Role and potential for therapeutic targeting of MYB in leukemia

Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia

(2012) Jolanta Grembecka et al.   Nature Chemical Biology

Protein–protein interaction inhibitors get into the groove

(2012) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Estrogen receptor-α recruits P-TEFb to overcome transcriptional pausing in intron 1 of the MYB gene

(2012) Partha Mitra et al.   NUCLEIC ACIDS RESEARCH

Identification of a transforming MYB-GATA1 fusion gene in acute basophilic leukemia: a new entity in male infants

(2011) C. Quelen et al.   BLOOD

Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia

(2011) L. S. Chen et al.   BLOOD

Identification and characterization of Hoxa9 binding sites in hematopoietic cells

(2011) Y. Huang et al.   BLOOD

An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance

(2011) J. Zuber et al.   GENES & DEVELOPMENT

The Histone Acetyltransferase TIP60 Interacts with c-Myb and Inactivates Its Transcriptional Activity in Human Leukemia

(2011) Huiwu Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo expression of an aberrant MYB-GATA1 fusion induces leukemia in the presence of GATA1 reduced levels

(2011) E Belloni et al.   LEUKEMIA

Inhibition of Myb-dependent gene expression by the sesquiterpene lactone mexicanin-I

(2011) T Bujnicki et al.   LEUKEMIA

GSK3β inactivation induces apoptosis of leukemia cells by repressing the function of c-Myb

(2011) Fangfang Zhou et al.   MOLECULAR BIOLOGY OF THE CELL

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

(2011) Johannes Zuber et al.   NATURE

Integrated genome-wide chromatin occupancy and expression analyses identify key myeloid pro-differentiation transcription factors repressed by Myb

(2011) Liang Zhao et al.   NUCLEIC ACIDS RESEARCH

A recessive screen for genes regulating hematopoietic stem cells

(2010) P. Papathanasiou et al.   BLOOD

FLT3 as a therapeutic target in AML: still challenging after all these years

(2010) T. Kindler et al.   BLOOD

Leu628 of the KIX domain of CBP is a key residue for the interaction with the MLL transactivation domain

(2010) Munehito Arai et al.   FEBS LETTERS

c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis

(2010) Shenghao Jin et al.   JOURNAL OF CLINICAL INVESTIGATION

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

A functional SUMO-interacting motif in the transactivation domain of c-Myb regulates its myeloid transforming ability

(2010) T Sæther et al.   ONCOGENE

GSK3 regulates the expressions of human and mouse c-Myb via different mechanisms

(2010) Kyoko Kitagawa et al.   Cell Division

Hierarchical Maintenance of MLL Myeloid Leukemia Stem Cells Employs a Transcriptional Program Shared with Embryonic Rather Than Adult Stem Cells

(2009) Tim C.P. Somervaille et al.   Cell Stem Cell

The molecular biology of mixed lineage leukemia

(2009) R. K. Slany   HAEMATOLOGICA

Mutations in Multiple Domains of c-Myb Disrupt Interaction with CBP/p300 and Abrogate Myeloid Transforming Ability

(2009) D. R. Pattabiraman et al.   MOLECULAR CANCER RESEARCH

Direct inhibition of the NOTCH transcription factor complex

(2009) Raymond E. Moellering et al.   NATURE

Fbw7 promotes ubiquitin-dependent degradation of c-Myb: involvement of GSK3-mediated phosphorylation of Thr-572 in mouse c-Myb

(2009) K Kitagawa et al.   ONCOGENE

Conditional c-myb knockout in adult hematopoietic stem cells leads to loss of self-renewal due to impaired proliferation and accelerated differentiation

(2009) Y. K. Lieu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl-/- mice

(2008) M. Kauppi et al.   BLOOD

Requirement of c-Myb for p210BCR/ABL-dependent transformation of hematopoietic progenitors and leukemogenesis

(2008) M. R. Lidonnici et al.   BLOOD

Genome profiling of acute myelomonocytic leukemia: alteration of the MYB locus in MYST3-linked cases

(2008) A Murati et al.   LEUKEMIA

Double minute chromosomes containing MYB gene and NUP214-ABL1 fusion gene in T-cell leukemia detected by single nucleotide polymorphism DNA microarray and fluorescence in situ hybridization

(2008) Norihiko Kawamata et al.   LEUKEMIA RESEARCH

FLASH acts as a co-activator of the transcription factor c-Myb and localizes to active RNA polymerase II foci

(2008) A H Alm-Kristiansen et al.   ONCOGENE

Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins

(2008) J. E. Chipuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA