graciela Sala-Newby, Inigo Ruiz-Polo, Dhananjie Chandrasekera, Alison A. Ritchie, Andrew Benest, Costanza Emanueli
Summary: The research revealed that METTL3 regulates m(6)A RNA methylation in endothelial cells and is essential for angiogenesis, potentially through influencing the processing of let-7e and miR-17-92 cluster.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Tongshuai Chen, Chang Ma, Guanqi Fan, Hui Liu, Xie Lin, Jingyuan Li, Na Li, Shujian Wang, Mei Zeng, Yun Zhang, Peili Bu
Summary: Hyperglycemia accelerates endothelial cell dysfunction and vascular complications by inducing ECs senescence, with molecular mechanisms involving SIRT3-p53 pathway.
Article
Biochemistry & Molecular Biology
Heike Braun, Michael Hauke, Anne Ripperger, Christian Ihling, Matthew Fuszard, Robert Eckenstaler, Ralf A. Benndorf
Summary: Knockdown of DICER1 or DROSHA by RNAi does not profoundly affect the angiogenic capacity of HUVEC, suggesting a potential increase in certain angiogenic activities instead. Further studies are needed to clarify the influence of these enzymes in the context of human endothelial cell-related angiogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Qian Xiao, Dan Wang, Yingda Sheng, Jing Huang, Xiaoqin Ha
Summary: Thrombosis is a common problem with severe consequences. Endothelial progenitor cells (EPCs) have potential as thrombosis therapy due to their angiogenesis-promoting, thrombus-relieving, and anticoagulant functions. miRNA-126, highly enriched in EPCs and endothelial cells, regulates EPC functions through various pathways and cytokines. This review aims to clarify the role of miR-126 in thrombosis through regulation of EPCs, providing insights for alternative thrombotic disease therapies.
DNA AND CELL BIOLOGY
(2023)
Article
Neurosciences
Eun Seon Kim, Kyu-Sung Kim, Chan Hee Lee, Min-Tae Jeon, Sung Bae Lee, Jong Hwa Lee, Do-Geun Kim
Summary: Brain endothelial cells heavily rely on glycolysis to maintain and regulate the permeability of the blood-brain barrier (BBB). They metabolize glucose to lactate with minimal consumption of glucose. Inhibition of glycolysis leads to impaired transcellular permeability of the BBB.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Zhe Qing, Hanfei Huang, Qun Luo, Jie Lin, Shikun Yang, Tao Liu, Zhong Zeng, Tingfeng Ming
Summary: This study identified a specific miRNA-mRNA network associated with hypoxia-induced proliferation of LSECs through whole transcriptome sequencing and bioinformatics analysis, which helps elucidate the potential mechanisms involved in hypoxia-promoting liver regeneration during LR.
Article
Plant Sciences
Junxiao Xi, Yuezhao Rong, Zifeng Zhao, Yihai Huang, Pu Wang, Huiling Luan, Yan Xing, Siyuan Li, Jun Liao, Yue Dai, Jingyu Liang, Feihua Wu
Summary: The study found that Scutellarin can protect vascular endothelial cells against high glucose-induced injury by regulating mitophagy, potentially involving the modulation of multiple signaling pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Jia-Ning Syu, Hung-Yu Lin, Tun Yu Huang, Der-Yen Lee, En-Pei Isabel Chiang, Feng-Yao Tang
Summary: In this study, it was found that trimethylamine-N-oxide (TMAO) has detrimental effects on the neovascularization of human endothelial progenitor cells (hEPCs), while docosahexaenoic acid (DHA) could alleviate these effects. The mechanism involves upregulation of miR-221 level, inactivation of Akt/eNOS and MAPK/ERK signaling cascades, suppression of ?-GCS protein, and decreased levels of glutathione (GSH) and GSH/GSSG ratio. DHA reverses these effects by suppressing miR-221 level, activating Akt/eNOS and MAPK/ERK signaling cascades, increasing expression of ?-GCS protein, and increasing cellular GSH level and GSH/GSSG ratio in hEPCs.
Article
Medicine, General & Internal
Hui Li, Hui-Min Zhang, Li-Juan Fan, Han-Han Li, Zi-Tan Peng, Jia-Peng Li, Xiao-Yu Zhang, Yuan Xiang, Chao-Jiang Gu, Xing-Hua Liao, Li Wang, Tong-Cun Zhang
Summary: Endothelial cell proliferation disorder caused by vascular injury may be one of the causes of atherosclerosis, and miR-15a-5p could be a therapeutic target for coronary artery atherosclerosis.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Cell Biology
Namita Chatterjee, Eugenia Fraile-Bethencourt, Adrian Baris, Cristina Espinosa-Diez, Sudarshan Anand
Summary: The study demonstrates the functional role of miR-494 in ER stress, showing that its expression is affected by ER stress inducers and hyperglycemia. Pre-treatment with miR-494 can mitigate ER stress induced by ER stress inducers and increase cell viability. It is suggested that ER stress-driven miR-494 may function in a feedback inhibitory loop.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Wenxue Ma, Tingting Zhong, Junqiu Chen, Xiao Ke, Huihua Zuo, Qiang Liu
Summary: This study aimed to investigate the effect of exogenous hydrogen sulfide (H2S) on high glucose-induced injury in endothelial progenitor cells (EPCs) and its underlying mechanisms. The results showed that H2S reversed the inhibitory effects of high glucose on EPCs proliferation, migration, and tube formation, promoting autophagic flux and reducing reactive oxygen species (ROS) production.
Article
Ophthalmology
R. Filek, P. Hooper, T. Sheidow, J. Gonder, D. K. Varma, L. Heckler, W. Hodge, S. Chakrabarti, C. M. L. Hutnik
Article
Endocrinology & Metabolism
Christine A. Beamish, Sofia Mehta, Brenda J. Strutt, Subrata Chakrabarti, Manami Hara, David J. Hill
JOURNAL OF ENDOCRINOLOGY
(2017)
Article
Cardiac & Cardiovascular Systems
Biao Feng, Shali Chen, Andrew Devon Gordon, Subrata Chakrabarti
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2017)
Article
Multidisciplinary Sciences
Shali Chen, Biao Feng, Anu Alice Thomas, Subrata Chakrabarti
Article
Gastroenterology & Hepatology
Tisha R. Joy, Charles A. McKenzie, Rommel G. Tirona, Kelly Summers, Shannon Seney, Subrata Chakrabarti, Neel Malhotra, Melanie D. Beaton
WORLD JOURNAL OF GASTROENTEROLOGY
(2017)
Review
Endocrinology & Metabolism
Anu Alice Thomas, Biao Feng, Subrata Chakrabarti
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2018)
Article
Multidisciplinary Sciences
Mohammed Abdelhameed, Diego Rota Martir, Shalimar Chen, William Z. Xu, Olabode O. Oyeneye, Subrata Chakrabarti, Eli Zysman-Colman, Paul A. Charpentier
SCIENTIFIC REPORTS
(2018)
Review
Gastroenterology & Hepatology
Lina Chen, Abdulaziz Almudaires, May Alzahrani, Karim Qumosani, Subrata Chakrabarti
Summary: IgG4-related disease involving the digestive tract is rare, and causing gastric outlet obstruction is even rarer. In this reported case, Whipple's procedure diagnosed IgG4-related disease, and symptoms were resolved with mycophenolate mofetil and prednisone without recurrence.
BMC GASTROENTEROLOGY
(2021)
Article
Pharmacology & Pharmacy
Rong Chen, Shiqing Zhang, Fang Liu, Lin Xia, Chong Wang, Siamak Sandoghchian Shotorbani, Huaxi Xu, Subrata Chakrabarti, Tianqing Peng, Zhaoliang Su
Summary: Cardiac-resident macrophages (CRMs) have important roles in cardiac homeostasis, function, and regeneration. This study investigated the changes of CRMs during cardiac ontogeny and their contribution to cardiac regeneration. The findings reveal the dynamic subsets of CRMs during development and their ability to regulate cardiomyocyte proliferation, highlighting their potential in cardiac repair and regeneration.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Multidisciplinary Sciences
Parisa Sooshtari, Biao Feng, Saumik Biswas, Michael Levy, Hanxin Lin, Zhaoliang Su, Subrata Chakrabarti
Summary: This study found that ANRIL gene alteration may play an important role in diabetic nephropathy by regulating the expression of multiple pathogenetic molecules, affecting various metabolic pathways, apoptosis, and synthesis and degradation of extracellular matrix proteins. ANRIL may be a potential drug target for DN and other chronic diabetic complications.
Article
Ophthalmology
Richard Filek, Phil Hooper, Tom G. Sheidow, John Gonder, Subrata Chakrabarti, Cindy M. L. Hutnik
CLINICAL OPHTHALMOLOGY
(2019)
Article
Ophthalmology
Richard Filek, Phil Hooper, Tom G. Sheidow, Hong Liu, Subrata Chakrabarti, Cindy M. L. Hutnik
CLINICAL OPHTHALMOLOGY
(2019)
Article
Endocrinology & Metabolism
Andrew Devon Gordon, Saumik Biswas, Biao Feng, Subrata Chakrabarti
ENDOCRINOLOGY DIABETES & METABOLISM
(2018)
Article
Ophthalmology
Anu Alice Thomas, Biao Feng, Subrata Chakrabarti
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2017)
Article
Urology & Nephrology
Ana M. Pena, Shali Chen, Biao Feng, Lu Cai, Xiaokun Li, Guang Liang, Subrata Chakrabarti
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.