The nature of chemical innovation: new enzymes by evolution

Expanding the Enzyme Universe: Accessing Non-Natural Reactions by Mechanism-Guided Directed Evolution

(2015) Hans Renata et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Enzyme-Catalyzed Aziridination Enabled by Active-Site Evolution of a Cytochrome P450

(2015) Christopher C. Farwell et al.   ACS Central Science

Non-natural Olefin Cyclopropanation Catalyzed by Diverse Cytochrome P450s and Other Hemoproteins

(2014) Thomas Heel et al.   CHEMBIOCHEM

Expanding P450 catalytic reaction space through evolution and engineering

(2014) John A McIntosh et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Connectivity between Catalytic Landscapes of the Metallo-β-Lactamase Superfamily

(2014) Florian Baier et al.   JOURNAL OF MOLECULAR BIOLOGY

Enzyme-Controlled Nitrogen-Atom Transfer Enables Regiodivergent C–H Amination

(2014) Todd K. Hyster et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Imidation of Sulfides via Enzyme-Catalyzed Intermolecular Nitrogen-Atom Transfer

(2014) Christopher C. Farwell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

P450-Catalyzed Intramolecular sp3 C–H Amination with Arylsulfonyl Azide Substrates

(2014) Ritesh Singh et al.   ACS Catalysis

Enantioselective Intramolecular CH Amination Catalyzed by Engineered Cytochrome P450 Enzymes In Vitro and In Vivo

(2013) John A. McIntosh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Flexibility and Reactivity in Promiscuous Enzymes

(2013) Pietro Gatti-Lafranconi et al.   CHEMBIOCHEM

Molecular Engineering of Organophosphate Hydrolysis Activity from a Weak Promiscuous Lactonase Template

(2013) Monika M. Meier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo

(2013) Pedro S Coelho et al.   Nature Chemical Biology

Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes

(2012) P. S. Coelho et al.   SCIENCE

Catalytic C–H functionalization by metalloporphyrins: recent developments and future directions

(2010) Hongjian Lu et al.   CHEMICAL SOCIETY REVIEWS

What makes an enzyme promiscuous?

(2010) Ann Babtie et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Enzyme (re)design: lessons from natural evolution and computation

(2009) John A Gerlt et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Protein Dynamism and Evolvability

(2009) N. Tokuriki et al.   SCIENCE