Journal
LANGMUIR
Volume 30, Issue 28, Pages 8551-8557Publisher
AMER CHEMICAL SOC
DOI: 10.1021/la501080c
Keywords
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Funding
- National Research Foundation of Korea - Ministry of Education, Science, and Technology (MEST) [NRF-2012R1A2A2A01017435]
- Korea Health Promotion Institute [HI12C0851020014] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2012R1A2A2A01017435, 22A20130000065] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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In this study, we propose a new scaffold fabrication method, direct electro-hydrodynamic jet process, using the initial jet of an electrospinning process and ethanol media as a target. The fabricated three-dimensional (3D) fibrous structure was configured with multilayered microsized struts consisting of randomly entangled micro/nanofibrous architecture, similar to that of native extracellular matrixes. The fabrication of the structure was highly dependent on various processing parameters, such as the surface tension of the target media, and the flow rate and weight fraction of the polymer solution. As a tissue regenerative material, the 3D fibrous scaffold was cultured with preosteoblasts to observe the initial cellular activities in comparison with a solid-freeform fabricated 3D scaffold sharing a similar structural geometry. The cell-culture results showed that the newly developed scaffold provided outstanding microcellular environmental conditions to the seeded cells (about 3.5-fold better initial cell attachment and 2.1-fold better cell proliferation).
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