Article
Genetics & Heredity
Cuie Wei, Wentao Sun, Changhai Liu, Fanjun Meng, Lele Sun, Xiangsheng Ding
Summary: The study revealed that hsa_circ_0062270 is up-regulated in melanoma and has diagnostic and prognostic potentials. Inhibition of hsa_circ_0062270 can attenuate the malignant functions of melanoma cells and stabilize the expression of CDC45.
FRONTIERS IN GENETICS
(2022)
Review
Biochemistry & Molecular Biology
Sana Hibino, Tetsuro Kawazoe, Hidenori Kasahara, Shinji Itoh, Takatsugu Ishimoto, Mamiko Sakata-Yanagimoto, Koji Taniguchi
Summary: Inflammation plays a pivotal role in tumorigenesis and metastasis by suppressing anti-tumor immunity. Different types of tumors may have diverse responses to inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Michael Rangel, Jerry Kong, Vrushank Bhatt, Khoosheh Khayati, Jessie Yanxiang Guo
Summary: Autophagy is a crucial cellular process that degrades waste and recycles nutrients to maintain cellular homeostasis. In cancer, upregulated autophagy supports tumor growth and survival through various mechanisms, making it a potential target for novel cancer treatments.
Review
Biochemistry & Molecular Biology
Fabrice Tolle, Viktor Umansky, Jochen Utikal, Stephanie Kreis, Sabrina Brechard
Summary: Neutrophils, once underestimated in cancer research, now are recognized for their dual roles in tumorigenesis. While they can promote tumor progression, they also possess anti-tumorigenic properties, highlighting the importance of understanding their functions for developing effective therapeutic strategies in cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Shailendra Kumar Gangwar, Aviral Kumar, Sandra Jose, Mohammed S. Alqahtani, Mohamed Abbas, Gautam Sethi, Ajaikumar B. Kunnumakkara
Summary: Oral cancer is a global concern and targeting nuclear receptors could be a potential strategy for the prevention and treatment of oral malignancies.
Article
Immunology
Mei-Ling Dong, Xu Wen, Xin He, Ji-Hua Ren, Hai-Bo Yu, Yi-Ping Qin, Zhen Yang, Min-Li Yang, Chong-Yang Zhou, Hui Zhang, Sheng-Tao Cheng, Juan Chen
Summary: The study found that DDX17 plays an important role in the replication of HBV and the metastasis of HBV-related HCC. By promoting HBV replication and transcription as well as HBx-mediated HCC metastasis, DDX17 has a promotive effect on the development of HBV and HCC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ahlem Jebali, Maxime Battistella, Celeste Lebbe, Nicolas Dumaz
Summary: The network involving PI3K, AKT, and mTOR is important in melanoma oncogenesis, with RICTOR overexpression associated with poor prognosis. RICTOR enhances melanoma-initiating cells with stemness properties and contributes to resistance to BRAF inhibitors. An interaction between RICTOR and STAT3 in resistant cells, as well as a connection between RAS and RICTOR in resistant melanoma, were identified, suggesting RICTOR as a valuable therapeutic target in melanoma.
Article
Oncology
Tobias Schatton, Yuta Itoh, Christina Martins, Erik Rasbach, Praveen Singh, Mariana Silva, Kyla Mucciarone, Markus V. Heppt, Jenna Geddes-Sweeney, Kate Stewart, Anne Brandenburg, Jennifer Liang, Charles J. Dimitroff, Martin C. Mihm, Jennifer Landsberg, Christoph Schlapbach, Christine G. Lian, George F. Murphy, Thomas S. Kupper, Matthew R. Ramsey, Steven R. Barthel
Summary: Tim-3 is an intrinsic growth-suppressive receptor in melanoma cells, and blocking it may promote MAPK-dependent tumorigenesis, counteracting the antitumor activity of T-cell-directed Tim-3 inhibition.
Article
Medicine, Research & Experimental
Liantao Guo, Faminzi Li, Hanqing Liu, Deguang Kong, Chuang Chen, Shengrong Sun
Summary: Our study investigates the role and mechanism of SIX1 upregulation in breast cancer carcinogenesis. We found that SIX1 expression varies among different subtypes of breast cancer and that it upregulates breast cancer grading and lymph node metastasis. Additionally, SIX1 participates in the rewiring of several cancer signaling pathways and interacts with cancer stem cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Dermatology
Michael J. Bernhardt, Aaron J. Bernhardt
Summary: This review discusses the tumorigenesis and metastatic capabilities of melanoma, highlighting the importance of clinicians staying informed about the latest research advances to assist in early diagnosis.
JOURNAL OF DRUGS IN DERMATOLOGY
(2022)
Review
Oncology
Jian Li
Summary: Claudin proteins play crucial roles in maintaining tissue integrity and human health, and are associated with signal transduction and tumorigenesis. Their diverse roles in tumor biology make them potential targets for treatment or biomarkers for cancer diagnosis and prognosis. Factors such as organ type, environmental context, and genetic confounders need to be considered when studying the biological functions and targeting of claudins in cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Lianghui Zhi, Lianmei Zhao, Xue Zhang, Wei Liu, Bo Gao, Feifei Wang, Xiaoran Wang, Guiying Wang
Summary: SLCO1B3, a gene encoding OATP1B3, is associated with poor overall survival in CRC patients and influences tumor differentiation, disease stage, invasion, metastasis, and DNA repair through the regulation of various associated genes. Inhibition of SLCO1B3 may provide therapeutic benefits in CRC treatment.
Article
Biochemistry & Molecular Biology
Scott Gross, Robert Hooper, Dhanendra Tomar, Alexander P. Armstead, No'ad Shanas, Pranava Mallu, Hinal Joshi, Suravi Ray, Parkson Lee-Gau Chong, Igor Astsaturov, Jeffrey M. Farma, Kathy Q. Cai, Kumaraswamy Naidu Chitrala, John W. Elrod, M. Raza Zaidi, Jonathan Soboloff
Summary: The study reveals the critical role of store-operated Ca2+ entry (SOCE) suppression in melanoma metastasis. UV-induced cholesterol biosynthesis is crucial for the suppression of SOCE and subsequent metastasis. Functional analyses show that increased glucose uptake leads to metabolic shifts critical for melanoma metastasis.
Review
Oncology
Jahangir Alam, Md Nazmul Huda, Alan J. Tackett, Sayem Miah
Summary: Signaling pathways play critical roles in executing and controlling important biological processes within cells. Dysregulation of signaling pathways can modulate chromatin modifications, thereby contributing to tumorigenesis and metastasis. Understanding the role of these pathways in disease pathogenesis is crucial for developing targeted therapies.
CANCER AND METASTASIS REVIEWS
(2023)
Review
Immunology
Lushan Peng, Dan Wang, Yingying Han, Tao Huang, Xiaoyun He, Junpu Wang, Chunlin Ou
Summary: CAF-derived exosomes play a crucial role in tumorigenesis, tumor progression, and clinical characteristics of cancer patients, and have the potential to serve as diagnostic biomarkers and therapeutic targets in human cancers.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Marijn A. Scheijde-Vermeulen, Lennart A. Kester, Liset Westera, Bastiaan B. J. Tops, Friederike A. G. Meyer-Wentrup
Summary: This study aimed to evaluate the feasibility of integrating state-of-the-art sequencing techniques and flow cytometry into the diagnostic workup of pediatric lymphoma. The results showed that this integration is not only feasible but also provides additional diagnostic information.
LABORATORY INVESTIGATION
(2024)
Article
Medicine, Research & Experimental
Enrico Berrino, Sara Erika Bellomo, Anita Chesta, Paolo Detillo, Alberto Bragoni, Amedeo Gagliardi, Alessio Naccarati, Matteo Cereda, Gianluca Witel, Anna Sapino, Benedetta Bussolati, Gianni Bussolati, Caterina Marchi
Summary: Formalin-fixed paraffin-embedded (FFPE) samples are crucial for tissue-based analysis in precision medicine, but the quality of these samples can affect the reliability of sequencing data. The use of acid-deprived fixatives guarantees the highest DNA preservation and sequencing performance, enabling more complex molecular profiling of tissue samples.
LABORATORY INVESTIGATION
(2024)
Article
Medicine, Research & Experimental
Roope A. Kallionpaa, Sirkku Peltonen, Kim My Le, Eija Martikkala, Mira Jaaskelainen, Elnaz Fazeli, Pilvi Riihila, Pekka Haapaniemi, Anne Rokka, Marko Salmi, Ilmo Leivo, Juha Peltonen
Summary: This study investigated the immune microenvironment of cutaneous neurofibromas (cNFs) in patients with neurofibromatosis 1 (NF1). The results showed that cNFs have substantial populations of T cells and macrophages, which may be tumor-specific. T cell populations in cNFs were found to be different from those in the skin, and cNFs exhibited lower expression of proteins related to T cell-mediated immunity compared to the skin.
LABORATORY INVESTIGATION
(2024)