The myeloid-binding peptide adenoviral vector enables multi-organ vascular endothelial gene targeting

Adeno-associated Virus–mediated Delivery of a Recombinant Single-chain Antibody Against Misfolded Superoxide Dismutase for Treatment of Amyotrophic Lateral Sclerosis

(2014) Priyanka Patel et al.   MOLECULAR THERAPY

Gene-Based Therapy for Alpha-1 Antitrypsin Deficiency

(2013) Christian Mueller et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Gene Therapy to Stimulate Angiogenesis to Treat Diffuse Coronary Artery Disease

(2013) Stephen M. Kaminsky et al.   HUMAN GENE THERAPY

Assessment of a novel, capsid-modified adenovirus with an improved vascular gene transfer profile

(2013) Katie M White et al.   Journal of Cardiothoracic Surgery

Signaling effectors underlying pathologic growth and remodeling of the heart

(2013) Jop H. van Berlo et al.   JOURNAL OF CLINICAL INVESTIGATION

Coagulation factor X shields adenovirus type 5 from attack by natural antibodies and complement

(2013) Zhili Xu et al.   NATURE MEDICINE

Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo

(2013) Kiran Yanamandra et al.   NEURON

The Long-Term Differentiation of Embryonic Stem Cells into Cardiomyocytes: An Indirect Co-Culture Model

(2013) Dong-Bo Ou et al.   PLoS One

Transcriptional Targeting of Primary and Metastatic Tumor Neovasculature by an Adenoviral Type 5 Roundabout4 Vector in Mice

(2013) Zhi Hong Lu et al.   PLoS One

Retargeting of gene expression using endothelium specific hexon modified adenoviral vector

(2013) Sergey A. Kaliberov et al.   VIROLOGY

Parkinson's Disease: Gene Therapies

(2013) P. G. Coune et al.   Cold Spring Harbor Perspectives in Medicine

Cellular therapy promotes endogenous stem cell repair

(2012) Forum Kamdar et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

A myeloid cell-binding adenovirus efficiently targets gene transfer to the lung and escapes liver tropism

(2012) M O Alberti et al.   GENE THERAPY

Long-Term Follow-Up Assessment of a Phase 1 Trial of Angiogenic Gene Therapy Using Direct Intramyocardial Administration of an Adenoviral Vector Expressing the VEGF121 cDNA for the Treatment of Diffuse Coronary Artery Disease

(2012) Todd K. Rosengart et al.   HUMAN GENE THERAPY

Biodistribution and inflammatory profiles of novel penton and hexon double-mutant serotype 5 adenoviruses

(2012) Angela C. Bradshaw et al.   JOURNAL OF CONTROLLED RELEASE

The art of gene therapy for glioma: a review of the challenging road to the bedside

(2012) Alex Tobias et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Advances in Cell and Gene-based Therapies for Cystic Fibrosis Lung Disease

(2012) Mayumi Oakland et al.   MOLECULAR THERAPY

Sustained miRNA-mediated Knockdown of Mutant AAT With Simultaneous Augmentation of Wild-type AAT Has Minimal Effect on Global Liver miRNA Profiles

(2012) Christian Mueller et al.   MOLECULAR THERAPY

Manipulation of adenovirus interactions with host factors for gene therapy applications

(2012) Margaret R Duffy et al.   Nanomedicine

DNA secondary structures: stability and function of G-quadruplex structures

(2012) Matthew L. Bochman et al.   NATURE REVIEWS GENETICS

Gene therapy for brain tumors: Basic developments and clinical implementation

(2012) Hikmat Assi et al.   NEUROSCIENCE LETTERS

Derivation of a Myeloid Cell-Binding Adenovirus for Gene Therapy of Inflammation

(2012) Michael O. Alberti et al.   PLoS One

Gene transfer for congestive heart failure: update 2013

(2012) Tong Tang et al.   Translational Research

Gene therapy for cardiovascular disease: Perspectives and potential

(2012) Angela C. Bradshaw et al.   VASCULAR PHARMACOLOGY

Conditional HIF-1 induction produces multistage neovascularization with stage-specific sensitivity to VEGFR inhibitors and myeloid cell independence

(2011) S. S. Oladipupo et al.   BLOOD

Endothelial Cells Create a Stem Cell Niche in Glioblastoma by Providing NOTCH Ligands That Nurture Self-Renewal of Cancer Stem-Like Cells

(2011) T. S. Zhu et al.   CANCER RESEARCH

The Evolution of Endothelial Regulatory Paradigms in Cancer Biology and Vascular Repair

(2011) J. W. Franses et al.   CANCER RESEARCH

The Art of MicroRNA Research

(2011) Eva van Rooij   CIRCULATION RESEARCH

Secreted factors from brain endothelial cells maintain glioblastoma stem-like cell expansion through the mTOR pathway

(2011) Eva Maria Galan-Moya et al.   EMBO REPORTS

Gene therapy for alpha-1 antitrypsin deficiency

(2011) T. R. Flotte et al.   HUMAN MOLECULAR GENETICS

E-selectin is a viable route of infection for polymer-coated adenovirus retargeting in TNF-α-activated human umbilical vein endothelial cells

(2011) Houria Bachtarzi et al.   JOURNAL OF DRUG TARGETING

Gene therapy for Huntington's disease

(2011) Shilpa Ramaswamy et al.   NEUROBIOLOGY OF DISEASE

Combination therapy utilizing shRNA knockdown and an optimized resistant transgene for rescue of diseases caused by misfolded proteins

(2011) C. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A randomised, double-blind, placebo-controlled, multicentre study of the safety and efficacy of BIOBYPASS (AdGVVEGF121.10NH) gene therapy in patients with refractory advanced coronary artery disease: the NOVA trial

(2011) Jens Kastrup et al.   EuroIntervention

Selective targeting of adenovirus to αvβ3 integrins, VEGFR2 and Tie2 endothelial receptors by angio-adenobodies

(2010) Hidde J. Haisma et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Substitution of Adenovirus Serotype 3 Hexon onto a Serotype 5 Oncolytic Adenovirus Reduces Factor X Binding, Decreases Liver Tropism, and Improves Antitumor Efficacy

(2010) J. J. Short et al.   MOLECULAR CANCER THERAPEUTICS

Transcriptional targeting of tumor endothelial cells for gene therapy

(2009) Zhihong Dong et al.   ADVANCED DRUG DELIVERY REVIEWS

Use of in vivo phage display to engineer novel adenoviruses for targeted delivery to the cardiac vasculature

(2009) Campbell G. Nicol et al.   FEBS LETTERS

Eight-year safety follow-up of coronary artery disease patients after local intracoronary VEGF gene transfer

(2009) M Hedman et al.   GENE THERAPY

The influence of innate and pre-existing immunity on adenovirus therapy

(2009) Anne K. Zaiss et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Adenovirus Serotype 5 Hexon Mediates Liver Gene Transfer

(2008) Simon N. Waddington et al.   CELL

Targeting neutrophil elastase in cystic fibrosis

(2008) Emer Kelly et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Drug-inducible and simultaneous regulation of endogenous genes by single-chain nuclear receptor-based zinc-finger transcription factor gene switches

(2008) L Magnenat et al.   GENE THERAPY

Cell vehicle targeting strategies

(2008) J C Roth et al.   GENE THERAPY

Endothelial-targeted Gene Transfer of Hypoxia-inducible Factor-1α Augments Ischemic Neovascularization Following Systemic Administration

(2008) Reshef Tal et al.   MOLECULAR THERAPY