Article
Chemistry, Physical
T. A. Gillam, C. K. Goh, N. Ninan, K. Bilimoria, H. S. Shirazi, S. Saboohi, S. Al-Bataineh, J. Whittle, A. Blencowe
Summary: The study presents the innovative use of plasma polymerization to convert povidone-iodine into nanoscale coatings for medical devices and wound dressings. These coatings provide sustained release of iodine over a period of 24 hours, showing high antimicrobial activity against clinically relevant microbes responsible for wound infections. This novel approach offers broad-spectrum antiseptic coatings for various biomedical applications.
APPLIED SURFACE SCIENCE
(2021)
Article
Polymer Science
Nikoletta Roka, Olga Kokkorogianni, Philippos Kontoes-Georgoudakis, Ioannis Choinopoulos, Marinos Pitsikalis
Summary: Recent advances in the controlled RAFT polymerization of complex macromolecular architectures based on PNVP are summarized in this review, with a focus on the synthesis of statistical copolymers, block copolymers, star polymers and copolymers, graft copolymers, and more complex architectures. The advantages and limitations of the synthetic methodologies are discussed in detail.
Article
Engineering, Environmental
Mohammad Ali Vafaei, Alireza Shakeri, Hasan Salehi, Seyed Reza Razavi, Narges Salari, Mahdi Taghvay Nakhjiri
Summary: Cellulose nanofibers (CNFs) were used to improve the performance of poly (acrylic acid-co-N-vinyl pyrrolidone) hydrogel as a forward osmosis (FO) draw agent. The successful incorporation of CNFs was confirmed by various analyses. The results showed that the addition of CNFs increased the swelling ratio and water flux of the hydrogel, but a higher CNF concentration led to a slight decrease in water flux. Furthermore, the CNF-based hydrogel exhibited acceptable recycling capability in five consecutive FO cycles and was able to efficiently treat Direct Red-80 dye.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2023)
Article
Polymer Science
Elena Yu. Kozhunova, Anna V. Plutalova, Elena V. Chernikova
Summary: Reversible addition-fragmentation chain transfer polymerization was successfully used to synthesize gradient copolymers of acrylic acid and vinyl acetate in selective solvents. The gradient of the copolymer was controlled by the monomer feed. The monomer conversion affected the ability of the copolymer to self-assemble in aqueous solutions and throughout copolymerization in selective solvents.
Article
Materials Science, Multidisciplinary
Wenna Liu, Cuicui Su, Peipei Su, Huidong Yang, Peng Lu, Zhentao Du, Yumin Ye
Summary: This study presents a method for fabricating sub-20 nm bilayer hydrophilic coatings on nanofiltration membranes using iCVD, reducing membrane fouling while minimizing impacts on water flux and salt rejection. The modified NF membranes exhibit significantly lower microbial adhesion with minimal effects on permeation and salt rejection performance, highlighting a potential novel approach for reducing membrane fouling in desalination and industrial wastewater treatment.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2021)
Article
Polymer Science
Anna M. Nechaeva, Alexander A. Artyukhov, Anna L. Luss, Mikhail Shtilman, Alina Yu Svistunova, Mikhail Motyakin, Irina I. Levina, Efrem G. Krivoborodov, Ilya Yu Toropygin, Evgeniy M. Chistyakov, Aristides M. Tsatsakis, Leonid Gurevich, Yaroslav O. Mezhuev
Summary: This paper focuses on the development of polymeric nanocarriers based on amphiphilic copolymers. The length of the hydrophilic block is found to determine the size of the nanoaggregates, impacting their steric stabilization efficiency and the probability of interchain hydrogen bond formation. The presence of acrylic acid residues enhances the affinity for doxorubicin and allows for slower release, reducing its cardiac toxicity.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2022)
Article
Polymer Science
Nikoletta Roka, Marinos Pitsikalis
Summary: Block copolymers of NVP and BzMA, PNVP-b-PBzMA, were synthesized using RAFT polymerization and sequential monomer addition. The copolymers were characterized by SEC and NMR spectroscopy, and their thermal properties were studied using DSC, TGA, and DTG. Micellization behavior in THF and aqueous solutions was investigated using dilute solution viscometry, SLS, and DLS. The efficient encapsulation of hydrophobic curcumin in the micellar core was demonstrated by UV-Vis spectroscopy and DLS measurements.
Article
Polymer Science
Denitsa Nikolova, Christo Tzachev, Lachezar Christov, Elena Vassileva
Summary: The study presents the development of novel hydrogels for the delivery of timolol maleate (TM) in contact lenses. The copolymer networks showed different swelling kinetics depending on the composition, with VP hydrophilicity and SB physical network playing important roles. The loading efficiency of TM slightly increased with an increase in VP monomeric units, while the release of TM was prolonged with an increase in SB monomeric units. The transparency of the hydrogels was also studied, showing their potential as materials for soft contact lenses.
Article
Chemistry, Multidisciplinary
Marjorie Yon, Laure Gibot, Stephane Gineste, Pascale Laborie, Christian Bijani, Christophe Mingotaud, Olivier Coutelier, Franck Desmoulin, Carine Pestourie, Mathias Destarac, Diana Ciuculescu-Pradines, Jean-Daniel Marty
Summary: Due to the potential life-threatening side effects caused by specific antibodies to poly(ethylene glycol) (PEG), it is necessary to develop alternatives to PEGylated copolymers for treatment and diagnostic methods. A new approach involves block copolymers containing a poly(N-vinyl-2-pyrrolidone) (PVP) segment as vectors without PEG block. A synthesized poly(acrylic acid)-block-poly(N-vinyl-2-pyrrolidone) (PAA-b-PVP) copolymer, when combined with lanthanide cations (Gd3+, Eu3+, Y3+), forms stable hybrid polyion complexes that prevent lanthanide cytotoxicity and enhance in vitro cell penetration, resulting in enhanced T-1 MRI contrast when administered to mice intravenously without leaching of gadolinium ions.
Article
Polymer Science
Anna Nechaeva, Alexander Artyukhov, Anna Luss, Mikhail Shtilman, Inessa Gritskova, Anton Shulgin, Mikhail Motyakin, Irina Levina, Efrem Krivoborodov, Ilya Toropygin, Evgeniy Chistyakov, Leonid Gurevich, Yaroslav Mezhuev
Summary: This study reports a method for synthesizing nanoaggregates that can covalently immobilize doxorubicin and incorporate paclitaxel simultaneously. The performance of the nanoaggregates can be controlled by adjusting the composition of the copolymers. These novel nanocarriers have potential applications in the delivery and co-delivery of various pharmacological preparations for combined therapy in cancer and other diseases.
Article
Polymer Science
Belen Santillan-Gonzalez, Lorena Duarte-Pena, Emilio Bucio
Summary: Polymers are versatile compounds that have a wide range of applications due to their physical and chemical properties. Polydimethylsiloxane (PDMS) is commonly used in the biomedical field due to its high biocompatibility and stability. However, its hydrophobic nature makes it susceptible to bacterial pollution. This research proposed a solution by grafting stimuli-sensitive polymers onto PDMS, providing hydrophilicity and allowing the creation of a drug delivery system. The resulting material showed promising properties such as hydrophilicity and pH-response, and successfully loaded and released ciprofloxacin with potential antimicrobial effects.
Article
Chemistry, Physical
Alexey A. Zharikov, Rodion A. Vinogradov, Elena A. Zezina, Alexander S. Pozdnyakov, Vladimir Feldman, Alexandr L. Vasiliev, Alexey A. Zezin
Summary: Gold nanoparticles of controlled size and high stability can be prepared using a radiation-chemical approach in aqueous solutions and polymer complex suspensions.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2022)
Article
Polymer Science
Wei-Ting Du, Esam A. Orabi, Mohamed Gamal Mohamed, Shiao-Wei Kuo
Summary: Two isomeric hydroxyphenylmaleimide (HPMI) monomers were synthesized and copolymerized with styrene to form two near-perfect alternating copolymers. Characterization using various techniques revealed differences in hydrogen bonding interactions between oHPMI and PVP compared to pHPMI, leading to weaker interactions between oHPMI and PVP.
Article
Chemistry, Multidisciplinary
Shiv Kumar, Carole Body, Tom Leyssens, Kristof Van Hecke, Gilles Berger, Arie Van der Lee, Danielle Laurencin, Sebastien Richeter, Sebastien Clement, Franck Meyer
Summary: This study investigates the mechanism and stability of thiophene derivatives in halogen bonding-driven self-assemblies through X-ray diffraction analysis and density functional theory calculations. The results confirm that halogen bonding plays a crucial role as a structure-directing agent for designing functional materials. Additionally, the study discovers the presence of chalcogen bonding between sulfur and nitrogen in thiophene derivatives, expanding the application of thiophene derivatives in supramolecular chemistry and suggesting further exploration in materials science.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Biochemistry & Molecular Biology
Jon Andrade del Olmo, Leyre Perez-Alvarez, Miguel Angel Pacha-Olivenza, Leire Ruiz-Rubio, Oihane Gartziandia, Jose Luis Vilas-Vilela, Jose Maria Alonso
Summary: Different polymeric antibacterial coatings were developed and analyzed for Ti6Al4V surface covering in this study, showing good cytocompatibility and antibacterial properties, which confirms their effectiveness against bacterial infections for future applications in protecting biomedical implants.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Peter J. Haddow, Marcelo A. da Silva, Daulet B. Kaldybekov, Cecile A. Dreiss, Ewelina Hoffman, Victoria Hutter, Vitaliy V. Khutoryanskiy, Stewart B. Kirton, Najet Mahmoudi, William J. McAuley, Michael T. Cook
Summary: Thermoreversible gels transitioning between liquid-like and solid-like states have enabled breakthroughs in novel healthcare technologies. This study synthesized ABA copolymers with varying molecular weights of PDEA and PEG blocks, revealing the necessity of high molecular weight PEG blocks for forming solid-like thermoreversible gels. Optimization led to a mucoadhesive, stable, and non-toxic thermoreversible gel with controlled release of hydrophobic drugs, showcasing high promise for healthcare applications.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Polymer Science
Anna P. Constantinou, Valeria Nele, James J. Doutch, Joana S. Correia, Roman Moiseev, Martina Cihova, David C. A. Gaboriau, Jonathan Krell, Vitaliy V. Khutoryanskiy, Molly M. Stevens, Theoni K. Georgiou
Summary: In this study, thermoresponsive polymers and their gelling behavior are investigated. A cost-effective biocompatible alternative to commercially available polymers is reported, which forms gels at low concentrations. The differences in gelling mechanisms between the investigated polymer and Poloxamer P407 (Pluronic F127) are elucidated through nanoscale self-assembly and rheological analysis.
Article
Polymer Science
D. S. Kazybayeva, G. S. Irmukhametova, V. V. Khutoryanskiy
Summary: This review focuses on the synthesis of novel organic compounds and polymer materials using click chemistry concept, specifically highlighting thiol-ene reactions and their diverse applications in biocompatible materials, cell culture, block copolymer synthesis, degradable materials, and various functionalized systems.
POLYMER SCIENCE SERIES B
(2022)
Review
Chemistry, Multidisciplinary
Nathalie Hock, Giuseppe Francesco Racaniello, Sam Aspinall, Nunzio Denora, Vitaliy V. Khutoryanskiy, Andreas Bernkop-Schnuerch
Summary: This review discusses the interface between thiol chemistry and nanoparticles, highlighting the various functionalities gained by thiolation. These include enhanced bio- and mucoadhesive properties, improved cellular uptake, and permeation enhancement. Various applications such as drug delivery, targeted therapy, and diagnostics can benefit from thiolated nanoparticles.
Article
Chemistry, Applied
Stephanie P. Bull, Vitaliy V. Khutoryanskiy, Jane K. Parker, Marianthi Faka, Lisa Methven
Summary: This study found that heated whey protein concentrate has a longer retention time in the oral cavity compared to unheated WPC, causing structural changes, increased free thiol concentration, and exposure of hydrophobic regions. These factors contribute to increased mucoadhesive strength and mouthdrying perception.
Article
Pharmacology & Pharmacy
Roman Moiseev, Fraser Steele, Vitaliy V. Khutoryanskiy
Summary: As drug delivery to the eye has advanced, researchers have focused on finding better treatments for ocular diseases. This study evaluated different polyaphron formulations and found that the 3% polyquaternium 10-based formulation had the best corneal retention, while the 10% poloxamer 188 and 1% polyquaternium 10-based formulations were the most stable. Toxicological evaluations showed that all four formulations had good biocompatibility with ocular tissues. These drug delivery systems have great potential for ocular drug delivery.
Review
Chemistry, Multidisciplinary
Adaeze Linda Onugwu, Chinekwu Sherridan Nwagwu, Obinna Sabastine Onugwu, Adaeze Chidiebere Echezona, Chinazom Precious Agbo, Stella Amarachi Ihim, Prosper Emeh, Petra Obioma Nnamani, Anthony Amaechi Attama, Vitaliy V. Khutoryanskiy
Summary: Diseases affecting the anterior segment of the eye are a major cause of vision impairment and blindness worldwide. Drug delivery to the eye through the topical ocular route is challenging due to structural and physiological constraints. Nanotechnology-based drug delivery systems have been investigated as effective alternatives to conventional ocular delivery systems for treating anterior segment diseases. This review discusses different nanotechnology-based delivery systems and their prospects in clinical use.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Sam R. Aspinall, Vitaliy V. Khutoryanskiy
Summary: This study synthesized and tested a range of functionalized silica particles and found that the particles with modified surfaces can significantly improve the retention of oral care formulations on oral mucosal surfaces.
Article
Polymer Science
Fhataheya Buang, Afroditi Chatzifragkou, Mohd Cairul Iqbal Mohd Amin, Vitaliy V. V. Khutoryanskiy
Summary: Non-ionic hydroxyethylcellulose (HEC) was chemically modified with glycidyl methacrylate to enhance its mucoadhesive properties. The modification was confirmed by H-1 NMR and FTIR spectroscopy, and quantification of methacryloyl groups was done using HPLC. Toxicity studies showed no toxicological effects of the modified HEC. Mucoadhesive wafers developed from the modified HEC exhibited significantly better mucoadhesive properties compared to unmodified HEC.
Article
Pharmacology & Pharmacy
Nadezda E. Kashapova, Ruslan R. Kashapov, Albina Y. Ziganshina, Dmitry O. Nikitin, Irina I. Semina, Vadim V. Salnikov, Vitaliy V. Khutoryanskiy, Rouslan I. Moustafine, Lucia Y. Zakharova
Summary: A water-soluble form of haloperidol was obtained by coaggregation with calix[4]resorcinol to form vesicular nanoparticles. The nanoparticles showed mucoadhesive and thermosensitive properties, making them potentially effective drug delivery systems. In pharmacological studies, haloperidol formulated with calix[4]resorcinol exhibited a cataleptogenic effect in rats both when administered intranasally and intraperitoneally.
Article
Polymer Science
Regina R. Vildanova, Svetlana F. Petrova, Sergey V. Kolesov, Vitaliy V. Khutoryanskiy
Summary: Preparation of stable hydrogels using charge-complementary polyelectrolyte chains offers practical advantages over the use of organic crosslinking agents. This study utilizes natural polyelectrolytes-chitosan and pectin-with their biocompatibility and biodegradability. Different molecular weights of pectin are used to prepare hydrogels with varying rheological characteristics and swelling kinetics. These polyelectrolyte hydrogels can release the cytostatic drug cisplatin over an extended period, potentially improving the effectiveness of cancer treatment.
Article
Pharmacology & Pharmacy
Fhataheya Buang, Manfei Fu, Afroditi Chatzifragkou, Mohd Cairul Iqbal Mohd Amin, Vitaliy V. Khutoryanskiy
Summary: Hydroxyethylcellulose (HEC) is a water-soluble polymer with poor mucoadhesive properties. This study explores the modification of HEC by conjugation with maleimide groups to improve its mucoadhesive properties. The modified HEC exhibits superior mucoadhesive properties compared to unmodified HEC, forming a strong bond with mucin. The safety and efficacy of the newly synthesized polymer derivatives were also evaluated.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Physical
Saul J. Hunter, Mahmoud H. Abu Elella, Edwin C. Johnson, Laura Taramova, Emma E. Brotherton, Steven P. Armes, Vitaliy V. Khutoryanskiy, Mark J. Smallridge
Summary: Spherical aldehyde-functionalized nanoparticles were prepared through aqueous emulsion polymerization, and when combined with oil droplets, formed nanoemulsions. The aldehyde-functionalized nanoparticles showed stronger adhesion to sheep nasal mucosal tissue due to the formation of imine bonds.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Physical
Zhiwei Huang, Roman V. Moiseev, Solomon S. Melides, Wooli Bae, Izabela Jurewicz, Vitaliy V. Khutoryanskiy, Joseph L. Keddie
Summary: This study evaluated the use of nanoparticles-stabilised Pickering emulsions for the confinement of organic components in ocular drug delivery. The results showed that these emulsions had good stability and mucoadhesive properties, and were non-toxic to tissues. These emulsions have distinct advantages for ocular drug delivery and could serve as a reference for future formulation design for drug delivery.
Article
Chemistry, Multidisciplinary
Sergey K. Filippov, Ramil Khusnutdinov, Anastasiia Murmiliuk, Wali Inam, Lucia Ya. Zakharova, Hongbo Zhang, Vitaliy V. Khutoryanskiy
Summary: This focus article provides a detailed analysis of transmission electron microscopy (TEM) and dynamic light scattering (DLS) as two common methods for studying nanoparticle sizes in pharmaceutics and drug delivery. The article highlights the importance of controlling nanoparticle size and shape in biomedical systems and discusses the discrepancies in size measurements obtained from TEM and DLS. The authors convincingly demonstrate that properly conducted experimental procedures and careful analysis of results can eliminate or reduce the mismatch between DLS and TEM data.
MATERIALS HORIZONS
(2023)