Article
Chemistry, Multidisciplinary
Jialing Hu, Bingjie Zhao, Rongrong Wen, Xuebo Zhang, Yunxiang Zhang, Daniel S. S. Kohane, Qian Liu
Summary: Researchers have developed a new design strategy using a squaraine-based dye to enhance the light absorption ability and stability of upconversion nanoparticles. The dye, SQ-739, has a maximum absorption at 739 nm and shows improved chemical- and photostability compared to the commonly used cyanine-based dye IR-806. The study provides a new approach for developing highly stable and efficient NIR upconversion probes.
Article
Chemistry, Applied
Jianyang Zang, Wan Feng, Xingmao Chang, Ke Liu, Haonan Peng, Liping Ding, Taihong Liu, Yu Fang
Summary: The drastic changes in two-photon absorption coefficients resulting from slight changes of electronic delocalization through coordination interaction play a significant role in enhancing the nonlinear optical properties of multi-chromophore structures. Experimental results demonstrate that the 2PA phenomenon is the dominant factor contributing to the NLO properties of the complexes, with the values of degenerate 2PA cross sections being noticeably enhanced by coordination interactions. Importantly, the complexes exhibit high 2PA values and multiple excitation wavelengths, potentially offering a novel approach for creating useful nonlinear absorbing materials.
Article
Chemistry, Physical
Olga A. Mass, Christopher K. Wilson, German Barcenas, Ewald A. Terpetschnig, Olena M. Obukhova, Olga S. Kolosova, Anatoliy L. Tatarets, Lan Li, Bernard Yurke, William B. Knowlton, Ryan D. Pensack, Jeunghoon Lee
Summary: This study investigates the influence of dye hydrophobicity on the strength of excitonic coupling in squaraine aggregates templated by DNA Holliday Junction. It shows a strong correlation between squaraine hydrophobicity and the strength of excitonic coupling, with dimers of dichloroindolenine squaraine exhibiting the strongest coupling strength. The research provides insights into how dye structures affect excitonic coupling in dye aggregates templated by DNA, offering guidance for the design of exciton-based materials and devices.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Chemistry, Multidisciplinary
Daniel Timmer, Fulu Zheng, Moritz Gittinger, Thomas Quenzel, Daniel C. Luenemann, Katrin Winte, Yu Zhang, Mohamed E. Madjet, Jennifer Zablocki, Arne Luetzen, Jin-Hui Zhong, Antonietta De Sio, Thomas Frauenheim, Sergei Tretiak, Christoph Lienau
Summary: Squaraines are quadrupolar charge-transfer chromophores that have attracted much attention due to their applications in solution-processed photovoltaics, fluorescent probes, and aggregates. Through experimental and theoretical investigations, we found that squaraines have small Huang-Rhys factors, indicating weak vibronic coupling. This makes squaraines interesting for studying strong coupling between excitons and localized light modes.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Review
Pharmacology & Pharmacy
Le Zeng, Ling Huang, Gang Han
Summary: Phototherapy is a noninvasive cancer treatment that utilizes the interaction between light and photoactive agents. The use of functional dye-doped metal-organic frameworks (MOFs) in phototherapy has attracted significant interest due to the enhanced treatment efficacy. This review focuses on the emerging development of phototherapeutic MOFs that outperform the involved dye units, as well as the related mechanisms and future directions.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Chemistry, Physical
Christoph Lambert, Joscha Hoche, Maximilian H. Schreck, Marco Holzapfel, Alexander Schmiedel, Joshua Selby, Arthur Turkin, Roland Mitric
Summary: In this study, a squaraine heterotriad composed of three different covalently linked squaraine chromophores was synthesized, and its absorption spectra were analyzed using Kasha's exciton coupling theory. Experimental and simulation results indicate that energy transfer from one terminal squaraine chromophore to another occurs within 30 fs. The study also highlights the relationship between internal conversion and energy transfer in the intermediate to weak coupling regime, attributed to excitation localization caused by molecular vibrations.
JOURNAL OF PHYSICAL CHEMISTRY A
(2021)
Article
Spectroscopy
Vladimir Stamentovic, Daniel Collado, Ezequiel Perez-Inestrosa
Summary: An aminonaphthalimide-squaraine non-conjugated system was designed and synthesized for fluorescent imaging in the 650-700 nm region via energy transfer between covalently linked naphthalimide and squaraine chromophores. The molecule exhibited efficient accumulation in the cytoplasm of N13 Microglial cells, indicating its potential as a subcellular probe for fluorescence imaging in both one- and two-photon excitation modes. The optical behavior, two-photon absorption spectrum, and fluorescence properties were thoroughly characterized using spectroscopic techniques, demonstrating its suitability for biological imaging applications.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Materials Science, Biomaterials
Xiaoli Li, Song Guo, Weixing Deng, Si Wu, Pengfei Sun, Yuanli Liu
Summary: A novel water-soluble squaric acid nanoparticle (SQ-POEGMA) was synthesized in this study, which exhibited low toxicity and excellent photostability. The nanoparticle was constructed by attaching a water-soluble oligomer (POEGMA) to the small molecule squaric acid through a click chemistry reaction. The SQ-POEGMA showed a high photothermal conversion efficiency and effectively inhibited cancer cell growth with a 94% tumor inhibition rate under 808 nm laser irradiation, without causing noticeable side effects.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Applied
Kirill Kniazev, Tianle Guo, Canjia Zhai, Rananjaya S. Gamage, Sushrut Ghonge, Pavel A. Frantsuzov, Masaru Kuno, Bradley Smith
Summary: Squaraine Figure Eight (SF8) dyes are deep-red fluorescent dyes with unique self-threaded molecular architecture, providing structural rigidity and protection for the fluorochrome. Studies have shown that SF8 dyes have significantly higher photostability and improved emission quantum yields, longer times to photobleaching, and enhanced total photon yields at the single molecule level compared to conventional dyes. SF8-based dye SF8(D4)2 exhibits three-fold larger emission quantum yield, order of magnitude longer average times before photobleaching, and twenty times larger photon yields compared to Cy5. These features, along with water solubility, fluorochrome encapsulation, and biomarker targeting capability, make SF8-based dyes promising for biological labeling, microscopy, and single molecule tracking applications.
Article
Chemistry, Physical
Nan Zhang, Lu Liu, Haixia Chang, Ke Liu, Taihong Liu, Liping Ding, Yu Fang
Summary: Versatile coupling theories have been developed to explain the unusual aggregation phenomena of multipolar chromophores. This study investigates the diverse excitonic couplings and tunability of a quadrupolar squaraine dye protonated by trifluoroacetic acid in different solvation media. Subtle changes in the solvent and ion pair lead to significant variations in the aggregation and optical properties of the donor-acceptor-donor (D-A-D)-type SQC6.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Physical
Elena S. Yurina, Natalia Sh. Lebedeva, Aleksey N. Kiselev, Mikhail A. Lebedev, Irina A. Skorobogatkina, Yury A. Gubarev, Sergey A. Syrbu
Summary: Novel water-soluble asymmetric porphyrins containing three sulfo-phenyl fragments and small heterocyclic residues (benzothiazole, benzoxazole, and benzo-N-methylimidazole) were synthesized using metal-complex catalysis. The porphyrins exhibited different behaviors in water, with protonation and self-association processes observed for benzothiazole and benzoxazole residues, and protonation processes dominating for benzo-N-methylimidazole residue. The formation of associates in the porphyrins was found to be due to specific bindings involving sulfo groups and monoheteryl substitutes. Potentiometric titrations were conducted to determine pKa values reflecting the protonation process.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Physical
Krishna Chaitanya Gunturu, Carola Schulzke
Summary: Two sets of anilinosquaraine dye derivatives were computationally analysed, revealing different crystal structures and intermolecular charge transfer effects on the panchromaticity of the materials. Insights into intra-stack and inter-stack interactions based on crystal packing effects were provided, supporting experimentalists in shaping applications of squaraine derivative materials.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2021)
Article
Chemistry, Applied
Junjie Cui, Ji Eon Kwon, Dong Ryeol Whang, Soo Young Park
Summary: A simple and versatile strategy was developed to fabricate a highly luminescent and deep-red emitting supramolecular hydrogel by using water-soluble and highly luminescent bis-pyridine molecule in combination with commercial poly(acrylic acid). The resulting hydrogel has a high water content, homogeneous and transparency, with efficient deep-red fluorescence.
Article
Chemistry, Physical
Ambarish Kumar Singh, Jayaraj Nithyanandhan
Summary: The study explored a series of amphiphilic indoline-based unsymmetrical squaraine dyes, where alkyl groups and glycolic chain were systematically modified to control self-assembly and improve interfacial properties. In nonaqueous DSSCs, increasing the number of carbon atoms in alkyl groups enhanced photovoltaic efficiencies. Addition of chenodeoxycholic acid improved efficiency, while increased carbon atoms in the alkyl groups had a detrimental effect on aqueous DSSC efficiency.
ACS APPLIED ENERGY MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Shekhar Gupta, Yuki Yamawaki, Safalmani Pradhan, Shyam S. S. Pandey, Tamaki Kato
Summary: Novel amine-functionalized symmetrical squaraine dye and FITC-SQ-FITC dye conjugate were successfully synthesized. The symmetrical SQ dye showed complete fluorescence quenching in polar solvents, while the FITC-SQ-FITC dye conjugate exhibited a 47-fold enhancement in far-red fluorescence at 674 nm. This enhancement was attributed to the suppression of aggregation-induced quenching (ACQ) and photoinduced electron transfer (PET). The FITC-SQ-FITC dye conjugate also showed complete quenching of far-red fluorescence in phosphate buffer saline (PBS) due to strong dye aggregation, but it could be reversed by the presence of bovine serum albumin (BSA), resulting in a 117-fold increase in fluorescence.
PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Sylvain David, Hao-Jung Chang, Cesar Lopes, Carl Braennlund, Boris Le Guennic, Gerard Berginc, Eric Van Stryland, Mykailo Bondar, David Hagan, Denis Jacquemin, Chantal Andraud, Olivier Maury
Summary: This study describes aza-boron dipyrromethenes with benzothiadiazole substitutions and investigates the impact of these substitutions on intramolecular charge transfer. The benzothiadiazole moiety enhances accepting strength, leading to improved optical power limiting performances. The substituted dyes show significantly enhanced two-photon absorption, making them a good starting point for further improvement of optical power limiting in the short-wave IR range.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Chemistry, Physical
Karthik Sambath, Xiangshan Liu, Zhaoxiong Wan, Lauren Hutnik, Kevin D. Belfield, Yuanwei Zhang
Summary: This study summarizes a type of fluorescent probe that interacts with potassium ions and generates fluorescence signals. The properties of ionophores and fluorophores, as well as molecular structure design and sensing mechanisms, are discussed, along with applications in cell imaging.
Article
Chemistry, Multidisciplinary
Zhanjun Li, Yang Zhao, Kai Huang, Ling Huang, Yuanwei Zhang, Hong Yang, Gang Han
Summary: The dye-sensitization strategy was found to effectively enhance the renewable PersL signals of NIR emitting ZGC nanoparticles under long-wavelength LED light. This new method enables simultaneous tumor localization and microscopic tumor cell detection in pathological diagnosis during tumorectomy procedure.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Yevgeniy O. Shaydyuk, Nataliia Bashmakova, Andriy M. Dmytruk, Olexiy D. Kachkovsky, Serhii Koniev, Alexander Strizhak, Igor Komarov, Kevin D. Belfield, Mykhailo Bondar, Oleg Babii
Summary: A fluorescently labeled peptide with fast excited state intramolecular proton transfer (ESIPT) was synthesized and comprehensively investigated for its electronic properties, revealing efficient stimulated emission ability and superluminescence properties. The study also involved femtosecond transient absorption pump-probe technique to explore the nature of ESIPT processes in the peptide's chromophore moiety.
Article
Multidisciplinary Sciences
S-C A. Yeh, J. Hou, J. W. Wu, S. Yu, Y. Zhang, K. D. Belfield, F. D. Camargo, C. P. Lin
Summary: This study developed an intravital ratiometric analysis method to measure the extracellular calcium ion concentration and pH in mouse bone marrow. The researchers found that the average calcium ion concentration in the bone marrow was not significantly different from the blood serum, but HSCs were located in areas with elevated local calcium ion concentration. With aging, there was a significant increase in calcium ion concentration in M-type cavities.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Zhaoxiong Wan, Shupei Yu, Qi Wang, John Tobia, Hao Chen, Zhanjun Li, Xuan Liu, Yuanwei Zhang
Summary: A far-red ratiometric HCIO fluorescence probe based on BODIPY chromophore and aldoxime sensing group was developed and demonstrated its feasibility for HCIO monitoring in biosamples. The probe exhibited color change and increased emission ratios upon the introduction of HCIO, and the monitoring was successfully conducted using a confocal microscope.
Article
Chemistry, Physical
Mykhailo Bondar, Sanaz Faryadras, Natalia Munera, Hao-Jung Chang, Mehrun Uddin, Kevin D. Belfield, Olexiy D. Kachkovsky, Eric W. Van Stryland, David J. Hagan
Summary: The linear and nonlinear optical properties of a new squaraine derivative with efficient near-infrared emission were comprehensively analyzed using spectroscopy, photochemistry, two-photon absorption measurements, and quantum chemical analysis. The electronic structure, rotational volumes, and extinction coefficient of the compound were studied, and its superluminescence emission and photostability were also investigated. The results suggest that this squaraine derivative has potential applications in two-photon fluorescent bioimaging and lasing.
JOURNAL OF PHYSICAL CHEMISTRY B
(2022)
Correction
Multidisciplinary Sciences
S-C. A. Yeh, J. Hou, J. W. Wu, S. Yu, Y. Zhang, K. D. Belfield, F. D. Camargo, C. P. Lin
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Judit Morla-Folch, Guillem Vargas-Nadal, Edgar Fuentes, Silvia Illa-Tuset, Mariana Koeber, Cristina Sissa, Silvia Pujals, Anna Painelli, Jaume Veciana, Jordi Faraudo, Kevin D. Belfield, Lorenzo Albertazzi, Nora Ventosa
Summary: The development of bright fluorescent nanoparticles is essential for improving the resolution and signal-to-noise ratio in fluorescence imaging techniques. In this study, we developed FRET-based nanovesicles with different dye loadings and investigated their optical properties at the nanoscopic level. The results show that the dye's molecular diffusion in fluid-like membranes can modulate the optical properties of the nanoparticles, resulting in highly efficient and stable nanoprobes.
CHEMISTRY OF MATERIALS
(2022)
Article
Substance Abuse
Agnieszka Agas, Arun Reddy Ravula, Xiaotang Ma, Yiming Cheng, Kevin D. Belfield, James Haorah
Summary: Hemorrhage is a significant aspect of traumatic brain injury (TBI), and alcohol consumption prior to TBI can alter iron regulation, exacerbate TBI-induced microglia activation, and sustain the expression of regulatory proteins for several days post-injury. Additionally, microglia may play a role in iron management through red blood cell clearance. This study provides valuable insights into the relationship between alcohol and TBI, as well as the importance of iron management in brain injury recovery.
Article
Chemistry, Multidisciplinary
Jie Dou, Shupei Yu, Ojasvita Reddy, Yuanwei Zhang
Summary: A new PEGylated macroiniferter was prepared for the development of temperature-sensitive drug carriers for cancer treatment. The resulting polymers showed low toxicity and high drug release efficiency.
Article
Chemistry, Multidisciplinary
H. Grebel, Shupei Yu, Yuanwei Zhang
Summary: In this study, a new strategy of introducing gold nanoparticles (AuNPs) to the dielectric of a capacitor was used to achieve amplification effect in supercapacitors. The results showed that by keeping the AuNPs in close proximity to the electrodes, substantial amplification of polarization effect can be maintained.
NANOSCALE ADVANCES
(2022)
Article
Chemistry, Multidisciplinary
Yevgeniy O. Shaydyuk, Nataliia V. Bashmakova, George V. Klishevich, Andriy M. Dmytruk, Olexiy D. Kachkovsky, Iaroslav B. Kuziv, Igor Ya. Dubey, Kevin D. Belfield, Mykhailo V. Bondar
Summary: In this research, the properties of coumarin derivatives in terms of their photophysics, photochemistry, fast vibronic relaxations, and two-photon absorption were comprehensively analyzed. The results revealed their unique characteristics such as large Stokes shifts, specific solvatochromic behavior, weak electronic pi -> pi* transitions, and adherence to Kasha's rule. The study also investigated the stability and optical gain potential of the derivatives, as well as their two-photon absorption properties. Quantum-chemical calculations were performed to analyze the electronic nature of these coumarins, which showed agreement with experimental data.
Article
Nanoscience & Nanotechnology
Shupei Yu, Ojasvita Reddy, Alperen Abaci, Yongling Ai, Yanmei Li, Hao Chen, Murat Guvendiren, Kevin D. Belfield, Yuanwei Zhang
Summary: Photobase generators (PBGs) are compounds that utilize light-sensitive chemical-protecting groups to control the release of organic bases upon light irradiation. This study reports two novel BODIPY-based PBGs that are sensitive to visible light and can efficiently activate thiol-ene Michael click reactions and polymerizations. These PBGs exhibit extraordinary activity and can be used in surface coating and polymer network formation using various thiol and vinyl monomers.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Biomaterials
Zhaoxiong Wan, Shupei Yu, Qi Wang, Karthik Sambath, Roshena Harty, Xiangshan Liu, Hao Chen, Chen Wang, Xuan Liu, Yuanwei Zhang
Summary: Far-red BODIPY-based oxime esters were designed and studied for photo-uncaging to release molecules with carboxylic acids. The mechanism and kinetics of the uncaging process were investigated using a 1H NMR spectrometer. In vitro tests demonstrated the drug delivery strategy for releasing valproic acid on demand using this far-red BODIPY photo-uncaging system.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
