Critical mechanistic features of HIV-1 viral capsid assembly

Strain and rupture of HIV-1 capsids during uncoating

(2022) Alvin Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A stable immature lattice packages IP6 for HIV capsid maturation

(2021) Donna L. Mallery et al.   Science Advances

HIV-1 Capsid Core: A Bullet to the Heart of the Target Cell

(2021) Elenia Toccafondi et al.   Frontiers in Microbiology

Curvature of the Retroviral Capsid Assembly Is Modulated by a Molecular Switch

(2021) Tyrone Thames et al.   Journal of Physical Chemistry Letters

Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A

(2020) Tao Ni et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Atomic-scale characterization of mature HIV-1 capsid stabilization by inositol hexakisphosphate (IP6)

(2020) Alvin Yu et al.   Science Advances

Off-Pathway Assembly: A Broad-Spectrum Mechanism of Action for Drugs That Undermine Controlled HIV-1 Viral Capsid Formation

(2019) Alexander J. Pak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biochemical Reconstitution of HIV-1 Assembly and Maturation

(2019) Iga Kucharska et al.   JOURNAL OF VIROLOGY

Cellular IP6 Levels Limit HIV Production while Viruses that Cannot Efficiently Package IP6 Are Attenuated for Infection and Replication

(2019) Donna L. Mallery et al.   Cell Reports

Inositol phosphates are assembly co-factors for HIV-1

(2018) Robert A. Dick et al.   NATURE

Advances in coarse-grained modeling of macromolecular complexes

(2018) Alexander J Pak et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

IP6 Regulation of HIV Capsid Assembly, Stability, and Uncoating

(2018) Robert Dick et al.   Viruses-Basel

Physical properties of the HIV-1 capsid from all-atom molecular dynamics simulations

(2017) Juan R. Perilla et al.   Nature Communications

HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis

(2016) David A. Jacques et al.   NATURE

The structure and flexibility of conical HIV-1 capsids determined within intact virions

(2016) Simone Mattei et al.   SCIENCE

Molecular Architecture of the Retroviral Capsid

(2016) Juan R. Perilla et al.   TRENDS IN BIOCHEMICAL SCIENCES

In vitro protease cleavage and computer simulations reveal the HIV-1 capsid maturation pathway

(2016) Jiying Ning et al.   Nature Communications

Coarse-grained simulation reveals key features of HIV-1 capsid self-assembly

(2016) John M. A. Grime et al.   Nature Communications

Cyclophilin A stabilizes the HIV-1 capsid through a novel non-canonical binding site

(2016) Chuang Liu et al.   Nature Communications

RNA and Nucleocapsid Are Dispensable for Mature HIV-1 Capsid Assembly

(2015) Simone Mattei et al.   JOURNAL OF VIROLOGY

HIV-1 assembly, release and maturation

(2015) Eric O. Freed   NATURE REVIEWS MICROBIOLOGY

Maturation of the HIV-1 core by a non-diffusional phase transition

(2015) Gabriel A. Frank et al.   Nature Communications

XSEDE: Accelerating Scientific Discovery

(2014) John Towns et al.   COMPUTING IN SCIENCE & ENGINEERING

Electron Cryotomography Studies of Maturing HIV-1 Particles Reveal the Assembly Pathway of the Viral Core

(2014) Cora L. Woodward et al.   JOURNAL OF VIROLOGY

Moltemplate a Coarse-Grained Model Assembly Tool

(2013) Andrew I. Jewett et al.   BIOPHYSICAL JOURNAL

Structure and Dynamics of Full-Length HIV-1 Capsid Protein in Solution

(2013) Lalit Deshmukh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Two-Pronged Structural Analysis of Retroviral Maturation Indicates that Core Formation Proceeds by a Disassembly-Reassembly Pathway Rather than a Displacive Transition

(2013) P. W. Keller et al.   JOURNAL OF VIROLOGY

Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics

(2013) Gongpu Zhao et al.   NATURE

HIV-1 Assembly, Budding, and Maturation

(2013) W. I. Sundquist et al.   Cold Spring Harbor Perspectives in Medicine

Extreme Genetic Fragility of the HIV-1 Capsid

(2013) Suzannah J. Rihn et al.   PLoS Pathogens

Early Stages of the HIV-1 Capsid Protein Lattice Formation

(2012) John M.A. Grime et al.   BIOPHYSICAL JOURNAL

Unclosed HIV-1 Capsids Suggest a Curled Sheet Model of Assembly

(2012) Zhiheng Yu et al.   JOURNAL OF MOLECULAR BIOLOGY

The Host Proteins Transportin SR2/TNPO3 and Cyclophilin A Exert Opposing Effects on HIV-1 Uncoating

(2012) V. B. Shah et al.   JOURNAL OF VIROLOGY

Structure of the immature retroviral capsid at 8 Å resolution by cryo-electron microscopy

(2012) Tanmay A. M. Bharat et al.   NATURE

Protease Cleavage Leads to Formation of Mature Trimer Interface in HIV-1 Capsid

(2012) Xin Meng et al.   PLoS Pathogens

CPSF6 Defines a Conserved Capsid Interface that Modulates HIV-1 Replication

(2012) Amanda J. Price et al.   PLoS Pathogens

Simulated Self-Assembly of the HIV-1 Capsid: Protein Shape and Native Contacts Are Sufficient for Two-Dimensional Lattice Formation

(2011) Bo Chen et al.   BIOPHYSICAL JOURNAL

The Molecular Architecture of HIV

(2011) John A.G. Briggs et al.   JOURNAL OF MOLECULAR BIOLOGY

Atomic-level modelling of the HIV capsid

(2011) Owen Pornillos et al.   NATURE

Structural Convergence between Cryo-EM and NMR Reveals Intersubunit Interactions Critical for HIV-1 Capsid Function

(2009) In-Ja L. Byeon et al.   CELL

X-Ray Structures of the Hexameric Building Block of the HIV Capsid

(2009) Owen Pornillos et al.   CELL

Nonequilibirum Assembly, Retroviruses, and Conical Structures

(2009) Artem Levandovsky et al.   PHYSICAL REVIEW LETTERS

Structure and assembly of immature HIV

(2009) J. A. G. Briggs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-Dimensional Analysis of Budding Sites and Released Virus Suggests a Revised Model for HIV-1 Morphogenesis

(2008) Lars-Anders Carlson et al.   Cell Host & Microbe

The structural biology of HIV assembly

(2008) Barbie K Ganser-Pornillos et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY