Article
Plant Sciences
Ernawati Sinaga, Ami Fitrayadi, Asrori Asrori, Sri Endarti Rahayu, Suprihatin Suprihatin, Vivitri Dewi Prasasty
Summary: The study found that Pandanus odoratissimus extract significantly reduced hepatic enzyme activities and protein levels in paracetamol-induced rat serum, indicating its potential hepatoprotective effect.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
E. S. Said, A. H. Mohammed, H. M. Ali, A. Y. Babiker, R. Alnughaymishi, N. Z. Althaqeel, A. S. Ahmed
Summary: The protective effects of sodium copper chlorophyllin and nebivolol were evaluated in a mice model of CCL4 induced hepatotoxicity. Co-administration of either silymarin, nebivolol, or sodium copper chlorophyllin with CCl4 ameliorated hepatic injury through their anti-inflammatory and antioxidant activities.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Medicine, Research & Experimental
Neelum Iqbal, Hafiz Muhammad Zubair, Mikhlid H. Almutairi, Muhammad Abbas, Muhammad Furqan Akhtar, Lotfi Aleya, Mohamed Kamel, Ammara Saleem, Qaiser Jabeen, Sobia Noreen, Mirza Muhammad Faran Ashraf Baig, Mohamed M. Abdel-Daim
Summary: Cordia rothii Roem. & Schult. possesses strong antioxidant and hepatoprotective activities, which may involve the Nrf2-NF kappa B pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Nao Sukeda, Hidetsugu Fujigaki, Tatsuya Ando, Honomi Ando, Yasuko Yamamoto, Kuniaki Saito
Summary: Cisplatin is a chemotherapeutic drug used for treating malignant tumors, but nephrotoxicity is a dose-limiting factor. The study identified 2',4',6'-trihydroxyacetophenone (THA) as an inhibitor of cisplatin-induced nephrotoxicity. THA pretreatment can effectively alleviate cisplatin-induced kidney damage.
MOLECULAR CANCER THERAPEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Shameenii A. P. P. Thanebal, Senty Vun-Sang, Mohammad Iqbal
Summary: The study demonstrated that Pandanus amaryllifolius has antioxidant properties and can protect rats from acute hepatic damage caused by carbon tetrachloride. The extract contains various phytochemical constituents, showing significant antioxidant enzyme activity and reducing the extent of liver damage.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Integrative & Complementary Medicine
Khadijah B. Alkinani, Ehab M. M. Ali, Turki M. Al-Shaikh, Jalaluddin A. Awlia Khan, Tahani M. Al-naomasi, Soad S. Ali, Asaad A. Abduljawad, Osama F. Mosa, Tariq A. Zafar
Summary: In the carbon tetrachloride-induced acute liver injury model, epicatechin and silymarin significantly decreased liver function enzyme levels raised by CCl4 administration and increased serum albumin and total protein concentrations. Hepatic malondialdehyde levels were significantly reduced with upregulated levels of antioxidant enzymes in the EC-treated groups. Histological assessments further confirmed the hepatoprotective effects of the study.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Plant Sciences
Edinilze S. C. Oliveira, Leonard D. R. Acho, Ruben Dario Morales-Gamba, Alessandro S. do Rosario, Jose Fernando M. Barcellos, Emerson S. Lima, Marcos B. Machado
Summary: The dry extract of Myrcia multiflora leaves has a hypoglycemic effect on diabetic mice and exerts nephro- and hepatoprotective effects. It has the potential to be an adjuvant for diabetes mellitus type 2, similar to acarbose.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Integrative & Complementary Medicine
Tewodros Mengesha, N. Gnana Sekaran, Tsegaye Mehare
Summary: This study found that rats in the fructose control group developed characteristics of fatty liver disease, including dyslipidemia, oxidative stress, and mild steatosis, which were ameliorated by silymarin treatment. The results suggest that silymarin may have a hepatoprotective effect against fructose-induced NAFLD.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2021)
Article
Chemistry, Multidisciplinary
Mikk Kaasik, Pan-Pan Chen, Sebastijan Ricko, Karl Anker Jorgensen, K. N. Houk
Summary: This study describes the novel asymmetric aminocatalytic cycloadditions between formyl cycloheptatrienes and 6,6-dimethylfulvene. The reactions result in [4 + 2], [6 + 2], and [4 + 6] cycloadducts. The position of the formyl functionality in the cycloheptatriene core determines the reaction course and each formyl cycloheptatriene isomer exhibits distinct reactivity patterns.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Medicinal
Quang-Vinh Nguyen, Thi-Tuoi Vu, Minh-Trang Tran, Phuong Tham Ho Thi, Huynh Thu, Thuy Hang Le Thi, Hoang Van Chuyen, Minh-Hiep Dinh
Summary: The study found that cultivated Ophiocordyceps sinensis exopolysaccharides (EPS) have antioxidant and liver-protective effects, significantly reducing liver damage induced by CCl4.
NATURAL PRODUCT COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Shu-Yun Hao, Jin-Yang Li, Chong-Qiang Mu, Deng-Shuo Liu, Yu Yang, Yan-Tuan Li, Tie-Min Liu, Xue-Kun Wang, Fang Liu
Summary: Exploring solid forms with low toxicity and high safety is important in drug research. This study developed a new cocrystal using baicalein to optimize the hepatotoxicity of the antituberculosis drug pyrazinamide. The cocrystal significantly improved water solubility, bioavailability, and hepatoprotective effect, almost eliminating the toxicity of PZA.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Multidisciplinary Sciences
Lana S. Akree, Zahra A. Amin, Hiwa O. Ahmad
Summary: This study investigated the hepatoprotective effect of 5-benzylidine-2-thiohydantoin (5B2T) on liver injury induced by diethylnitrosamine (DEN) in male rats. Results showed that 5B2T improved liver function and reduced inflammation caused by DEN. Histopathological and immunohistochemical findings supported these results. Molecular docking studies indicated strong binding of 5B2T with TNF-alpha and human IL-6.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Nopawit Khamto, Lada Chaichuang, Puracheth Rithchumpon, Worrapong Phupong, Phuangthip Bhoopong, Suriya Tateing, Wilart Pompimon, Natthawat Semakul, Ni-orn Chomsri, Puttinan Meepowpan
Summary: This study synthesized thirty-three DMC derivatives and evaluated their cytotoxicity against six carcinoma cell lines in vitro, with most derivatives showing higher cytotoxicity than DMC. Derivatives with 4'-O-caproylation and 4'-O-methylation displayed the strongest cytotoxicity against specific cell lines. Structure-activity relationship analysis highlighted the importance of 2'-OH and the derivatization pattern of 4'-OH. Additionally, molecular docking simulation studies provided insights into the interactions of these bioactive compounds with cyclin-dependent kinase 2 (CDK2).
Article
Nutrition & Dietetics
Woojae Hong, Jeon Hwang-Bo, Hyelin Jeon, Minsung Ko, Joongyeon Choi, Yong-Joon Jeong, Jae-Hyun Park, Inhye Kim, Tae-Woo Kim, Hyunggun Kim, Se-Chan Kang
Summary: The study investigated the hepatoprotective effect of Centella asiatica 50% ethanol extract (CA-HE50) in a lipopolysaccharide/galactosamine (LPS-D-Gal)-induced acute liver failure (ALF) animal model. The results showed that CA-HE50 had antioxidant and hepatoprotective effects comparable to silymarin, Lentinus edodes mycelia (LEM), ursodeoxycholic acid (UDCA), and dimethyl diphenyl bicarboxylate (DDB) in reducing liver injury indicators and potentially serving as a prophylactic and therapeutic agent for ALF.
Article
Biochemistry & Molecular Biology
Aline Boveto Santamarina, Ruan Carlos Macedo Moraes, Victor Nehmi Filho, Gilson Masahiro Murata, Jessica Alves de Freitas, Danielle Araujo de Miranda, Anderson Romerio Azevedo Cerqueira, Soraia Katia Pereira Costa, Ana Flavia Fernandes Ferreira, Luiz Roberto Britto, Juliana Alves de Camargo, Daniela Rodrigues de Oliveira, Flavia Neto de Jesus, Jose Pinhata Otoch, Ana Flavia Marcal Pessoa
Summary: The study found that the new nutraceutical could improve insulin resistance and hepatic steatosis by regulating gene expression of IL-6, IL-10, and Pgc-1α.
Article
Oncology
Jean C. Benassi, Flavio A. R. Barbosa, Valdelucia M. A. S. Grinevicius, Fabiana Ourique, Daniela Coelho, Karina B. Felipe, Antonio L. Braga, Danilo W. Filho, Rozangela C. Pedrosa
Summary: This study evaluated the cytotoxic and antiproliferative potential of Se-DHPM on cancer cells, with 49H showing selective cytotoxicity to HepG2 cells and inducing apoptosis. Molecular assays revealed interactions between 49H and DNA, impacting DNA structure and cell cycle regulation.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Mirna Clemente, Marilis D. Miguel, Karina B. Felipe, Caroline Gribner, Paula F. Moura, Ana A. R. Rigoni, Eduardo B. Parisotto, Railson Henneberg, Josiane de Fatima Gaspari Dias, Marina T. Piltz, Erick F. Clemente, Christian B. Schonhofen, Joao L. S. Carvalho, Luiz C. Fernandes, Obdulio G. Miguel
Summary: This study aimed to investigate whether overweight individuals could improve or maintain their serum lipid and oxidative stress markers by taking standardized extract of Nasturtium officinale (SENO) as a supplement. The results showed a significant improvement in levels of low-density lipoprotein cholesterol, creatinine, and lipid peroxidation with SENO supplementation. Further research is suggested to clarify the outcomes of this clinical trial.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jean C. Benassi, Flavio A. R. Barbosa, Graziani Candiotto, Valdelucia M. A. S. Grinevicius, Danilo Wilhelm Filho, Antonio L. Braga, Rozangela C. Pedrosa
Summary: The study evaluated the cytotoxic and antiproliferative potential of new dihydropyrimidinone-derived selenoesters compounds against breast cancer cells, with 49A and 49F compounds showing the highest cytotoxicity for MCF-7 cells and selectivity for non-tumor cells. Compound 49F demonstrated antiproliferative potential by reducing colony formation. Molecular assays indicated different interactions with CT-DNA, with compound 49A causing hyperchromism and 49F causing hypochromism, while docking and molecular dynamics simulations suggested both compounds act as minor groove ligands stabilized by hydrogen bonds and hydrophobic interactions, with 49A being more energetically favorable. Despite some ADMET violations for 49F, overall results suggest it as a promising leader compound with anti-tumor potential for breast cancer.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Plant Sciences
Monica Surek, Mariana M. Fachi, Alexandre de Fatima Cobre, Favizia F. de Oliveira, Roberto Pontarolo, Amanda R. Crisma, Wesley M. de Souza, Karina B. Felipe
Summary: Propolis extracts exhibit antitumor, antibacterial properties and can be a potential source of antineoplastics and antibiotics. They show selective cytotoxicity against tumor cells and synergistic effects in combination with doxorubicin and gentamicin. The natural products may help reduce adverse effects and resistance associated with doxorubicin and gentamicin.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
M. Clemente, M. D. Miguel, K. B. Felipe, C. Gribner, R. E. Cidade, J. F. G. Dias, D. F. C. Junior, L. C. Fernandez, E. F. Clemente, O. G. Miguel
Summary: This study investigated the use of herbal medicines and conventional drugs by individuals with cerebral palsy, finding that herbal medicines are often used to alleviate side effects of conventional drugs. While none of the participants reported clinical evidence of interactions, there is still a need to be vigilant about potential risks.
JOURNAL OF HERBAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Aline Aita Naime, Flavio Augusto Rocha Barbosa, Diones Caeran Bueno, Rozangela Curi Pedrosa, Romulo Faria Santos Canto, Dirleise Colle, Antonio Luiz Braga, Marcelo Farina
Summary: The study focused on the temporal events mediating the prevention of ferroptosis and found that the protective effects of anti-ferroptotic agents were reduced when delivered at time-points characterized by increased lipoperoxidation. Direct antioxidant efficacy was not significantly associated with cytoprotective effects.
FREE RADICAL RESEARCH
(2021)
Article
Plant Sciences
Andressa F. Santos, Nadia S. R. Santos Mota, Elberth M. Schiefer, Regiane S. da Cunha, Allan M. Junkert, Andrea E. M. Stinghen, Roberto Pontarolo, Amanda R. Crisma, Almeriane M. Weffort-Santos, Rozangela C. Pedrosa, Wesley M. de Souza, Karina B. Felipe
Summary: The indole alkaloid-rich fraction (IAF) of A. subincanum selectively induces toxic and antiproliferative effects on MCF7 cells by regulating apoptosis markers and oxidative status, suggesting its potential as a novel anti-cancer agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Food Science & Technology
Monica Surek, Alexandre de Fatima Cobre, Mariana Millan Fachi, Thalita Gilda Santos, Roberto Pontarolo, Amanda Rabello Crisma, Karina Bettega Felipe, Wesley Mauricio de Souza
Summary: This study aimed to authenticate propolis using mid-infrared spectroscopy and chemometric analyses. A chemometric model, based on attenuated total reflection- infrared spectroscopy, was developed to classify and differentiate propolis samples. The model was found to be sensitive, specific, and accurate in determining the quality of propolis for authentication purposes.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Giovanna Oliveira de Brito, Bruna Cabral Reis, Eduardo A. Ferreira, Nilton T. Vilela Junqueira, Livia C. L. Sa-Barreto, Fulvio Mattivi, Urska Vrhovsek, Eliana Fortes Gris
Summary: Tapereba peel extract exhibits significant phenolic compound content and antioxidant activity, with high retention of phenolic compounds when microencapsulated with chitosan. This study provides valuable insights into the composition and stability of tapereba peel extract.
Article
Cardiac & Cardiovascular Systems
Marianne Lucena da Silva, Ivo Vieira de Sousa Neto, Alexandra C. G. B. de Lima, Fabricio Barin, Otavio de Toledo Nobrega, Rita de Cassia Marqueti, Graziella F. B. Cipriano, Joao Luiz Quagliotti Durigan, Eduardo Antonio Ferreira, Martim Bottaro, Ross Arena, Larry P. Cahalin, Jose Alberto Neder, Gerson Cipriano Junior
Summary: This study investigated the effects of home-based low-frequency electrical stimulation (LFES) on plasma cytokines profile, oxidative stress biomarkers, metalloproteinases (MMPs) activity, and exercise performance in heart failure (HF) patients. The results showed that LFES increased active-MMP2 activity and decreased active-MMP9 activity, but did not elicit changes in cytokines, oxidative stress biomarkers, or exercise performance.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Article
Health Care Sciences & Services
Joao de Sousa Pinheiro Barbosa, Leonardo Costa Pereira, Marileusa Dosolina Chiarello, Kerolyn Ramos Garcia, Giovanna Oliveira de Brito, Eliana Fortes Gris, Margo Gomes de Oliveira Karnikowski
Summary: This study analyzed the use of legal and illegal drugs by elderly individuals who received psychosocial assistance in the Federal District of Brazil. The majority of elderly users were male, with a higher consumption rate of illegal substances compared to legal ones. The elderly used drugs for a long period of time but had low adherence to treatment, with alcohol being the most prevalent psychoactive substance.
Article
Nanoscience & Nanotechnology
Jeovandro Maria Beltrame, Camila Guindani, Mara Gabriela Novy, Karina Bettega Felipe, Claudia Sayer, Rozangela Curi Pedrosa, Pedro Henrique Hermes de Araujo
Summary: The study introduces an engineered scaffold based on PGICL-NAC, which was obtained using the electrospinning technique to improve physical and chemical properties of PCL scaffolds. The addition of PGICL-NAC increased cell viability and proliferation, and enhanced cell adhesion on the scaffolds, suggesting promising potential for tissue regeneration applications.
ACS APPLIED BIO MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Daniela Coelho dos Santos, Jamal Rafique, Sumbal Saba, Gabriela M. Almeida, Tamila Siminski, Cynthia Padua, Danilo W. Filho, Ariane Zamoner, Antonio L. Braga, Rozangela C. Pedrosa, Fabiana Ourique
Summary: This study demonstrated the antitumor mechanism of selenylated imidazo[1,2-a]pyridine compound IP-Se-06 against HepG2 cells, showing high cytotoxicity and selectivity, as well as inhibition of cell proliferation, induction of apoptosis, and interference with cell cycle proteins and DNA fragmentation, both in vitro and in vivo.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)