Journal
LANGMUIR
Volume 29, Issue 46, Pages 14101-14107Publisher
AMER CHEMICAL SOC
DOI: 10.1021/la4033332
Keywords
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Funding
- National Natural Science Foundation of China [50830106, 21174126, 51103126, 51333005, 21374095]
- China National Funds for Distinguished Young Scientists [51025312]
- National Basic Research Program of China [2011CB606203]
- Open Project of State Key Laboratory of Supramolecular Structure and Materials [SKLSSM201316]
- Research Fund for the Doctoral Program of Higher Education of China [20110101110037, 20110101120049]
- Qianjiang Excellence Project of Zhejiang Province [2013R10035]
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The design of positively, charged ultrathin films for surface modification is of crucial importance for biomedical applications. Herein, we report the layer-by-layer assembly of pure positively charged ultrathin films based on the host-guest interaction of cucurbit[8]uril (CB[8]). Two positively charged poly(ethylenimine)s (PEI) functionalized with guest moieties methyl viologen (MV) and indole (ID) were alternately assembled with the formation of CB[8] ternary complex under basic conditions. The growth of the (PEI-MV@CB[8]/PEI-ID) films was monitored by spectroscopic ellipsometry and quartz crystal microbalance. The morphology and structure of the films were characterized by scanning electron microscopy and UV-vis spectroscopy, respectively. These positively charged (PEI-MV@CB[8]/PEI-ID) films were very stable in the pH range from 4 to 9 but disassembled immediately when subjected to a competitive guest adamantylamine. Finally, the films were successfully employed as nanocontainers for DNA loading and subsequent directing the transfection of the adhered cells.
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