Review
Polymer Science
Nahir Dib, Cristian M. O. Lepori, N. Mariano Correa, Juana J. Silber, R. Dario Falcone, Luis Garcia-Rio
Summary: This review discusses the formation and application of biocompatible water-in-oil microemulsions known as reverse micelles (RMs), emphasizing the use of biocompatible non-polar solvents and ionic liquids to create organized systems aligned with Green Chemistry principles. The versatility and importance of RMs in drug delivery and food science are highlighted, with a focus on the modification of properties through changes in surfactant and external solvents. The study emphasizes the need for deep analysis to understand the diverse properties of these novel systems.
Article
Thermodynamics
Max Crowder, Isabel Lizarraga, Joshua D. Patterson, Arun K. Sharma
Summary: Reverse micelles are utilized as nanoreactors for various applications, and their structure and dynamics have been extensively studied. In this study, the arrangement of water and dopants in AOT reverse micelles was investigated using molecular dynamics simulations. The results show that Cl- ions are embedded in the aqueous interior, while K+ ions have a strong affinity for the interface. Multiple layers of water and an ordered multi-layer ionic arrangement driven by the negatively charged surfactant headgroup are confirmed.
FLUID PHASE EQUILIBRIA
(2023)
Article
Energy & Fuels
Melanie L. Howe, Titan C. Paul, Jamil A. Khan
Summary: The study focused on the radiative properties of Nanoparticle Enhanced Ionic Liquids (NEILs) with different sizes and shapes of Al2O3 nanoparticles. The addition of nanoparticles increased light absorption capabilities of the ionic liquid, with significant differences observed at smaller concentrations. Different concentrations of NEILs were synthesized to investigate the concentration effect on radiative properties, showing variations in light transmittance based on nanoparticle type and concentration.
SOLAR ENERGY MATERIALS AND SOLAR CELLS
(2021)
Article
Polymer Science
Cesar Soto-Figueroa, Tomas Galicia-Garcia, Maria del Rosario Rodriguez-Hidalgo, Luis Vicente
Summary: Selective ionic load behavior and molecular transfer of a polymeric ionic liquid (PIL) in a biphasic system were investigated using simulations and models. The study found that the PIL can form stable micelles in an aqueous environment and has the ability to selectively separate anionic molecules in a mixture of organic dyes. At high temperatures, the micelles lose stability and transfer to the organic phase. The study contributes to the understanding of selective ionic transfer and micellar shuttle in biphasic systems under temperature effects.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Jocasta Avila, Chiara Corsini, Cintia M. Correa, Martin Rosenthal, Agilio Padua, Margarida Costa Gomes
Summary: This Perspective highlights the pathways to prepare porous ionic liquids using easily accessible materials for reduced environmental impact. The study demonstrates that suspensions of porous solids are stable in eutectic mixtures, which indicates their potential in preparing porous ionic liquids. Porous ionic liquids maintain the wide electrochemical window observed in their precursor pure ionic liquids, making them suitable for green electrochemical reactions, especially those involving gases with enhanced solubility in the porous suspensions. Furthermore, their capacity as gas-rich media suggests potential sustainable biomedical and pharmaceutical applications, provided that non-toxic, biocompatible ionic liquids and porous solids are utilized.
Article
Spectroscopy
Oksana Volkova, Anna Kuleshova, Alexander Saletsky
Summary: This study investigates the dimerization processes and thermodynamic parameters of fluoronic dyes in reverse micelles of AOT with different hydrodynamic radius Rh. The heavy atom effect and linear dependence of dimerization efficiency on Rh were observed. The dimerization reaction in the systems is controlled by enthalpy, with existence of enthalpy-entropy compensation. The higher molecular weight of the halogen contributes to the dimeric stability.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Multidisciplinary
Manuel Rothe, Martin Tress, Carina Allacher, Patrick Nuernberger, Werner Kunz
Summary: The study introduces a simple method to liquefy rare earth metals by incorporating the corresponding cations into polyvalent ionic liquids. It shows that these ILs have remarkably different properties despite the similarity of their cations, and possess interesting luminescent properties as non-conventional fluorophores.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Physical
M. Rothe, G. Quintard, M. Kronseder, P. Bauduin, T. Zemb, W. Kunz
Summary: This study investigates the microstructure of H[C8E5c] and its metal salts using X-ray scattering methods, which shows the existence of spherical micelles in diluted aqueous solutions and the interdigitation of head groups at high concentrations. The study also reveals the arrangement of metal cations between the micelles, which could be responsible for the unique properties of these systems.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Physical
Sunaina, Surinder K. Mehta, Ashok K. Ganguli, Sonalika Vaidya
Summary: This study utilized small-angle X-ray scattering technique to investigate the effect of surfactant structure on the shape, size, and structure of reverse micelles in water-in-oil microemulsions. Different surfactant types formed reverse micelles of different shapes, and appropriate models were selected to fit the SAXS data.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Physical
Andrzej Zywocinski, Piotr Bernatowicz, Damian Pociecha, Ewa Gorecka, Jacek Gregorowicz
Summary: The aggregation behavior of SDS in AMIMCl ionic liquid was studied, with the critical micelle concentration and average aggregation number determined accurately. Water content was found to have minimal impact on the aggregation process of SDS, but did affect the diffusion and chemical shifts of AMIMCl.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Engineering, Chemical
Robert Biro, Andrew J. Daugulis, J. Scott Parent
Summary: This study focuses on the application of imidazolium-based polymeric ionic liquids (PILs) as absorbents in two-phase partitioning bioreactors for the removal of n-butanol from dilute aqueous solutions. The synthesis and phase transition temperatures of poly(1-vinyl-3-alkylimidazolium) bromides with different alkyl groups, architectures, and compositions, as well as analogs with various inorganic and carboxylate anions, are described. Equilibrium experiments are conducted to quantify the solute affinity of each PIL, which is measured by the n-butanol partition coefficient (PCBuOH) and n-butanol/water selectivity (alpha(b/w)). A complete ternary phase diagram is created to propose a streamlined n-butanol recovery process.
Article
Engineering, Chemical
Lie Ma, Chi Zhang, Saisai Lin, Shengfu Chen, Zhikan Yao, Zhilin Sun, Congjie Gao, Lin Zhang
Summary: This study enhanced the antifouling property of polyamide reverse osmosis membranes by tethering the aminated imidazolium cation of ionic liquids onto the membrane surface, resulting in balanced charge, strong hydrophilicity, low protein adsorption, and excellent antifouling behavior. The integration of high performance ionic liquids and mild conditions is expected to expand the application of superb antifouling materials in various biofouling areas.
Article
Chemistry, Physical
Rolf Zeissler, Florian Pabst, Till Boehmer, Thomas Blochowicz
Summary: The shape of the structural relaxation peak in the susceptibility spectra of liquids provides important information about molecular mobilities and dynamic heterogeneity. Recent studies show a generic shape of this peak near the glass transition temperature, reducing the information contained in the peak shape. At higher temperatures, the peak shape varies strongly between different liquids. In this study, we investigate the influence of intramolecular dynamics on the peak shape at these temperatures using depolarized light scattering and dielectric spectroscopy.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Materials Science, Multidisciplinary
Wen-Xin Zhang, Yi-Ru Gao, Rong Xue, William Nguyen, Wei Chen, Jian-Hua Wang, Yang Shu
Summary: Ionic liquids have unique properties and great potential in biomedical applications. They can be used in various aspects of liquid formulations to meet specific application scenarios. Recent research has focused on the applications of ionic liquid-based microemulsions, micelles, vesicles, and solvents in the biomedical field.
MATERIALS TODAY PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Oliver S. Hammond, Naomi S. Elstone, James Doutch, Peixun Li, Karen J. Edler
Summary: This study demonstrates that pure and hydrated deep eutectic solvents (DES) can form self-assembled nanostructures similar to the bicontinuous L(3) phase in ionic liquids (ILs). The addition of surfactant AOT in the DES results in the formation of the L(3) sponge phase, characterized using the Teubner-Strey model. The local structure of the DES changes with increasing solvent water content, forming large, turbid lamellar phases and an L-3-to-L-alpha transition. Multi-contrast SANS fittings reveal that the surfactant headgroup region interacts primarily with poorly-soluble Na+ at low water contents and numerically-superior [cholinium](+) at higher water contents. The modified interfacial Gaussian curvature stabilizes the lamellar morphology, allowing for an increase in the bilayer aggregation number.
Article
Chemistry, Multidisciplinary
Jorge A. Gutierrez, M. Laura Japas, Juana J. Silber, R. Dario Falcone, N. Mariano Correa
Summary: Through the use of different alcohols in AOT reverse micelles, the study explores the interfacial activity and determines n-pentanol as the best cosurfactant that interacts with SO3- through H-bonds, altering the micellar interface curvature. The findings suggest that F-pentanol forms a polar core in RMs without affecting the AOT RM interface, paving the way for the creation of supercritical RMs without modified surfactants or fluorinated compounds.
Article
Chemistry, Physical
Jessica Otarola, Patricia G. Molina, Mariano Garrido, N. Mariano Correa
Summary: A detailed spectroscopic study was conducted to analyze the interaction between an active principle and a lipid-based drug delivery system. The study found that not all PX molecules were fully incorporated into the carrier system, with some molecules located inside the lipid core and others outside the nanocarrier. Spectroscopic techniques revealed the structural behavior of PX species, indicating that the enolic structure was predominant both inside and outside the NLCs.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Review
Polymer Science
Nahir Dib, Cristian M. O. Lepori, N. Mariano Correa, Juana J. Silber, R. Dario Falcone, Luis Garcia-Rio
Summary: This review discusses the formation and application of biocompatible water-in-oil microemulsions known as reverse micelles (RMs), emphasizing the use of biocompatible non-polar solvents and ionic liquids to create organized systems aligned with Green Chemistry principles. The versatility and importance of RMs in drug delivery and food science are highlighted, with a focus on the modification of properties through changes in surfactant and external solvents. The study emphasizes the need for deep analysis to understand the diverse properties of these novel systems.
Article
Chemistry, Physical
Jorge A. Gutierrez, Juana J. Silber, R. Dario Falcone, N. Mariano Correa
Summary: A simple modified methodology based on cationic reverse micelles was used to obtain gold nanoparticles with different morphologies and surface plasmon resonance. The gold nanoparticles showed clear crystallinity changes on different faces in the same solution, with two well-defined and intense absorption bands, making them potentially useful in cancer treatments through photothermic therapy.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Physical
Matias A. Crosio, Juana J. Silber, F. Eduardo Moran Vieyra, R. Dario Falcone, Claudio. D. Borsarelli, N. Mariano Correa
Summary: The study found that the interaction between ILs and water is primarily influenced by the size of the IL components, particularly the cation size. In some IL-water mixtures, the molecular probe 4-AP is mostly solvated by the IL, even at a low IL molar fraction.
JOURNAL OF PHYSICAL CHEMISTRY B
(2021)
Article
Chemistry, Physical
Jhon F. M. Sanchez, Miguel D. Sanchez, R. Dario Falcone, Hernan A. Ritacco
Summary: This study investigated the synthesis of metallic nanoparticles in microemulsions, finding a linear relationship between particle size and reaction rate, rather than a direct correlation with the actual reaction conditions.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Chemistry, Analytical
Marcos E. Farias, N. Mariano Correa, Lucas Sosa, Ana M. Niebylski, Patricia G. Molina
Summary: Soybean is the most produced crop in Argentina, with 99% being genetically modified soybean. A new electrochemical immunosensor for detecting CP4 EPSPS in soybean seeds was successfully developed, offering a simple, low-cost, fast, and reproducible device with high sensitivity and a low detection limit.
Review
Chemistry, Multidisciplinary
Nahir Dib, Juana J. Silber, N. Mariano Correa, R. Dario Falcone
Summary: This review describes the latest technology of converting pharmaceutically active ingredients into amphiphilic ionic liquids as alternative drug delivery systems. The compounds generated by ionic exchange show similar or even better surfactant properties compared to their precursors in water. Specific cations and anions have been widely studied as the components of these amphiphiles.
PHARMACEUTICAL RESEARCH
(2022)
Article
Chemistry, Physical
Diana Blach, Valeria R. Girardi, Juana J. Silber, N. Mariano Correa, R. Dario Falcone
Summary: The study investigates the impact of different organized media on the catalytic efficiency of enzyme reactions. It reveals that the catalytic efficiency of an aprotic IL:water mixture is significantly disrupted when confined in a cationic or anionic organized media. This finding holds significant implications for the technological applications of these organized systems.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Chemistry, Physical
Cristian M. O. Lepori, M. Soledad Orellano, N. Mariano Correa, Juana J. Silber, R. Dario Falcone
Summary: In this work, researchers investigated the absorption and emission behavior of a cationic hemicyanine compound in reverse micelles and examined the impact of the microenvironment created by these micelles on their properties as nanoreactors. The results showed significant differences in the photophysical behavior of the compound inside different reverse micelles, highlighting the importance of understanding the interfacial properties for their application as nanoreactors. Furthermore, the researchers evaluated the reverse micelles as reaction media for synthesizing chitosan nanoparticles and found that the microenvironment affected the size and crosslinking of the nanoparticles.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Multidisciplinary
Gustavo A. Monti, R. Dario Falcone, Fernando Moyano, N. Mariano Correa
Summary: In this study, we investigated the influence of water encapsulated in different reverse micelles on the enzymatic hydrolysis of 1-naphthyl phosphate. The results showed that alkaline phosphatase is active in both micellar systems studied, and the Michaelis-Menten kinetic model is applicable. We also found that the behavior of the micelles towards pH and the penetration of external solvents into the interfaces play a crucial role in the enzymatic reaction.
Article
Chemistry, Physical
Soledad Stagnoli, Cintia Garro, Ozlem Ertekin, Susanne Heid, Stefan Seyferth, Gaston Soria, N. Mariano Correa, Aldo Leal-Egana, Aldo R. Boccaccini
Summary: This study developed a system for delivering water-insoluble drugs, which can efficiently load drugs and increase the likelihood of drug uptake by cancer cells instead of healthy cells. The system also demonstrates high efficiency and stability during topical application, and it is less invasive compared to alternative methods.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Organic
Nahir Dib, Valeria R. Girardi, Juana J. Silber, N. Mariano Correa, R. Dario Falcone
Summary: The use of biocompatible solvents instead of toxic solvents in reverse micelles can enhance catalytic efficiency without compromising the performance of the micellar systems. This finding demonstrates that reverse micelles can be a promising alternative for efficient and sustainable chemistry.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Physical
M. Soledad Orellano, Luciana P. Bohl, Maria L. Breser, Paula Isaac, R. Dario Falcone, Carina Porporatto
Summary: The research evaluated the antimicrobial activity of differently-synthesized chitosan nanoparticles against bovine mastitis pathogens and their toxicity in bovine cells, to explore their attributes for preventing and treating intramammary infections. The results showed that chitosan nanoparticles had a significant bactericidal effect on bovine mastitis pathogens and were able to inhibit biofilm formation.
