Very small embryonic-like stem cells (VSELs) represent a real challenge in stem cell biology: recent pros and cons in the midst of a lively debate

Human Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer

(2013) Masahito Tachibana et al.   CELL

VSELs: Is Ideology Overtaking Science?

(2013) Henry Nicholls   Cell Stem Cell

Doubt cast over tiny stem cells

(2013) Alison Abbott   NATURE

Maternal imprinting at the H19–Igf2 locus maintains adult haematopoietic stem cell quiescence

(2013) Aparna Venkatraman et al.   NATURE

Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies

(2013) Andrew S Lee et al.   NATURE MEDICINE

Isolation, culture and evaluation of multilineage-differentiating stress-enduring (Muse) cells

(2013) Yasumasa Kuroda et al.   Nature Protocols

Murine Bone Marrow Lin−Sca-1+CD45− Very Small Embryonic-Like (VSEL) Cells Are Heterogeneous Population Lacking Oct-4A Expression

(2013) Krzysztof Szade et al.   PLoS One

Very Small Embryonic-Like Stem Cells: Implications in Reproductive Biology

(2013) Deepa Bhartiya et al.   Biomed Research International

Do Pluripotent Stem Cells Exist in Adult Mice as Very Small Embryonic Stem Cells?

(2013) Masanori Miyanishi et al.   Stem Cell Reports

The negative effect of prolonged somatotrophic/insulin signaling on an adult bone marrow-residing population of pluripotent very small embryonic-like stem cells (VSELs)

(2012) Magda Kucia et al.   AGE

Various types of stem cells, including a population of very small embryonic-like stem cells, are mobilized into peripheral blood in patients with Crohnʼs disease

(2012) Wojciech Marlicz et al.   INFLAMMATORY BOWEL DISEASES

Parental imprinting regulates insulin-like growth factor signaling: a Rosetta Stone for understanding the biology of pluripotent stem cells, aging and cancerogenesis

(2012) M Z Ratajczak et al.   LEUKEMIA

Very Small Embryonic-Like Stem Cells Purified from Umbilical Cord Blood Lack Stem Cell Characteristics

(2012) Ralitza Danova-Alt et al.   PLoS One

Paracrine Proangiopoietic Effects of Human Umbilical Cord Blood-Derived Purified CD133+ Cells—Implications for Stem Cell Therapies in Regenerative Medicine

(2012) Janina Ratajczak et al.   STEM CELLS AND DEVELOPMENT

Human Very Small Embryonic-Like Cells Generate Skeletal Structures, In Vivo

(2012) Aaron M. Havens et al.   STEM CELLS AND DEVELOPMENT

SALL4 is a key transcription regulator in normal human hematopoiesis

(2012) Chong Gao et al.   TRANSFUSION

The role of pluripotent embryonic-like stem cells residing in adult tissues in regeneration and longevity

(2011) Mariusz Z. Ratajczak et al.   DIFFERENTIATION

Higher number of stem cells in the bone marrow of circulating low Igf-1 level Laron dwarf mice—novel view on Igf-1, stem cells and aging

(2011) J Ratajczak et al.   LEUKEMIA

Reduced number of VSELs in the bone marrow of growth hormone transgenic mice indicates that chronically elevated Igf1 level accelerates age-dependent exhaustion of pluripotent stem cell pool: a novel view on aging

(2011) M Kucia et al.   LEUKEMIA

Hematopoietic differentiation of umbilical cord blood-derived very small embryonic/epiblast-like stem cells

(2011) J Ratajczak et al.   LEUKEMIA

Pivotal role of paracrine effects in stem cell therapies in regenerative medicine: can we translate stem cell-secreted paracrine factors and microvesicles into better therapeutic strategies?

(2011) M Z Ratajczak et al.   LEUKEMIA

Immunogenicity of induced pluripotent stem cells

(2011) Tongbiao Zhao et al.   NATURE

Multilineage-differentiating stress-enduring (Muse) cells are a primary source of induced pluripotent stem cells in human fibroblasts

(2011) S. Wakao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stem Cells, Including a Population of Very Small Embryonic-Like Stem Cells, are Mobilized Into Peripheral Blood in Patients After Skin Burn Injury

(2011) Justyna Drukała et al.   Stem Cell Reviews and Reports

Nonhematopoietic Cells are the Primary Source of Bone Marrow-Derived Lung Epithelial Cells

(2011) Susannah H. Kassmer et al.   STEM CELLS

Detection, Characterization, and Spontaneous Differentiation In Vitro of Very Small Embryonic-Like Putative Stem Cells in Adult Mammalian Ovary

(2011) Seema Parte et al.   STEM CELLS AND DEVELOPMENT

Very Small Embryonic-Like Stem Cells with Maximum Regenerative Potential Get Discarded During Cord Blood Banking and Bone Marrow Processing for Autologous Stem Cell Therapy

(2011) Deepa Bhartiya et al.   STEM CELLS AND DEVELOPMENT

Global Gene Expression Analysis of Very Small Embryonic-Like Stem Cells Reveals that the Ezh2-Dependent Bivalent Domain Mechanism Contributes to Their Pluripotent State

(2011) Dong-Myung Shin et al.   STEM CELLS AND DEVELOPMENT

Primitive Stem Cells Derived from Bone Marrow Express Glial and Neuronal Markers and Support Revascularization in Injured Retina Exposed to Ischemic and Mechanical Damage

(2011) Nitza Goldenberg-Cohen et al.   STEM CELLS AND DEVELOPMENT

Elutriated Stem Cells Derived from the Adult Bone Marrow Differentiate into Insulin-Producing Cells In Vivo and Reverse Chemical Diabetes

(2011) Svetlana Iskovich et al.   STEM CELLS AND DEVELOPMENT

Characterization of Rat Very Small Embryonic-Like Stem Cells and Cardiac Repair After Cell Transplantation for Myocardial Infarction

(2011) Jin-Hong Wu et al.   STEM CELLS AND DEVELOPMENT

Cellular Origin of Testis-Derived Pluripotent Stem Cells: A Case for Very Small Embryonic-Like Stem Cells

(2011) Deepa Bhartiya et al.   STEM CELLS AND DEVELOPMENT

Adipose Stem Cell Treatment in Mice Attenuates Lung and Systemic Injury Induced by Cigarette Smoking

(2010) Kelly S. Schweitzer et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Adult murine bone marrow-derived very small embryonic-like stem cells differentiate into the hematopoietic lineage after coculture over OP9 stromal cells

(2010) Janina Ratajczak et al.   EXPERIMENTAL HEMATOLOGY

Molecular signature of adult bone marrow-purified very small embryonic-like stem cells supports their developmental epiblast/germ line origin

(2010) D-M Shin et al.   LEUKEMIA

Molecular characterization of isolated from murine adult tissues very small embryonic/epiblast like stem cells (VSELs)

(2010) Dong-Myung Shin et al.   MOLECULES AND CELLS

Coexistence of Quiescent and Active Adult Stem Cells in Mammals

(2010) L. Li et al.   SCIENCE

Epiblast/Germ Line Hypothesis of Cancer Development Revisited: Lesson from the Presence of Oct-4+ Cells in Adult Tissues

(2010) Mariusz Z. Ratajczak et al.   Stem Cell Reviews and Reports

Prospective Identification and Skeletal Localization of Cells Capable of Multilineage Differentiation In Vivo

(2010) Russell S. Taichman et al.   STEM CELLS AND DEVELOPMENT

Bone Marrow Transplantation Temporarily Improves Pancreatic Function in Streptozotocin-Induced Diabetes: Potential Involvement of Very Small Embryonic-Like Cells

(2010) Yiming Huang et al.   TRANSPLANTATION

Very Small Embryonic/Epiblast-Like Stem Cells

(2009) Mariusz Z. Ratajczak et al.   AMERICAN JOURNAL OF PATHOLOGY

Fetal Liver Very Small Embryonic/Epiblast Like Stem Cells Follow Developmental Migratory Pathway of Hematopoietic Stem Cells

(2009) Ewa K. Zuba-Surma et al.   Annals of the New York Academy of Sciences

Resetting the Epigenome beyond Pluripotency in the Germline

(2009) Katsuhiko Hayashi et al.   Cell Stem Cell

Paracrine/endocrine mechanism of stem cells on kidney repair: role of microvesicle-mediated transfer of genetic information

(2009) Giovanni Camussi et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Erythrocyte-derived microvesicles may transfer phosphatidylserine to the surface of nucleated cells and falsely ‘mark’ them as apoptotic

(2009) Rui Liu et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Optimization of isolation and further characterization of umbilical cord blood-derived very small embryonic/ epiblast-like stem cells (VSELs)

(2009) Ewa K. Zuba-Surma et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Identification of small Sca-1+, Lin−, CD45− multipotential cells in the neonatal murine retina

(2009) Yongqing Liu et al.   EXPERIMENTAL HEMATOLOGY

Novel epigenetic mechanisms that control pluripotency and quiescence of adult bone marrow-derived Oct4+ very small embryonic-like stem cells

(2009) D M Shin et al.   LEUKEMIA

Clinical Evidence That Very Small Embryonic-Like Stem Cells Are Mobilized Into Peripheral Blood in Patients After Stroke

(2009) Edyta Paczkowska et al.   STROKE

Very small embryonic-like stem cells are present in adult murine organs: ImageStream-based morphological analysis and distribution studies

(2008) Ewa K. Zuba-Surma et al.   CYTOMETRY PART A

Putative stem cells with an embryonic character isolated from the ovarian surface epithelium of women with no naturally present follicles and oocytes

(2008) Irma Virant-Klun et al.   DIFFERENTIATION

An efficient two-step method to purify very small embryonic-like (VSEL) stem cells from umbilical cord blood (UCB).

(2008) Maciej Halasa et al.   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

High frequency of fetal cells within a primitive stem cell population in maternal blood

(2008) M. A. Mikhail et al.   HUMAN REPRODUCTION

Bone marrow-derived pluripotent very small embryonic-like stem cells (VSELs) are mobilized after acute myocardial infarction

(2008) Ewa K. Zuba-Surma et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mobilization of Bone Marrow-Derived Oct-4+ SSEA-4+ Very Small Embryonic-Like Stem Cells in Patients With Acute Myocardial Infarction

(2008) Wojciech Wojakowski et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Culture of embryonic-like stem cells from human umbilical cord blood and onward differentiation to neural cells in vitro

(2008) Colin McGuckin et al.   Nature Protocols

Evidence That Very Small Embryonic-Like Stem Cells Are Mobilized into Peripheral Blood

(2008) Magda J. Kucia et al.   STEM CELLS

Transplantation of Bone Marrow-Derived Very Small Embryonic-Like Stem Cells Attenuates Left Ventricular Dysfunction and Remodeling After Myocardial Infarction

(2008) Buddhadeb Dawn et al.   STEM CELLS