Review
Oncology
Mehmet Gunduz, Esra Gunduz, Shunji Tamagawa, Keisuke Enomoto, Muneki Hotomi
Summary: Although progress has been made in understanding cancer stem cells, particularly in oropharyngeal cancer, much remains unknown. These stem cells play roles in tumor invasion, metastasis, drug resistance, and recurrence, but there are still many unanswered questions.
Article
Biochemistry & Molecular Biology
Sota Saeki, Katsuhiro Tokutake, Masaki Takasu, Shigeru Kurimoto, Yuta Asami, Keiko Onaka, Masaomi Saeki, Hitoshi Hirata
Summary: The study successfully demonstrated the potential of xenotransplantation of fetal porcine neural stem cells into peripheral nerves for treating muscle atrophy. Transplanted neural cells engrafted at all gestational ages of pigs and led to functional recovery in the nude rats, especially at the E 22 and E 27 stages. This technology, combined with medical engineering, has promising implications for developing new paralysis therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Chenghai Li, Hua Zhao, Linna Cheng, Bin Wang
Summary: MSC-based therapeutics are available for a range of diseases, with autologous and allogeneic MSCs having their own advantages and disadvantages in medical practice. The interaction of transplanted MSCs with their microenvironment can be impacted by factors from different donors, potentially leading to uncertainty in safety and efficacy. Donor-controlled clinical practice is suggested to minimize potential harm in MSC-based therapies.
CELL AND BIOSCIENCE
(2021)
Article
Cell & Tissue Engineering
Nicholas E. Stone, Andrew P. Voigt, Robert F. Mullins, Todd Sulchek, Budd A. Tucker
Summary: Autologous photoreceptor cell replacement is a promising approach for treating inherited retinal degenerative blindness, but enrichment of photoreceptor cells and correction of disease-causing genetic mutations are crucial. While advanced retinal differentiation protocols can generate various cell types, most of them are unnecessary and may hinder successful transplantation.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Editorial Material
Medicine, Research & Experimental
Jose Maria Lamo-Espinosa, Felipe Prosper, Juan F. Blanco, Fermin Sanchez-Guijo, Mercedes Alberca, Veronica Garcia, Margarita Gonzalez-Vallinas, Javier Garcia-Sancho
Summary: The study found that using 10, 40, and 100 million autologous cells for knee osteoarthritis treatment provided similar and long-lasting results, providing strong evidence for the efficacy of single-cell injection therapy.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Mark Jakob, Mario Hambrecht, Jennifer L. Spiegel, Julia Kitz, Martin Canis, Ralf Dressel, Katrin Streckfuss-Bomeke
Summary: A multimodal therapeutic approach involving radiotherapy is essential for treating head and neck squamous cell carcinoma, but its use is limited due to the risk of damaging surrounding healthy tissue. Mesenchymal stem cells show promising therapeutic potential in cell-based tissue engineering and regenerative medicine due to their immunomodulatory properties. Generating induced pluripotent stem cell-derived mesenchymal stem cells in an autologous manner could be a novel personalized treatment option in regenerative medicine.
Review
Medicine, Research & Experimental
Robin Augustine, Pan Dan, Anwarul Hasan, Israa Magdi Khalaf, Parvathy Prasad, Kajal Ghosal, Carmine Gentile, Lana McClements, Pablo Maureira
Summary: Cardiovascular disease is a major cause of death globally, with promising cardiac tissue engineering strategies using biomaterial scaffolds and stem cells. Differentiated stem cells from various sources have the potential to repair damaged heart tissue. The stem cell microenvironment plays a crucial role in maintaining stemness and directing differentiation into cardiac-specific cell lineages within tissue engineering platforms.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Randal C. Paniello, Sarah Brookes, Hongji Zhang, Stacey Halum
Summary: Autologous muscle progenitor (stem) cells can improve the muscle function of patients with bilateral vocal fold paralysis. This study found that implantation of stem cells into the posterior cricoarytenoid muscles led to reduced glottal resistance and increased muscle strength. However, further research is needed to determine the optimal number of cells and timing of implantation.
Article
Medicine, Research & Experimental
Marina Vivarelli, Manuela Colucci, Mattia Algeri, Federica Zotta, Francesco Emma, Ines L'Erario, Marco Busutti, Stefano Rota, Chiara Capelli, Martino Introna, Marta Todeschini, Federica Casiraghi, Annalisa Perna, Tobia Peracchi, Andrea De Salvo, Nadia Rubis, Franco Locatelli, Giuseppe Remuzzi, Piero Ruggenenti
Summary: This study evaluated the therapeutic effects and immunomodulatory properties of autologous bone marrow-derived MSCs in children and young adults with severe steroid-dependent nephrotic syndrome. The results showed that BM-MSC infusion delayed the time to first relapse, reduced the number of relapses, and decreased the use of immunosuppressive drugs in treated children. No treatment benefit was observed in adults. Moreover, immunomodulatory studies suggested that repeating MSC infusions at 3-6 months may sustain the therapeutic benefits.
Article
Multidisciplinary Sciences
Masahide Takedachi, Keigo Sawada, Kazuma Sakura, Chiaki Morimoto, Asae Hirai, Tomoaki Iwayama, Junpei Shimomura, Kohsuke Kawasaki, Chiharu Fujihara, Yoichiro Kashiwagi, Akimitsu Miyake, Tomomi Yamada, Hanayuki Okura, Akifumi Matsuyama, Masahiro Saito, Masahiro Kitamura, Shinya Murakami
Summary: This study evaluated the safety and efficacy of autologous adipose tissue-derived multi-lineage progenitor cell (ADMPC) transplantation for periodontal tissue regeneration. The results showed that ADMPC transplantation reduced probing pocket depth, improved clinical attachment level, and induced neogenesis of alveolar bone, suggesting its potential as a therapy for severe periodontitis.
SCIENTIFIC REPORTS
(2022)
Review
Biotechnology & Applied Microbiology
Robert O. Dillman, Gabriel I. Nistor, Hans S. Keirstead
Summary: Autologous dendritic cell therapy loaded with autologous tumor antigens has shown promising results in treating cancer, particularly metastatic melanoma. Observations from over 200 patients receiving this therapy include high success rates in tumor cell cultures and dendritic cell production, well-tolerated injections, rapid immune response primarily involving TH1/TH17 cells, and efficacy demonstrated by regression of measurable tumors, progression-free survival in glioblastoma, and overall survival in melanoma.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2023)
Article
Hematology
Grace Gifford, Luke Hesson, Jason W. H. Wong, Adam Carroll, Sara Gabrielli, LiJun Bai, Wei Xia, William Stevenson, Matthew Greenwood
Summary: Clonal hematopoiesis of indeterminant potential (CHIP) increases with age and may affect the mobilization of autologous CD34+ peripheral blood stem cells. This study shows that somatic mutations in certain genes can predict poor mobilization of CD34+ PBSC, potentially reducing mobilization and graft failures.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Review
Medicine, Research & Experimental
Zhonglin Li, Ling Yang
Summary: Hematopoietic stem cell transplantation is an established therapy for many diseases, but there are still challenges in inducing stem cell proliferation and maintaining their stemness. This review discusses the latest research progress in autologous hematopoietic stem cells and induced pluripotent stem cells, and explores the application prospects and existing obstacles.
CURRENT RESEARCH IN TRANSLATIONAL MEDICINE
(2023)
Article
Engineering, Biomedical
Ju-Chan Park, Jumee Kim, Hyun-Ki Jang, Seung-Yeon Lee, Keun-Tae Kim, Eun-Ji Kwon, Seokwoo Park, Hyun Sik Lee, Hyewon Choi, Seung-Yeol Park, Hee-Jung Choi, Soon-Jung Park, Sung-Hwan Moon, Sangsu Bae, Hyuk-Jin Cha
Summary: This study successfully established multiple isogenic disease models of GNE myopathy by using base editors to construct hPSCs. Different mutations in different domains of the GNE gene were found to cause mutation-specific hyposialylation and gene expression changes, which were closely related to pathological clinical phenotypes. Furthermore, treatment with a drug candidate currently under clinical trials showed a mutation-specific drug response in GNE myopathy disease models.
Article
Veterinary Sciences
Aileen L. Rowland, Madison E. Burns, Gwendolyn J. Levine, Ashlee E. Watts
Summary: Research shows that there are significant differences between MSCs prepared with FBS and MSCs prepared without FBS, with FBS-prepared MSCs causing inflammation and antibody-mediated cytotoxicity. Additionally, the efficacy of FBS-prepared MSCs in treatment is reduced. Therefore, it is recommended to no longer use FBS in the preparation of MSCs.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Medicine, Research & Experimental
Maggie A. Kuhn, Amanda B. Black, M. Tausif Siddiqui, Jan A. Nolta, Peter C. Belafsky
Editorial Material
Cell & Tissue Engineering
Jan A. Nolta
Article
Neurosciences
Missy T. Pham, Kari M. Pollock, Melanie D. Rose, Whitney A. Cary, Heather R. Stewart, Ping Zhou, Jan A. Nolta, Ben Waldau
Article
Orthopedics
Alvin K. Shieh, Sohni G. Singh, Connor Nathe, Evan Lian, Dominik R. Haudenschild, Jan A. Nolta, Cassandra A. Lee, Eric Giza, Christopher D. Kreulen
Editorial Material
Cell & Tissue Engineering
Jan A. Nolta
Article
Cell & Tissue Engineering
Oliver Yuan, Clayton Lin, Joseph Wagner, Joehleen A. Archard, Peter Deng, Julian Halmai, Gerhard Bauer, Kyle D. Fink, Brian Fury, Nicholas H. Perotti, Jon E. Walker, Kari Pollock, Michelle Apperson, Janelle Butters, Peter Belafsky, D. Gregory Farwell, Maggie Kuhn, Jan Nolta, Johnathon D. Anderson
STEM CELLS AND DEVELOPMENT
(2019)
Article
Cell & Tissue Engineering
Elizabeth Cortez-Toledo, Melanie Rose, Emmanuel Agu, Heather Dahlenburg, Wei Yao, Jan A. Nolta, Ping Zhou
STEM CELLS AND DEVELOPMENT
(2019)
Article
Hematology
Fernando A. Fierro, Nataly Magner, Julie Beegle, Heather Dahlenburg, Jeannine Logan White, Ping Zhou, Karen Pepper, Brian Fury, Dane Philip Coleal-Bergum, Gerhard Bauer, William Gruenloh, Geralyn Annett, Christy Pifer, Jan A. Nolta
Article
Cell & Tissue Engineering
Kewa Gao, Priyadarsini Kumar, Elizabeth Cortez-Toledo, Dake Hao, Lizette Reynaga, Melanie Rose, Chuwang Wang, Diana Farmer, Jan Nolta, Jianda Zhou, Ping Zhou, Aijun Wang
STEM CELL RESEARCH & THERAPY
(2019)
Article
Biochemistry & Molecular Biology
Megan R. Showalter, Benjamin Wancewicz, Oliver Fiehn, Joehleen A. Archard, Shannon Clayton, Joseph Wagner, Peter Deng, Julian Halmai, Kyle D. Fink, Gerhard Bauer, Brian Fury, Nicholas H. Perotti, Michelle Apperson, Janelle Butters, Peter Belafsky, Gregory Farwell, Maggie Kuhn, Jan A. Nolta, Johnathon D. Anderson
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Cell & Tissue Engineering
Jan A. Nolta, Jacques Galipeau, Donald G. Phinney
Editorial Material
Cell & Tissue Engineering
Jan A. Nolta
Editorial Material
Cell & Tissue Engineering
Jan A. Nolta
Article
Cell & Tissue Engineering
Guido Moll, James A. Ankrum, Scott D. Olson, Jan A. Nolta
Summary: The number and types of mesenchymal stromal/stem cell (MSC) therapeutics and clinical applications have greatly increased, but there is also a risk of poorly regulated Stem Cell Clinics offering unproven interventions. It is important to critically evaluate the identity and suitability of MSC products for safe intravascular administration.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Editorial Material
Cell & Tissue Engineering
Daniel J. Weiss, Anthony Filiano, Jacques Galipeau, Maroun Khoury, Mauro Krampera, Manoj Lalu, Katarina Le Blanc, Jan Nolta, Donald G. Phinney, Patricia R. M. Rocco, Yufang Shi, Karin Tarte, Sowmya Viswanathan, Ivan Martin