☆ 4.7 Editorial Material

Can HIV-1 viral interference be used therapeutically?

LANCET INFECTIOUS DISEASES (2013)

Journal

LANCET INFECTIOUS DISEASES

Volume 13, Issue 1, Pages 9-10

Publisher

ELSEVIER SCI LTD

DOI: 10.1016/S1473-3099(12)70312-2

Keywords

-

Categories

Infectious Diseases

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7

Not enough ratings

Secondary Ratings

Novelty

-

Significance

-

Scientific rigor

-

Rate this paper

Recommended

Article Immunology

Anti-HIV-1 ADCC and HIV-1 Env Can Be Partners in Reducing Latent HIV Reservoir

Poonam Suryawanshi, Rajani Bagul, Ashwini Shete, Madhuri Thakar

Summary: The study demonstrated that HIV-1 Env could serve as a latency reversal agent (LRA), and only ADCC mediating antibodies were able to kill the reactivated HIV reservoirs. The findings have implications in designing antibody-mediated immunotherapy for eradicating latent HIV reservoir.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer

Stephin J. Vervoort, Sarah A. Welsh, Jennifer R. Devlin, Elisa Barbieri, Deborah A. Knight, Sarah Offley, Stefan Bjelosevic, Matteo Costacurta, Izabela Todorovski, Conor J. Kearney, Jarrod J. Sandow, Zheng Fan, Benjamin Blyth, Victoria McLeod, Joseph H. A. Vissers, Karolina Pavic, Ben P. Martin, Gareth Gregory, Elena Demosthenous, Magnus Zethoven, Isabella Y. Kong, Edwin D. Hawkins, Simon J. Hogg, Madison J. Kelly, Andrea Newbold, Kaylene J. Simpson, Otto Kauko, Kieran F. Harvey, Michael Ohlmeyer, Jukka Westermarck, Nathanael Gray, Alessandro Gardini, Ricky W. Johnstone

Summary: CDK9 regulates gene expression by controlling the pausing checkpoint during the transcription cycle, while PP2A counteracts CDK9-mediated phosphorylation. Loss of INTS6 leads to resistance to CDK9 inhibition-induced tumor cell death, and pharmacological activation of PP2A in combination with CDK9 inhibition provides therapeutic benefits in vivo.

CELL (2021)

Add to Collection

Editorial Material Chemistry, Multidisciplinary

Can proteins be used to stop a bullet?

Jonathan L. Sessler

Summary: In a recently published paper, researchers demonstrate that talin, a mechanosensitive protein in cells, can be modified to create shock-absorbing hydrogels capable of withstanding impacts from supersonic projectiles. This interdisciplinary achievement combines synthetic biology, chemistry, astrophysics, and materials science, leveraging millions of years of evolutionary optimization that protect mammalian cells from environmental forces.

CHEM (2023)

Add to Collection

Article Chemistry, Analytical

Can Microsaccades Be Used for Biometrics?

Kiril Alexiev, Teodor Vakarelski

Summary: This paper investigates microsaccades as a source of information for biometric analysis and explains why they are preferred over other fixational eye movements. The process of microsaccade extraction is described, including the definition and derivation of thirteen parameters for analysis. A gradient algorithm is used to solve the biometric problem and an assessment of parameter weights is made.

SENSORS (2023)

Add to Collection

Article Medicine, Research & Experimental

Can plant-derived anti-HIV compounds be used in COVID-19 cases?

Diptimayee Das, Atala Bihari Jena, Antara Banerjee, Arun Kumar Radhakrishnan, Asim K. Duttaroy, Surajit Pathak

Summary: People living with HIV are at higher risk of adverse health effects during the COVID-19 pandemic. The pandemic has caused disruption in healthcare for those with HIV, leading to challenges in achieving optimal care outcomes.

MEDICAL HYPOTHESES (2022)

Add to Collection

Article Biochemical Research Methods

Can transsynaptic viral strategies be used to reveal functional aspects of neural circuitry?

Alexandra Rogers, Kevin T. Beier

Summary: Viruses play a key role in elucidating neuronal connectivity relationships in various organisms, particularly through viral transneuronal mapping. However, there is currently little understanding of how these viruses transmit between neurons and whether biases exist in the types of cells labeled.

JOURNAL OF NEUROSCIENCE METHODS (2021)

Add to Collection

Article Multidisciplinary Sciences

Prolonged viral suppression with anti-HIV-1 antibody therapy

Christian Gaebler, Lilian Nogueira, Elina Stoffel, Thiago Y. Oliveira, Gaelle Breton, Katrina G. Millard, Martina Turroja, Allison Butler, Victor Ramos, Michael S. Seaman, Jacqueline D. Reeves, Christos J. Petroupoulos, Irina Shimeliovich, Anna Gazumyan, Caroline S. Jiang, Nikolaus Jilg, Johannes F. Scheid, Rajesh Gandhi, Bruce D. Walker, Michael C. Sneller, Anthony Fauci, Tae-Wook Chun, Marina Caskey, Michel C. Nussenzweig

Summary: Immunotherapy with anti-HIV-1 antibodies has the potential to suppress infection and increase the rate of clearance of infected cells. A clinical study showed that 76% of HIV-infected individuals who received a combination of antibodies maintained virologic suppression for at least 20 weeks without antiretroviral therapy. The administration of antibodies affected the HIV-1 reservoir, but further research is needed to define the precise effect of antibody immunotherapy.

NATURE (2022)

Add to Collection

Article Engineering, Civil

Can small reservoirs be used to gauge stream runoff?

Jerome Molenat, Cecile Dages, Maroua Bouteffeha, Insaf Mekki

Summary: This study demonstrates the use of small reservoirs for estimating stream runoff, especially at short temporal resolutions. The main factors contributing to estimation uncertainty are reservoir water level measurements and percolation rates.

JOURNAL OF HYDROLOGY (2021)

Add to Collection

Article Chemistry, Physical

Can molecular dynamics be used to simulate biomolecular recognition?

Malin Lueking, David van der Spoel, Johan Elf, Gareth A. A. Tribello

Summary: There are difficult problems in biochemistry that are challenging to study experimentally, but simulation methods provide a direct way to obtain atomic coordinates over time. However, molecular simulations face challenges in system size and time scales. Enhanced sampling algorithms can potentially overcome these limitations. This paper discusses a problem in biochemistry that serves as a benchmark for comparing machine learning approaches, focusing on the transitions of LacI between non-specific and specific DNA binding states.

JOURNAL OF CHEMICAL PHYSICS (2023)

Add to Collection

Article Engineering, Geological

Can DAS be used to monitor mining induced seismicity?

Hendrik J. du Toit, Gareth Goldswain, Gerrit Olivier

Summary: Distributed acoustic sensing (DAS) is being increasingly used in various geoscientific fields, including monitoring microseismicity in underground mines as shown in this study. By installing fiber optic cable and comparing it with geophone sensors, it was found that DAS data had relatively good agreement with the geophone data for larger seismic events. Additionally, DAS data was processed and located using PhaseNet, a machine-learning algorithm, and an interferometric method. However, challenges remain in terms of the background noise and the feasibility of using existing mining communication infrastructure for accurate seismic sensing.

INTERNATIONAL JOURNAL OF ROCK MECHANICS AND MINING SCIENCES (2022)

Add to Collection

Article Multidisciplinary Sciences

Critical mechanistic features of HIV-1 viral capsid assembly

Manish Gupta, Alexander J. Pak, Gregory A. Voth

Summary: Researchers use molecular dynamics simulations to reveal the molecular mechanism of HIV-1 capsid formation, including the role of IP6. This study shows that IP6 initially promotes curvature generation by trapping pentameric defects and shifts the assembly behavior towards kinetically favored outcomes. Additionally, IP6 can stabilize metastable capsid intermediates and induce structural pleomorphism in mature capsids.

SCIENCE ADVANCES (2023)

Add to Collection

Article Chemistry, Physical

Can carbon sponge be used as separator in Li metal batteries?

Ying Xu, Hanghang Yan, Tao Li, Yuan Liu, Jianmin Luo, Weiyang Li, Xiangyang Cui, Lei Chen, Qin Yue, Yijin Kang

Summary: The study introduces a strategy of using a nitrogen- and carboxyl-rich hollow carbon sponge reservoir to confine electrolyte, which effectively mitigates safety issues and cycling degradation caused by dendrite growth and high reactivity of Li in lithium metal batteries. The carboxyl groups in the carbon sponge can form hydrogen bonds with certain components in the electrolyte, enhancing Li mobility and suppressing dendrite growth.

ENERGY STORAGE MATERIALS (2021)

Add to Collection

Article Multidisciplinary Sciences

Economic games can be used to promote cooperation in the field

Stefan Meyer, Paulo Santos, Fue Yang

Summary: Experimental evidence shows that playing a game can increase real-life cooperation, leading to higher participation in collective activities aimed at reducing pest pressure. This increased cooperation reflects changes in understanding others' willingness to cooperate, rather than changes in understanding technological interdependencies.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Add to Collection

Review Psychology, Multidisciplinary

How can implementation intentions be used to modify gambling behavior?

Tom St Quinton

Summary: This mini review illustrates how implementation intentions can be used to facilitate change in gambling behavior and help reduce the number of people with gambling problems.

FRONTIERS IN PSYCHOLOGY (2022)

Add to Collection

Article Multidisciplinary Sciences

HIV-1 sequences in lentiviral vector genomes can be substantially reduced without compromising transduction efficiency

Helin Sertkaya, Mattia Ficarelli, Nathan P. Sweeney, Hannah Parker, Conrad A. Vink, Chad M. Swanson

Summary: Many lentiviral vectors for gene therapy are derived from HIV-1, and through systematic deletion analysis, it has been found that significant portions of the gag and env regions can be removed without compromising transduction efficiency. Long-read sequencing has also been utilized to study splice site usage, showing that specific deletions in the env sequence can reduce splicing events per transcript. These findings allow for the creation of lentiviral vectors with minimal HIV-1 sequence, potentially improving safety and reducing viral sequence transfer to patients' DNA.

SCIENTIFIC REPORTS (2021)

Add to Collection

Letter Infectious Diseases

Short-cycle therapy (5 days on/2 days off) with a lamivudine plus dolutegravir regimen in a cohort of virologically suppressed patients with HIV infection

Massimiliano Lanzafame, Emanuela Lattuada, Rossella Gottardo, Daniela Piacentini, Giorgia Be, Elisa Razzaboni, Paolo Cattaneo, Dora Luise, Sandro Vento

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2021)

Add to Collection

Article Genetics & Heredity

Case Report: First Two Identified Cases of Fabry Disease in Central Asia

Francesca Cainelli, Dias Argandykov, Dauren Kaldarbekov, Murat Mukarov, Lien Tran Thi Phuong, Dominique P. Germain

Summary: Fabry disease is a rare X-linked genetic disease that presents with neuropathic pain and multisystem disorders. Due to its rarity and non-specific symptoms, diagnosis and treatment may be delayed.

FRONTIERS IN GENETICS (2021)

Add to Collection

Letter Gastroenterology & Hepatology

Prevalence of liver fibrosis using transient elastography in the general population in Cambodia: a pilot study

Francesca Cainelli, Vannary Yi, Sandro Vento

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2021)

Add to Collection

Article Infectious Diseases

Seroprevalence and risk factors of hepatitis B, C and D virus infection amongst patients with features of hepatitis in a referral hospital in Botswana: A cross-sectional study

Sajini Souda, Julius C. Mwita, Francesca Cainelli, Naledi B. Mannathoko, Motswedi Anderson, Sikhulile Moyo

Summary: The study revealed a high prevalence rate of HBV, HCV, HDV infections, and HIV co-infection in patients with liver disease at Princess Marina Hospital in Botswana. Some patients showed immunity against HBV infection.

SOUTHERN AFRICAN JOURNAL OF INFECTIOUS DISEASES (2021)

Add to Collection

Article Infectious Diseases

Short-cycle therapy in HIV-infected adults: rilpivirine combination 4 days on/3 days off therapy

Dora Luise, Emanuela Lattuada, Sebastiano Rizzardo, Stefano Nicole, Lorenza Lambertenghi, Ilaria Coledan, Silvia Gambino, Rossella Gottardo, Massimiliano Lanzafame, Sandro Vento

Summary: Short-cycle therapy with rilpivirine-containing regimens could be an effective alternative to continuous therapy in selected HIV-infected patients with previous long-term virological suppression. The study found that short-cycle therapy can maintain good virological suppression and high patient satisfaction.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2022)

Add to Collection

Letter Virology

Is monoclonal antibody administration necessary in all vaccinated patients with breakthrough COVID-19 infections?

Massimiliano Lanzafame, Enrico Gibbin, Emanuela Lattuada, Sandro Vento

JOURNAL OF MEDICAL VIROLOGY (2022)

Add to Collection

Article Public, Environmental & Occupational Health

Research priorities to reduce the impact of COVID-19 in low- and middle-income countries

Ozren Polasek, Kerri Wazny, Davies Adeloye, Peige Song, Kit Y. Chan, Danladi A. Bojude, Sajjad Ali, Sheri Bastien, Francisco Becerra-Posada, Florencia Borrescio-Higa, Sohaila Cheema, Darien A. Cipta, Smiljana Cvjetkovic, Lina D. Castro, Bassey Ebenso, Omolade Femi-Ajao, Balasankar Ganesan, Anton Glasnovic, Longtao He, Jean M. Heraud, Chinonso Igwesi-Chidobe, Per O. Iversen, Bismeen Jadoon, Abdulkarim J. Karim, Johra Khan, Raaj K. Biswas, Giuseppe Lanza, Shaun W. H. Lee, You Li, Li-Lin Liang, Mat Lowe, Mohammad M. Islam, Ana Marusic, Suleiman Mshelia, Anthony M. Manyara, Mila N. N. Htay, Michelle Parisi, Prince Peprah, Emma Sacks, Kabiru O. Akinyemi, Fariba Shahraki-Sanavi, Konstantin Sharov, Elena S. Rotarou, Srdjan Stankov, Wenang Supriyatiningsih, Benjamin T. Y. Chan, Mark Tremblay, Dialechti Tsimpida, Sandro Vento, Josipa Glasnovic, Liang Wang, Xin Wang, Zhi X. Ng, Jianrong Zhang, Yanfeng Zhang, Harry Campbell, Mickey Chopra, Simon Cousens, Goran Krstic, Calum Macdonald, Parisa Mansoori, Smruti Patel, Aziz Sheikh, Mark Tomlinson, Alexander C. Tsai, Sachiyo Yoshida, Igor Rudan

Summary: This study used the CHNRI method to identify research priorities related to COVID-19, highlighting the importance of vaccination and healthcare delivery in low- and middle-income countries. The research emphasizes the urgent need for health policy and systems research in these countries.

JOURNAL OF GLOBAL HEALTH (2022)

Add to Collection

Letter Gastroenterology & Hepatology

Global multi-stakeholder endorsement of the MAFLD definition

Nahum Mendez-Sanchez, Elisabetta Bugianesi, Robert G. Gish, Frank Lammert, Herbert Tilg, Mindie H. Nguyen, Shiv K. Sarin, Nuria Fabrellas, Shira Zelber-Sagi, Jian-Gao Fan, Gamal Shiha, Giovanni Targher, Ming-Hua Zheng, Wah-Kheong Chan, Shlomo Vinker, Takumi Kawaguchi, Laurent Castera, Yusuf Yilmaz, Marko Korenjak, C. Wendy Spearman, Mehmet Ungan, Melissa Palmer, Mortada El-Shabrawi, Hans-Juergen Gruss, Jean-Francois Dufour, Anil Dhawan, Heiner Wedemeyer, Jacob George, Luca Valenti, Yasser Fouad, Manuel Romero-Gomez, Mohammed Eslam

LANCET GASTROENTEROLOGY & HEPATOLOGY (2022)

Add to Collection

Article Immunology

Dolutegravir Monotherapy and Body Weight Gain in Antiretroviral Naive Patients, by Rizzardo et al.

Massimiliano Lanzafame, Sebastiano Rizzardo, Emanuela Lattuada, Dora Luise, Sandro Vento

AIDS RESEARCH AND HUMAN RETROVIRUSES (2022)

Add to Collection

Article Public, Environmental & Occupational Health

Serum 25-hydroxyvitamin D and hyaluronic acid levels as markers of fibrosis in patients with chronic liver disease at the main tertiary referral hospital in Ghana: A case-control study design

Bartholomew Dzudzor, Harris Hammond, Kenneth Tachi, Anna Alisi, Sandro Vento, Richard Kwasi Gyasi, Justice Moses K. Aheto

Summary: Liver fibrosis is a major cause of chronic liver disease, with significant morbidity, mortality, and healthcare expenditure worldwide. This study aimed to evaluate the correlation between hyaluronic acid (HA) and 25-hydroxyvitamin D (25-OH vitamin D) serum levels as markers of fibrosis. The results showed that patients with liver disease had significantly reduced 25-OH vitamin D levels and elevated HA levels, both of which correlated with the degree of liver fibrosis.

HEALTH SCIENCE REPORTS (2023)

Add to Collection

Article Immunology

Short Cycle, Intermittent Therapy: A Valuable Option in Selected, Virologically Suppressed People Living with HIV

Massimiliano Lanzafame, Emanuela Lattuada, Dora Luise, Andrea Delama, Daniela Fait, Sandro Vento

Summary: Long-acting antiretroviral regimens may not be suitable for all HIV patients, and short-cycle therapy could be a feasible option for optimizing antiretroviral treatment in selected individuals. This review examines the clinical evidence of efficacy in suppressed HIV-infected patients.

AIDS RESEARCH AND HUMAN RETROVIRUSES (2023)

Add to Collection

Letter Medicine, General & Internal

Medicine should be learned in a conducive environment

Xin Ni, Zhe Li, Yingying Liu, Guoliang Bai, Xinping Li, Xiao Zhang

LANCET (2023)

Add to Collection

Review Infectious Diseases

Mini-review: Silico-tuberculosis

Massimiliano Lanzafame, Sandro Vento

Summary: Silicosis remains a serious global health issue, with increased risk for tuberculosis and challenges in diagnosis and treatment. Prevention efforts are crucial, requiring global collaboration and expansion of chemoprophylaxis programs.

JOURNAL OF CLINICAL TUBERCULOSIS AND OTHER MYCOBACTERIAL DISEASES (2021)

Add to Collection

No Data Available

© Peeref 2019-2024. All rights reserved.