Article
Chemistry, Multidisciplinary
Simona Ranallo, Daniela Sorrentino, Elisabetta Delibato, Gianfranco Ercolani, Kevin W. Plaxco, Francesco Ricci
Summary: Here we report the design and optimization of an antibody-responsive, DNA-based device that enables communication between non-interacting proteins. The device recognizes and binds a specific antibody, causing a conformational change that releases a DNA strand regulating the activity of a target protein. We demonstrate the antibody-induced control of thrombin and Taq DNA polymerase, showcasing the versatility of this strategy in regulating protein-protein communication in artificial networks.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Qiong Wu, Yingying Chai, Ridong Huang, Hai Chen, Yang He
Summary: Metallo-base pairs have attracted great interest, but uncertainties remain regarding the interactions between Ag+ and nucleic acid components. A novel base paired ionic crystal CH(+)-NO3- was formed in a complex hydrogel system, instead of the coordinated polymer embedded with Ag+ nanowires. The proton transfer between guanosine (G) and cytidine (C) in this multi-component system was characterized, providing valuable information for bio-inorganic chemistry research involving G- and C-rich genomic sequences.
Article
Chemistry, Multidisciplinary
Yu-Shen Liu, Rajan Deepan Chakravarthy, Abdelreheem Abdelfatah Saddik, Mohiuddin Mohammed, Hsin-Chieh Lin
Summary: This study presents the synthesis of hybrid hydrogels composed of peptide and polymer, and investigates their mechanical properties, pore sizes, and biocompatibility. The results show that the hydrogels with specific peptide-polymer compositions exhibit improved mechanical stiffness and smaller pore sizes compared to the original polymer. The materials are also found to be non-toxic and potentially suitable for biological applications.
Article
Physics, Multidisciplinary
Giorgio Schiro, Yann Fichou, Alex P. S. Brogan, Richard Sessions, Wiebke Lohstroh, Michaela Zamponi, Gerald J. Schneider, Francois-Xavier Gallat, Alessandro Paciaroni, Douglas J. Tobias, Adam Perriman, Martin Weik
Summary: The study revealed that solvent-free protein-polymer hybrids can replace hydration water, preserving protein structure and function, with dynamics similar to water's.
PHYSICAL REVIEW LETTERS
(2021)
Article
Engineering, Biomedical
Xujiao Zhou, Jia Lv, Gang Li, Tingting Qian, Hao Jiang, Jianjiang Xu, Yiyun Cheng, Jiaxu Hong
Summary: The boronic acid-rich polymer can efficiently deliver SOD into retinal cells, reducing oxidative stress and protecting retinal function with high bioactivity and low cytotoxicity. In a retinal ischemia injury model, the SOD nanoformulation demonstrated superior therapeutic efficacy by reducing RGC apoptosis and preserving retinal function.
Article
Multidisciplinary Sciences
Nika Marusic, Lado Otrin, Jonas Rauchhaus, Ziliang Zhao, Fotis L. Kyrilis, Farzad Hamdi, Panagiotis L. Kastritis, Rumiana Dimova, Ivan Ivanov, Kai Sundmacher
Summary: Biomimetic polymer/lipid hybrid compartments have great potential as substitutes for natural liposomes. This study explores the protein-free fusion of these semisynthetic membranes and finds that the membrane mixing of oppositely charged hybrids exceeds that of liposomes. The charge is not the sole determinant of the final adenosine triphosphate synthesis rate, and the fusion strategy can be used for the delivery of membrane proteins and the automation of synthetic cell assembly.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Esmail M. El-Fakharany, Marwa M. Abu-Serie, Noha H. Habashy, Marwa Eltarahony
Summary: There is an urgent need to discover biocompatible nanoformulations with low cytotoxicity in the field of medicine. Bovine lactoperoxidase (LP) and lactoferrin (LF) have shown antitumor activities and are considered safe proteins. Coating or adsorbing LP and LF onto copper and iron nanometals can create stable nanoformulations that enhance immunity and have strong anticancer effects. The combination of LP-CNPs and LF-FNPs exhibited the highest growth inhibitory efficacy and apoptotic effect against cancer cells.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
Diane Bruyere, Patrick Roncarati, Alizee Lebeau, Thomas Lerho, Florian Poulain, Elodie Hendrick, Charlotte Pilard, Celia Reynders, Marie Ancion, Margaux Luyckx, Michael Renard, Yves Jacob, Jean-Claude Twizere, Raphael Peiffer, Olivier Peulen, Philippe Delvenne, Pascale Hubert, Alison McBride, Nicolas Gillet, Murielle Masson, Michael Herfs
Summary: HPV-positive cancers are usually associated with a favorable outcome due to high sensitivity to radiation therapy. However, the impact of viral E6/E7 oncoproteins on cellular radiosensitivity and host DNA repair is still largely speculative.
Article
Polymer Science
Erika Yoshihara, Ahmed Nabil, Shinichi Mochizuki, Michihiro Iijima, Mitsuhiro Ebara
Summary: Temperature-responsive antibody-nanoparticles were prepared by introducing a chain transfer agent into immunoglobulin G and conducting precipitation polymerization of N-isopropylacrylamide in an aqueous medium. The resulting particles showed stability below the LCST and resistance against enzymatic treatment, making them useful for enhancing therapeutic potential of antibody-drug conjugates or immunoassays.
Article
Chemistry, Multidisciplinary
Dong Un Lim, Sae Byeok Jo, Jeong Ho Cho
Summary: The control of electrically heterogeneous charge-transferring interfaces is a popular method for improving the performance of organic photonic devices, but limitations arise from the rapid evolution of organic compounds. A hybrid graphene-organic barristor architecture shows promising results in achieving a highly photosensitive photodetector with rapid responses and a broad linear dynamic range, surpassing current organic photodiodes. This innovative architecture opens new possibilities for designing high-performance photodetectors for future photonics applications.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Biochemistry & Molecular Biology
Maria Sukhanova, Rashid O. Anarbaev, Ekaterina A. Maltseva, David Pastre, Olga Lavrik
Summary: Fused in sarcoma (FUS) is involved in the regulation of RNA and DNA metabolism. FUS undergoes phase transition and forms biomolecular condensates. Nucleic acid polymers and certain nucleic-acid-binding proteins affect the phase behavior of FUS-nucleic acid systems. DNA repair factor XRCC1 coassembles with FUS in the presence of poly(ADP-ribose).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Nan Zhang, Chaoren Yan, Changji Yin, Xiaoling Hu, Ping Guan, Yuan Cheng
Summary: Epigallocatechin-3gallate (EGCG) extracted from green tea is a promising small-molecule drug candidate for Alzheimer's disease. This study used molecular dynamics simulations and experiments to investigate the mechanism of EGCG-induced remodeling of Aβ fibrils.
Article
Polymer Science
Qi Sun, Zhenzhen Yang, Xianrong Qi
Summary: This article summarizes the advantages and challenges of polymer-protein systems in cancer therapy, presents the key considerations in designing polymer-protein systems, and summarizes the development of hybrid polymer-protein systems in cancer therapy over the past decades. Furthermore, it exemplifies the challenges for hybrid polymer-protein systems in cancer therapy and discusses the future perspectives of the field.
Article
Polymer Science
Devendra Kumar, Subrata Dolui, Bhanendra Sahu, Sanjib Banerjee
Summary: This article presents the synthesis of unprecedented amphiphilic block copolymers with dual stimuli-responsiveness. The cloud point of the block copolymers can be tuned by changing the monomer composition. These synthesized copolymers have potential applications in various fields, including stimuli-responsive materials and contaminant removal.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Chemistry, Analytical
Yapiao Li, Fangzhi Yu, Shaokun Chen, Ning Zhang, Hailin Wang, Qiang Zhao
Summary: This study presents an immunoassay mediated by a triply functional DNA probe for detecting small-molecule targets. The method allows for the separation of antibody-probe complexes using capillary electrophoresis (CE) and achieves simple and highly sensitive detection. The approach was demonstrated to simultaneously detect two model small-molecule targets, showing potential for wide applications.
ANALYTICAL CHEMISTRY
(2021)
Article
Polymer Science
Antonina Simakova, Saadyah Averick, Arman Moini Jazani, Krzysztof Matyjaszewski
Summary: This article reports a method for preparing cationic nanogels by atom transfer radical polymerization under inverse microemulsion conditions. The use of a hydrophilic inimer prevents the growth of droplets during polymerization. The surface functionality of the nanogels can be modulated by applying different reactive surfactants or grafting hydrophilic shells. The synthesized cationic nanogels are biocompatible and have a high complexation ability for plasmid DNA.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Chuao Ma, Jun Wei, Yuqiang Zhang, Xingchao Chen, Chan Liu, Shen Diao, Yuan Gao, Krzysztof Matyjaszewski, Hongliang Liu
Summary: Currently, there is a significant challenge in meeting the increasing demands for conductive ionogels with complex shapes and high processability for next-generation flexible electronics. In this study, highly processable ionogels with mechanical robustness are designed by self-assembly of a common triblock copolymer into a precursor in functional mixed ionic liquids. The viscosity of the self-assembled precursor can be adjusted, making it compatible with various fabrication technologies. By using 3D printing, an auxetic-structured ionogel is easily generated, showing improved sensitivity for monitoring small deformations. This research establishes a new approach for versatile and programmable fabrication of high-performance ionogels, focusing on designing functional mixed ionic liquids rather than synthesizing new polymers.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Mateusz Olszewski, Xiaolei Hu, Ting-Chih Lin, Krzysztof Matyjaszewski, Natalia Lebedeva, Philip Taylor
Summary: Star polymers were synthesized via ARGET ATRP and used as effective stabilizers for Pickering emulsions. The interfacial properties of PEO stars adsorbed at oil-water interfaces were investigated using interfacial tension and interfacial rheology. The results offer important insights into the interfacial rheology of PEO star polymers in the context of their application as stabilizers for Pickering emulsions.
Article
Polymer Science
Kriti Kapil, Arman Moini Jazani, Grzegorz Szczepaniak, Hironobu Murata, Mateusz Olszewski, Krzysztof Matyjaszewski
Summary: Photoinduced ATRP techniques using green light and dual catalysis have been developed for efficient and controlled polymerization. This method allows rapid synthesis of well-defined polymers without the need for deoxygenation, overcoming the limitations of UV light-induced polymerization. The system also enables temporal control and synthesis of various hydrophilic acrylate monomers.
Article
Polymer Science
Guanyi Hou, Yingxue Hao, Ruifeng Jiang, Sai Li, Yonglai Lu, Jun Liu, Liqun Zhang, Krzysztof Matyjaszewski
Summary: The rapidly developing aerospace industry has a severe requirement for rubber components utilized for spacecraft, especially the resistance to extreme temperature differences because of the complex space environment. However, it is difficult to increase the service temperature range of the existing elastomeric materials based on traditional methods. By introducing a new type of long-side chain siloxane, a novel silicone elastomer with an unprecedented wide temperature range (-149-400°C) is designed, which does not introduce other heteroatoms.
Article
Polymer Science
Yi Wang, Francesca Lorandi, Marco Fantin, Krzysztof Matyjaszewski
Summary: Polymerizations in aqueous dispersed media benefit from good heat transfer, low viscosity, low content of volatile compounds, and established industrial use. The implementation of ATRP in dispersed media has highlighted the possibility of achieving improved livingness and producing a variety of macromolecular architectures. ATRP techniques employing low-ppm catalyst loadings have enabled access to a larger variety of polymer architectures and functional polymer particles, which have found applications in molecular recognition, drug delivery, bio-quantification, and advanced coatings.
Article
Polymer Science
Yuqi Zhao, Rongguan Yin, Hanshu Wu, Zongyu Wang, Yue Zhai, Khidong Kim, Changwoo Do, Krzysztof Matyjaszewski, Michael R. Bockstaller
Summary: Van der Waals-driven self-healing in copolymers with lock-and-key architecture has been achieved by synthesizing lock-and-key copolymers with prescribed sequences. The recovery behavior of copolymers with different sequences was evaluated, and copolymers with alternating and statistical sequences showed a 10-fold increase in recovery rate compared to copolymers with a gradient sequence. The results provide strategies for designing and synthesizing engineering polymers with both structural and thermal stability and the ability to recover from structural damage.
Article
Chemistry, Multidisciplinary
Yilin Zhang, Liye Fu, Michael R. Martinez, Hui Sun, Valeria Nava, Jiajun Yan, Kurt Ristroph, Saadyah E. Averick, Benedetto Marelli, Juan Pablo Giraldo, Krzysztof Matyjaszewski, Robert D. Tilton, Gregory V. Lowry
Summary: Anticipated increases in extreme temperatures can harm crops, but the use of high aspect ratio polymer bottlebrushes can mitigate these effects by delivering stress-regulating agents to plants. These bottlebrushes have shown efficient uptake in leaves and can release encapsulated agents under elevated temperatures, promoting photosynthesis and providing long-term heat stress protection. They can also move through the phloem to protect other plant organs and manage phloem pathogens, making this delivery platform a valuable tool for protecting plants against climate-induced damage.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Jaepil Jeong, So Young An, Xiaolei Hu, Yuqi Zhao, Rongguan Yin, Grzegorz Szczepaniak, Hironobu Murata, Subha R. Das, Krzysztof Matyjaszewski
Summary: This study presents an approach to convert biomass RNA into an acrylic crosslinker by acyl imidazole chemistry, allowing for the fabrication of materials with tunable properties. It also explores reversible-deactivation radical polymerization methods and metallization of the biomass RNA-based material, expanding the opportunities in biomass-based biomaterial fabrication.
Article
Chemistry, Physical
Yuqi Zhao, Hanshu Wu, Rongguan Yin, Chenxi Yu, Krzysztof Matyjaszewski, Michael R. Bockstaller
Summary: The effect of sequence structure on the self-healing and shape-memory properties of copolymer-tethered brush particle films was investigated. It was found that statistical copolymer sequence provided the most rapid restoration of mechanical properties and an increase of the high T(g) (MMA) component improved the material's modulus while retaining self-healing ability. The reduction of flow in brush systems was attributed to slow cooperative relaxation due to the complex microstructure.
CHEMISTRY OF MATERIALS
(2023)
Article
Polymer Science
Krzysztof Jerczynski, Julita Muszynska, Gokhan Demirci, Onur Cetinkaya, Paulina Filipczak, Grzegorz Nowaczyk, Jaroslaw Grobelny, Krzysztof Matyjaszewski, Marcin Kozanecki, Joanna Pietrasik
Summary: This work reports on the efficient performance of hybrid particles with silver nanoparticles distributed within single polymer molecules as Surface Enhanced Raman Scattering (SERS) supports. Through controlled synthesis methods and structure parameters of polymer templates, the researchers successfully synthesized hybrid particles with star-like topology and achieved stable detection of analytes at nanomolar level.
Article
Polymer Science
Rongguan Yin, Yuqi Zhao, Jaepil Jeong, Jirameth Tarnsangpradit, Tong Liu, So Young An, Yue Zhai, Xiaolei Hu, Michael R. Bockstaller, Krzysztof Matyjaszewski
Summary: Gradient copolymer brush nanoparticles with different compositional ratios were synthesized from surface-modified silica nanoparticles, and they demonstrated better mechanical properties and uniform microstructures.
Article
Chemistry, Multidisciplinary
Izabela Zaborniak, Martyna Korbecka, Zuzanna Michno, Pawel Chmielarz, Krzysztof Matyjaszewski
Summary: In this study, a high molecular weight water-soluble polymer was synthesized through polymerization in a vegetable oil-based inverse emulsion, resulting in low dispersity and high molecular weight. This approach offers advantages in terms of environmental friendliness and can replace toxic organic solvents.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Kostas Parkatzidis, Nghia P. Truong, Krzysztof Matyjaszewski, Athina Anastasaki
Summary: A photocatalytic ATRP depolymerization method is introduced, which lowers the reaction temperature and enables temporal control, achieving high monomer recovery and end-group fidelity.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)