Journal
LANGMUIR
Volume 28, Issue 37, Pages 13373-13379Publisher
AMER CHEMICAL SOC
DOI: 10.1021/la301712h
Keywords
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Funding
- NIH [R21RR026235]
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We report the imaging of the cell-substrate adhesion of a single cell with subcellular spatial resolution. Osmotic pressure was introduced to provide a controllable mechanical stimulation to the cell attached to a substrate, and high-resolution surface plasmon resonance microscopy was used to map the response of the cell, from which local cell-substrate adhesion was determined. In addition to high spatial resolution, the approach is noninvasive and fast and allows for the continuous mapping of cell substrate interactions and single-cell movements.
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