Article
Biochemistry & Molecular Biology
Cyrielle Garreau, Corinne Gablin, Didier Leonard, Thierry Delair, Guillaume Sudre, Stephane Trombotto
Summary: This study describes an innovative method for regiospecific chemical grafting of chitosan oligomers onto silicon wafers. The grafting conditions were optimized to achieve functionalized surfaces, which were fully characterized. The study also showed that the addition of a reducing agent could improve grafting density and stability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Wei Zhao, Wenjie Zou, Fengyang Liu, Fang Zhou, N. Emre Altun
Summary: The effect of grafting rate on the water solubility of chitosan-grafted polyacrylamide (Chi-gPAM) was investigated using molecular dynamics simulations. The results showed that the intramolecular hydrogen bonding of Chi-gPAM played a dominant role in its water solubility. Additionally, the interaction between Chi-gPAM and water increased with grafting rate.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING
(2024)
Article
Materials Science, Multidisciplinary
Pedro M. Alves, Ruben F. Pereira, Beatriz Costa, Natalia Tassi, Catia Teixeira, Victoria Leiro, Claudia Monteiro, Paula Gomes, Fabiola Costa, M. Cristina L. Martins
Summary: In this study, a highly efficient reaction method, TNPC, was explored for grafting AMP onto chitosan, resulting in the fabrication of antibacterial biomaterials with high conjugation yield.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Engineering, Biomedical
Diana R. Fonseca, Ana Moura, Victoria Leiro, Ricardo Silva-Carvalho, Berta N. Estevinho, Catarina L. Seabra, Patricia C. Henriques, Monica Lucena, Catia Teixeira, Paula Gomes, Paula Parreira, M. Cristina L. Martins
Summary: The bioengineered approach of grafting MSI-78A onto chitosan microspheres enhances its bactericidal performance against Helicobacter pylori. The conjugation does not compromise the antimicrobial activity of MSI-78A and even boosts its effectiveness against H. pylori, making it a potential alternative for antibiotic therapy.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Chemical
Keitumetse Cathrine Monyake, Lana Alagha
Summary: This study investigated the use of a novel polymer, Chi-g-PAM, as a depressant for pyrite in the flotation process of base metal sulfide minerals. The synthesized polymer showed high selectivity towards pyrite, potentially improving the separation efficiency of valuable base metal sulfides. Experimental results suggested that Chi-g-PAM could outperform traditional depressants in producing less pyrite-diluted flotation concentrates.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Polymer Science
Flavien Mouillard, Tom Ferte, Emilie Voirin, Stephane Mery, Patrick Masson, Adele Carrado
Summary: The characterization of polymer chains grafted onto substrates is challenging and requires the selective cleavage of chains without polymer degradation for analysis. This study presents a technique for the selective cleavage of PMMA grafted onto titanium substrate using an anchoring molecule combining an ATRP initiator and a UV-cleavable moiety. The technique demonstrates the efficiency of ATRP on titanium substrates and verifies the homogeneous growth of the chains.
Article
Chemistry, Multidisciplinary
Hanene Belkahla, Andrei Alexandru Constantinescu, Tijani Gharbi, Florent Barbault, Alexandre Chevillot-Biraud, Philippe Decorse, Olivier Micheau, Miryana Hemadi, Souad Ammar
Summary: TRAIL is a promising agent for cancer therapy as it can induce apoptosis in tumor cells while sparing normal cells. Attaching TRAIL to nanoparticles enhanced its therapeutic effect, with CO-TRAIL@NPs-NH showing a stronger pro-apoptotic effect. Computational studies indicated that attachment to nanoparticles does not affect DR4 recognition.
Article
Polymer Science
Maria Giulia Faga, Donatella Duraccio, Mattia Di Maro, Christelle Kowandy, Giulio Malucelli, Federico Davide Mussano, Tullio Genova, Xavier Coqueret
Summary: Surface functionalization of materials using chitosan via electron-beam irradiation technique showed that high ATZ loadings can negatively impact both the irradiation process and chitosan grafting reaction. The presence of oxidised species during the irradiation process is believed to have a detrimental effect on cell viability, despite promoting cell adhesion through electrostatic interactions.
Article
Biochemistry & Molecular Biology
Mohamed A. Mohamady Hussein, Jose Manuel Olmos, Michal K. Pieranski, Mariusz Grinholc, Eva Miriam Buhl, Oguzhan Gunduz, Ahmed M. Youssef, Carlos M. Pereira, Ibrahim M. El-Sherbiny, Mosaad Megahed
Summary: The present study proposes two unique systems for combining Ag, chitosan (CS), and gallic acid (GA) into a single particulate nanostructure using free radical-induced grafting reactions. The grafting of GA into CS-AgNPs was confirmed, and the obtained hybrid NPs II showed lower toxicity, higher antioxidant, and antibacterial activity compared to other samples. The results suggest that grafting GA to CS-AgNPs is a unique process with potential future applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Weronika Szczesna, Justyna Ciejka, Lilianna Szyk-Warszynska, Ewelina Jarek, Kazimiera A. Wilk, Piotr Warszynski
Summary: This up-to-date review focuses on the design, fabrication approaches, properties, and applications of hydrophobically decorated polyelectrolytes (HD-PEs). The chemical structure, self-assembling behavior, and interfacial properties of HD-PEs are influenced by the overall hydrophobicity, as well as the length, number, and type of side chains and ionizable groups. The linking entity structure between the hydrophobic side chain and the charged polyelectrolyte backbone plays a crucial role in the self-aggregation behavior in water and at interfaces.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Physical
Christian A. Contreras, Ryan A. Hackler, Justin M. Notestein, Peter C. Stair
Summary: Organic ligands grafted onto oxide surfaces are used for various applications, and their structure provides the opportunity to encode information onto surfaces. Through surface enhanced Raman spectroscopy, the molecular structure and orientation of chiral 1,1'-bi-2-naphthol (BINOL) supported on TiO2 and Al2O3 were probed. The results indicate differences in the orientation of BINOL on TiO2 and Al2O3 surfaces, suggesting strategies for the development of new functional hybrid and oxide materials.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Biochemistry & Molecular Biology
Alenka Vesel, Nina Recek, Rok Zaplotnik, Albert Kurincic, Katja Kuzmic, Lidija Fras Zemljic
Summary: This study presents a method for immobilizing an antibacterial chitosan coating on polymeric urinary medical catheters using a two-step plasma-treatment procedure. The plasma treatment modifies the polymer surface to enhance the adsorption and binding of chitosan, resulting in a successful immobilization of the coating.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Zhiguo Jiang, Jiaolong Wang, Dong Xiang, Zhengke Zhang
Summary: In this study, p-hydroxybenzoic acid-grafted chitosan (PA-g-CS) conjugates with different grafting degrees were synthesized and developed into films. The PA-g-CS films showed comprehensive performance improvements compared to the chitosan films and exerted a beneficial effect on the quality of fresh-cut jackfruit.
Article
Biochemistry & Molecular Biology
Na Liu, Shuzhen Ni, Hailong Gao, Yongjie Chang, Yingjuan Fu, Wenxia Liu, Menghua Qin
Summary: By using biografting technique, a multifunctional chitosan copolymer, Lac/LG-CTS, with enhanced antioxidant property, hydrophobicity, and moisture barrier property, was successfully prepared. Although the swelling capacity and acid solubility of the copolymer film decreased significantly, the tensile strength and elongation were slightly weakened.
Article
Biochemistry & Molecular Biology
Wenying Liao, Xiaoli Liu, Qing Zhao, Zhanhui Lu, Anqi Feng, Xin Sun
Summary: This study investigated the properties and antibacterial activity of antimicrobial films prepared from chitosan, bacterial cellulose, and e-polylysine. The results showed that the addition of 0.5% e-polylysine improved the texture stability and tensile strength of the films, as well as exhibited good antibacterial properties and a certain effect in delaying the deterioration of certain foods.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Elza Chu, Tashnia Babar, Michael F. Bruist, Alexander Sidorenko
ACS APPLIED MATERIALS & INTERFACES
(2015)
Article
Nanoscience & Nanotechnology
Oleg Davydovich, Elza Chu, Zachary Friar, Detlef-M Smilgies, Preston Moore, Alexander Sidorenko
ACS APPLIED MATERIALS & INTERFACES
(2018)
Article
Biophysics
Manasi Chawathe, Atithi Patel, Sriramakamal Jonnalagadda, Alexander Sidorenko
Article
Biophysics
Manasi Chawathe, Atithi Patel, Sriramakamal Jonnalagadda, Alexander Sidorenko
Article
Nanoscience & Nanotechnology
Desirae L. Hall-Edgefield, Tony Shi, Kimmy Nguyen, Alexander Sidorenko
ACS APPLIED MATERIALS & INTERFACES
(2014)
Article
Polymer Science
Timothy P. Enright, Daniel Hagaman, Maryana Kokoruz, Natalia Coleman, Alexander Sidorenko
JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS
(2010)
Article
Polymer Science
Daniel Hagaman, Timothy P. Enright, Alexander Sidorenko
Article
Chemistry, Multidisciplinary
Vrushali Waknis, Elza Chu, Roxana Schlam, Alexander Sidorenko, Sherif Badawy, Shawn Yin, Ajit S. Narang
PHARMACEUTICAL RESEARCH
(2014)
Article
Polymer Science
Daniel Hagaman, Jacob Gredzik, Patricia A. Peart, J. Michael McCaffery, John D. Tovar, Alexander Sidorenko
Article
Materials Science, Multidisciplinary
Andrea M. Della Pelle, Ashok Maliakal, Alexander Sidorenko, S. Thayumanavan
Article
Polymer Science
Gia Storti, Rebekah Jauhola-Straight, James R. Hannigan, Alexander Sidorenko
Summary: Hybrid molecular brushes (HMBs) are polymeric constructs with a linear polymeric backbone and polymeric side chains, while hybrid-block graft copolymers (HCPs) have a backbone consisting of more than one polymer. In this study, we developed a facile method for synthesizing amphiphilic, biodegradable HCPs composed of a hydrophilic block of poly(ethylene glycol) and a hydrophobic block of poly(2-oxazolines) modified by side chains of polycaprolactone. We determined the critical micelle concentration, investigated the uptake and partitioning of beta-carotene in the micelles, and studied the brush architecture of the HCPs.
Article
Chemistry, Medicinal
Timothy P. Enright, Dominic L. Garcia, Gia Storti, Jason E. Heindl, Alexander Sidorenko
Summary: Infections caused by multidrug-resistant Gram-negative bacteria are a urgent global health threat and efforts are being made to develop new antibiotics and understand resistance mechanisms. Anti-Microbial Peptides (AMPs) are being explored as a novel drug design strategy due to their broad spectrum activity and efficacy against resistant organisms. However, naturally occurring AMPs have limitations, leading to the development of synthetic analogs with optimal selectivity. This study focuses on the development of chitosan-graft-polypeptide structures as novel antimicrobial agents, which showed activity against clinically significant pathogens and disrupted biofilm formation.
Article
Materials Science, Multidisciplinary
Gia Storti, Giulia Romano, Kristen Gilmore, Nicholas Sadowski, Andrii Tiiara, Igor Luzinov, Alexander Sidorenko
Summary: This study investigates the effect of polymer architectures on skin permeability. It is found that the structure of the polymer is related to the skin permeation characteristics, with critical micelle concentration and particle size being important factors. Comparing with homopolymer, amphiphilic block copolymers show partial permeation, while hybrid block-graft copolymers exhibit complete penetration. Therefore, by designing the polymer structure, the delivery of therapeutic agents through the skin can be improved.
Article
Nanoscience & Nanotechnology
Manasi Chawathe, Darya Asheghali, Sergiy Minko, Sriramakamal Jonnalagadda, Alexander Sidorenkeo
ACS APPLIED BIO MATERIALS
(2020)