Article
Endocrinology & Metabolism
Kamel Mohammedi, Yawa Abouleka, Charlyne Carpentier, Louis Potier, Severine Dubois, Ninon Foussard, Vincent Rigalleau, Jean-Francois Gautier, Pierre Gourdy, Guillaume Charpentier, Ronan Roussel, Andre Scheen, Bernard Bauduceau, Samy Hadjadj, Francois Alhenc-Gelas, Michel Marre, Gilberto Velho
Summary: This study is the first to find an independent association between the ACE D allele and increased risk of LLA, mainly minor amputations, in patients with type 1 diabetes.
Article
Endocrinology & Metabolism
Kamel Mohammedi, Yawa Abouleka, Charlyne Carpentier, Louis Potier, Severine Dubois, Ninon Foussard, Vincent Rigalleau, Jean-Francois Gautier, Pierre Gourdy, Guillaume Charpentier, Ronan Roussel, Andre Scheen, Bernard Bauduceau, Samy Hadjadj, Francois Alhenc-Gelas, Michel Marre, Gilberto Velho
Summary: This study identified a potential association between the ACE gene's D allele and plasma ACE concentration with increased risk of lower-limb amputation in patients with type 1 diabetes, particularly minor amputations.
Article
Endocrinology & Metabolism
Yawa Abouleka, Kamel Mohammedi, Charlyne Carpentier, Severine Dubois, Pierre Gourdy, Jean-Francois Gautier, Ronan Roussel, Andre Scheen, Francois Alhenc-Gelas, Samy Hadjadj, Gilberto Velho, Michel Marre
Summary: The deletion (D) allele of the ACE insertion/deletion (I/D) polymorphism is associated with an increased risk of major kidney events and all-cause death in patients with long-standing type 1 diabetes.
Article
Biochemistry & Molecular Biology
Aastha Malik, Sarama Saha, Rajesh Kumar Morya, Sanjay Kumar Bhadada, Praveen Kumar Singh, Satya Vati Rana
Summary: Uncontrolled diabetes mellitus can affect various parts of the gastrointestinal tract and negatively impact quality of life. The study conducted at PGIMER in Chandigarh showed that ACE gene polymorphism may play a significant role in influencing gut motility, particularly in Type2 diabetes mellitus patients.
BIOCHEMICAL GENETICS
(2021)
Article
Genetics & Heredity
Kristina Jevnikar, Luka Lapajne, Daniel Petrovic, Andrej Meglic, Mateja Logar, Natasa Vidovic Valentincic, Mojca Globocnik Petrovic, Ines Cilensek, Polona Jaki Mekjavic
Summary: This study found that the presence of the AGTR2 rs1403543-AA genotype is associated with an increased risk of COVID-19 retinopathy. However, the genotype frequencies of other selected gene polymorphisms are not significantly associated with the presence or severity of COVID-19.
Article
Medicine, Research & Experimental
Shilong Li, Rangaprasad Sarangarajan, Tomi Jun, Yu-Han Kao, Zichen Wang, Ke Hao, Emilio Schadt, Michael A. Kiebish, Elder Granger, Niven R. Narain, Rong Chen, Eric E. Schadt, Li Li
Summary: The study found that the use of ACE-I/ARB during hospitalization was significantly associated with a reduced in-hospital mortality rate in COVID-19 positive African American patients. Specifically, ARB hospital use was significantly associated with reduced in-hospital mortality in the African American population.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Geriatrics & Gerontology
Robert MacLachlan, Patrick Gavin Kehoe, J. Scott Miners
Summary: The activity of angiotensin-converting enzyme-1 (ACE-1) is induced in the early stages of Alzheimer's disease (AD), independently from the normal physiological changes in ACE-1 protein during aging.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Medicine, Research & Experimental
Mauro G. Silva, Gerardo R. Corradi, Juan Perez Duhalde, Myriam Nunez, Eliana M. Cela, Daniel H. Gonzales Maglio, Ana Brizzio, Martin R. Salazar, Walter G. Espeche, Mariela M. Gironacci
Summary: This study found that COVID-19 patients have higher levels of ACE2 expression and enzymatic activity in their blood compared to healthy individuals, while levels of AngII and Ang-(1-7) are lower. Even when excluding COVID-19 patients under RAS blockade treatment, ACE2 expression and enzymatic activity remain higher in COVID-19 patients, suggesting the involvement of RAS in COVID-19.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Endocrinology & Metabolism
Kyuho Kim, Ji Hye Moon, Chang Ho Ahn, Soo Lim
Summary: This study suggests that olmesartan has beneficial effects on serum ACE2 and Ang-(1-7) levels, as well as kidney and vascular function in patients with type 2 diabetes and hypertension.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Endocrinology & Metabolism
Yuanyuan Fu, Ling Hu, Hong-Wei Ren, Yi Zuo, Shaoqiu Chen, Qiu-Shi Zhang, Chen Shao, Yao Ma, Lin Wu, Jun-Jie Hao, Chuan-Zhen Wang, Zhanwei Wang, Richard Yanagihara, Youping Deng
Summary: This study identified specific clinical factors associated with COVID-19 outcomes in patients with type 2 diabetes (T2D) and developed an individualized risk prediction tool to assist in early prediction of survival rates in diabetic patients.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Steven D. Brooks, Rachel L. Smith, Aline S. Moreira, Hans C. Ackerman
Summary: Lisinopril increases ACE2 expression in tissues relevant to COVID-19, while adding losartan prevents the lisinopril-induced increase. A sex difference was observed with higher ACE2 levels in the kidneys of male mice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Mona Mohamed Taha, Heba Mahdy-Abdallah, Eman Mohamed Shahy, Mona Adel Helmy, Lamia Samir ElLaithy
Summary: Diabetic nephropathy (DN) is the main cause of chronic kidney disease in patients with type 2 diabetes mellitus (T2DM). This study assessed potential biomarkers, including cystatin-c and hemeoxygenase, as well as genetic factors, ACE I/D polymorphism and ACE G2350A genotypes, in predicting kidney disease susceptibility in T2DM patients. The results showed significant elevations in cystatin-c and hemeoxygenase levels in diabetic groups compared to controls, and an association between G2350A genotype of ACE gene and increased cystatin-c and hemeoxygenase levels.
SCIENTIFIC REPORTS
(2023)
Article
Physiology
Ana Paula Renno Sierra, Bryan Steve Martinez Galan, Cesar Augustus Zocoler de Sousa, Duane Cardoso de Menezes, Jessica Lais de Oliveira Branquinho, Raquel Leao Neves, Julia Galanakis Arata, Clarissa Azevedo Bittencourt, Hermes Vieira Barbeiro, Heraldo Possolo de Souza, Joao Bosco Pesquero, Maria Fernanda Cury-Boaventura
Summary: The study aims to evaluate the role of ACE I/D and BDKRB2 +9/-9 polymorphism on exercise-induced cytokine response. The results showed the association between BDKRB2 genotype and exercise-induced cytokine response related to muscle repair and cardioprotection, while ACE I/D genotype was associated with inflammatory response.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Hooria Younas, Tahira Ijaz, Nakhshab Choudhry
Summary: This study investigated the association of Angiotensin-1 converting enzyme 2 polymorphism, G8790A, with the increased risk of type 2 diabetes mellitus (T2DM) development with the complication of diabetic nephropathy (DN) in the Pakistani population. The results showed that female AG/AA genotype and male A genotype were associated with T2DM as a genetic risk factor but were not associated with diabetic nephropathy.
Article
Multidisciplinary Sciences
Thomas L. Williams, Gregory Strachan, Robyn G. C. Macrae, Rhoda E. Kuc, Duuamene Nyimanu, Anna L. Paterson, Sanjay Sinha, Janet J. Maguire, Anthony P. Davenport
Summary: ACE2 is a membrane protein that regulates the cardiovascular system and acts as a receptor for human coronaviruses, including SARS-CoV-2. A newly discovered short ACE2 isoform, deltaACE2, may affect individual susceptibility to viral infection and likelihood of developing Long COVID. Research shows that deltaACE2 is more expressed in the lung and liver compared to full-length ACE2.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Samia Hadj Ahmed, Nadia Koubaa, Wafa Kharroubi, Amira Zarrouk, Amira Mnari, Fethi Batbout, Habib Gamra, Sonia Hammami, Gerard Lizard, Mohamed Hammami
PROSTAGLANDINS & OTHER LIPID MEDIATORS
(2017)
Article
Cardiac & Cardiovascular Systems
Sonia Hammami, Sounira Mehri, Said Hajem, Nadia Koubaa, Mohamed A. Frih, Samy Kammoun, Mohamed Hammami, Fathi Betbout
BMC CARDIOVASCULAR DISORDERS
(2011)
Article
Hematology
Nadia Koubaa, Amel Nakbi, Sonia Hammami, Sounira Mehri, Nabil Attia, Mohamed Ben Farhat, Mohamed Hammami
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2010)
Article
Medical Laboratory Technology
Nadia Koubaa, Arnel Nakbi, Sonia Hammami, Nabil Attia, Sounira Mehri, Khaldoun Ben Hamda, Mohamed Ben Farhat, Abdelhedi Miled, Mohamed Hammami
CLINICAL BIOCHEMISTRY
(2009)
Article
Medical Laboratory Technology
Sounira Mehri, Nadia Koubaa, Amel Nakbi, Sonia Hammami, Raja Chaaba, Sinda Mahjoub, Bechir Zouari, Mohamed Abid, Saida Ben Arab, Bruno Baudin, Mohamed Hammami
CLINICAL BIOCHEMISTRY
(2010)
Article
Medical Laboratory Technology
Nadia Koubaa, Sonia Hammami, Amel Nakbi, Khaldoun Ben Hamda, Sylvia Mahjoub, Testsuya Kosaka, Mohamed Hammami
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2008)
Article
Chemistry, Applied
A. Nakbi, M. Issaoui, S. Dabbou, N. Koubaa, A. Echbili, M. Hammami, N. Attia
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2010)
Article
Nutrition & Dietetics
Abir Kasdallah-Grissa, Amel Nakbi, Nadia Koubaa, Saloua El-Fazaa, NaJoua Gharbi, Abdelaziz Kamoun, Mohamed Hammami
NUTRITION RESEARCH
(2008)
Article
Public, Environmental & Occupational Health
S. Hammami, S. Hajem, A. Barhoumi, N. Koubaa, L. Gaha, C. Laouani Kechrid
REVUE D EPIDEMIOLOGIE ET DE SANTE PUBLIQUE
(2012)
Article
Endocrinology & Metabolism
Sonia Hammami, Sounira Mehri, Said Hajem, Nadia Koubaa, Hala Souid, Mohamed Hammami
BMC ENDOCRINE DISORDERS
(2012)
Article
Chemistry, Applied
A. Mnari Bhouri, H. Ghnimi, Z. Amri, N. Koubaa, M. Hammami
Summary: The effect of pomegranate peel extract on the oxidative stability of corn oil during heating was studied. It was found that pomegranate peel extract showed significant antioxidant activity and could delay the oxidation process of oil.
Article
Medical Laboratory Technology
N. Koubaa, A. Nakbi, A. Smaoui, N. Abid, R. Chaaba, A. Abid, A. Hammami
CLINICAL BIOCHEMISTRY
(2007)
Article
Biochemistry & Molecular Biology
M. Smaoui, N. Koubaa, S. Hammami, N. Abid, M. Feki, R. Chaaba, N. Attia, M. Abid, M. Hammami
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
(2006)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.