Journal
LANGMUIR
Volume 27, Issue 10, Pages 6528-6533Publisher
AMER CHEMICAL SOC
DOI: 10.1021/la2005612
Keywords
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Funding
- National Aeronautics and Space Administration Cooperative Agreements Cooperative Agreements [NNX08BA47A, NNX10AQ16A]
- National Institutes of Health [P01-HG000205]
- NASA [126807, NNX10AQ16A] Funding Source: Federal RePORTER
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Most of the research in the field of nanopore-based platforms is focused on monitoring ion currents and forces as individual molecules translocate through the nanopore. Molecular gating, however, can occur when target analytes interact with receptors appended to the nanopore surface. Here we show that a solid state nanopore functionalized with polyelectrolytes can reversibly bind metal ions, resulting in a reversible, real-time signal that is concentration dependent. Functionalization of the sensor is based on electrostatic interactions, requires no covalent bond formation, and can be monitored in real time. Furthermore, we demonstrate how the applied voltage can be employed to tune the binding properties of the sensor. The sensor has wide-ranging applications and, its simplest incarnation can be used to study binding thermodynamics using purely electrical measurements with no need for labeling.
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