Journal
LANGMUIR
Volume 30, Issue 50, Pages 15041-15046Publisher
AMER CHEMICAL SOC
DOI: 10.1021/la503720b
Keywords
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Funding
- Fundamental Research Funds for the Central Universities [2242014R30023, 2242014K40002]
- National Natural Science Foundation of China [21405014]
- Natural Science Foundation of Jiangsu [BK20140619]
- Science and Technology Development Program of Suzhou [ZXY201439]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1222]
- Technology Invocation Team of the Qinglan Project of Jiangsu Province
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We report a method for the bottom-up fabrication of paper-based capillary microchips by the blade coating of cellulose microfibers on a patterned surface. The fabrication process is similar to the paper-making process in which an aqueous suspension of cellulose microfibers is used as the starting material and is blade-coated onto a polypropylene substrate patterned using an inkjet printer. After water evaporation, the cellulose microfibers form a porous, hydrophilic, paperlike pattern that wicks aqueous solution by capillary action. This method enables simple, fast, inexpensive fabrication of paper-based capillary channels with both width and height down to about 10 mu m. When this method is used, the capillary microfluidic chip for the colorimetric detection of glucose and total protein is fabricated, and the assay requires only 0.30 mu L of sample, which is 240 times smaller than for paper devices fabricated using photolithography.
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