Bortezomib down-modulates the survival factor interferon regulatory factor 4 in Hodgkin lymphoma cell lines and decreases the protective activity of Hodgkin lymphoma-associated fibroblasts

Prolonged early G1 arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle-coupled loss of IRF4

(2012) X. Huang et al.   BLOOD

Analyzing primary Hodgkin and Reed-Sternberg cells to capture the molecular and cellular pathogenesis of classical Hodgkin lymphoma

(2012) E. Tiacci et al.   BLOOD

Hodgkin lymphoma requires stabilized NIK and constitutive RelB expression for survival

(2012) S. M. Ranuncolo et al.   BLOOD

Dual Inhibition of Canonical and Noncanonical NF- B Pathways Demonstrates Significant Antitumor Activities in Multiple Myeloma

(2012) C. Fabre et al.   CLINICAL CANCER RESEARCH

Hodgkin lymphoma

(2012) Ralf Küppers et al.   JOURNAL OF CLINICAL INVESTIGATION

Mast cells promote the growth of Hodgkin's lymphoma cell tumor by modifying the tumor microenvironment that can be perturbed by bortezomib

(2012) H Mizuno et al.   LEUKEMIA

Phase I study of bortezomib plus ICE (BICE) for the treatment of relapsed/refractory Hodgkin lymphoma

(2011) Michelle Fanale et al.   BRITISH JOURNAL OF HAEMATOLOGY

Bone marrow stromal cells protect lymphoma B-cells from rituximab-induced apoptosis and targeting integrin α-4-β-1 (VLA-4) with natalizumab can overcome this resistance

(2011) Marek Mraz et al.   BRITISH JOURNAL OF HAEMATOLOGY

Interaction of tumor cells with the microenvironment

(2011) Hendrik Ungefroren et al.   Cell Communication and Signaling

Novel Proteasome Inhibitors to Overcome Bortezomib Resistance

(2011) Amy M. Ruschak et al.   JNCI-Journal of the National Cancer Institute

The role of CD40/CD40L and interferon regulatory factor 4 in Hodgkin lymphoma microenvironment

(2011) Donatella Aldinucci et al.   LEUKEMIA & LYMPHOMA

Novel treatment strategies for patients with relapsed classical Hodgkin lymphoma

(2010) Adam Jona et al.   BLOOD REVIEWS

IRF4 silencing inhibits Hodgkin lymphoma cell proliferation, survival and CCL5 secretion

(2010) Donatella Aldinucci et al.   BRITISH JOURNAL OF HAEMATOLOGY

Antitumor activity of gold(III)-dithiocarbamato derivatives on prostate cancer cells and xenografts

(2010) Lara Cattaruzza et al.   INTERNATIONAL JOURNAL OF CANCER

Blood-derived human osteoclast resorption activity is impaired by Hyaluronan-CD44 engagement via a p38-dependent mechanism

(2010) Eliana Pivetta et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The classical Hodgkin's lymphoma microenvironment and its role in promoting tumour growth and immune escape

(2010) Donatella Aldinucci et al.   JOURNAL OF PATHOLOGY

Beyond chemotherapy: new agents for targeted treatment of lymphoma

(2010) Anas Younes   Nature Reviews Clinical Oncology

MUM1/IRF4

(2010) Gabriela Gualco et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

IRF4 is modulated by CD40L and by apoptotic and anti-proliferative signals in Hodgkin lymphoma

(2009) Donatella Aldinucci et al.   BRITISH JOURNAL OF HAEMATOLOGY

IRF4: Immunity. Malignancy! Therapy?

(2009) A. L. Shaffer et al.   CLINICAL CANCER RESEARCH

Functional coexpression of Interleukin (IL)-7 and its receptor (IL-7R) on Hodgkin and Reed-Sternberg cells: Involvement of IL-7 in tumor cell growth and microenvironmental interactions of Hodgkin's lymphoma

(2009) Lara Cattaruzza et al.   INTERNATIONAL JOURNAL OF CANCER

TNF-α-converting enzyme (TACE/ADAM17)-dependent loss of CD30 induced by proteasome inhibition through reactive oxygen species

(2009) A M Vahdat et al.   LEUKEMIA

Bortezomib-Induced Apoptosis with Limited Clinical Response Is Accompanied by Inhibition of Canonical but not Alternative Nuclear Factor- B Subunits in Head and Neck Cancer

(2008) C. Allen et al.   CLINICAL CANCER RESEARCH

Bortezomib overcomes cell adhesion-mediated drug resistance through downregulation of VLA-4 expression in multiple myeloma

(2008) K Hatano et al.   ONCOGENE

Expression of CCR5 receptors on Reed–Sternberg cells and Hodgkin lymphoma cell lines: Involvement of CCL5/Rantes in tumor cell growth and microenvironmental interactions

(2007) Donatella Aldinucci et al.   INTERNATIONAL JOURNAL OF CANCER