Article
Cell Biology
Lijie Yao, Liqing Xu, Lijuan Zhou, Shuizhen Wu, Weihao Zou, Min Chen, Jiating Chen, Hongjuan Peng
Summary: Toxoplasma gondii evades host innate immune responses by promoting the degradation of TRIM21 through interacting with its virulence factor ROP18, TRIM21 plays a significant role in combating T. gondii infection, and its function can modulate parasitophorous vacuole membrane acidification through ubiquitin labeling, affecting the parasite's growth.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Parasitology
Guanghao Guo, Jianmin Cui, Lindong Song, Lvqing Tang, Sijie Fan, Bang Shen, Rui Fang, Min Hu, Junlong Zhao, Yanqin Zhou
Summary: This study found that the newly identified type 1 Toxoplasma strain T.gHB1 can activate the host NF-kappa B signaling pathway, unlike the classical type 1 strain RH. T.gHB1 strain has a unique GRA15 protein structure that activates NF-kappa B signaling by inducing phosphorylation of I kappa B alpha and nuclear translocation of p65.
PARASITES & VECTORS
(2022)
Article
Plant Sciences
Yu Nan Lu, Xin Yu Shen, Jing Mei Lu, Guang Nan Jin, Hui Wen Lan, Xiang Xu, Lian Xun Piao
Summary: This study demonstrates the inhibitory effects of resveratrol (RSV) on the proliferation of Toxoplasma gondii and T.g.HSP70 expression, as well as the amelioration of lung injury caused by T. gondii infection through the intervention of T.g.HSP70 and HMGB1-mediated TLR4/NF-kappa B signaling pathway activation.
Article
Immunology
Zhiyan Zhou, Ranhui Xi, Jiaxin Liu, Xian Peng, Lei Zhao, Xuedong Zhou, Jiyao Li, Xin Zheng, Xin Xu
Summary: The study identified multiple subtypes of taste receptors in human gingival fibroblasts and highlighted TAS2R16's role in inhibiting pro-inflammatory responses by regulating NF-kappa B signaling. This provides a new target and paradigm for the treatment of periodontitis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
LuLu Qian, Jun-Zhao Li, XueMei Sun, Jie-Bin Chen, Ying Dai, Qiu-Xiang Huang, Ying-Ji Jin, Qing-Ning Duan
Summary: The study demonstrates that safinamide can inhibit the production of pro-inflammatory cytokines by macrophages, reduce the release of inflammatory mediators, prevent leukocyte migration, and decrease the generation of related enzymes. These effects are mainly achieved through safinamide's inhibition of the TLR4/NF-kappa B signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Environmental Sciences
John D. Hansen, Keith A. Loftin, Zachary Laughrey, Ondrej Adamovsky
Summary: Various stressors can have profound impacts on immunity to pathogens, with little research into the effects of cyanobacterial toxins on disease resistance in mammals. Recent studies suggest that freshwater cyanotoxins may alter disease susceptibility parameters for fish, wildlife, and human health through interaction with specific components of innate immunity. However, the results of this study indicate that the tested toxins did not directly interact with key pathogen recognition receptors for innate immunity in humans.
Article
Immunology
Pin Wan, Ge Yang, Simeng Zhang, Yaru Zhang, Yaling Jia, Xu Che, Zhen Luo, Pan Pan, Geng Li, Xulin Chen, Qiwei Zhang, Wen Zhang, Qiuping Tan, Yongkui Li, Jianguo Wu
Summary: This study demonstrates that ASB17 enhances inflammation by interacting with TRAF6 to maintain TRAF6 protein stability, thus promoting LPS-induced NF-κB signal activation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jing-Mei Lu, Guang-Nan Jin, Yu-Nan Lu, Xu-Dong Zhao, Hui-Wen Lan, Shuai-Ru Mu, Xin-Yu Shen, Guang-Hua Xu, Cheng-Hua Jin, Juan Ma, Xuejun Jin, Xiang Xu, Lian-Xun Piao
Summary: The study demonstrates that resveratrol can protect liver injury induced by T. gondii infection by intervening in the HMGB1/TLR4/NF-kappa B signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Immunology
Attinder Chadha, Kris Chadee
Summary: Protozoan parasites evade host defenses by hijacking host cellular signaling pathways and transcription factors, with the NF-kappa B pathway being a key target. These parasites manipulate the NF-kappa B pathway to thwart immune responses and ensure survival in the host.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Li Yin, Xiaomin Wei, Yanjun Zhang, Chengshu Lu, Huakun Wang
Summary: The aim of this study was to investigate the effect of citrulline on the pyroptosis of mouse macrophage RAW264.7 and the mechanism. The results showed that citrulline promoted cell viability and inhibited LPS-induced pyroptosis of RAW264.7 cells. Furthermore, citrulline inactivated the NF-κB/p65 signaling pathway by suppressing p65 nuclear translocation induced by LPS. Therefore, the inhibition of pyroptosis induced by citrulline may be closely related to the inactivation of the NF-κB/p65 signaling pathway.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Cell Biology
Qiushi Qin, Rui Li, Lan Li, Yue Zhang, Shuwei Deng, Liuluan Zhu
Summary: This study reveals that Blimp-1 regulates the production of multiple pro-inflammatory cytokines by controlling nuclear translocation and transcriptional activity. This finding may offer potential therapeutic strategies for cytokine storm-related diseases.
INFLAMMATION RESEARCH
(2023)
Article
Medicine, Research & Experimental
Xiaoyu Zhang, Yuan Kang, Ximeng Li, Yunfeng Huang, Ruijuan Qi, Yixin Han, Runlan Cai, Yuan Gao, Yun Qi
Summary: Potentilla discolor Bunge (PD) is a traditional Chinese medicine with strong anti-inflammatory effects by suppressing the expressions of iNOS, TNF-α, and MCP-1, as well as inhibiting the activation of NF-kappa B and AP-1. The ethanol extract of the whole herbs of PD (EPD) shows promising therapeutic potential for inflammatory diseases, especially intestinal inflammation, through its ability to modulate inflammatory mediators and signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Domenico Somma, Fatma O. Kok, David Kerrigan, Christine A. Wells, Ruaidhri J. Carmody
Summary: NF-kappa B is a crucial regulator of immune response, playing important roles in immune development, inflammation, and disease. Loss of function mutations in the NFKB1 gene are the most common monogenic cause of common variable immunodeficiencies in Europeans. By using CRISPR/Cas9 gene editing, researchers have generated a model of NFKB1(-/-) human macrophages, which exhibit pro-inflammatory characteristics and reduced expression of co-stimulatory factors important for adaptive immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Psychiatry
Qichao Gong, Weifen Li, Tahir Ali, Yue Hu, Shengnan Mou, Zizhen Liu, Chengyou Zheng, Ruyan Gao, Axiang Li, Tao Li, Ningning Li, Zhijian Yu, Shupeng Li
Summary: Translational defects are a common feature of neurological disorders, and they may lead to depressive symptoms through synaptic protein dysregulation. This study explores the interplay between eIF4E and TrkB/BDNF signaling in the presence of neuroinflammation and uncovers their significance in regulating depressive behaviors.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Zhanqi Zhang, Yiwen Zhang, Yongjie Cai, Di Li, Jinlin He, Zhihui Feng, Qiong Xu
Summary: Periodontitis is a chronic inflammatory disease caused by bacterial pathogens and the immune response. Macrophages play a crucial role in the development of periodontitis. NAT10 was found to be downregulated in macrophages during LPS-induced inflammation. Knockdown of NAT10 reduced the production of inflammatory factors, while overexpression of NAT10 had the opposite effect.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)